Engineering exosomes as refined biological nanoplatforms for drug delivery

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

Suk, J. S., Xu, Q., Kim, N., Hanes, J., & Ensign, L. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.012 · Cited by 4,523

Exosomes as drug delivery vehicles for Parkinson’s disease therapy

Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., Patel, T., Piroyan, A., Sokolsky, M., Kabanov, A. V., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.033 · Cited by 2,009

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

Ohno, S.-I., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A., Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2012.180 · Cited by 1,666

Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

Wolfers, J., Lozier, A., Raposo, G., Regnault, A., Théry, C., Masurier, C., Flament, C., Pouzieux, S., Faure, F., Tursz, T., et al. (2001) · Nature Medicine · doi:10.1038/85438 · Cited by 1,640

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W., Miller, D., & Zhang, H.-G. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,572

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

Melo, S. A., Sugimoto, H., O’Connell, J. T., Kato, N., Villanueva, A., Vidal, A., Qiu, L., Vitkin, E., Perelman, L. T., Melo, C. A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.005 · Cited by 1,531

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Kim, M. S., Haney, M. J., Zhao, Y., Mahajan, V., Deygen, I., Klyachko, N. L., Inskoe, E., Piroyan, A., Sokolsky, M., Okolie, O., et al. (2016) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2015.10.012 · Cited by 1,410

Extracellular vesicles for drug delivery.

Vader, P., Mol, E. A., Pasterkamp, G., & Schiffelers, R. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.02.006 · Cited by 1,319

Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

Escudier, B., Dorval, T., Chaput, N., André, F., Caby, M.-P., Novault, S., Flament, C., Leboulaire, C., Borg, C., Amigorena, S., et al. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-10 · Cited by 1,280

The Smart Drug Delivery System and Its Clinical Potential

Liu, D., Yang, F., Xiong, F., & Gu, N. (2016) · Theranostics · doi:10.7150/thno.14858 · Cited by 1,066

Using exosomes, naturally-equipped nanocarriers, for drug delivery

Batrakova, E. V., & Kim, M. S. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.07.030 · Cited by 1,041

Indirect activation of naïve CD4+ T cells by dendritic cell–derived exosomes

Théry, C., Duban, L., Segura, E., Véron, P., Lantz, O., & Amigorena, S. (2002) · Nature Immunology · doi:10.1038/ni854 · Cited by 960

Bovine milk-derived exosomes for drug delivery

Munagala, R., Aqil, F., Jeyabalan, J., & Gupta, R. C. (2016) · Cancer Letters · doi:10.1016/j.canlet.2015.10.020 · Cited by 931

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

Lai, C. P., Mardini, O., Ericsson, M., Prabhakar, S., Maguire, C. A., Chen, J. W., Tannous, B. A., & Breakefield, X. O. (2014) · ACS Nano · doi:10.1021/nn404945r · Cited by 902

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

Zomer, A., Maynard, C., Verweij, F. J., Kamermans, A., Schäfer, R., Beerling, E., Schiffelers, R. M., de Wit, E., Berenguer, J., Ellenbroek, S. I. J., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.042 · Cited by 869

Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

Ju, S., Mu, J., Dokland, T., Zhuang, X., Wang, Q., Jiang, H., Xiang, X., Deng, Z.-B., Wang, B., Zhang, L., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.64 · Cited by 862

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

Pascucci, L., Coccè, V., Bonomi, A., Ami, D., Ceccarelli, P., Ciusani, E., Viganò, L., Locatelli, A., Sisto, F., Doglia, S. M., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.07.042 · Cited by 846

Tumor-Derived Exosomes and Their Role in Cancer Progression

(2016) · Advances in Clinical Chemistry · doi:10.1016/bs.acc.2015.12.005 · Cited by 755

Engineering hybrid exosomes by membrane fusion with liposomes

Sato, Y. T., Umezaki, K., Sawada, S., Mukai, S.-A., Sasaki, Y., Harada, N., Shiku, H., & Akiyoshi, K. (2016) · Scientific Reports · doi:10.1038/srep21933 · Cited by 744

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

Fuhrmann, G., Serio, A., Mazo, M., Nair, R., & Stevens, M. M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.11.029 · Cited by 742

Exosome mediated communication within the tumor microenvironment

Milane, L., Singh, A., Mattheolabakis, G., Suresh, M., & Amiji, M. M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.029 · Cited by 742

