Cited by 372DNA Repair MechanismsDNA and Nucleic Acid ChemistryGenetic factors in colorectal cancer

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Low fidelity DNA synthesis by human DNA polymerase-η

Matsuda, Toshiro, Bebenek, Katarzyna, Masutani, Chikahide, Hanaoka, Fumio, Kunkel, Thomas A.·2000·Nature

Open this paper in CoChat — free account

Abstract

A superfamily of DNA polymerases that bypass lesions in DNA has been described. Some family members are described as error-prone because mutations that inactivate the polymerase reduce damage-induced mutagenesis. In contrast, mutations in the skin cancer susceptibility gene XPV, which encodes DNA polymerase (pol)-eta, lead to increased ultraviolet-induced mutagenesis. This, and the fact that pol-eta primarily inserts adenines during efficient bypass of thymine-thymine dimers in vitro, has led to the description of pol-eta as error-free. However, here we show that human pol-eta copies undamaged DNA with much lower fidelity than any other template-dependent DNA polymerase studied. Pol-eta lacks an intrinsic proofreading exonuclease activity and, depending on the mismatch, makes one base substitution error for every 18 to 380 nucleotides synthesized. This very low fidelity indicates a relaxed requirement for correct base pairing geometry and indicates that the function of pol-eta may be tightly controlled to prevent potentially mutagenic DNA synthesis.

Integrity signals

Registry

Crossref · 10.1038/35010014

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η
Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., & Hanaoka, F. (1999) · Nature · doi:10.1038/21447 · Cited by 1,292
Self-citation
DNA Replication Fidelity
Kunkel, T. A., & Bebenek, K. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.497 · Cited by 1,003
Self-citation
The accuracy of reverse transcriptase from HIV-1
Roberts, J. D., Bebenek, K., & Kunkel, T. A. (1988) · Science · doi:10.1126/science.2460925 · Cited by 997
Self-citation
Efficient Bypass of a Thymine-Thymine Dimer by Yeast DNA Polymerase, Polη
Johnson, R. E., Prakash, S., & Prakash, L. (1999) · Science · doi:10.1126/science.283.5404.1001 · Cited by 736
hRAD30 Mutations in the Variant Form of Xeroderma Pigmentosum
Johnson, R. E., Kondratick, C. M., Prakash, S., & Prakash, L. (1999) · Science · doi:10.1126/science.285.5425.263 · Cited by 732
Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ
Nelson, J. R., Lawrence, C. W., & Hinkle, D. C. (1996) · Science · doi:10.1126/science.272.5268.1646 · Cited by 660
Xeroderma pigmentosum variant (XP‐V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity
Masutani, C., Araki, M., Yamada, A., Kusumoto, R., Nogimori, T., Maekawa, T., Iwai, S., & Hanaoka, F. (1999) · The EMBO Journal · doi:10.1093/emboj/18.12.3491 · Cited by 434
Self-citation
Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA.
Kim, S.-R., Maenhaut-Michel, G., Yamada, M., Yamamoto, Y., Matsui, K., Sofuni, T., Nohmi, T., & Ohmori, H. (1997) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.94.25.13792 · Cited by 343
Frequency of ultraviolet light-induced mutations is higher in xeroderma pigmentosum variant cells than in normal human cells
MAHER, V. M., OUELLETTE, L. M., CURREN, R. D., & MCCORMICK, J. J. (1976) · Nature · doi:10.1038/261593a0 · Cited by 333
The Saccharomyces cerevisiae RAD30 Gene, a Homologue of Escherichia coli dinB and umuC, Is DNA Damage Inducible and Functions in a Novel Error-Free Postreplication Repair Mechanism
McDonald, J. P., Levine, A. S., & Woodgate, R. (1997) · Genetics · doi:10.1093/genetics/147.4.1557 · Cited by 314

Flagged first, then by citations

Show all 27 references

Research works printed but not linked: 1

Roberts,J. D. & Kunkel,T. A. in DNA Replication in Eukaryotic Cells: Concepts, Enzymes and Systems (ed. Pamphilis, M. D.) 217 –247 (Cold Spring Harbor Laboratory Press, New York, 1996).

