Cited by 2,804Sleep and Wakefulness ResearchCircadian rhythm and melatoninNeuroscience of respiration and sleep

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Hypothalamic regulation of sleep and circadian rhythms

Saper, Clifford B., Scammell, Thomas E., Lu, Jun·2005·Nature

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Abstract

A series of findings over the past decade has begun to identify the brain circuitry and neurotransmitters that regulate our daily cycles of sleep and wakefulness. The latter depends on a network of cell groups that activate the thalamus and the cerebral cortex. A key switch in the hypothalamus shuts off this arousal system during sleep. Other hypothalamic neurons stabilize the switch, and their absence results in inappropriate switching of behavioural states, such as occurs in narcolepsy. These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake-sleep cycles into the optimal pattern for survival.

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Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Brain stem reticular formation and activation of the EEG
Moruzzi, G., & Magoun, H. W. (1949) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(49)90219-9 · Cited by 4,307
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878
The rat nervous system
Paxinos, G. (1985) · Cited by 3,715
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation
Van Dongen, H. P. A., Maislin, G., Mullington, J. M., & Dinges, D. F. (2003) · Sleep · doi:10.1093/sleep/26.2.117 · Cited by 3,173
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Self-citation
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613
Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat
Moore, R. Y., & Eichler, V. B. (1972) · Brain Research · doi:10.1016/0006-8993(72)90054-6 · Cited by 2,135
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., et al. (2000) · Nature Medicine · doi:10.1038/79690 · Cited by 2,118
Reduced Number of Hypocretin Neurons in Human Narcolepsy
Thannickal, T. C., Moore, R. Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M., & Siegel, J. M. (2000) · Neuron · doi:10.1016/s0896-6273(00)00058-1 · Cited by 2,089
Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle
Aston-Jones, G., & Bloom, F. (1981) · The Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00876.1981 · Cited by 1,960
Effect of Reducing Interns' Work Hours on Serious Medical Errors in Intensive Care Units
Landrigan, C. P., Rothschild, J. M., Cronin, J. W., Kaushal, R., Burdick, E., Katz, J. T., Lilly, C. M., Stone, P. H., Lockley, S. W., Bates, D. W., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041406 · Cited by 1,760 · cited 1×
“Similarly, sleep loss might impair performance among adolescents who arise early for school, shift workers, overnight long-haul truckers and even medical personnel working in hospital”
Background
Differential expression of orexin receptors 1 and 2 in the rat brain
Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1190 · Cited by 1,659
Self-citation
The sleep switch: hypothalamic control of sleep and wakefulness
Saper, C. B., Chou, T. C., & Scammell, T. E. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02002-6 · Cited by 1,656
Self-citation
The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon
Wisden, W., Laurie, D. J., Monyer, H., & Seeburg, P. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-01040.1992 · Cited by 1,543
Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans
Dijk, D., & Czeisler, C. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03526.1995 · Cited by 1,356
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.050 · Cited by 1,195
From Lesions to Leptin
Elmquist, J. K., Elias, C. F., & Saper, C. B. (1999) · Neuron · doi:10.1016/s0896-6273(00)81084-3 · Cited by 1,160
Self-citation
Activation of ventrolateral preoptic neurons during sleep
Sherin, J. E., Shiromani, P. J., McCarley, R. W., & Saper, C. B. (1996) · Science · doi:10.1126/science.271.5246.216 · Cited by 1,111
Self-citation
Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice
Yamanaka, A., Beuckmann, C. T., Willie, J. T., Hara, J., Tsujino, N., Mieda, M., Tominaga, M., Yagami, K.-I., Sugiyama, F., Goto, K., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00331-3 · Cited by 958
A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock
Jin, X., Shearman, L. P., Weaver, D. R., Zylka, M. J., Vries, G. J. D., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80959-9 · Cited by 891
Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle
Lee, M., Hassani, O. K., & Jones, B. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1887-05.2005 · Cited by 870
The α2-Adrenoceptor Agonist Dexmedetomidine Converges on an Endogenous Sleep-promoting Pathway to Exert Its Sedative Effects
Nelson, L. E., Lu, J., Guo, T., Saper, C. B., Franks, N. P., & Maze, M. (2003) · Anesthesiology · doi:10.1097/00000542-200302000-00024 · Cited by 854
Self-citation
Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons
Mileykovskiy, B. Y., Kiyashchenko, L. I., & Siegel, J. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.035 · Cited by 841
Restoration of brain energy metabolism as the function of sleep
Benington, J. H., & Heller, H. C. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(94)00057-o · Cited by 828
Sustained attention performance during sleep deprivation: evidence of state instability.
