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Molecular physiology of weight regulation in mice and humans

Leibel, R L·2008·International Journal of Obesity
DOI 10.1038/ijo.2008.245PMC PMC2682360
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Crossref · 10.1038/ijo.2008.245

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  • The reduction in TEE during maintenance of reduced body weight is accompanied by increased skeletal muscle work efficiency, decreased plasma levels of leptin and T3, associated with low SNS activity.

    “it is accompanied by increased skeletal muscle work efficiency, decreased plasma levels of leptin and T3 associated with low SNS activity [23••, 63].”

    From Changes in energy expenditure with weight gain and weight loss in humans (2016) · cites this paper as [63]

    The Human weight perturbation section (page unavailable) reports reduced total energy expenditure during maintenance of reduced weight and attributes much of the decline to increased skeletal-muscle work efficiency. The Leptin section (page unavailable) describes relative leptin deficiency, reduced T3, and sympathetic-autonomic changes in the weight-reduced state, but does not specify that SNS activity is low. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Leptin has no thermogenic effect at normal or high concentrations, whereas the effect becomes apparent after leptin levels fall below a threshold level invoking a mass-independent decrease in energy expenditure.

    “Leptin has no thermogenic effect at normal or high concentrations, whereas the effect becomes apparent after leptin levels fall below a threshold level invoking a mass-independent decrease in EE.”

    From Changes in energy expenditure with weight gain and weight loss in humans (2016) · cites this paper as [63]

    The Leptin section says high leptin levels elicit little response, while reduced levels lead to lower energy expenditure. The Human weight perturbation section reports an expenditure decrease beyond that predicted by changes in mass and body composition. However, the paper presents a minimum threshold for body fat as a hypothetical construct, rather than establishing a specific leptin threshold below which the effect appears. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • The reduction in TEE during maintenance of reduced body weight relates to adaptive thermogenesis in the non-resting component of energy expenditure.

    “This relates to AT in the non-resting component of EE”

    From Changes in energy expenditure with weight gain and weight loss in humans (2016) · cites this paper as [63]

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Metadata

Authors
Leibel, R. L.
Venue
International Journal of Obesity
Publisher
Springer Science and Business Media LLC
Published
2008-12
Volume
32
Issue
S7
Pages
S98-S108
ISSN
  • 0307-0565
  • 1476-5497
DOI
10.1038/ijo.2008.245
PMC
PMC2682360
Cited by
120
References
11
Language
en
Licence
www.springer.com/tdm (tdm)

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