Cited by 2,804Sleep and Wakefulness ResearchCircadian rhythm and melatoninNeuroscience of respiration and sleep

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Hypothalamic regulation of sleep and circadian rhythms

Saper, Clifford B., Scammell, Thomas E., Lu, Jun·2005·Nature

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Abstract

A series of findings over the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex. A key switch in the hypothalamus shuts off this arousal system during sleep. Other hypothalamic neurons stabilize the switch, and their absence results in inappropriate switching of behavioural states, such as occurs in narcolepsy. These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake-sleep cycles into the optimal pattern for survival.

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Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Brain stem reticular formation and activation of the EEG
Moruzzi, G., & Magoun, H. W. (1949) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(49)90219-9 · Cited by 4,307
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
The rat nervous system
Paxinos, G. (1985) · Cited by 3,715
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation
Van Dongen, H. P. A., Maislin, G., Mullington, J. M., & Dinges, D. F. (2003) · Sleep · doi:10.1093/sleep/26.2.117 · Cited by 3,173
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Self-citation
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613
Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat
Moore, R. Y., & Eichler, V. B. (1972) · Brain Research · doi:10.1016/0006-8993(72)90054-6 · Cited by 2,135

Show all 102 references

Research works printed but not linked: 4

Verret, L. et al. Localization of the neurones potentially responsible for the inhibition of locus coeruleus noradrenergic neurones during paradoxical sleep in the rat. J. Comp. Neurol. (in the press).
Chou, T. C. Regulation of Wake-Sleep Timing: Circadian Rhythms and Bistability of Sleep-Wake States, 82–99. Thesis, Harvard Univ. (2003).
Yoshida, K., McCormack, S., Espana, R. A., Crocker, A. D. & Scammell, T. E. Afferents to the orexin neurons. J. Comp. Neurol. (in the press).
Nyholm, H. Zur okologie von Myotis mystacinus (Leisl.) und M. daubentoni (Leisl.) (Chiroptera). Ann. Zool. Fenn. 2, 77–123 (1955).

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Slats, D., Claassen, J. A. H. R., Lammers, G. J., Melis, R. J. F., Verbeek, M. M., & Overeem, S. (2012) · Current Alzheimer Research · doi:10.2174/156720512804142840 · Cited by 69
A Review of Sleep and Its Disorders in Patients with Parkinson's Disease in Relation to Various Brain Structures
French, I. T., & Muthusamy, K. A. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00114 · Cited by 69
Adverse Effects of Psychotropic Medications on Sleep
Doghramji, K., & Jangro, W. C. (2016) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2016.04.009 · Cited by 69
Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder
Provenza, N. R., Reddy, S., Allam, A. K., Rajesh, S. V., Diab, N., Reyes, G., Caston, R. M., Katlowitz, K. A., Gandhi, A. D., Bechtold, R. A., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03125-0 · Cited by 68
“One possibility is that the 9-Hz circadian rhythm that we observed is produced by pattern generators in the hypothalamus, as are many other such rhythms 43 .”
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Goel, M., Mittal, A., Jain, V. R., Bharadwaj, A., Modi, S., Ahuja, G., Jain, A., & Kumar, K. (2024) · Annals of Neurosciences · doi:10.1177/09727531241255492 · Cited by 68
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Silver, W. G., & Rapin, I. (2012) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2011.10.010 · Cited by 68
Entrainment of temperature and activity rhythms to restricted feeding in orexin knock out mice
Kaur, S., Thankachan, S., Begum, S., Blanco‐Centurion, C., Sakurai, T., Yanagisawa, M., & Shiromani, P. J. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.026 · Cited by 68
Abnormal daytime sleepiness in dementia with Lewy bodies compared to Alzheimer’s disease using the Multiple Sleep Latency Test
Ferman, T. J., Smith, G. E., Dickson, D. W., Graff‐Radford, N. R., Lin, S.-C., Wszołek, Z. K., van Gerpen, J. A., Uitti, R. J., Knopman, D. S., Petersen, R. C., et al. (2014) · Alzheimer s Research & Therapy · doi:10.1186/s13195-014-0076-z · Cited by 68
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Dong, H., Li, M., Yan, Y., Qian, T., Lin, Y., Ma, X., Vischer, H. F., Liu, C., Li, G., Wang, H., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.02.024 · Cited by 67
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van Santen, H. M., van Schaik, J., van Roessel, I. M. A. A., Beckhaus, J., Boekhoff, S., & Müller, H. L. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad009 · Cited by 67
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Mogavero, M. P., Silvani, A., Lanza, G., DelRosso, L. M., Ferini‐Strambi, L., & Ferri, R. (2023) · Nature and Science of Sleep · doi:10.2147/nss.s201994 · Cited by 67
Efferent and afferent connections of the dorsal and median raphe nuclei in the rat
Vertes, R. P., & Linley, S. B. (2008) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8561-3_3 · Cited by 67
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Rudic, R. D., & Fulton, D. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00661.2009 · Cited by 67
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Riemann, D. W., KLOEPFER, C., & Berger, T. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06721.x · Cited by 67
Effects of cocaine place conditioning, chronic escalating-dose “binge” pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague–Dawley rats
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Authors: Saper, C. B., Scammell, T. E., & Lu, J.
Affiliations: Beth Israel Deaconess Medical Center (US)
Corresponding author: Saper, Clifford B.
ORCID: Saper, Clifford B.
Scammell, Thomas E.
Lu, Jun
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2005-10-26
Volume: 437
Issue: 7063
Pages: 1257-1263
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature04284
OpenAlex: W2002293846
Cited by: 2,804
References: 102
Citations by year: 2026: 101 · 2025: 121 · 2024: 162 · 2023: 136 · 2022: 134 · 2021: 161 · 2020: 119 · 2019: 166 · 2018: 145 · 2017: 132 · 2016: 151 · 2015: 122 · 2014: 122 · 2013: 151 · 2012: 144
FWCI: 8.23
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: U.S. Public Health Service
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: hypothalamus, sleep regulation, circadian rhythm, wakefulness, sleep-wake cycle, arousal system, thalamus, cerebral cortex, narcolepsy, neurotransmitters, sleep-promoting neurons, sleep medication
MeSH terms: Orexins, Animals, Arousal, Circadian Rhythm, Humans, Hypothalamus, Neuropeptides, Sleep, Wakefulness, Intracellular Signaling Peptides and Proteins

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Hypothalamic regulation of sleep and circadian rhythms

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