Doran, S. M., Dongen, H. P. A. V., & Dinges, D. F. (2001) · PubMed · Cited by 801
Dopaminergic Role in Stimulant-Induced Wakefulness
Wisor, J. P., Nishino, S., Sora, I., Uhl, G. R., Mignot, E. J.-M., & Edgar, D. M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01787.2001 · Cited by 779
Functional Neuroimaging Evidence for Hyperarousal in Insomnia
Nofzinger, E. A., Buysse, D. J., Germain, A., Price, J. C., Miewald, J. M., & Kupfer, D. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.2126 · Cited by 752 · cited 1×
“Positron-emission tomography studies during sleep in humans with insomnia also show increased activity in corticolimbic sites, including the medial prefrontal cortex and medial temporal lobe, compared with sleeping subjects without insomni”
Background
Innervation of Histaminergic Tuberomammillary Neurons by GABAergic and Galaninergic Neurons in the Ventrolateral Preoptic Nucleus of the Rat
Sherin, J. E., Elmquist, J. K., Torrealba, F., & Saper, C. B. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-12-04705.1998 · Cited by 746
Self-citation
SLEEP AS A PROBLEM OF LOCALIZATION
von Economo, C. (1930) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-193003000-00001 · Cited by 691
Efferent projections of the suprachiasmatic nucleus: I. Studies using anterograde transport of Phaseolus vulgaris leucoagglutinin in the rat
Watts, A. G., Swanson, L. W., & Sanchez‐Watts, G. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902580204 · Cited by 678
The “other” circadian system: food as a Zeitgeber
Stephan, F. K. (2002) · Journal of Biological Rhythms · doi:10.1177/074873002129002591 · Cited by 672
HYPOTHALAMIC REGULATION OF SLEEP IN RATS. AN EXPERIMENTAL STUDY
Nauta, W. J. H. (1946) · Journal of Neurophysiology · doi:10.1152/jn.1946.9.4.285 · Cited by 668
Effect of Lesions of the Ventrolateral Preoptic Nucleus on NREM and REM Sleep
Lu, J., Greco, M. A., Shiromani, P. J., & Saper, C. B. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03830.2000 · Cited by 667
Self-citation
Fos Expression in Orexin Neurons Varies with Behavioral State
Estabrooke, I. V., McCarthy, M. T., Ko, E., Chou, T. C., Chemelli, R. M., Yanagisawa, M., Saper, C. B., & Scammell, T. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01656.2001 · Cited by 654
Self-citation
A neural circuit for circadian regulation of arousal
Aston-Jones, G., Chen, S., Zhu, Y., & Oshinsky, M. L. (2001) · Nature Neuroscience · doi:10.1038/89522 · Cited by 632
The origins of cholinergic and other subcortical afferents to the thalamus in the rat
Hallanger, A. E., Levey, A. I., Lee, H. J., Rye, D. B., & Wainer, B. H. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902620109 · Cited by 595
Afferents to the orexin neurons of the rat brain
Yoshida-Court, K., McCormack, S. L., España, R. A., Crocker, A. J., & Scammell, T. E. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20859 · Cited by 592
Self-citation
Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms
Chou, T. C., Scammell, T. E., Gooley, J. J., Gaus, S. E., Saper, C. B., & Lu, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10691.2003 · Cited by 576
Self-citation
The hypothalamic integrator for circadian rhythms
Saper, C. B., Lü, J., Chou, T. C., & Gooley, J. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2004.12.009 · Cited by 548
Self-citation
Arousal systems
Jones, B. E. (2003) · Frontiers in bioscience · doi:10.2741/1074 · Cited by 532
Analysis of GABA A Receptor Function and Dissection of the Pharmacology of Benzodiazepines and General Anesthetics Through Mouse Genetics
Rudolph, U., & Möhler, H. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121429 · Cited by 528
Identification of sleep-promoting neurons in vitro
Gallopin, T., Fort, P., Eggermann, E., Cauli, B., Luppi, P.-H., Rossier, J., Audinat, E., Mühlethaler, M., & Serafin, M. (2000) · Nature · doi:10.1038/35010109 · Cited by 504
Afferents to the Ventrolateral Preoptic Nucleus