Sorted by citations

Items 101–200 of 372

Variations on a theme: Eukaryotic Y-family DNA polymerases
Washington, M. T., Carlson, K. D., Freudenthal, B., & Pryor, J. M. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.07.004 · Cited by 90
Control of Genome Integrity by RFC Complexes; Conductors of PCNA Loading onto and Unloading from Chromatin during DNA Replication
Shiomi, Y., & Nishitani, H. (2017) · Genes · doi:10.3390/genes8020052 · Cited by 87
Complementation of defective translesion synthesis and UV light sensitivity in xeroderma pigmentosum variant cells by human and mouse DNA polymerase
Yamada, A., Masutani, C., Iwai, S., & Hanaoka, F. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.13.2473 · Cited by 88
Self-citation
Preferential Misincorporation of Purine Nucleotides by Human DNA Polymerase η Opposite Benzo[a]pyrene 7,8-Diol 9,10-Epoxide Deoxyguanosine Adducts
Chiapperino, D., Kroth, H., Kramarczuk, I. H., Sayer, J. M., Masutani, C., Hanaoka, F., Jerina, D. M., & Cheh, A. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112139200 · Cited by 87
Self-citation
Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line
Zhang, W., Bardwell, P. D., Woo, C. J., Poltoratsky, V. P., Scharff, M. D., & Martín, A. (2001) · International Immunology · doi:10.1093/intimm/13.9.1175 · Cited by 85
Palm Mutants in DNA Polymerases α and η Alter DNA Replication Fidelity and Translesion Activity
Niimi, A., Limsirichaikul, S., Yoshida, S., Iwai, S., Masutani, C., Hanaoka, F., Kool, E. T., Nishiyama, Y., & Suzuki, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2734-2746.2004 · Cited by 84
Self-citation
Kinetic Mechanism of DNA Polymerases: Contributions of Conformational Dynamics and a Third Divalent Metal Ion
Raper, A. T., Reed, A. J., & Suo, Z. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00685 · Cited by 83
Xeroderma pigmentosum genes: Functions inside and outside DNA repair
Sugasawa, K. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm282 · Cited by 83
Highly Frequent Frameshift DNA Synthesis by Human DNA Polymerase μ
Zhang, Y., Wu, X., Yuan, F., Xie, Z., & Wang, Z. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.23.7995-8006.2001 · Cited by 83
Association between DNA repair-deficiency and high level of p53 mutations in melanoma of Xeroderma pigmentosum.
Spatz, A., Giglia‐Mari, G., Benhamou, S., & Sarasin, A. R. (2001) · PubMed · Cited by 82
Structure-based interpretation of missense mutations in Y-family DNA polymerases and their implications for polymerase function and lesion bypass
Boudsocq, F. (2002) · DNA Repair · doi:10.1016/s1568-7864(02)00019-8 · Cited by 79
Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases
Zhao, L., & Washington, M. T. (2017) · Genes · doi:10.3390/genes8010024 · Cited by 82
Roles of Saccharomyces cerevisiae DNA polymerases Pol and Pol in response to irradiation by simulated sunlight
Kozmin, S. G. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg489 · Cited by 78
Two-step error-prone bypass of the (+)- and (−)-trans-anti-BPDE-N2-dG adducts by human DNA polymerases η and κ
Zhang, Y., Wu, X., Guo, D., Rechkoblit, O., Geacintov, N. E., & Wang, Z. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00249-x · Cited by 78
Mechanism of somatic hypermutation at the WA motif by human DNA polymerase η
Zhao, Y., Gregory, M., Biertümpfel, C., Hua, Y., Hanaoka, F., & Yang, W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303126110 · Cited by 77
Self-citation
Proofreading of DNA Polymerase η-dependent Replication Errors
Bebenek, K., Matsuda, T., Masutani, C., Hanaoka, F., & Kunkel, T. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000690200 · Cited by 76
Self-citation
BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells
Słupianek, A., Nowicki, M. O., Koptyra, M., & Skórski, T. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.10.005 · Cited by 80
Requirement of Watson-Crick Hydrogen Bonding for DNA Synthesis by Yeast DNA Polymerase η
Washington, M. T., Helquist, S. A., Kool, E. T., Prakash, L., & Prakash, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.14.5107-5112.2003 · Cited by 75
