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DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

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Structure of the Catalytic Core of S. cerevisiae DNA Polymerase η

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THE SOS RESPONSE: Recent Insights into umuDC -Dependent Mutagenesis and DNA Damage Tolerance

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Preferential cis–syn thymine dimer bypass by DNA polymerase η occurs with biased fidelity

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DNA Repair Mechanisms and the Bypass of DNA Damage in Saccharomyces cerevisiae

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Interactions in the Error-prone Postreplication Repair Proteins hREV1, hREV3, and hREV7

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Fidelity and Processivity of DNA Synthesis by DNA Polymerase κ, the Product of the Human DINB1 Gene

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DNA polymerase θ (POLQ), double-strand break repair, and cancer

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Co-localization in replication foci and interaction of human Y-family members, DNA polymerase polη and REVl protein

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The Translesion DNA Polymerase ζ Plays a Major Role in Ig and bcl-6 Somatic Hypermutation

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Preferential Incorporation of G Opposite Template T by the Low-Fidelity Human DNA Polymerase ι

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Interaction with PCNA Is Essential for Yeast DNA Polymerase η Function

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Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein

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Base excision repair in a network of defence and tolerance

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Clustered Mutation Signatures Reveal that Error-Prone DNA Repair Targets Mutations to Active Genes

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Origins of Spontaneous Mutations: Specificity and Directionality of Base-Substitution, Frameshift, and Sequence-Substitution Mutageneses

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Localization of DNA polymerases η and ι to the replication machinery is tightly co‐ordinated in human cells

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Clusters of Multiple Mutations: Incidence and Molecular Mechanisms

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Error-prone lesion bypass by human DNA polymerase eta

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Endogenous DNA damage and mutation

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Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.

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129-derived Strains of Mice Are Deficient in DNA Polymerase ι and Have Normal Immunoglobulin Hypermutation

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Error rate and specificity of human and murine DNA polymerase η

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The expanding polymerase universe

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Two novel human and mouse DNA polymerases of the polX family

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Polymerase theta-mediated end joining of replication-associated DNA breaks in C. elegansPreprint

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Human DNA repair genes

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A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown

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Highly error-free role of DNA polymerase η in the replicative bypass of UV-induced pyrimidine dimers in mouse and human cells

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Response of human DNA polymerase iota to DNA lesions

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Genetic instability in cancer: Theory and experiment

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Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres

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A Reexamination of the Nucleotide Incorporation Fidelity of DNA Polymerases

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Multinucleotide mutations cause false inferences of lineage-specific positive selection

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Modification of PCNA by ISG15 Plays a Crucial Role in Termination of Error-Prone Translesion DNA Synthesis

Park, J. M., Yang, S. W., Yu, K. R., Ka, S. H., Lee, S. W., Seol, J. H., Jeon, Y. J., & Chung, C. H. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.031 · Cited by 144

Somatic hypermutation at A·T pairs: polymerase error versus dUTP incorporation

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Structure of DNA Polymerase β with the Mutagenic DNA Lesion 8-Oxodeoxyguanine Reveals Structural Insights into Its Coding Potential

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The hMsh2-hMsh6 Complex Acts in Concert with Monoubiquitinated PCNA and Pol η in Response to Oxidative DNA Damage in Human Cells

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Extremely rare variants reveal patterns of germline mutation rate heterogeneity in humans

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Error-Prone DNA Polymerases

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Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity

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Unique Error Signature of the Four-subunit Yeast DNA Polymerase ϵ

Shcherbakova, P. V., Pavlov, Y. I., Chilkova, O., Rogozin, I. B., Johansson, E., & Kunkel, T. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306893200 · Cited by 129

Role of DNA Polymerase η in the UV Mutation Spectrum in Human Cells

Stary, A., Kannouche, P. L., Lehmann, A. R., & Sarasin, A. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211838200 · Cited by 133

The Efficiency and Specificity of Apurinic/Apyrimidinic Site Bypass by Human DNA Polymerase η and Sulfolobus solfataricus Dpo4

Kokoska, R. J., McCulloch, S. D., & Kunkel, T. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308515200 · Cited by 125

Functions of human DNA polymerases η, κ and ι suggested by their properties, including fidelity with undamaged DNA templates

Kunkel, T. A., Pavlov, Y. I., & Bebenek, K. (2003) · DNA Repair · doi:10.1016/s1568-7864(02)00224-0 · Cited by 125

Viral reverse transcriptases

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Yeast DNA Polymerase η Utilizes an Induced-Fit Mechanism of Nucleotide Incorporation

Washington, M. T., Prakash, L., & Prakash, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00613-4 · Cited by 123

DNA Polymerase ζ Introduces Multiple Mutations when Bypassing Spontaneous DNA Damage in Saccharomyces cerevisiae