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

Wahlgren, J., Karlson, T. D. L., Brisslert, M., Vaziri Sani, F., Telemo, E., Sunnerhagen, P., & Valadi, H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks463 · Cited by 715

Saponins as cytotoxic agents: a review

Podolak, I., Galanty, A., & Sobolewska, D. (2010) · Phytochemistry Reviews · doi:10.1007/s11101-010-9183-z · Cited by 704

Production and characterization of clinical grade exosomes derived from dendritic cells

Lamparski, H. G., Metha-Damani, A., Yao, J.-Y., Patel, S., Hsu, D.-H., Ruegg, C., & Le Pecq, J.-B. (2002) · Journal of Immunological Methods · doi:10.1016/s0022-1759(02)00330-7 · Cited by 700

Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics

Armstrong, J. P. K., Holme, M. N., & Stevens, M. M. (2017) · ACS Nano · doi:10.1021/acsnano.6b07607 · Cited by 602

Exosomes and tumor-mediated immune suppression

Whiteside, T. L. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81136 · Cited by 569

Surface Functionalization of Exosomes Using Click Chemistry

Smyth, T., Petrova, K., Payton, N. M., Persaud, I., Redzic, J. S., Graner, M. W., Smith-Jones, P., & Anchordoquy, T. J. (2014) · Bioconjugate Chemistry · doi:10.1021/bc500291r · Cited by 532

Exosomes: New players in cell–cell communication

Bang, C., & Thum, T. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.08.007 · Cited by 505

Fas Ligand–Positive Membranous Vesicles Isolated from Sera of Patients with Oral Cancer Induce Apoptosis of Activated T Lymphocytes

Kim, J. W., Wieckowski, E., Taylor, D. D., Reichert, T. E., Watkins, S., & Whiteside, T. L. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.1010.11.3 · Cited by 497

Extracellular Membrane Vesicles as a Mechanism of Cell-to-Cell Communication: Advantages and Disadvantages

Turturici, G., Tinnirello, R., Sconzo, G., & Geraci, F. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2013 · Cited by 483

Extracellular vesicles as drug delivery systems: Lessons from the liposome field

van der Meel, R., Fens, M. H. A. M., Vader, P., van Solinge, W. W., Eniola-Adefeso, O., & Schiffelers, R. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.07.049 · Cited by 482

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

Qi, H., Liu, C., Long, L., Ren, Y., Zhang, S., Chang, X., Qian, X., Jia, H., Zhao, J., Sun, J., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b06939 · Cited by 459

Dendritic Cell-Derived Exosomes Promote Natural Killer Cell Activation and Proliferation: A Role for NKG2D Ligands and IL-15Rα

Viaud, S., Terme, M., Flament, C., Taieb, J., André, F., Novault, S., Escudier, B., Robert, C., Caillat-Zucman, S., Tursz, T., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004942 · Cited by 437

Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments

Taylor, D. D., & Gercel-Taylor, C. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-010-0234-8 · Cited by 383

Pair correlation microscopy reveals the role of nanoparticle shape in intracellular transport and site of drug release

Hinde, E., Thammasiraphop, K., Duong, H. T. T., Yeow, J., Karagoz, B., Boyer, C., Gooding, J. J., & Gaus, K. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2016.160 · Cited by 374

Exosome-based tumor antigens–adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA

Morishita, M., Takahashi, Y., Matsumoto, A., Nishikawa, M., & Takakura, Y. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.031 · Cited by 369

A review of nanocarriers for the delivery of small interfering RNA

Kesharwani, P., Gajbhiye, V., & Jain, N. K. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.068 · Cited by 368

Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung

Thomas, M., Lu, J. J., Ge, Q., Zhang, C., Chen, J., & Klibanov, A. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502067102 · Cited by 366

Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites

Wang, Q., Ren, Y., Mu, J., Egilmez, N. K., Zhuang, X., Deng, Z., Zhang, L., Yan, J., Miller, D., & Zhang, H.-G. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3095 · Cited by 366

Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

Nakase, I., & Futaki, S. (2015) · Scientific Reports · doi:10.1038/srep10112 · Cited by 295

Cationic liposome-mediated delivery of siRNAs in adult mice

Sioud, M., & Sørensen, D. R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.057 · Cited by 286

