Memory in monkeys severely impaired by combined but not by separate removal of amygdala and hippocampus

MISHKIN, MORTIMER·1978·Nature

DOI 10.1038/273297a0

Open this paper in CoChat — free account

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/273297a0

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Place navigation impaired in rats with hippocampal lesions
Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
The Medial Temporal Lobe Memory System
Squire, L. R., & Zola-Morgan, S. (1991) · Science · doi:10.1126/science.1896849 · Cited by 3,282
The Medial Temporal Lobe and Recognition Memory
Eichenbaum, H., Yonelinas, A. P., & Ranganath, C. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094328 · Cited by 2,580
Hippocampus, space, and memory
Olton, D. S., Becker, J. T., & Handelmann, G. E. (1979) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00062713 · Cited by 2,018
Episodic memory, amnesia, and the hippocampal–anterior thalamic axis
Aggleton, J. P., & Brown, M. W. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99002034 · Cited by 1,879
The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543
Computational analysis of the role of the hippocampus in memory
Treves, A., & Rolls, E. T. (1994) · Hippocampus · doi:10.1002/hipo.450040319 · Cited by 1,272
New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: The striatopallidal, amygdaloid, and corticopetal components of substantia innominata
Alheid, G. F., & Heimer, L. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90217-5 · Cited by 1,217
Amygdalo‐cortical projections in the monkey ( Macaca fascicularis )
Amaral, D. G., & Price, J. L. (1984) · Journal of Comparative Neurology · doi:10.1002/cne.902300402 · Cited by 1,162
The acute effects of corticosteroids on cognition: integration of animal and human model studies
LUPIEN, S., & MCEWEN, B. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00004-0 · Cited by 1,024
Distant influences of amygdala lesion on visual cortical activation during emotional face processing
Vuilleumier, P., Richardson, M. P., Armony, J. L., Driver, J., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1341 · Cited by 955
Critical role of the hippocampus in memory for sequences of events
Fortin, N. J., Agster, K. L., & Eichenbaum, H. B. (2002) · Nature Neuroscience · doi:10.1038/nn834 · Cited by 881
Analysis of the elements of attention: A neuropsychological approach
Mirsky, A. F., Anthony, B. J., Duncan, C. C., Ahearn, M. B., & Kellam, S. G. (1991) · Neuropsychology Review · doi:10.1007/bf01109051 · Cited by 874
On Neurodegenerative Diseases, Models, and Treatment Strategies: Lessons Learned and Lessons Forgotten a Generation Following the Cholinergic Hypothesis
Bartus, R. T. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7397 · Cited by 829
The Cognitive Neuroscience of Human Memory Since H.M.
Squire, L. R., & Wixted, J. T. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113720 · Cited by 749
Involvement of the amygdala in stimulus-reward associations: interaction with the ventral striatum
Cador, M., Robbins, T. W., & Everitt, B. J. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90354-0 · Cited by 652
Remembering the past: two facets of episodic memory explored with positron emission tomography
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.11.1576 · Cited by 593
The Neuropsychology of Human Memory
Squire, L. R. (1982) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.05.030182.001325 · Cited by 574
Associations across time: The hippocampus as a temporary memory store
Rawlins, J. N. P. (1985) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00001291 · Cited by 561
Subcortical efferent projections of the medial geniculate nucleus mediate emotional responses conditioned to acoustic stimuli
LeDoux, J., Sakaguchi, A., & Reis, D. (1984) · The Journal of Neuroscience · doi:10.1523/jneurosci.04-03-00683.1984 · Cited by 532
Region-specific changes in prefrontal function with age: a review of PET and fMRI studies on working and episodic memory
Rajah, M. N., & D'Esposito, M. (2005) · Brain · doi:10.1093/brain/awh608 · Cited by 513
Spatial memory deficits in patients with lesions to the right hippocampus and to the right parahippocampal cortex
Bohbot, V. D., Kalina, M., Stepankova, K., Spackova, N., Petrides, M., & Nadel, L. (1998) · Neuropsychologia · doi:10.1016/s0028-3932(97)00161-9 · Cited by 516
Scene-Specific Memory for Objects: A Model of Episodic Memory Impairment in Monkeys with Fornix Transection
Gaffan, D. (1994) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1994.6.4.305 · Cited by 484
Estrogen Effects on Cognitive and Synaptic Health Over the Lifecourse
Hara, Y., Waters, E. M., McEwen, B. S., & Morrison, J. H. (2015) · Physiological Reviews · doi:10.1152/physrev.00036.2014 · Cited by 470
Concept cells: the building blocks of declarative memory functions
Quiroga, R. Q. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3251 · Cited by 472
A unified framework for the functional organization of the medial temporal lobes and the phenomenology of episodic memory
Ranganath, C. (2010) · Hippocampus · doi:10.1002/hipo.20852 · Cited by 375
Memory for places learned long ago is intact after hippocampal damage
Teng, E., & Squire, L. R. (1999) · Nature · doi:10.1038/23276 · Cited by 372