What role for AID: mutator, or assembler of the immunoglobulin mutasome?
Reynaud, C., Aoufouchi, S., Faili, A., & Weill, J. (2003) · Nature Immunology · doi:10.1038/ni0703-631 · Cited by 72
Hypermutation in bacteria and other cellular systems
Bridges, B. A. (2001) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0745 · Cited by 71
Mechanistic Comparison of High-Fidelity and Error-Prone DNA Polymerases and Ligases Involved in DNA Repair
Showalter, A. K., Lamarche, B. J., Bakhtina, M., Su, M., Tang, K., & Tsai, M. (2006) · Chemical Reviews · doi:10.1021/cr040487k · Cited by 71
DNA polymerases and somatic hypermutation of immunoglobulin genes
Seki, M., Gearhart, P. J., & Wood, R. D. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400582 · Cited by 71
Accuracy of lesion bypass by yeast and human DNA polymerase η
Washington, M. T., Johnson, R. E., Prakash, L., & Prakash, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121007298 · Cited by 71
The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy
Ahn, S., Ansari, A. A., Kim, J., Kim, D., Chun, S., Kim, J., Kim, T. W., Park, I. J., Yu, C. S., & Jang, S. J. (2016) · Oncotarget · doi:10.18632/oncotarget.11862 · Cited by 72
DNA binding properties of human DNA polymerase η: implications for fidelity and polymerase switching of translesion synthesis
Kusumoto, R., Masutani, C., Shimmyo, S., Iwai, S., & Hanaoka, F. (2004) · Genes to Cells · doi:10.1111/j.1365-2443.2004.00797.x · Cited by 69
Self-citation
APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis
Wörmann, S. M., Zhang, A. X. W., Thege, F. I., Cowan, R. W., Rupani, D. N., Wang, R., Manning, S. L., Gates, C., Wu, W.-S., Levin-Klein, R., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00268-8 · Cited by 69
A Role for DNA Polymerase θ in Promoting Replication through Oxidative DNA Lesion, Thymine Glycol, in Human Cells
Yoon, J.-H., Choudhury, J. R., Park, J., Prakash, S., & Prakash, L. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.556977 · Cited by 68
Streisinger Revisited: DNA Synthesis Errors Mediated by Substrate Misalignments
BEBENEK, K., & KUNKEL, T. A. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.81 · Cited by 65
Self-citation
DNA Polymerases η and θ Function in the Same Genetic Pathway to Generate Mutations at A/T during Somatic Hypermutation of Ig Genes
Masuda, K., Ouchida, R., Hikida, M., Kurosaki, T., Yokoi, M., Masutani, C., Seki, M., Wood, R. D., Hanaoka, F., & Wang, J. O. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611849200 · Cited by 65
Self-citation
Mechanism of Efficient and Accurate Nucleotide Incorporation Opposite 7,8-Dihydro-8-Oxoguanine by Saccharomyces cerevisiae DNA Polymerase η
Carlson, K. D., & Washington, M. T. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.6.2169-2176.2005 · Cited by 67
Expression of DNA Translesion Synthesis Polymerase η in Head and Neck Squamous Cell Cancer Predicts Resistance to Gemcitabine and Cisplatin-Based Chemotherapy
Zhou, W., Chen, Y., Liu, X., Chu, P. G., Loria, S., Wang, Y., Yen, Y., & Chou, K.-M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083978 · Cited by 62
Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene
Yuasa, M., Masutani, C., Eki, T., & Hanaoka, F. (2000) · Oncogene · doi:10.1038/sj.onc.1203842 · Cited by 61
Self-citation
REV3L 3′UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility
Zhang, S., Chen, H., Zhao, X., Cao, J., Tong, J., Lü, J., Wu, W., Shen, H., Wei, Q., & Lu, D. (2012) · Oncogene · doi:10.1038/onc.2012.32 · Cited by 61
DNA polymeraseη protein expression predicts treatment response and survival of metastatic gastric adenocarcinoma patients treated with oxaliplatin-based chemotherapy
Teng, K.-Y., Qiu, M., Li, Z. H., Luo, H., Zeng, Z.-L., Luo, R.-Z., Zhang, H.-Z., Wang, Z., Li, Y., & Xu, R. (2010) · Journal of Translational Medicine · doi:10.1186/1479-5876-8-126 · Cited by 61
Reconstitution of recombination-associated DNA synthesis with human proteins
Sneeden, J. L., Grossi, S. M., Tappin, I., Hurwitz, J., & Heyer, W. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt192 · Cited by 61
