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cAMP/PKA signaling and RIM1α mediate presynaptic LTP in the lateral amygdala

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Fourcaudot, Elodie, Gambino, Frédéric, Humeau, Yann, Casassus, Guillaume, Shaban, Hamdy, Poulain, Bernard, Lüthi, Andreas·2008·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0806938105PMC PMC2567504
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Abstract

NMDA receptor-dependent long-term potentiation (LTP) of glutamatergic synaptic transmission in sensory pathways from auditory thalamus or cortex to the lateral amygdala (LA) underlies the acquisition of auditory fear conditioning. Whereas the mechanisms of postsynaptic LTP at thalamo-LA synapses are well understood, much less is known about the sequence of events mediating presynaptic NMDA receptor-dependent LTP at cortico-LA synapses. Here, we show that presynaptic cortico-LA LTP can be entirely accounted for by a persistent increase in the vesicular release probability. At the molecular level, we found that signaling via the cAMP/PKA pathway is necessary and sufficient for LTP induction. Moreover, by using mice lacking the active-zone protein and PKA target RIM1alpha (RIM1alpha(-/-)), we demonstrate that RIM1alpha is required for both chemically and synaptically induced presynaptic LTP. Further analysis of cortico-LA synaptic transmission in RIM1alpha(-/-) mice revealed a deficit in Ca(2+)-release coupling leading to a lower baseline release probability. Our results reveal the molecular mechanisms underlying the induction of presynaptic LTP at cortico-LA synapses and indicate that RIM1alpha-dependent LTP may involve changes in Ca(2+)-release coupling.

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  • All forms of presynaptic long-term plasticity investigated-both LTP and LTD-are blocked by the constitutive knockout of RIM1α.

    “Strikingly, up to now all forms of presynaptic long-term plasticity investigated—both long-term potentiation (LTP) and long-term depression (LTD)—are blocked by the constitutive knockout of RIM1α (which only partly impairs basal release since all other RIM isoforms are still present), suggesting that the amount of RIM1α available at a synapse is crucial (Castillo et al., 2002; Chevaleyre et al., 2”

    From The Presynaptic Active Zone (2012) · cites this paper as Fourcaudot et al., 2008

    The Results section, “The Active-Zone Protein RIM1α Is Necessary for Presynaptic LTP,” reports that two forms of LTP were abolished in RIM1α-deficient mice. It does not establish that all investigated forms of presynaptic long-term plasticity, including LTD, are blocked; the evidence here concerns LTP at cortico–lateral amygdala synapses. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Fourcaudot, E., Gambino, F., Humeau, Y., Casassus, G., Shaban, H., Poulain, B., & Lüthi, A.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Friedrich Miescher Institute (CH)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2008-09-30
Volume
105
Issue
39
Pages
15130-15135
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0806938105
PMC
PMC2567504
OpenAlex
W2089019834
Cited by
105
References
1
Citations by year
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FWCI
4.33
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
lateral amygdala, cAMP/PKA signaling, NMDA receptor, auditory fear conditioning, active zone, glutamatergic neurotransmission
MeSH terms
Amygdala, Animals, Calcium, Male, Mice, Mutant Strains, Synaptic Transmission, Signal Transduction, Presynaptic Terminals, Long-Term Potentiation, GTP-Binding Proteins, Mice, Cyclic AMP-Dependent Protein Kinase RIalpha Subunit

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