Developmental regulation of the growth plate

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6

Akiyama, H., Chaboissier, M.-C., Martin, J. F., Schedl, A., & de Crombrugghe, B. (2002) · Genes & Development · doi:10.1101/gad.1017802 · Cited by 1,721

Heparan sulphate proteoglycans fine-tune mammalian physiology

Bishop, J. R., Schuksz, M., & Esko, J. D. (2007) · Nature · doi:10.1038/nature05817 · Cited by 1,631

Matrix-embedded cells control osteoclast formation

Xiong, J., Onal, M., Jilka, R. L., Weinstein, R. S., Manolagas, S. C., & O'Brien, C. A. (2011) · Nature Medicine · doi:10.1038/nm.2448 · Cited by 1,304

Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1

Gereben, B., Zavacki, A. M., Ribich, S., Kim, B. W., Huang, S. A., Simonides, W. S., Zeöld, A., & Bianco, A. C. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0019 · Cited by 891

Estrogens and androgens in skeletal physiology and pathophysiology

Almeida, M., Laurent, M. R., Dubois, V., Claessens, F., O'Brien, C. A., Bouillon, R., Vanderschueren, D., & Manolagas, S. C. (2017) · Physiological Reviews · doi:10.1152/physrev.00033.2015 · Cited by 860

The aging of Wolff’s “law”: Ontogeny and responses to mechanical loading in cortical bone

Pearson, O. M., & Lieberman, D. E. (2004) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20155 · Cited by 745

Genetic Control of Bone Formation

Karsenty, G., Kronenberg, H. M., & Settembre, C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113308 · Cited by 667

Passing the baton: the HIF switch

Koh, M. Y., & Powis, G. (2012) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2012.06.004 · Cited by 589

The Role of Reactive Oxygen Species in Mesenchymal Stem Cell Adipogenic and Osteogenic Differentiation: A Review

Atashi, F., Modarressi, A., & Pepper, M. S. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0484 · Cited by 603

Role of Thyroid Hormones in Skeletal Development and Bone Maintenance

Bassett, J. H. D., & Williams, G. R. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1106 · Cited by 540

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

Saito, T., Fukai, A., Mabuchi, A., Ikeda, T., Yano, F., Ohba, S., Nishida, N., Akune, T., Yoshimura, N., Nakagawa, T., et al. (2010) · Nature Medicine · doi:10.1038/nm.2146 · Cited by 532

Skeletal stem cells

Bianco, P., & Robey, P. G. (2015) · Development · doi:10.1242/dev.102210 · Cited by 402

Scaffolds based bone tissue engineering: the role of chitosan

Costa-Pinto, A. R., Reis, R. L., & Neves, N. M. (2011) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2010.0704 · Cited by 355

The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-β Signaling Pathways

Fukada, T., Civic, N., Furuichi, T., Shimoda, S., Mishima, K., Higashiyama, H., Idaira, Y., Asada, Y., Kitamura, H., Yamasaki, S., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003642 · Cited by 287

Thyroid diseases and bone health

Williams, G. R., & Bassett, J. H. D. (2018) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0753-4 · Cited by 276

Autophagy modulates osteoarthritis‐related gene expression in human chondrocytes

Sasaki, H., Takayama, K., Matsushita, T., Ishida, K., Kubo, S., Matsumoto, T., Fujita, N., Oka, S., Kurosaka, M., & Kuroda, R. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34323 · Cited by 266

The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate

Dentice, M., Bandyopadhyay, A., Gereben, B., Callebaut, I., Christoffolete, M. A., Kim, B. W., Nissim, S., Mornon, J.-P., Zavacki, A. M., Zeöld, A., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1272 · Cited by 227

Hedgehog Signaling in Mature Osteoblasts Regulates Bone Formation and Resorption by Controlling PTHrP and RANKL Expression

Mak, K. K., Bi, Y., Wan, C., Chuang, P.-T., Clemens, T., Young, M., & Yang, Y. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.02.003 · Cited by 202

Bone and skeletal muscle: neighbors with close ties

DiGirolamo, D. J., Kiel, D. P., & Esser, K. A. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1969 · Cited by 193