Regulation of DNA damage tolerance in mammalian cells by post-translational modifications of PCNA
Kanao, R., & Masutani, C. (2017) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2017.06.004 · Cited by 64
Self-citation
Human DNA polymerase η activity and translocation is regulated by phosphorylation
Chen, Y., Cleaver, J. E., Hatahet, Z., Honkanen, R. E., Chang, J., Yen, Y., & Chou, K.-M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808589105 · Cited by 65
A DNA Polymerase with Specificity for Five Base Pairs
Showalter, A. K., & Tsai, M. (2001) · Journal of the American Chemical Society · doi:10.1021/ja005758x · Cited by 59
The Mutational Specificity of the Dbh Lesion Bypass Polymerase and Its Implications
Potapova, O., Grindley, N. D. F., & Joyce, C. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202607200 · Cited by 59
DNA polymerase zeta generates clustered mutations during bypass of endogenous DNA lesions in Saccharomyces cerevisiae
Stone, J. E., Lujan, S. A., & Kunkel, T. A. (2012) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21728 · Cited by 55
Self-citation
Interaction with DNA polymerase η is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells
Akagi, J., Masutani, C., Kataoka, Y., Kan, T., Ohashi, E., Mori, T., Ohmori, H., & Hanaoka, F. (2009) · DNA repair · doi:10.1016/j.dnarep.2008.12.006 · Cited by 59
Self-citation
Human DNA polymerase‐η, an A‐T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase
Franklin, A., Milburn, P. J., Blanden, R. V., & Steele, E. J. (2004) · Immunology and Cell Biology · doi:10.1046/j.0818-9641.2004.01221.x · Cited by 56
Emerging links between hypermutation of antibody genes and DNA polymerases
Gearhart, P. J., & Wood, R. D. (2001) · Nature reviews. Immunology · doi:10.1038/35105009 · Cited by 56
Mutations in human DNA polymerase η motif II alter bypass of DNA lesions
Glick, E., Vigna, K. L., & Loeb, L. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7303 · Cited by 54
Human DNA Polymerase ι Utilizes Different Nucleotide Incorporation Mechanisms Dependent upon the Template Base
Washington, M. T., Johnson, R. E., Prakash, L., & Prakash, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.936-943.2004 · Cited by 55
Minor Groove Interactions at the DNA Polymerase β Active Site Modulate Single-base Deletion Error Rates
Osheroff, W. P., Beard, W. A., Yin, S., Wilson, S. H., & Kunkel, T. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003462200 · Cited by 54
Self-citation
Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
Ma, X., Liu, H., Li, J., Wang, Y., Ding, Y., Shen, H., Yang, Y., Sun, C., Huang, M., Tu, Y., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02164-1 · Cited by 54
Replication of UV-damaged DNA: new insights into links between DNA polymerases, mutagenesis and human disease
Lehmann, A. R. (2000) · Gene · doi:10.1016/s0378-1119(00)00250-x · Cited by 52
Involvement of DNA polymerase β in DNA replication and mutagenic consequences
Servant, L., Bieth, A., Hayakawa, H., Cazaux, C., & Hoffmann, J. (2002) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.5307 · Cited by 53
Dynamic regulation of PCNA ubiquitylation/deubiquitylation
Fox, J. T., Lee, K., & Myung, K. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.053 · Cited by 50
Generation of mutator mutants during carcinogenesis
Venkatesan, R. N., Bielas, J. H., & Loeb, L. A. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.10.012 · Cited by 49
Mammalian Translesion DNA Synthesis across an Acrolein-derived Deoxyguanosine Adduct
Yang, I.-Y., Miller, H., Wang, Z., Frank, E. G., Ohmori, H., Hanaoka, F., & Moriya, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212535200 · Cited by 49
Self-citation
Mutator effects of overproducing DNA polymerase η (Rad30) and its catalytically inactive variant in yeast
Pavlov, Y. I., Nguyen, D., & Kunkel, T. A. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00131-2 · Cited by 50
Self-citation
The N2-Ethylguanine and the O6-Ethyl- and O6-Methylguanine Lesions in DNA: Contrasting Responses from the “Bypass” DNA Polymerase η and the Replicative DNA Polymerase α