Towards a functional organization of episodic memory in the medial temporal lobe
Eichenbaum, H., Sauvage, M., Fortin, N., Komorowski, R., & Lipton, P. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.006 · Cited by 354
Conscious and Unconscious Memory Systems
Squire, L. R., & Dede, A. J. O. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021667 · Cited by 366
Severity of memory impairment in monkeys as a function of locus and extent of damage within the medial temporal lobe memory system
Zola‐Morgan, S., Squire, L. R., & Ramus, S. J. (1994) · Hippocampus · doi:10.1002/hipo.450040410 · Cited by 362
Projections from the amygdala to basoventral and mediodorsal prefrontal regions in the rhesus monkey
Barbas, H., & de Olmos, J. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.903000409 · Cited by 324
The Neuropsychology of Memory: Parallel Findings in Humans and Nonhuman Primatesa
ZOLA‐MORGAN, S., & SQUIRE, L. R. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb48905.x · Cited by 318
The thalamus and behavior: Effects of anatomically distinct strokes
Carrera, E., & Bogousslavsky, J. (2006) · Neurology · doi:10.1212/01.wnl.0000219679.95223.4c · Cited by 290
Long-Lasting Novelty-Induced Neuronal Reverberation during Slow-Wave Sleep in Multiple Forebrain Areas
Ribeiro, S., Gervasoni, D., Soares, E. S., Zhou, Y., Lin, S.-C., Pantoja, J., Lavine, M., & Nicolelis, M. A. L. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020024 · Cited by 272
Independence of memory functions and emotional behavior: Separate contributions of the hippocampal formation and the amygdala
Zola‐Morgan, S., Squire, L. R., Clower, R. P., & Alvarez‐Royo, P. (1991) · Hippocampus · doi:10.1002/hipo.450010208 · Cited by 265
Depletion of Perineuronal Nets Enhances Recognition Memory and Long-Term Depression in the Perirhinal Cortex
Romberg, C., Yang, S., Melani, R., Andrews, M. R., Horner, A. E., Spillantini, M. G., Bussey, T. J., Fawcett, J. W., Pizzorusso, T., & Saksida, L. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.6267-11.2013 · Cited by 231
Is the avian hippocampus a functional homologue of the mammalian hippocampus?
Colombo, M., & Broadbent, N. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00016-6 · Cited by 237
Neuronal activity in the hippocampus during delayed non‐match to sample performance in rats: Evidence for hippocampal processing in recognition memory
Otto, T., & Eichenbaum, H. (1992) · Hippocampus · doi:10.1002/hipo.450020310 · Cited by 232
The consolidation of object and context recognition memory involve different regions of the temporal lobe
Balderas, I., Rodriguez-Ortiz, C. J., Salgado-Tonda, P., Chavez-Hurtado, J., McGaugh, J. L., & Bermudez-Rattoni, F. (2008) · Learning & Memory · doi:10.1101/lm.1028008 · Cited by 213
Transient memory impairment in monkeys with bilateral lesions of the entorhinal cortex
Leonard, B., Amaral, D., Squire, L., & Zola-Morgan, S. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05637.1995 · Cited by 174
The cognitive map as a hippocampus
O'Keefe, J., & Nadel, L. (1979) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00064256 · Cited by 125
Functional Neuroanatomy of the Medial Temporal Lobe Memory System
SUZUKI, W., & AMARAL, D. (2004) · Cortex · doi:10.1016/s0010-9452(08)70958-4 · Cited by 111
An analysis of independence and interactions of brain substrates that subserve multiple attributes, memory systems, and underlying processes
Kesner, R. P., & Rogers, J. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.05.007 · Cited by 95
The effects of excitotoxic lesions of the basal forebrain on the acquisition, retention and serial reversal of visual discriminations in marmosets
Roberts, A. C., Robbins, T. W., Everitt, B. J., Jones, G. H., sirkia, T. E., Wilkinson, J., & Page, K. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90142-q · Cited by 93
Analysis of alpha-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys
Arnsten, A. F. T., & Goldman-Rakic, P. S. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90021-q · Cited by 88
What H.M. Taught us
Eichenbaum, H. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00285 · Cited by 87
Altered glucose metabolism in the hippocampal head in memory impairment
Ouchi, Y., Nobezawa, S., Okada, H., Yoshikawa, E., Futatsubashi, M., & Kaneko, M. (1998) · Neurology · doi:10.1212/wnl.51.1.136 · Cited by 85
Brief Report: Recognition Memory and Stimulus-Reward Associations: Indirect Support for the Role of Ventromedial Prefrontal Dysfunction in Autism
Dawson, G., Osterling, J., Rinaldi, J., Carver, L., & McPartland, J. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1010751404865 · Cited by 73
Involvement of hippocampal CAMKII/CREB signaling in the spatial memory retention induced by creatine
Souza, M. A., Magni, D. V., Guerra, G. P., Oliveira, M. S., Furian, A. F., Pereira, L., Marquez, S. V., Ferreira, J., Fighera, M. R., & Royes, L. F. F. (2012) · Amino Acids · doi:10.1007/s00726-012-1329-4 · Cited by 42

Authors: MISHKIN, M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1978-05
Volume: 273
Issue: 5660
Pages: 297-298
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/273297a0
OpenAlex: W2092082847
Cited by: 1,196
References: 0
FWCI: 20.43
Type: journal article
Language: en
Open access: closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review