Cited by 10,728MicroRNA in disease regulationDevelopmental Biology and Gene RegulationPlant Molecular Biology Research

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The functions of animal microRNAs

Ambros, Victor·2004·Nature

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Abstract

MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and many of these are phylogenetically conserved. With miRNA roles identified in developmental timing, cell death, cell proliferation, haematopoiesis and patterning of the nervous system, evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.

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Authors: Ambros, V.
Affiliations: Dartmouth College (US)
Corresponding author: Ambros, Victor
ORCID: Ambros, Victor
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2004-09
Volume: 431
Issue: 7006
Pages: 350-355
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature02871
OpenAlex: W2014946489
Cited by: 10,728
References: 52
Citations by year: 2026: 123 · 2025: 229 · 2024: 318 · 2023: 353 · 2022: 486 · 2021: 646 · 2020: 725 · 2019: 738 · 2018: 769 · 2017: 785 · 2016: 704 · 2015: 787 · 2014: 701 · 2013: 655 · 2012: 610
FWCI: 13.22
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: microRNA, gene expression regulation, post-transcriptional regulation, developmental timing, cell death, cell proliferation, hematopoiesis, phylogenetic conservation, animal development
MeSH terms: Animals, Gene Expression Regulation, Multigene Family, Substrate Specificity, Genomics, MicroRNAs

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