Perrino, F. W., Blans, P., Harvey, S. E., Gelhaus, S. L., McGrath, C. E., Akman, S. A., Jenkins, G. S., LaCourse, W. R., & Fishbein, J. C. (2003) · Chemical Research in Toxicology · doi:10.1021/tx034164f · Cited by 48
Highly Tolerated Amino Acid Substitutions Increase the Fidelity of Escherichia coli DNA Polymerase I
Loh, E., Choe, J., & Loeb, L. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611294200 · Cited by 49
Translesion synthesis DNA polymerases and control of genome stability
Polina, V. S. (2006) · Frontiers in bioscience · doi:10.2741/1985 · Cited by 46
A unique error signature for human DNA polymerase ν
Arana, M. E., Takata, K., García–Díaz, M., Wood, R. D., & Kunkel, T. A. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.09.012 · Cited by 46
Self-citation
Immunoglobulin Somatic Hypermutation: Double-Strand DNA Breaks, AID and Error-Prone DNA Repair
Wu, X., Feng, J., Komori, A., Kim, E. C., Zan, H., & Casali, P. (2003) · Journal of Clinical Immunology · doi:10.1023/a:1024571714867 · Cited by 46
DNA polymerase η undergoes alternative splicing, protects against UV sensitivity and apoptosis, and suppresses Mre11‐dependent recombination
Thakur, M., Wernick, M., Collins, C. C., Limoli, C. L., Crowley, E., & Cleaver, J. E. (2001) · Genes Chromosomes and Cancer · doi:10.1002/gcc.1186 · Cited by 48
The Mechanism of Nucleotide Incorporation by Human DNA Polymerase η Differs from That of the Yeast Enzyme
Washington, M. T., Johnson, R. E., Prakash, L., & Prakash, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.8316-8322.2003 · Cited by 45
Frameshifts and deletions during in vitro translesion synthesis past Pt–DNA adducts by DNA polymerases β and η
Bassett, E., Vaisman, A., Leeman, K. T., McCall, C. M., Masutani, C., Hanaoka, F., & Chaney, S. G. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00150-7 · Cited by 45
Self-citation
Mechanistic Role of Residue Gln151 in Error Prone DNA Synthesis by Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase (RT)
Weiss, K. K., Bambara, R. A., & Kim, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200202200 · Cited by 44
The Role of Polymerase η in Somatic Hypermutation Determined by Analysis of Mutations in a Patient with Xeroderma Pigmentosum Variant
Yavuz, Ş., Yavuz, A. S., Kraemer, K. H., & Lipsky, P. E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3825 · Cited by 43
Activation-induced cytidine deaminase structure and functions: A species comparative view
Barreto, V. M., & Magor, B. G. (2011) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2011.02.005 · Cited by 42
Implications of Active Site Constraints on Varied DNA Polymerase Selectivity
Strerath, M., Cramer, J., Restle, T., & Marx, A. (2002) · Journal of the American Chemical Society · doi:10.1021/ja027060k · Cited by 42
Evolutionary Shortcuts via Multinucleotide Substitutions and Their Impact on Natural Selection Analyses
Lucaci, A. G., Zehr, J. D., Enard, D., Thornton, J. W., & Pond, S. L. K. (2023) · Molecular Biology and Evolution · doi:10.1093/molbev/msad150 · Cited by 39
Mechanism of replication blocking and bypass of Y-family polymerase η by bulky acetylaminofluorene DNA adducts
Kath‐Schorr, S., Schneider, S., Lammens, K., Hopfner, K., & Carell, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008894107 · Cited by 41
Recent Insight into the Kinetic Mechanisms and Conformational Dynamics of Y-Family DNA Polymerases
Maxwell, B. A., & Suo, Z. (2014) · Biochemistry · doi:10.1021/bi5000405 · Cited by 41
Characterization of human translesion DNA synthesis across a UV-induced DNA lesion
Hedglin, M., Pandey, B., & Benkovic, S. J. (2016) · eLife · doi:10.7554/elife.19788 · Cited by 41
Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases
Wickramaratne, S., Ji, S., Mukherjee, S., Su, Y. R., Pence, M. G., Lior-Hoffmann, L., Fu, I., Broyde, S. B., Guengerich, F. P., Distefano, M. D., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.745257 · Cited by 40
DNA polymerase η lacking the ubiquitin-binding domain promotes replicative lesion bypass in humans cells