Dendritic Cells Release HLA-B-Associated Transcript-3 Positive Exosomes to Regulate Natural Killer Function

Simhadri, V. R., Reiners, K. S., Hansen, H. P., Topolar, D., Simhadri, V. L., Nohroudi, K., Kufer, T. A., Engert, A., & Pogge von Strandmann, E. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003377 · Cited by 262

Antitumor Activity of Small Interfering RNA/Cationic Liposome Complex in Mouse Models of Cancer

Yano, J., Hirabayashi, K., Nakagawa, S.-I., Yamaguchi, T., Nogawa, M., Kashimori, I., Naito, H., Kitagawa, H., Ishiyama, K., Ohgi, T., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1049 · Cited by 238

Dendrimer nanoarchitectures for cancer diagnosis and anticancer drug delivery

Sharma, A. K., Gothwal, A., Kesharwani, P., Alsaab, H., Iyer, A. K., & Gupta, U. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2016.09.013 · Cited by 226

Internally Cationic Polyamidoamine PAMAM-OH Dendrimers for siRNA Delivery: Effect of the Degree of Quaternization and Cancer Targeting

Patil, M. L., Zhang, M., Taratula, O., Garbuzenko, O. B., He, H., & Minko, T. (2009) · Biomacromolecules · doi:10.1021/bm8009973 · Cited by 213

Methods for the physical characterization and quantification of extracellular vesicles in biological samples

Rupert, D. L. M., Claudio, V., Lässer, C., & Bally, M. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.07.028 · Cited by 212

Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Christiansen, G., Gurevich, L., Moos, T., & Duroux, M. (2016) · Cytotechnology · doi:10.1007/s10616-016-9952-7 · Cited by 210

Exosomes – Structure, Biogenesis and Biological Role in Non‐Small‐Cell Lung Cancer

Frydrychowicz, M., Kolecka‐Bednarczyk, A., Madejczyk, M., Yasar, S., & Dworacki, G. (2015) · Scandinavian Journal of Immunology · doi:10.1111/sji.12247 · Cited by 209

Post Isolation Modification of Exosomes for Nanomedicine Applications

Hood, J. L. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0102 · Cited by 201

Quantification of human urinary exosomes by nanoparticle tracking analysis

Oosthuyzen, W., Sime, N. E. L., Ivy, J. R., Turtle, E. J., Street, J. M., Pound, J., Bath, L. E., Webb, D. J., Gregory, C. D., Bailey, M. A., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.264069 · Cited by 197

Extracellular Vesicles: Satellites of Information Transfer in Cancer and Stem Cell Biology

Desrochers, L. M., Antonyak, M. A., & Cerione, R. A. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.04.019 · Cited by 178

Exosomes Released from Breast Cancer Carcinomas Stimulate Cell Movement

Harris, D. A., Patel, S. H., Gucek, M., Hendrix, A., Westbroek, W., & Taraska, J. W. (2015) · PLOS ONE · doi:10.1371/journal.pone.0117495 · Cited by 169

Integrating Protein Engineering and Bioorthogonal Click Conjugation for Extracellular Vesicle Modulation and Intracellular Delivery

Wang, M., Altinoglu, S., Takeda, Y. S., & Xu, Q. (2015) · PLOS ONE · doi:10.1371/journal.pone.0141860 · Cited by 164

Dendritic Cell-Derived Exosomes may be a Tool for Cancer Immunotherapy by Converting Tumor Cells into Immunogenic Targets.

Romagnoli, G. G., Zelante, B. B., Toniolo, P. A., Migliori, I. K., & Barbuto, J. A. M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00692 · Cited by 152

Identification and characterization of EGF receptor in individual exosomes by fluorescence‐activated vesicle sorting

Higginbotham, J. N., Zhang, Q., Jeppesen, D. K., Scott, A. M., Manning, H. C., Ochieng, J., Franklin, J. L., & Coffey, R. J. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.29254 · Cited by 135

The potential of protein–nanomaterial interaction for advanced drug delivery

Peng, Q., & Mu, H. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.041 · Cited by 134

Tumour‐derived exosomes as antigen delivery carriers in dendritic cell‐based immunotherapy for malignant mesothelioma

Mahaweni, N. M., Kaijen-Lambers, M. E. H., Dekkers, J., Aerts, J. G. J. V., & Hegmans, J. P. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.22492 · Cited by 119

Exosomes: Tunable Nano Vehicles for Macromolecular Delivery of Transferrin and Lactoferrin to Specific Intracellular Compartment

Malhotra, H., Sheokand, N., Kumar, S., Chauhan, A. S., Kumar, M., Jakhar, P., Boradia, V. M., Raje, C. I., & Raje, M. (2016) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2016.2229 · Cited by 114

Modulation of Immune Responses by Exosomes Derived from Antigen-Presenting Cells

Shenoda, B. B., & Ajit, S. K. (2016) · Clinical Medicine Insights Pathology · doi:10.4137/cpath.s39925 · Cited by 106

Copper-free azide–alkyne cycloaddition of targeting peptides to porous silicon nanoparticles for intracellular drug uptake

Wang, C., Mäkilä, E. M., Kaasalainen, M. H., Liu, D., Sarparanta, M. P., Airaksinen, A. J., Salonen, J., Hirvonen, J. J., & Santos, H. A. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.065 · Cited by 105

Strategies of polymeric nanoparticles for enhanced internalization in cancer therapy

Sun, L., Wu, Q., Peng, F., Liu, L., & Gong, C. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.07.013 · Cited by 102

A systematic approach to exosome‐based translational nanomedicine

Hood, J. L., & Wickline, S. A. (2012) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1174 · Cited by 98

Myeloid suppressor cells regulate the adaptive immune response to cancer

Frey, A. B. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29906 · Cited by 94

Controllable mineral coatings on PCL scaffolds as carriers for growth factor release

Suárez-González, D., Barnhart, K., Migneco, F., Flanagan, C. L., Hollister, S. J., & Murphy, W. L. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.095 · Cited by 92

The functions and clinical applications of tumor-derived exosomes

Shao, Y., Shen, Y., Chen, T., Xu, F., Chen, X., & Zheng, S. S. (2016) · Oncotarget · doi:10.18632/oncotarget.11177 · Cited by 90

Disposition and safety of inhaled biodegradable nanomedicines: Opportunities and challenges

Haque, S., Whittaker, M. R., McIntosh, M. P., Pouton, C. W., & Kaminskas, L. M. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.03.002 · Cited by 87

DC-HIL/Glycoprotein Nmb Promotes Growth of Melanoma in Mice by Inhibiting the Activation of Tumor-Reactive T Cells

Tomihari, M., Chung, J., Akiyoshi, H., Cruz, P. D., & Ariizumi, K. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2538 · Cited by 85

The Drug Discovery by NanoMedicine and its Clinical Experience

Matsumura, Y. (2014) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyu046 · Cited by 82

The Novel Methods for Analysis of Exosomes Released from Endothelial Cells and Endothelial Progenitor Cells

Wang, J., Guo, R., Yang, Y., Jacobs, B. S., Chen, S., Iwuchukwu, I. O., Gaines, K. J., Chen, Y., Simman, R., Lv, G., et al. (2016) · Stem Cells International · doi:10.1155/2016/2639728 · Cited by 63

Tumor priming using metronomic chemotherapy with neovasculature-targeted, nanoparticulate paclitaxel

Luan, X., Guan, Y., Lovell, J. F., Zhao, M., Lu, Q., Liu, Y., Liu, H.-J., Gao, Y., Dong, X., Yang, S., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.04.008 · Cited by 63

Extracellular vesicles as a next-generation drug delivery platform

Herrmann, I. K., Wood, M. J. A., & Fuhrmann, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00931-2 · Cited by 1,948

Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications

Zhang, Y., Bi, J., Huang, J., Tang, Y., Du, S., & Li, P. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s264498 · Cited by 1,323

Exosomes: key players in cancer and potential therapeutic strategy

Dai, J., Su, Y., Zhong, S., Cong, L., Liu, B., Yang, J., Tao, Y., He, Z., Chen, C., & Jiang, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00261-0 · Cited by 1,186

Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake

Kimiz-Gebologlu, I., & Oncel, S. S. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.027 · Cited by 722

Prospects and challenges of extracellular vesicle-based drug delivery system: considering cell source

Meng, W., He, C., Hao, Y., Wang, L., Li, L., & Zhu, G. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1748758 · Cited by 592