Chou, T. C., Bjørkum, A. A., Gaus, S. E., Lu, J., Scammell, T. E., & Saper, C. B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00977.2002 · Cited by 493
Self-citation
Cholinergic and noradrenergic modulation of thalamocortical processing
McCormick, D. A. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90125-2 · Cited by 488
A Broad Role for Melanopsin in Nonvisual Photoreception
Gooley, J. J., Lü, J., Fischer, D., & Saper, C. B. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07093.2003 · Cited by 476
Self-citation
A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep
Verret, L., Goutagny, R., Fort, P., Cagnon, L., Salvert, D., Léger, L., Boissard, R., Salin, P. A., Peyron, C., & Luppi, P. (2003) · BMC Neuroscience · doi:10.1186/1471-2202-4-19 · Cited by 468
Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice
Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., Kageyama, H., Kunita, S., Takahashi, S., Goto, K., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.03.010 · Cited by 468
Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study
Porkka‐Heiskanen, T., Strecker, R. E., & McCarley, R. W. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00220-7 · Cited by 463
Two sexually dimorphic cell groups in the human brain
Allen, L., Hines, M., Shryne, J. E., & Gorski, R. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-02-00497.1989 · Cited by 461
Sleep–waking discharge patterns of ventrolateral preoptic/anterior hypothalamic neurons in rats
Szymusiak, R. S., Alam, N., Steininger, T. L., & McGinty, D. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00631-3 · Cited by 458
Cholinergic Basal Forebrain Neurons Burst with Theta during Waking and Paradoxical Sleep
Lee, M., Hassani, O. K., Alonso, Á., & Jones, B. E. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0178-05.2005 · Cited by 439
Sleep Suppression after Basal Forebrain Lesions in the Cat
McGinty, D., & Sterman, M. B. (1968) · Science · doi:10.1126/science.160.3833.1253 · Cited by 438
CSF hypocretin/orexin levels in narcolepsy and other neurological conditions
Ripley, B., Overeem, S., Fujiki, N., Nevsimalova, S., Uchino, M., Yesavage, J., Di Monte, D., Dohi, K., Melberg, A., Lammers, G. J., et al. (2001) · Neurology · doi:10.1212/wnl.57.12.2253 · Cited by 415
25 Vagus Nerve Stimulation
Schachter, S. C., & Saper, C. B. (2020) · Thieme eBooks · doi:10.1055/b-0040-177306 · Cited by 397
Self-citation
Behavioral State Instability in Orexin Knock-Out Mice
Mochizuki, T., Crocker, A. J., McCormack, S. L., Yanagisawa, M., Sakurai, T., & Scammell, T. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0586-04.2004 · Cited by 397
Self-citation
From TCR Engagement to T Cell Activation
Lanzavecchia, A., Iezzi, G., & Viola, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80952-6 · Cited by 380
Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei
Elmquist, J. K., Ahima, R. S., Elias, C. F., Flier, J. S., & Saper, C. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.741 · Cited by 376
Self-citation
Vagus Nerve Stimulation
Schachter, S. C., & Saper, C. B. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb01151.x · Cited by 373
Self-citation
Mathematical models of sleep regulation
Achermann, P. (2003) · Frontiers in Bioscience · doi:10.2741/1064 · Cited by 358
Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state
Strecker, R. E., Morairty, S. R., Thakkar, M. M., Porkka‐Heiskanen, T., Basheer, R., Dauphin, L., Rainnie, D. G., Portas, C. M., Greene, R. W., & McCarley, R. W. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00258-8 · Cited by 356
SOMNOLENCE CAUSED BY HYPOTHALAMIC LESIONS IN THE MONKEY
Ranson, S. W. (1939) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1939.02270130011001 · Cited by 354
ASCENDING CONDUCTION IN RETICULAR ACTIVATING SYSTEM, WITH SPECIAL REFERENCE TO THE DIENCEPHALON