Acharya, N., Yoon, J. H., Hurwitz, J., Prakash, L., & Prakash, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005492107 · Cited by 42
DNA polymerase η mutational signatures are found in a variety of different types of cancer
Rogozin, I. B., Goncearenco, A., Lada, A. G., De, S., Yurchenko, V., Nudelman, G., Panchenko, A. R., Cooper, D. N., & Pavlov, Y. I. (2018) · Cell Cycle · doi:10.1080/15384101.2017.1404208 · Cited by 39
Error-prone Translesion Synthesis Past DNA-Peptide Cross-links Conjugated to the Major Groove of DNA via C5 of Thymidine
Wickramaratne, S., Boldry, E. J., Buehler, C., Wang, Y.-C., Distefano, M. D., & Tretyakova, N. Y. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.613638 · Cited by 39
Nucleotide excision repair “a legacy of creativity”
Cleaver, J. E., Karplus, K. J., Kashani–Sabet, M., & Limoli, C. L. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(00)00073-2 · Cited by 39
Orbital interactions and charge redistribution in weak hydrogen bonds: The Watson–Crick AT mimic adenine-2,4-difluorotoluene
Guerra, C. F., & Bickelhaupt, F. M. (2003) · The Journal of Chemical Physics · doi:10.1063/1.1592494 · Cited by 38
Mutagenic and Nonmutagenic Bypass of DNA Lesions byDrosophila DNA Polymerases dpolη and dpolι
Ishikawa, T., Uematsu, N., Mizukoshi, T., Iwai, S., Iwasaki, H., Masutani, C., Hanaoka, F., Ueda, R., Ohmori, H., & Todo, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009822200 · Cited by 37
Self-citation
UV-induced T->C transition at a TT photoproduct site is dependent on Saccharomyces cerevisiae polymerase etain vivo
Zhang, H. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.5.1262 · Cited by 38
Aberrant expression of alternative DNA polymerases: A source of mutator phenotype as well as replicative stress in cancer
Hoffmann, J., & Cazaux, C. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.10.001 · Cited by 40
Translesion DNA Synthesis by Yeast DNA Polymerase η on Templates Containing N 2-Guanine Adducts of 1,3-Butadiene Metabolites
Minko, I. G., Washington, M. T., Prakash, L., Prakash, S., & Lloyd, R. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007867200 · Cited by 37
Quantitative analysis of the efficiency and mutagenic spectra of abasic lesion bypass catalyzed by human Y-family DNA polymerases
Sherrer, S. M., Fiala, K. A., Fowler, J. D., Newmister, S. A., Pryor, J. M., & Suo, Z. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq719 · Cited by 36
Enhancement of the mutagenicity of benzo(a)pyrene diol epoxide by a nonmutagenic dose of ultraviolet A radiation.
Nia, A. B., & Pfeifer, G. P. (2003) · PubMed · Cited by 36
Yeast DNA polymerase η makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate
Washington, M. T., Wolfle, W. T., Spratt, T. E., Prakash, L., & Prakash, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0837578100 · Cited by 35
Scientists and clinicians test their metal–back to the future with platinum compounds
Guminski, A. D., Harnett, P. R., & DeFazio, A. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00733-7 · Cited by 34
Characterization of a Y‐Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana
Kashiwagi, S., Kuraoka, I., Fujiwara, Y., Hitomi, K., Cheng, Q. J., Fuss, J. O., Shin, D. S., Masutani, C., Tainer, J. A., Hanaoka, F., et al. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/701472 · Cited by 34
Self-citation
Defect of Dpb2p, a noncatalytic subunit of DNA polymerase ε, promotes error prone replication of undamaged chromosomal DNA in Saccharomyces cerevisiae
Kraszewska, J., Garbacz, M. A., Jonczyk, P., Fijałkowska, I. J., & Jaszczur, M. M. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.06.002 · Cited by 33
An essential role for REV3 in mammalian cell survival: absence of REV3 induces p53-independent embryonic death
Wang, J. O., Kajiwara, K., Kawamura, K., Kimura, M., Miyagishima, H., Koseki, H., & Tagawa, M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00341-8 · Cited by 33
Pre‐Steady‐State Kinetic Analysis of Truncated and Full‐Length Saccharomyces cerevisiae DNA Polymerase Eta