Fibronectin and stem cell differentiation – lessons from chondrogenesis

Singh, P., & Schwarzbauer, J. E. (2012) · Journal of Cell Science · doi:10.1242/jcs.095786 · Cited by 191

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte

Ohba, S., He, X., Hojo, H., & McMahon, A. P. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.013 · Cited by 179

Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia

Ruiz-Perez, V. L., Blair, H. J., Rodriguez-Andres, M. E., Blanco, M. J., Wilson, A., Liu, Y.-N., Miles, C., Peters, H., & Goodship, J. A. (2007) · Development · doi:10.1242/dev.007542 · Cited by 175

The role of hedgehog signalling in skeletal health and disease

Alman, B. A. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.84 · Cited by 141

Ablation of the Sam68 RNA Binding Protein Protects Mice from Age-Related Bone Loss

Richard, S., Torabi, N., Franco, G. V., Tremblay, G. A., Chen, T., Vogel, G., Morel, M., Cléroux, P., Forget-Richard, A., Komarova, S., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010074 · Cited by 133

Role and Mechanisms of Actions of Thyroid Hormone on the Skeletal Development

Kim, H.-Y., & Mohan, S. (2013) · Bone Research · doi:10.4248/br201302004 · Cited by 117

Mutant IDH is sufficient to initiate enchondromatosis in mice

Hirata, M., Sasaki, M., Cairns, R. A., Inoue, S., Puviindran, V., Li, W. Y., Snow, B. E., Jones, L. D., Wei, Q., Sato, S., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424400112 · Cited by 115

Stem cell‐derived exosomes: A promising strategy for fracture healing

Hao, Z., Lu, J., Wang, S., Wu, H., Zhang, Y., & Xu, S. (2017) · Cell Proliferation · doi:10.1111/cpr.12359 · Cited by 106

Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome

Napierala, D., Sam, K., Morello, R., Zheng, Q., Munivez, E., Shivdasani, R. A., & Lee, B. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn125 · Cited by 104

Engineered Microsystems for Spheroid and Organoid Studies

Kang, S., Kim, D., Lee, J., Takayama, S., & Park, J. Y. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202001284 · Cited by 100

Engineering cartilage or endochondral bone: A comparison of different naturally derived hydrogels

Sheehy, E. J., Mesallati, T., Vinardell, T., & Kelly, D. J. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.11.031 · Cited by 98

The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation

Melrose, J., Shu, C., Whitelock, J. M., & Lord, M. S. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.01.008 · Cited by 96

Programmed cell senescence in skeleton during late puberty

Li, C., Chai, Y., Wang, L., Gao, B., Chen, H., Gao, P., Zhou, F.-Q., Luo, X., Crane, J. L., Yu, B., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01509-0 · Cited by 92

Iron, Zinc, Copper, Cadmium, Mercury, and Bone Tissue

Ciosek, Ż., Kot, K., & Rotter, I. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20032197 · Cited by 86

Thyroid Hormones Regulate Fibroblast Growth Factor Receptor Signaling during Chondrogenesis

Barnard, J. C., Williams, A. J., Rabier, B., Chassande, O., Samarut, J., Cheng, S.-Y., Bassett, J. H. D., & Williams, G. R. (2005) · Endocrinology · doi:10.1210/en.2005-0762 · Cited by 85

Master regulator for chondrogenesis, sox9, regulates transcriptional activation of the endoplasmic reticulum stress transducer BBF2H7/CREB3L2 in chondrocytes

Hino, K., Saito, A., Kido, M., Kanemoto, S., Asada, R., Takai, T., Cui, M., Cui, X., & Imaizumi, K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.543322 · Cited by 84

Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength

Bassett, J. H. D., Gogakos, A., White, J. K., Evans, H., Jacques, R. M., van der Spek, A. H., Sanger Mouse Genetics Project, Ramirez-Solis, R., Ryder, E., Sunter, D., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002858 · Cited by 82

Latent developmental potential to form limb-like skeletal structures in zebrafish

Hawkins, M. B., Henke, K., & Harris, M. P. (2021) · Cell · doi:10.1016/j.cell.2021.01.003 · Cited by 80