Starzl, T. E., Taylor, C. W., & Magoun, H. W. (1951) · Journal of Neurophysiology · doi:10.1152/jn.1951.14.6.461 · Cited by 337
Contrasting Effects of Ibotenate Lesions of the Paraventricular Nucleus and Subparaventricular Zone on Sleep–Wake Cycle and Temperature Regulation
Lu, J., Zhang, Y.-H., Chou, T. C., Gaus, S. E., Elmquist, J. K., Shiromani, P. J., & Saper, C. B. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04864.2001 · Cited by 335
Self-citation
Brainstem projections to midline and intralaminar thalamic nuclei of the rat
Krout, K. E., Belzer, R. E., & Loewy, A. D. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10236 · Cited by 328
Selective Activation of the Extended Ventrolateral Preoptic Nucleus during Rapid Eye Movement Sleep
Lu, J., Bjørkum, A. A., Xu, M., Gaus, S. E., Shiromani, P. J., & Saper, C. B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04568.2002 · Cited by 328
Self-citation
Loss of entrainment and anatomical plasticity after lesions of the hamster retinohypothalamic tract
Johnson, R. F., Moore, R. Y., & Morin, L. P. (1988) · Brain Research · doi:10.1016/0006-8993(88)90374-5 · Cited by 325
Central Autonomic System
Saper, C. B., & Stornetta, R. L. (2004) · Elsevier eBooks · doi:10.1016/b978-0-12-374245-2.00023-1 · Cited by 325
Self-citation
Organization of cerebral cortical afferent systems in the rat. II. Hypothalamocortical projections
Saper, C. B. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902370103 · Cited by 324
Self-citation
GABA Neuron Systems in Hypothalamus and the Pituitary Gland
Vincent, S. R., Hökfelt, T. G. M., & Wu, J. (2008) · Neuroendocrinology · doi:10.1159/000123288 · Cited by 311
Ventrolateral preoptic nucleus contains sleep-active, galaninergic neurons in multiple mammalian species
Gaus, S. E., Strecker, R. E., Tate, B. A., Parker, R. A., & Saper, C. B. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00308-1 · Cited by 288
Self-citation
Brain Glycogen Decreases with Increased Periods of Wakefulness: Implications for Homeostatic Drive to Sleep
Kong, J., Shepel, P. N., Holden, C. P., Mackiewicz, M., Pack, A. I., & Geiger, J. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05581.2002 · Cited by 281
Indirect projections from the suprachiasmatic nucleus to major arousal-promoting cell groups in rat: Implications for the circadian control of behavioural state
Deurveilher, S., & Semba, K. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.030 · Cited by 277
An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons
Scammell, T. E., Gerashchenko, D., Mochizuki, T., McCarthy, M. T., Estabrooke, I. V., Sears, C., Saper, C. B., Urade, Y., & Hayaishi, O. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00383-9 · Cited by 269
Self-citation
Sleep–waking discharge of neurons in the posterior lateral hypothalamus of the albino rat
Steininger, T. L., Alam, M. N., Gong, H., Szymusiak, R. S., & McGinty, D. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01648-0 · Cited by 257
The neurobiology, diagnosis, and treatment of narcolepsy
Scammell, T. E. (2003) · Annals of Neurology · doi:10.1002/ana.10444 · Cited by 255
Self-citation
Adenosine analogs and sleep in rats.
Radulovacki, M. G., Virus, R. M., Djuricic-Nedelson, M., & Green, R. D. (1984) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21636-6 · Cited by 251
Brain mechanisms of sleep
Hughes, J. R. (1985) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(85)91080-6 · Cited by 249
Entrainment of rat circadian rhythms by daily injection of melatonin depends upon the hypothalamic suprachiasmatic nuclei.
Cassone, V. M., Chesworth, M. J., & Armstrong, S. (1986) · Physiology and Behavior · doi:10.1016/0031-9384(86)90488-9 · Cited by 237
Cataplexy-Active Neurons in the Hypothalamus
John, J., Wu, M., Boehmer, L. N., & Siegel, J. M. (2004) · Neuron · doi:10.1016/s0896-6273(04)00247-8 · Cited by 227
The sexually dimorphic nucleus of the preoptic area in the human brain: a comparative morphometric study.
