Psychiatric outcomes following severe deprivation in early childhood: Follow-up of a randomized controlled trial at age 16.
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OBJECTIVE: Early psychosocial deprivation is associated with increased risk for psychopathology, yet few studies have examined outcomes in adolescents. METHOD: At baseline (M age 22 months), 136 children from Bucharest, Romania, living in large institutions, were randomized into foster care (FCG) or to care as usual (CAUG). Caregivers completed psychiatric interviews regarding their children (52 FCG; 51 CAUG) at age 16 years (M = 16.67 years; SD = 0.78) to assess past year diagnoses and symptom counts. In addition, never-institutionalized community comparison children (n = 47) were included. RESULTS: Ever-institutionalized children had higher rates of meeting criteria for any psychiatric disorder and higher symptom counts of internalizing, externalizing, attention-deficit/hyperactivity, and substance use disorders compared to never-institutionalized children (ps < .05). Using intent-to-treat analyses, we found that children in the CAUG had more than twice the rate of psychiatric disorders than children in the FCG (OR = 2.48, 95% CI [1.12, 5.48]). Furthermore, children in foster care who remained in their original placement did not significantly differ in their rates of psychiatric disorders compared to never-institutionalized children. CONCLUSIONS: There are many ways children can be separated from parents, including placement into institutional care. The current findings indicate that such placements are associated with significant risks for psychopathology. Moreover, we provide causal evidence for the long-lasting positive effect of foster care in reducing the risk of psychopathology in adolescence, especially among those in stable placements. These results provide strong evidence that early and stable placements into quality foster care may mitigate risk for psychopathology following severe early psychosocial deprivation. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
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Foster care intervention was linked to fewer internalizing symptoms during childhood and adolescence, particularly among girls.
“foster care intervention was linked to fewer internalizing symptoms during childhood and adolescence, particularly among girls (Bick et al., 2015;Humphreys et al., 2020;King et al., 2023;McLaughlin et al., 2012).”
From Resilience following severe early life neglect: A review of longitudinal evidence from the Bucharest Early Intervention Project (2026) · cites this paper as Humphreys et al., 2020
The Results (Disorder Rates by Intent-to-Treat Grouping; page unavailable) report fewer internalizing disorders in the foster-care group at age 16. The paper describes earlier benefits as shifting from internalizing to externalizing disorders across development, so it does not establish fewer internalizing symptoms throughout childhood and adolescence. The Results (Analyses by Sex; page unavailable) say the intervention effect on any psychiatric disorder was similar in magnitude for boys and girls, although statistically significant only for girls; they do not establish a stronger effect on girls’ internalizing symptoms. (LLM, conf=0.88)
Experimental — accuracy not yet measuredFoster care intervention was associated with weak improvements in internalizing symptoms for boys and strong improvements for girls.
“Strong improvements in attachment disorder symptoms; moderate improvements in externalizing symptoms and adaptive functioning; weak improvements in internalizing symptoms for boys (strong for girls)”
From Resilience following severe early life neglect: A review of longitudinal evidence from the Bucharest Early Intervention Project (2026) · cites this paper as Humphreys et al., 2020
The Results (Disorder Rates by Intent-to-Treat Grouping; page unavailable) report fewer internalizing disorders in the foster-care group. But the Results (Analyses by Sex; page unavailable) say the intervention effect on any psychiatric disorder was similar in magnitude for boys and girls, though statistically significant only for girls. That does not establish weak improvement in boys versus strong improvement in girls specifically for internalizing symptoms. (LLM, conf=0.86)
Experimental — accuracy not yet measuredWithin the FCG, more stable caregiving placements have been associated with improved mental health outcomes during adolescence.
“Within the FCG, more stable caregiving placements have been associated with improved mental health outcomes during adolescence (Humphreys et al., 2020)”
From Resilience following severe early life neglect: A review of longitudinal evidence from the Bucharest Early Intervention Project (2026) · cites this paper as Humphreys et al., 2020
Within the FCG, more stable caregiving environments during childhood have been associated with better mental health outcomes in adolescence.
“within the FCG, more stable caregiving environments during childhood have been associated with better mental health outcomes in adolescence (Humphreys et al., 2020)”
From Resilience following severe early life neglect: A review of longitudinal evidence from the Bucharest Early Intervention Project (2026) · cites this paper as Humphreys et al., 2020
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- Authors
- Humphreys, K. L., Guyon-Harris, K. L., Tibu, F., Wade, M., Nelson, C. A., Fox, N. A., & Zeanah, C. H.
- Affiliations
- Vanderbilt University (US)
- Ştefan cel Mare University of Suceava (RO)
- University of Toronto (CA)
- Boston Children's Hospital (US)
- University of Maryland, College Park (US)
- Tulane University (US)
- ORCID
- Venue
- Journal of Consulting and Clinical Psychology
- Published
- 2020-12
- Volume
- 88
- Issue
- 12
- Pages
- 1079-1090
- ISSN
- 0022-006X (ISSN-L)
- 1939-2117
- PMC
- PMC7909607
- OpenAlex
- W3113867032
- Cited by
- 26
- References
- 47
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 2
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Consulting and Clinical Psychology (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (MH091363)
- John D. and Catherine T. MacArthur Foundation
- Jacobs Foundation (2017-1261-05)
- Sponsor name not included (T32HP22240)
- ERA-Net Neuron (UEFISCDI 102/2019)
- Topics
- Social Sciences › Safety Research › Child Welfare and Adoption
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- early childhood deprivation, institutional care, foster care, psychopathology, mental illness, internalizing disorders, externalizing disorders, attention deficit hyperactivity disorder, substance use disorders, child mental health, long-term outcomes
- MeSH terms
- Adolescent, Mental Disorders, Child, Institutionalized, Female, Follow-Up Studies, Foster Home Care, Humans, Male, Psychopathology, Psychosocial Deprivation, Romania
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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