Cited by 2,804Sleep and Wakefulness ResearchCircadian rhythm and melatoninNeuroscience of respiration and sleep

The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.

Hypothalamic regulation of sleep and circadian rhythms

Saper, Clifford B., Scammell, Thomas E., Lu, Jun·2005·Nature

Open this paper in CoChat — free account

Abstract

A series of findings over the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex. A key switch in the hypothalamus shuts off this arousal system during sleep. Other hypothalamic neurons stabilize the switch, and their absence results in inappropriate switching of behavioural states, such as occurs in narcolepsy. These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake-sleep cycles into the optimal pattern for survival.

Integrity signals

Registry

Crossref · 10.1038/nature04284

Cites

102 of 102 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Brain stem reticular formation and activation of the EEG
Moruzzi, G., & Magoun, H. W. (1949) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(49)90219-9 · Cited by 4,307
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
The rat nervous system
Paxinos, G. (1985) · Cited by 3,715
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation
Van Dongen, H. P. A., Maislin, G., Mullington, J. M., & Dinges, D. F. (2003) · Sleep · doi:10.1093/sleep/26.2.117 · Cited by 3,173
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Self-citation
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613
Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat
Moore, R. Y., & Eichler, V. B. (1972) · Brain Research · doi:10.1016/0006-8993(72)90054-6 · Cited by 2,135

Show all 102 references

Research works printed but not linked: 4

Verret, L. et al. Localization of the neurones potentially responsible for the inhibition of locus coeruleus noradrenergic neurones during paradoxical sleep in the rat. J. Comp. Neurol. (in the press).
Chou, T. C. Regulation of Wake-Sleep Timing: Circadian Rhythms and Bistability of Sleep-Wake States, 82–99. Thesis, Harvard Univ. (2003).
Yoshida, K., McCormack, S., Espana, R. A., Crocker, A. D. & Scammell, T. E. Afferents to the orexin neurons. J. Comp. Neurol. (in the press).
Nyholm, H. Zur okologie von Myotis mystacinus (Leisl.) und M. daubentoni (Leisl.) (Chiroptera). Ann. Zool. Fenn. 2, 77–123 (1955).