Harfe, B. D., & Jinks-Robertson, S. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00145-3 · Cited by 122

Biochemical, Structural, and Physiological Characterization of Terminal Deoxynucleotidyl Transferase

Fowler, J. D., & Suo, Z. (2006) · Chemical Reviews · doi:10.1021/cr040445w · Cited by 119

Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase η during copying of a mouse immunoglobulin κ light chain transgene

Pavlov, Y. I., Rogozin, I. B., Galkin, A. P., Aksenova, A. Y., Hanaoka, F., Rada, C., & Kunkel, T. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152126799 · Cited by 120

DNA Damage Control by Novel DNA Polymerases: Translesion Replication and Mutagenesis

Livneh, Z. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100019200 · Cited by 119

Oxygen Free Radical Damage to DNA

Kuraoka, I., Robins, P., Masutani, C., Hanaoka, F., Gasparutto, D., Cadet, J., Wood, R. D., & Lindahl, T. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107779200 · Cited by 116

The translesion DNA polymerase θ plays a dominant role in immunoglobulin gene somatic hypermutation

Zan, H., Shima, N., Xu, Z., Al-Qahtani, A. A., Evinger, A. J., Zhong, Y., Schimenti, J. C., & Casali, P. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600833 · Cited by 115

Replication of damaged DNA in mammalian cells: new solutions to an old problem

Lehmann, A. R. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00227-0 · Cited by 112

Mutation Rates and Intrinsic Fidelity of Retroviral Reverse Transcriptases

Menéndez‐Arias, L. (2009) · Viruses · doi:10.3390/v1031137 · Cited by 114

Human DNA polymerase kappa synthesizes DNA with extraordinarily low fidelity

Zhang, Y. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.21.4147 · Cited by 109

Mutating for Good: DNA Damage Responses During Somatic Hypermutation

Pilzecker, B., & Jacobs, H. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00438 · Cited by 117

Participation of DNA Polymerase ζ in Replication of Undamaged DNA in Saccharomyces cerevisiae

Northam, M. R., Robinson, H. A., Kochenova, O. V., & Shcherbakova, P. V. (2009) · Genetics · doi:10.1534/genetics.109.107482 · Cited by 114

Low Fidelity DNA Synthesis by a Y Family DNA Polymerase Due to Misalignment in the Active Site

Kokoska, R. J., Bębenek, K., Boudsocq, F., Woodgate, R., & Kunkel, T. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202021200 · Cited by 107

Lesion Bypass Activity of DNA Polymerase θ (POLQ) Is an Intrinsic Property of the Pol Domain and Depends on Unique Sequence Inserts

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The Frameshift Infidelity of Human DNA Polymerase λ

Bebenek, K., Garcia-Diaz, M., Blanco, L., & Kunkel, T. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305705200 · Cited by 104

Molecular basis of fidelity of DNA synthesis and nucleotide specificity of retroviral reverse transcriptases

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Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase in Saccharomyces cerevisiae

Parker, J. L., Bielen, A. B., Đikić, I., & Ulrich, H. D. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl1102 · Cited by 108

The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases and

McCulloch, S. D., Kokoska, R. J., Garg, P., Burgers, P., & Kunkel, T. A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp103 · Cited by 106

DNA Repair in Mammalian Cells

Kunz, C., Saito, Y., & Schär, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8739-9 · Cited by 104

How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability

Jeggo, P. A., & Löbrich, M. (2015) · Biochemical Journal · doi:10.1042/bj20150582 · Cited by 108

Interactions of Carcinogen-Bound DNA with Individual DNA Polymerases

Guengerich, F. P. (2006) · Chemical Reviews · doi:10.1021/cr0404693 · Cited by 99

Translesion synthesis by the UmuC family of DNA polymerases

Wang, Z. (2001) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(01)00089-1 · Cited by 97

Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluorene

Guo, D. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.13.2875 · Cited by 98

Protein interactions with platinum–DNA adducts: from structure to function

Chaney, S. G., Campbell, S. L., Temple, B. R. S., Bassett, E., Wu, Y., & Faldu, M. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.04.024 · Cited by 99

Secondary Reactions and Strategies To Improve Quantitative Protein Footprinting

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Addendum

Kannouche, P. L., de Henestrosa, A. R. F., Coull, B. J., Vidal, A. E., Gray, C., Zicha, D., Woodgate, R., & Lehmann, A. R. (2003) · The EMBO Journal · doi:10.1093/emboj/7595006 · Cited by 98

Increased Susceptibility to UV-Induced Skin Carcinogenesis in Polymerase η–deficient Mice

Lin, Q., Clark, A. B., McCulloch, S. D., Yuan, T., Bronson, R. T., Kunkel, T. A., & Kucherlapati, R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1862 · Cited by 95

Mutator phenotypes due to DNA replication infidelity

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