Cited by 248Nutrition and Health in AgingFrailty in Older AdultsBalance, Gait, and Falls Prevention

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The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI Study

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Stenholm, S, Alley, D, Bandinelli, S, Griswold, M E, Koskinen, S, Rantanen, T, Guralnik, J M, Ferrucci, L·2009·International Journal of Obesity

DOI 10.1038/ijo.2009.62PMC PMC2697265

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Abstract

Objective Both obesity and muscle impairment are increasingly prevalent among older persons and negatively affect health and physical functioning. However, the combined effect of coexisting obesity and muscle impairment on physical function decline has been little studied. We examined whether obese persons with low muscle strength experience significantly greater declines in walking speed and mobility than persons with only obesity or low muscle strength.Design Community-dwelling adults aged > or = 65 years (n = 930) living in the Chianti geographic area (Tuscany, Italy) were followed for 6 years in the population-based InCHIANTI study.Measurements On the basis of baseline measurements (1998-2000), obesity was defined as body mass index (BMI) > or = 30 kg/m(2) and low muscle strength as lowest sex-specific tertile of knee extensor strength. Walking speed and self-reported mobility disability (ability to walk 400 m or climb one flight of stairs) were assessed at baseline and at 3- and 6-year follow-up.Results At baseline, obese persons with low muscle strength had significantly lower walking speed compared with all other groups (P < or = 0.05). In longitudinal analyses, obese participants with low muscle strength had steeper decline in walking speed and high risk of developing new mobility disability over the 6-year follow-up compared with those without obesity or low muscle strength. After the age of 80, the differences between groups were substantially attenuated. The differences seen in walking speed across combination of low muscle strength and obesity groups were partly explained by 6-year changes in muscle strength, BMI and waist circumference.Conclusions Obesity combined with low muscle strength increases the risk of decline in walking speed and developing mobility disability, especially among persons < 80 years old.

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Authors: Stenholm, S., Alley, D., Bandinelli, S., Griswold, M. E., Koskinen, S., Rantanen, T., Guralnik, J. M., & Ferrucci, L.
Affiliations: National Institute on Aging (US)
University of Maryland, Baltimore (US)
Azienda Sanitaria di Firenze (IT)
Johns Hopkins University (US)
Finnish Institute for Health and Welfare (FI)
University of Jyväskylä (FI)
National Institutes of Health (US)
Corresponding author: Stenholm, S
ORCID: Stenholm, S
Bandinelli, S
Rantanen, T
Guralnik, J M
Ferrucci, L
Venue: International Journal of Obesity
Publisher: Springer Science and Business Media LLC
Published: 2009-04-21
Volume: 33
Issue: 6
Pages: 635-644
ISSN: 0307-0565 (ISSN-L)
1476-5497
DOI: 10.1038/ijo.2009.62
PMC: PMC2697265
OpenAlex: W2123960494
Cited by: 248
References: 46
Citations by year: 2026: 10 · 2025: 6 · 2024: 8 · 2023: 35 · 2022: 7 · 2021: 6 · 2020: 13 · 2019: 13 · 2018: 18 · 2017: 19 · 2016: 20 · 2015: 22 · 2014: 13 · 2013: 17 · 2012: 13
FWCI: 9.06
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: International Journal of Obesity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders: National Institutes of Health
National Institute on Aging (N.1‐AG‐1‐2111, N.1-AG-1-1, N01 AG000005, N01 AG-5-0002)
National Institute on Minority Health and Health Disparities (263MD9164, 263MD 821336, R01MD009164)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
Keywords: obesity, muscle weakness, mobility decline, walking speed, mobility impairment, older adults, quadriceps strength, body mass index, waist circumference, physical function, InCHIANTI study
MeSH terms: Activities of Daily Living, Aged, Female, Health Surveys, Humans, Italy, Locomotion, Male, Obesity, Risk Factors, Geriatric Assessment, Body Mass Index, Walking, Muscle, Skeletal, Muscle Strength

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The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI Study

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