Sorted by citations

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358
European guideline for the diagnosis and treatment of insomnia
Riemann, D., Baglioni, C., Bassetti, C., Bjorvatn, B., Dolenc Groselj, L., Ellis, J. G., Espie, C. A., Garcia‐Borreguero, D., Gjerstad, M., Gonçalves, M., et al. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12594 · Cited by 2,049
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
The hyperarousal model of insomnia: A review of the concept and its evidence
Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.04.002 · Cited by 1,789
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611
Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477
General Anesthesia, Sleep, and Coma
Brown, E. N., Lydic, R., & Schiff, N. D. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0808281 · Cited by 1,413
Delirium
Wilson, J. E., Mart, M. F., Cunningham, C. M., Shehabi, Y., Girard, T. D., MacLullich, A. M. J., Slooter, A. J. C., & Ely, E. W. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00223-4 · Cited by 1,371
A putative flip–flop switch for control of REM sleep
Lu, J., Sherman, D. L., Devor, M. G., & Saper, C. B. (2006) · Nature · doi:10.1038/nature04767 · Cited by 1,265
Self-citation
Histamine in the Nervous System
Haas, H. L., Sergeeva, O. A., & Selbach, O. (2008) · Physiological Reviews · doi:10.1152/physrev.00043.2007 · Cited by 1,251
Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System
Dani, J. A., & Bertrand, D. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105214 · Cited by 1,197
Selective neuronal vulnerability in Parkinson disease
Surmeier, D. J., Obeso, J. A., & Halliday, G. M. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.178 · Cited by 1,116
Generation of circadian rhythms in the suprachiasmatic nucleus
Hastings, M. H., Maywood, E. S., & Brancaccio, M. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0026-z · Cited by 1,065
Tuning arousal with optogenetic modulation of locus coeruleus neurons
Carter, M. E., Yizhar, O., Chikahisa, S., Nguyen, H., Adamantidis, A., Nishino, S., Deisseroth, K., & de Lecea, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2682 · Cited by 993
New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation
Zisapel, N. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14116 · Cited by 947
Bruxism physiology and pathology: an overview for clinicians*
Lavigne, G. J., Khoury, S., Abe, S., Yamaguchi, T., & Raphael, K. G. (2008) · Journal of Oral Rehabilitation · doi:10.1111/j.1365-2842.2008.01881.x · Cited by 928
Disorders of consciousness after acquired brain injury: the state of the science
Giacino, J. T., Fins, J. J., Laureys, S., & Schiff, N. D. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.279 · Cited by 913
Sleep, insomnia, and depression
Riemann, D. W., Krone, L. B., Wulff, K., & Nissen, C. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0411-y · Cited by 901
Migraine: Multiple Processes, Complex Pathophysiology
Burstein, R., Noseda, R., & Borsook, D. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0373-15.2015 · Cited by 892
Clinical Electroencephalography for Anesthesiologists
Purdon, P. L., Sampson, A. L., Pavone, K. J., & Brown, E. N. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000841 · Cited by 889
Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways
Jansen, P. R., Watanabe, K., Stringer, S., Skene, N., Bryois, J., Hammerschlag, A. R., de Leeuw, C., Benjamins, J. S., Muñoz‐Manchado, A. B., Nagel, M., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0333-3 · Cited by 869
Melatonin—A pleiotropic, orchestrating regulator molecule
Hardeland, R., Cardinali, D. P., Srinivasan, V., Spence, D. W., Brown, G. M., & Pandi-Perumal, S. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.12.004 · Cited by 843
The Neurology of mTOR
Lipton, J. O., & Şahin, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.034 · Cited by 771
Circadian rhythms, sleep, and metabolism
Huang, W., Ramsey, K. M., Marcheva, B., & Bass, J. T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46043 · Cited by 749
Insomnia disorder
Morin, C. M., Drake, C. L., Harvey, A. G., Krystal, A. D., Manber, R., Riemann, D., & Spiegelhalder, K. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.26 · Cited by 746
Circadian clocks and insulin resistance
Stenvers, D. J., Scheer, F. A. J. L., Schrauwen, P., la Fleur, S. E., & Kalsbeek, A. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0122-1 · Cited by 733
Sleep, sleep deprivation, autonomic nervous system and cardiovascular diseases
Tobaldini, E., Costantino, G., Solbiati, M., Cogliati, C. B., Kára, T., Nobili, L., & Montano, N. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.004 · Cited by 708
Neuromodulation of Brain States
Lee, S., & Dan, Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.012 · Cited by 697
Alerting effects of light
Cajochen, C. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.009 · Cited by 652
Autonomic Control of the Eye
McDougal, D. H., & Gamlin, P. D. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140014 · Cited by 645
Circadian rhythm disturbances in depression
Germain, A., & Kupfer, D. J. (2008) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.964 · Cited by 644
Neurobiology of the Sleep-Wake Cycle: Sleep Architecture, Circadian Regulation, and Regulatory Feedback
Fuller, P. M., Gooley, J. J., & Saper, C. B. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730406294627 · Cited by 636
Self-citation
Circadian time signatures of fitness and disease
Bass, J. T., & Lazar, M. A. (2016) · Science · doi:10.1126/science.aah4965 · Cited by 635
British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders
Wilson, S., Nutt, D., Alford, C., Argyropoulos, S., Baldwin, D., Bateson, A., Britton, T., Crowe, C., Dijk, D.-J., Espie, C., et al. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110379307 · Cited by 634
The Hormonal Control of Food Intake
Coll, A. P., Farooqi, I. S., & O’Rahilly, S. (2007) · Cell · doi:10.1016/j.cell.2007.04.001 · Cited by 624
Delirium pathophysiology: An updated hypothesis of the etiology of acute brain failure
Maldonado, J. R. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4823 · Cited by 617
Bidirectional relationship between sleep and Alzheimer’s disease: role of amyloid, tau, and other factors