Brown, J. A., Zhang, L., Sherrer, S. M., Taylor, J., Burgers, P., & Suo, Z. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/871939 · Cited by 32
Non-bulky Lesions in Human DNA: The Ways of Formation, Repair, and Replication
Ignatov, А. V., Bondarenko, K. A., & Makarova, A. V. (2017) · Acta Naturae · doi:10.32607/20758251-2017-9-3-12-26 · Cited by 31
Immunoglobulin gene rearrangement, repertoire diversity, and the allergic response
Collins, A. M., Sewell, W. A., & Edwards, M. R. (2003) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.07.002 · Cited by 31
Molecular mechanisms of xeroderma pigmentosum (XP) proteins
Koch, S. C., Simon, N., Ebert, C., & Carell, T. (2016) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583515000268 · Cited by 33
Interferon-Stimulated Gene 15 in the Control of Cellular Responses to Genotoxic Stress
Jeon, Y. J., Park, J. H., & Chung, C. H. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.0027 · Cited by 30
Two Distinct Translesion Synthesis Pathways across a Lipid Peroxidation-derived DNA Adduct in Mammalian Cells
Yang, I.-Y., Hashimoto, K., de Wind, N., Blair, I. A., & Moriya, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806414200 · Cited by 30
DNA Polymerases η and ι
Vaisman, A., Lehmann, A. R., & Woodgate, R. (2004) · Advances in protein chemistry · doi:10.1016/s0065-3233(04)69007-3 · Cited by 30
Polymerase η and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation
Cleaver, J. E. (2002) · DNA repair · doi:10.1016/s1568-7864(01)00004-0 · Cited by 30
Polycythemia vera and essential thrombocythemia in young patients.
Frezzato, M., Ruggeri, M., Castaman, G., & Rodeghiero, F. (1993) · PubMed · Cited by 30
Analysis of UV-induced mutation spectra in Escherichia coli by DNA polymerase η from Arabidopsis thaliana
Santiago, M. J., Alejandre-Durán, E., & Ruiz‐Rubio, M. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.05.036 · Cited by 30
Impact of Age on Hypermutation of Immunoglobulin Variable Genes in Humans
Rosner, K., Winter, D. B., Kasmer, C., Skovgaard, G. L., Tarone, R. E., Bohr, V. A., & Gearhart, P. J. (2001) · Journal of Clinical Immunology · doi:10.1023/a:1011003821798 · Cited by 29
DNA polymerases η and κ are responsible for error-free translesion DNA synthesis activity over a cis–syn thymine dimer in Xenopus laevis oocyte extracts
Yagi, Y., Ogawara, D., Iwai, S., Hanaoka, F., Akiyama, M., & Maki, H. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.06.010 · Cited by 28
Self-citation
Genesis of the strand‐biased signature in somatic hypermutation of rearranged immunoglobulin variable genes
Steele, E. J., Franklin, A., & Blanden, R. V. (2004) · Immunology and Cell Biology · doi:10.1046/j.0818-9641.2004.01224.x · Cited by 27
Fidelity and Damage Bypass Ability of Schizosaccharomyces pombe Eso1 Protein, Comprised of DNA Polymerase η and Sister Chromatid Cohesion Protein Ctf7
Madril, A. C., Johnson, R. E., Washington, M. T., Prakash, L., & Prakash, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106917200 · Cited by 28

Authors: Matsuda, T., Bebenek, K., Masutani, C., Hanaoka, F., & Kunkel, T. A.
Affiliations: National Institutes of Health (US)
The University of Osaka (JP)
RIKEN (JP)
Corresponding author: Kunkel, Thomas A.
ORCID: Masutani, Chikahide
Hanaoka, Fumio
Kunkel, Thomas A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2000-04
Volume: 404
Issue: 6781
Pages: 1011-1013
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35010014
OpenAlex: W1581466567
Cited by: 372
References: 27
Citations by year: 2026: 3 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 12 · 2016: 15 · 2015: 16 · 2014: 10 · 2013: 16 · 2012: 9
FWCI: 15.66
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords: DNA polymerase eta, DNA synthesis fidelity, error-prone DNA replication, thymine-thymine dimers, DNA damage bypass, proofreading exonuclease, XPA, mutagenesis
MeSH terms: DNA Polymerase iota, Y-Family DNA Polymerases, DNA, DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, Humans, Mutagenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Low fidelity DNA synthesis by human DNA polymerase-η

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks