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Cited by 316Wound Healing and TreatmentsSkin Protection and AgingDermatologic Treatments and Research

The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.

Ageing and wound healing

Ashcroft, Gillian S., Mills, Stuart J., Ashworth, Jason J.·2002·Biogerontology
DOI 10.1023/a:1021399228395
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Abstract

Cutaneous wound healing is a complex process encompassing a number of overlapping events including leukocyte recruitment, matrix deposition, epithelialization, and ultimately resolution of inflammation with the formation of a mature scar. Morbidity associated with age-related delayed wound healing imposes an enormous social and financial burden; unless improved wound care strategies are developed the projected relative and absolute increase in the elderly population will further exacerbate this problem. In recent years insight has been gained into the impact of ageing on cellular and tissue responses, resulting from impaired cytokine signal transduction, unchecked inflammation, an altered balance of protein synthesis and degradation, and subsequent downstream effects on the rate and quality of the wound healing response. Further understanding of the complex interaction between the ageing cell and its microenvironment is essential in order to develop focussed therapeutic strategies to improve healing in the elderly.

Overview

Integrity signals

Registry

Crossref · 10.1023/a:1021399228395

Cites

78 of 78 references verified0 citation errors · 0 not checkable

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Verification

Claims the paper makes

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Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In the hemostasis phase, platelet aggregation and degranulation are enhanced in the elderly.

    “In the hemostasis phase, aggregation and degranulation of platelets are enhanced in the elderly [263].”

    From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [263]

  • Phagocytic activity of wound macrophages in aged mice is decreased compared with young mice.

    “Moreover, the phagocytic activity of wound macrophages in aged mice is decreased compared with young mice, which may account for increased production of proinflammatory cytokines, including IL-1, IL-6, TNF-α, but decreased secretion of VEGF [74, 263, 265].”

    From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [263]

Citations

Cites

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Research works printed but not linked: 3

  1. Compton CC (1993) Wound healing potential of cultured epithelium. Wounds Compend Skin Res Pract 5: 97-111
  2. Katsuda S, Okada Y, Okada Y, Imai K and Nakanishi I (1994) matrix metalloproteinase-9 can degrade arterial elastin. Am J Pathol 145: 1208-1218
  3. Pieraggi MJ, Bouissou H, Angelier C, Uhart D, Magnol J and Kokolo J (1985) Le fibroblaste. Ann Path 5: 65-76

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Metadata

Authors
Ashcroft, G. S., Mills, S. J., & Ashworth, J. J.
Affiliations
University of Manchester (GB)
Corresponding author
Ashcroft, Gillian S.
ORCID
Mills, Stuart J.
Venue
Biogerontology
Publisher
Springer Science and Business Media LLC
Published
2002-11
Volume
3
Issue
6
Pages
337-345
ISSN
  • 1389-5729 (ISSN-L)
  • 1573-6768
DOI
10.1023/a:1021399228395
OpenAlex
W1530924711
Cited by
309
References
78
Citations by year
2026: 13 · 2025: 20 · 2024: 17 · 2023: 16 · 2022: 14 · 2021: 15 · 2020: 15 · 2019: 19 · 2018: 14 · 2017: 8 · 2016: 8 · 2015: 14 · 2014: 15 · 2013: 11 · 2012: 4
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biogerontology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords
aging, skin wound healing, delayed wound healing, older adults, cytokine signaling, chronic inflammation, protein synthesis and degradation, re-epithelialization, scar formation, wound care, cell microenvironment
MeSH terms
Aging, Extracellular Matrix, Humans, Inflammation, Wound Healing, Neovascularization, Physiologic

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