Wang, C., & Holtzman, D. M. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0478-5 · Cited by 615
Sleep as a fundamental property of neuronal assemblies
Krueger, J. M., Rector, D. M., Roy, S., Van Dongen, H. P. A., Belenky, G., & Panksepp, J. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2521 · Cited by 596
General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis
Brown, E. N., Purdon, P. L., & Dort, C. J. V. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153200 · Cited by 578
Arousal and reward: a dichotomy in orexin function
Harris, G. C., & Aston‐Jones, G. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.08.002 · Cited by 567
Light as a modulator of cognitive brain function.
Vandewalle, G., Maquet, P., & Dijk, D.-J. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.07.004 · Cited by 556
Examining the Effects of Sleep Deprivation on Workplace Deviance: A Self-Regulatory Perspective
Christian, M. S., & Ellis, A. P. J. (2011) · Academy of Management Journal · doi:10.5465/amj.2010.0179 · Cited by 556
Multimodal General Anesthesia: Theory and Practice
Brown, E. N., Pavone, K. J., & Naranjo, M. (2018) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000003668 · Cited by 557
PER3 polymorphism predicts sleep structure and waking performance
Viola, A. U., Archer, S. N., James, L. M., Groeger, J. A., Lo, J. C. Y., Skene, D. J., von Schantz, M., & Dijk, D.-J. (2007) · Current Biology · doi:10.1016/j.cub.2007.01.073 · Cited by 520
Reassessment of the structural basis of the ascending arousal system
Fuller, P., Sherman, D., Pedersen, N. P., Saper, C. B., & Lu, J. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22559 · Cited by 465
Self-citation
Circadian rhythm as a therapeutic target
Ruan, W., Yuan, X., & Eltzschig, H. K. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00109-w · Cited by 518
Abnormal melatonin synthesis in autism spectrum disorders
Melke, J., Goubran Botros, H., Chaste, P., Betancur, C., Nygren, G., Anckarsäter, H., Rastam, M., Ståhlberg, O., Gillberg, I. C., Delorme, R., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002016 · Cited by 511
The subcallosal cingulate gyrus in the context of major depression
Hamani, C., Mayberg, H., Stone, S., Laxton, A., Haber, S., & Lozano, A. M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.034 · Cited by 508
Circadian Rhythms and Metabolic Syndrome
Maury, E., Ramsey, K. M., & Bass, J. T. (2010) · Circulation Research · doi:10.1161/circresaha.109.208355 · Cited by 509
The Role of Cytokines in Sleep Regulation
Krueger, J. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786549281 · Cited by 507
Metabolism and Circadian Rhythms—Implications for Obesity
Froy, O. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0014 · Cited by 505
The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of tsai and substantia nigra compacta
Jhou, T. C., Geisler, S., Marinelli, M., Degarmo, B. A., & Zahm, D. S. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21891 · Cited by 503
Sleep in elite athletes and nutritional interventions to enhance sleep
Halson, S. L. (2014) · Sports Medicine · doi:10.1007/s40279-014-0147-0 · Cited by 502
Coffee, caffeine, and sleep: a systematic review of epidemiological studies and randomized controlled trials
Clark, I., & Landolt, H. P. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.01.006 · Cited by 499
Orexin/Hypocretin: A Neuropeptide at the Interface of Sleep, Energy Homeostasis, and Reward System
Tsujino, N., & Sakurai, T. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001321 · Cited by 499
Comorbidity of insomnia and depression
Staner, L. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.09.003 · Cited by 481
Identification of Wake-Active Dopaminergic Neurons in the Ventral Periaqueductal Gray Matter
Lu, J., Jhou, T. C., & Saper, C. B. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2244-05.2006 · Cited by 475
Self-citation
Unresponsiveness ≠ unconsciousness
Sanders, R. D., Tononi, G., Laureys, S., Sleigh, J. W., & Warner, D. S. (2012) · Anesthesiology · doi:10.1097/aln.0b013e318249d0a7 · Cited by 474
Central Thalamic Contributions to Arousal Regulation and Neurological Disorders of Consciousness
Schiff, N. D. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.029 · Cited by 463
Is the cortisol awakening rise a response to awakening?
Wilhelm, I., Born, J., Kudielka, B. M., Schlotz, W., & Wüst, S. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.01.008 · Cited by 454
Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans
Samuels, E., & Szabadi, E. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777193 · Cited by 454
Sleep function: Toward elucidating an enigma
Krueger, J. M., Frank, M. G., Wisor, J. P., & Roy, S. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.08.005 · Cited by 440
The Pathophysiology of Insomnia
Levenson, J. C., Kay, D. B., & Buysse, D. J. (2015) · CHEST Journal · doi:10.1378/chest.14-1617 · Cited by 438
Shift work and the assessment and management of shift work disorder (SWD)
Wright, K. P., Bogan, R. K., & Wyatt, J. K. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.02.002 · Cited by 437
Lack of sleep and unethical conduct
Barnes, C. M., Schaubroeck, J. M., Huth, M., & Ghumman, S. S. (2011) · Organizational Behavior and Human Decision Processes · doi:10.1016/j.obhdp.2011.01.009 · Cited by 434
Circadian clocks: regulators of endocrine and metabolic rhythms
Hastings, M., O’Neill, J. S., & Maywood, E. S. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0378 · Cited by 426
Sleep deprivation, vigilant attention, and brain function: a review
Hudson, A. N., Dongen, H. P. A. V., & Honn, K. A. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0432-6 · Cited by 426
Sleep and Circadian Rhythms in Humans
Czeisler, C. A., & Gooley, J. J. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.064 · Cited by 425
The human sexual response cycle: Brain imaging evidence linking sex to other pleasures
Georgiadis, J. R., & Kringelbach, M. L. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.004 · Cited by 422
Approved and Investigational Uses of Modafinil
Kumar, R. (2008) · Drugs · doi:10.2165/00003495-200868130-00003 · Cited by 418
Astrocyte morphology: Diversity, plasticity, and role in neurological diseases
Zhou, B., Zuo, Y., & Jiang, R. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13123 · Cited by 417
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia
Tong, Q., Ye, C., McCrimmon, R. J., Dhillon, H., Choi, B., Kramer, M. D., Yu, J., Yang, Z., Christiansen, L. M., Lee, C. E., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.04.001 · Cited by 413
Epidemiology of Parkinson’s disease
Alves, G. W., Forsaa, E. B., Pedersen, K. F., Gjerstad, M. D., & Larsen, J. P. (2008) · Journal of Neurology · doi:10.1007/s00415-008-5004-3 · Cited by 405
Wake–sleep circuitry: an overview
Saper, C. B., & Fuller, P. M. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.03.021 · Cited by 383
Self-citation
Circadian system, sleep and endocrinology
Morris, C. J., Aeschbach, D., & Scheer, F. A. J. L. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.003 · Cited by 403
Insomnia disorder: State of the science and challenges for the future
Riemann, D. W., Benz, F., Dressle, R. J., Espie, C. A., Johann, A. F., Blanken, T. F., Leerssen, J., Wassing, R., Henry, A. L., Kyle, S. D., et al. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13604 · Cited by 398
Cytokines and sleep
Opp, M. R. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.01.002 · Cited by 393
Changes in the composition of brain interstitial ions control the sleep-wake cycle
Ding, F., O’Donnell, J., Xu, Q., Kang, N., Goldman, N., & Nedergaard, M. (2016) · Science · doi:10.1126/science.aad4821 · Cited by 393
Functions and Mechanisms of Sleep
Zielinski, M. R., McKenna, J. T., & McCarley, R. W. (2016) · AIMS neuroscience · doi:10.3934/neuroscience.2016.1.67 · Cited by 392
A genomic atlas of mouse hypothalamic development
Shimogori, T., Lee, D. A., Miranda-Angulo, A., Yang, Y., Wang, H., Jiang, L., Yoshida, A. C., Kataoka, A., Mashiko, H., Avetisyan, M., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2545 · Cited by 382
Sleep Regulation, Physiology and Development, Sleep Duration and Patterns, and Sleep Hygiene in Infants, Toddlers, and Preschool-Age Children
Bathory, E., & Tomopoulos, S. (2017) · Current Problems in Pediatric and Adolescent Health Care · doi:10.1016/j.cppeds.2016.12.001 · Cited by 382
Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins
Meng, Q., Logunova, L., Maywood, E. S., Gallego, M., Lebiecki, J., Brown, T. M., Sládek, M., Semikhodskii, A. G., Glossop, N. R. J., Piggins, H. D., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.019 · Cited by 375
Impaired consciousness in epilepsy
Blumenfeld, H. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70188-6 · Cited by 374
Circadian Rhythms, Sleep, and Disorders of Aging
Mattis, J., & Sehgal, A. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.02.003 · Cited by 369
Noradrenergic modulation of arousal
Berridge, C. W. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.10.013 · Cited by 368
Orexinergic System Dysregulation, Sleep Impairment, and Cognitive Decline in Alzheimer Disease
Liguori, C., Romigi, A., Nuccetelli, M., Zannino, S., Sancesario, G., Martorana, A., Albanese, M., Mercuri, N. B., Izzi, F., Bernardini, S., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2510 · Cited by 365
Noradrenergic modulation of wakefulness/arousal
Berridge, C. W., Schmeichel, B. E., & España, R. A. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.12.003 · Cited by 360
Melatonin and its analogs in insomnia and depression
Cardinali, D. P., Srinivasan, V., Brzezinski, A., & Brown, G. M. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00962.x · Cited by 360
S3-Leitlinie Nicht erholsamer Schlaf/Schlafstörungen
Riemann, D. W., Baum, E., Cohrs, S., Crönlein, T., Hajak, G., Hertenstein, E., Klose, P., Langhorst, J., Mayer, G., Nissen, C., et al. (2017) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1007/s11818-016-0097-x · Cited by 354
Sex differences in circadian timing systems: implications for disease
Bailey, M., & Silver, R. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.003 · Cited by 348
The histaminergic network in the brain: basic organization and role in disease
Panula, P., & Nuutinen, S. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3526 · Cited by 346
An essential role for orexins in emergence from general anesthesia
Kelz, M. B., Sun, Y., Chen, J., Cheng Meng, Q., Moore, J. T., Veasey, S. C., Dixon, S., Thornton, M., Funato, H., & Yanagisawa, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707146105 · Cited by 341
When prevention promotes creativity: The role of mood, regulatory focus, and regulatory closure.
Baas, M., Dreu, C. K. W. D., & Nijstad, B. A. (2011) · Journal of Personality and Social Psychology · doi:10.1037/a0022981 · Cited by 334
Forward-genetics analysis of sleep in randomly mutagenized mice
Funato, H., Miyoshi, C., Fujiyama, T., Kanda, T., Sato, M., Wang, Z., Ma, J., Nakane, S., Tomita, J., Ikkyu, A., et al. (2016) · Nature · doi:10.1038/nature20142 · Cited by 335
Arousal Effect of Caffeine Depends on Adenosine A2A Receptors in the Shell of the Nucleus Accumbens
Lazarus, M., Shen, H.-Y., Cherasse, Y., Qu, W.-M., Huang, Z.-L., Bass, C. E., Winsky-Sommerer, R., Semba, K., Fredholm, B. B., Boison, D., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6730-10.2011 · Cited by 327
Dopaminergic Control of Sleep–Wake States
Dzirasa, K., Ribeiro, S. T. G., Costa, R. M., Santos, L. M., Lin, S., Grosmark, A., Sotnikova, T. D., Gainetdinov, R. R., Caron, M. G., & Nicolelis, M. A. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1767-06.2006 · Cited by 326
Sleep Bruxism: A Comprehensive Overview for the Dental Clinician Interested in Sleep Medicine
Carra, M. C., Huynh, N. T., & Lavigne, G. J. (2012) · Dental Clinics of North America · doi:10.1016/j.cden.2012.01.003 · Cited by 320
Daytime Light Exposure Dynamically Enhances Brain Responses
Vandewalle, G., Balteau, E., Phillips, C., Degueldre, C., Moreau, V., Sterpenich, V., Albouy, G., Darsaud, A., Desseilles, M., Dang-Vu, T. T., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.031 · Cited by 313
British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: an update
Wilson, S., Anderson, K., Baldwin, D., Dijk, D.-J., Espie, A., Espie, C., Gringras, P., Krystal, A., Nutt, D., Selsick, H., et al. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119855343 · Cited by 312
The Serotonergic Raphe Promote Sleep in Zebrafish and Mice
Oikonomou, G., Altermatt, M., Zhang, R., Coughlin, G. M., Montz, C. J., Gradinaru, V., & Prober, D. A. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.038 · Cited by 309

Authors: Saper, C. B., Scammell, T. E., & Lu, J.
Affiliations: Beth Israel Deaconess Medical Center (US)
Corresponding author: Saper, Clifford B.
ORCID: Saper, Clifford B.
Scammell, Thomas E.
Lu, Jun
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2005-10-26
Volume: 437
Issue: 7063
Pages: 1257-1263
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature04284
OpenAlex: W2002293846
Cited by: 2,804
References: 102
Citations by year: 2026: 101 · 2025: 121 · 2024: 162 · 2023: 136 · 2022: 134 · 2021: 161 · 2020: 119 · 2019: 166 · 2018: 145 · 2017: 132 · 2016: 151 · 2015: 122 · 2014: 122 · 2013: 151 · 2012: 144
FWCI: 8.23
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: U.S. Public Health Service
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: hypothalamus, sleep regulation, circadian rhythm, wakefulness, sleep-wake cycle, arousal system, thalamus, cerebral cortex, narcolepsy, neurotransmitters, sleep-promoting neurons, sleep medication
MeSH terms: Orexins, Animals, Arousal, Circadian Rhythm, Humans, Hypothalamus, Neuropeptides, Sleep, Wakefulness, Intracellular Signaling Peptides and Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hypothalamic regulation of sleep and circadian rhythms

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks