Cited by 210Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMemory and Neural MechanismsPosttraumatic Stress Disorder Research

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Fear conditioning in panic disorder: Enhanced resistance to extinction

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Michael, Tanja, Blechert, Jens, Vriends, Noortje, Margraf, Jürgen, Wilhelm, Frank H.·2007·Journal of Abnormal Psychology

DOI 10.1037/0021-843x.116.3.612

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Abstract

Enhanced conditionability has been proposed as a crucial factor in the etiology and maintenance of panic disorder (PD). To test this assumption, the authors of the current study examined the acquisition and extinction of conditioned responses to aversive stimuli in PD. Thirty-nine PD patients and 33 healthy control participants took part in a differential aversive conditioning experiment. A highly annoying but not painful electrical stimulus served as the unconditioned stimulus (US), and two neutral pictures were used as either the paired conditioned stimulus (CS+) or the unpaired conditioned stimulus (CS-). Results indicate that PD patients do not show larger conditioned responses during acquisition than control participants. However, in contrast to control participants, PD patients exhibited larger skin conductance responses to CS+ stimuli during extinction and maintained a more negative evaluation of them, as indicated by valence ratings obtained several times throughout the experiment. This suggests that PD patients show enhanced conditionability with respect to extinction.

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Authors: Michael, T., Blechert, J., Vriends, N., Margraf, J., & Wilhelm, F. H.
Affiliations: University of Basel (CH)
ORCID: Michael, Tanja
Blechert, Jens
Margraf, Jürgen
Wilhelm, Frank H.
Venue: Journal of Abnormal Psychology
Publisher: American Psychological Association (APA)
Published: 2007-08
Volume: 116
Issue: 3
Pages: 612-617
ISSN: 0021-843X (ISSN-L)
1939-1846
DOI: 10.1037/0021-843x.116.3.612
OpenAlex: W2027993054
Cited by: 210
References: 40
Citations by year: 2026: 3 · 2025: 1 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 10 · 2020: 12 · 2019: 9 · 2018: 12 · 2017: 9 · 2016: 20 · 2015: 15 · 2014: 29 · 2013: 20 · 2012: 13
FWCI: 11.94
Type: journal article
Language: en
Open access: green
doi.org
Locations: Journal of Abnormal Psychology (publishedVersion)
PubMed (publishedVersion)
edoc (University of Basel) (acceptedVersion)
edoc (University of Basel)
Funders: Swiss National Science Foundation (105311-104038; 105311-105850)
Freiwillige Akademische Gesellschaft Basel
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords: panic disorder, fear conditioning, extinction, conditioned response acquisition, skin conductance response, aversive stimuli, stimulus valence, differential conditioning
MeSH terms: Adolescent, Adult, Aged, Attitude, Conditioning, Classical, Extinction, Psychological, Fear, Female, Humans, Male, Middle Aged, Panic Disorder

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Fear conditioning in panic disorder: Enhanced resistance to extinction

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