Regulation of Proliferation and Chondrogenic Differentiation of Human Mesenchymal Stem Cells by Laminin‐5 (Laminin‐332)

Hashimoto, J., Kariya, Y., & Miyazaki, K. (2006) · STEM CELLS · doi:10.1634/stemcells.2005-0605 · Cited by 67

MicroRNA-140 Provides Robustness to the Regulation of Hypertrophic Chondrocyte Differentiation by the PTHrP-HDAC4 Pathway

Papaioannou, G., Mirzamohammadi, F., Lisse, T. S., Nishimori, S., Wein, M. N., & Kobayashi, T. (2015) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2438 · Cited by 62

IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis

Tan, Z., Kong, M., Wen, S., Tsang, K. Y., Niu, B., Hartmann, C., Chan, D., Hui, C.-C., & Cheah, K. S. E. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4132 · Cited by 52

The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner

Hwang, S.-H., White, K. A., Somatilaka, B. N., Shelton, J. M., Richardson, J. A., & Mukhopadhyay, S. (2018) · Development · doi:10.1242/dev.154054 · Cited by 60

Dual growth factor delivery using biocompatible core–shell microcapsules for angiogenesis

Choi, D. H., Subbiah, R., Kim, I. H., Han, D. K., & Park, K. (2013) · Small · doi:10.1002/smll.201300427 · Cited by 60

Abolition of chondral mineralization by group III metabotropic glutamate receptors expressed in rodent cartilage

Wang, L., Hinoi, E., Takemori, A., Takarada, T., & Yoneda, Y. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706358 · Cited by 36

TGF‐β Suppresses Ift88 Expression in Chondrocytic ATDC5 Cells

Kawasaki, M., Ezura, Y., Hayata, T., Notomi, T., Izu, Y., & Noda, M. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25005 · Cited by 26

Expression of vascular endothelial growth factor in the growth plate is stimulated by estradiol and increases during pubertal development

Emons, J., Chagin, A. S., Malmlöf, T., Lekman, M., Tivesten, Å., Ohlsson, C., Wit, J. M., Karperien, M., & Sävendahl, L. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0337 · Cited by 25

Differential regulation of cellular maturation in chondrocytes and osteoblasts by glycine

Takahata, Y., Takarada, T., Osawa, M., Hinoi, E., Nakamura, Y., & Yoneda, Y. (2008) · Cell and Tissue Research · doi:10.1007/s00441-008-0607-7 · Cited by 22

Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair

Rivera, K. O., Cuylear, D. L., Duke, V. R., O’Hara, K. M., Zhong, J. X., Elghazali, N. A., Finbloom, J. A., Kharbikar, B. N., Kryger, A. N., Miclau, T., et al. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1190371 · Cited by 22

Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3

Jones, D. C., Schweitzer, M. N., Wein, M., Sigrist, K., Takagi, T., Ishii, S., & Glimcher, L. H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003727107 · Cited by 21

Targeting aging with the healthy skeletal system: The endocrine role of bone

Zheng, X.-Q., Lin, J.-L., Huang, J., Wu, T., & Song, C.-L. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09812-6 · Cited by 19

Human Immunodeficiency Virus Type 1 Enhancer-binding Protein 3 Is Essential for the Expression of Asparagine-linked Glycosylation 2 in the Regulation of Osteoblast and Chondrocyte Differentiation

Imamura, K., Maeda, S., Kawamura, I., Matsuyama, K., Shinohara, N., Yahiro, Y., Nagano, S., Setoguchi, T., Yokouchi, M., Ishidou, Y., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.520585 · Cited by 19

Effects of maternal consumption of morphine on rat skeletal system development

Saeidinezhad, M., Razban, V., Safizadeh, H., & Ezzatabadipour, M. (2021) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-021-04321-6 · Cited by 12

Role of Thyroid Hormone Receptor-α1 in Endochondral Ossification

Williams, G. R. (2014) · Endocrinology · doi:10.1210/en.2014-1527 · Cited by 8

Variants in the SOX9 transactivation middle domain induce axial skeleton dysplasia and scoliosis

(2025) · doi:10.1073/pnas.2313978121 · Cited by 4