The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.
The functions of animal microRNAs
Abstract
MicroRNAs (miRNAs) are small RNAs that regulate the expression of complementary messenger RNAs. Hundreds of miRNA genes have been found in diverse animals, and many of these are phylogenetically conserved. With miRNA roles identified in developmental timing, cell death, cell proliferation, haematopoiesis and patterning of the nervous system, evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
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“miRNA targeting of mRNAs inhibits their expression through mRNA destabilization, repression of translation, or a combination of both processes (8–10).”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [8]
In the citing paper
“a class of noncoding RNAs, termed microRNAs (miRNAs), has emerged as critical regulators of gene expression acting predominantly at the posttranscriptional level (8–10).”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [8]
In the citing paper
“MicroRNAs (miRNAs) are 19-to 24-nucleotide (nt) noncoding RNAs that act as important regulators of posttranscriptional gene expression (Ambros, 2004;Kim, 2005).”
From Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes (2013) · cites this paper as Ambros, 2004
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“In this role, they control essential cell processes in health and disease (Ambros 2004; Mendell and Olson 2012).”
From Toward the human cellular microRNAome (2017) · cites this paper as Ambros 2004
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Metadata
- Authors
- Ambros, V.
- Affiliations
- Dartmouth College (US)
- Corresponding author
- Ambros, Victor
- ORCID
- Ambros, Victor
- Venue
- Nature
- Published
- 2004-09
- Volume
- 431
- Issue
- 7006
- Pages
- 350-355
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2014946489
- Cited by
- 10,728
- References
- 52
- Citations by year
- 2026: 123 · 2025: 229 · 2024: 318 · 2023: 353 · 2022: 486 · 2021: 646 · 2020: 725 · 2019: 738 · 2018: 769 · 2017: 785 · 2016: 704 · 2015: 787 · 2014: 701 · 2013: 655 · 2012: 610
- FWCI
- 13.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- microRNA, gene expression regulation, post-transcriptional regulation, developmental timing, cell death, cell proliferation, hematopoiesis, phylogenetic conservation, animal development
- MeSH terms
- Animals, Gene Expression Regulation, Multigene Family, Substrate Specificity, Genomics, MicroRNAs
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