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Cited by 322Autism Spectrum Disorder ResearchNeuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.

Density and Distribution of Hippocampal Neurotransmitter Receptors in Autism: An Autoradiographic Study

Blatt, Gene J., Fitzgerald, Claudia M., Guptill, Jeffrey T., Booker, Anne B., Kemper, Thomas L., Bauman, Margaret L.·2001·Journal of Autism and Developmental Disorders
DOI 10.1023/a:1013238809666
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Abstract

Neuropathological studies in autistic brains have shown small neuronal size and increased cell packing density in a variety of limbic system structures including the hippocampus, a change consistent with curtailment of normal development. Based on these observations in the hippocampus, a series of quantitative receptor autoradiographic studies were undertaken to determine the density and distribution of eight types of neurotransmitter receptors from four neurotransmitter systems (GABAergic, serotoninergic [5-HT], cholinergic, and glutamatergic). Data from these single concentration ligand binding studies indicate that the GABAergic receptor system (3[H]-flunitrazepam labeled benzodiazepine binding sites and 3[H]-muscimol labeled GABA(A) receptors) is significantly reduced in high binding regions, marking for the first time an abnormality in the GABA system in autism. In contrast, the density and distribution of the other six receptors studied (3[H]-80H-DPAT labeled 5-HT1A receptors, 3[H]-ketanserin labeled 5-HT2 receptors, 3[H]-pirenzepine labled M1 receptors, 3[H]-hemicholinium labeled high affinity choline uptake sites, 3[H]-MK801 labeled NMDA receptors, and 3[H]-kainate labeled kainate receptors) in the hippocampus did not demonstrate any statistically significant differences in binding.

Overview

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Crossref · 10.1023/a:1013238809666

Cites

32 of 32 references verified0 citation errors · 0 not checkable

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  • Reduced GABAA and GABAB receptor density and system activity have been reported in the brains of autistic patients.

    “Additionally, other studies have reported reduced GABAA [129, 130] and GABAB [124, 130] receptor density and system activity in the brains of autistic patients.”

    From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [129]

Citations

Cites

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1 of the 33 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

  1. Arin, D. M., Bauman, M. L., & Kemper, T. L. (1991). The distribution of Purkinje cell loss in the cerebellum in autism. Neurology, 41, 307.
  2. Bauman, M. L., & Kemper, T. L. (1994). Neuroanatomic observations of the brain in autism. In Bauman, M. L., & Kemper, T. L. (eds.), The Neurobiology of Autism. (pp. 119–145), Baltimore: Johns Hopkins University Press.
  3. Kemper, T. L., & Bauman, M. L. (1992). Neuropathology of infantile autism. In N. Naruse & E. M. Ornitz (Eds.), Neurobiology of Infantile Autism (pp. 43–57), Amsterdam: Elsevier.
  4. Mohler, H., Benke, D., Fritschy, J. M., & Benson, J. (2000). The benzodiazepine site of GABAA receptors. In GABA in the Nervous System: The View at Fifty Years, (pp. 97–112), Martin, D. L. & Olsen, R. W. (Eds.), Philadelphia: Lippincott Williams and Wilkens.
  5. Whiting, P. J., Wafford, K. A., & McKernan, R. M. (2000). Pharmacologic subtypes of GABAA receptors based on subunit composition. In GABA in the Nervous System: The View at Fifty Years, (pp. 113–126), Martin, D. L., & Olsen, R. W. (Eds.), Philadelphia: Lippincott Williams and Wilkens.

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Metadata

Authors
Blatt, G. J., Fitzgerald, C. M., Guptill, J. T., Booker, A. B., Kemper, T. L., & Bauman, M. L.
Affiliations
Boston University (US)
Corresponding author
Blatt, Gene J.
ORCID
Venue
Journal of Autism and Developmental Disorders
Publisher
Springer Science and Business Media LLC
Published
2001-12
Volume
31
Issue
6
Pages
537-543
ISSN
  • 0162-3257 (ISSN-L)
  • 1573-3432
DOI
10.1023/a:1013238809666
OpenAlex
W1488489801
Cited by
322
References
33
Citations by year
2026: 5 · 2025: 1 · 2024: 1 · 2023: 14 · 2022: 16 · 2021: 12 · 2020: 14 · 2019: 7 · 2018: 12 · 2017: 11 · 2016: 17 · 2015: 18 · 2014: 22 · 2013: 15 · 2012: 23
FWCI
3.49
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Autism and Developmental Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, hippocampus, neurotransmitter receptors, receptor density, GABAergic system, benzodiazepine binding site, GABAA receptor, serotonin receptors, 5-HT1A receptor, 5-HT2 receptor, M1 muscarinic receptor, NMDA receptor, kainate receptors, limbic system
MeSH terms
Adolescent, Adult, Autistic Disorder, Autoradiography, Binding Sites, Cell Count, Flunitrazepam, Hippocampus, Humans, Male, Muscimol, Receptors, Neurotransmitter, Receptors, GABA, GABA Modulators, Culture Techniques

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