Hofman, M. A., & Swaab, D. F. (1989) · PubMed · Cited by 177
CNS inputs to the suprachiasmatic nucleus of the rat
Krout, K. E., Kawano, J., Mettenleiter, T. C., & Loewy, A. D. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00551-6 · Cited by 172
MODERN PROBLEMS IN NEUROLOGY
Wilson, S. A. K. (1928) · BMJ · doi:10.1136/bmj.2.3541.914 · Cited by 146
Brain mechanisms of sleep
McGinty, D. (1985) · Raven Press eBooks · Cited by 142
Effects of adenosine on gabaergic synaptic inputs to identified ventrolateral preoptic neurons
Chamberlin, N. L., Arrigoni, E., Chou, T. C., Scammell, T. E., Greene, R. W., & Saper, C. B. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00246-x · Cited by 123
Self-citation
Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2–saporin on sleep in Long–Evans rats
Gerashchenko, D., Blanco‐Centurion, C., Greco, M. A., & Shiromani, P. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00575-4 · Cited by 118
Activity of serotonin-containing neurons in nucleus raphe magnus in freely moving cats
Fornal, C. A., Auerbach, S. B., & Jacobs, B. L. (1985) · Experimental Neurology · doi:10.1016/0014-4886(85)90074-3 · Cited by 115
The interstitial nuclei of the human anterior hypothalamus: an investigation of sexual variation in volume and cell size, number and density
Byne, W. M., Lasco, M. S., Kemether, E. M., Shinwari, A., Edgar, M. A., Morgello, S., Jones, L. B., & Tobet, S. A. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02458-0 · Cited by 112
Galanin immunoreactivity in hypothalamic histamine neurons: Further evidence for multiple chemical messengers in the tuberomammillary nucleus
Köhler, C., Ericson, H., Watanabe, T., Polak, J. M., Palay, S. L., Chan‐Palay, V., & Chan‐Palay, V. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902500105 · Cited by 110
Wake-related activity of tuberomammillary neurons in rats
Ko, E. M., Estabrooke, I. V., McCarthy, M. T., & Scammell, T. E. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.044 · Cited by 103
Self-citation
Stress and the Individual: Mechanisms Leading to Disease
McEwen, B. S. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410180039004 · Cited by 103
Ultrastructural localization of dynorphin in the dentate gyrus in human temporal lobe epilepsy: A study of reorganized mossy fiber synapses
Zhang, N., & Houser, C. R. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990322)405:4 · Cited by 100
Assessment of sleepiness and unintended sleep in Parkinson's disease patients taking dopamine agonists
Roth, T. G. (2003) · Sleep Medicine · doi:10.1016/s1389-9457(03)00058-3 · Cited by 94
Prevalent sleep problems in the aged
Ancoli‐Israel, S., & Kripke, D. F. (1991) · Applied Psychophysiology and Biofeedback · doi:10.1007/bf00999989 · Cited by 86
Modafinil: a drug in search of a mechanism.
Saper, C. B., & Scammell, T. E. (2004) · PubMed · Cited by 62
Self-citation
Age impairments in sleep, metabolic and immune functions
Prinz, P. N. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.06.023 · Cited by 57
Effect of the GABAAagonist gaboxadol on nocturnal sleep and hormone secretion in healthy elderly subjects
Lancel, M., Wetter, T. C., Steiger, A., & Mathias, S. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.1.e130 · Cited by 52
Modern Problems in Neurology
Wilson, S. A. K. (1929) · Southern Medical Journal · doi:10.1097/00007611-192905000-00033 · Cited by 22
Purine level regulation during energy depletion associated with graded excitatory stimulation in brain
Shepel, P. N., Ramonet, D., Stevens, P., & Geiger, J. D. (2005) · Neurological Research · doi:10.1179/016164105x21832 · Cited by 17
Untitled work
(1996) · doi:10.1002/(sici)1096-9861(19961202)376:1

Research works printed but not linked: 4

Verret, L. et al. Localization of the neurones potentially responsible for the inhibition of locus coeruleus noradrenergic neurones during paradoxical sleep in the rat. J. Comp. Neurol. (in the press).
Chou, T. C. Regulation of Wake-Sleep Timing: Circadian Rhythms and Bistability of Sleep-Wake States, 82–99. Thesis, Harvard Univ. (2003).
Yoshida, K., McCormack, S., Espana, R. A., Crocker, A. D. & Scammell, T. E. Afferents to the orexin neurons. J. Comp. Neurol. (in the press).
Nyholm, H. Zur okologie von Myotis mystacinus (Leisl.) und M. daubentoni (Leisl.) (Chiroptera). Ann. Zool. Fenn. 2, 77–123 (1955).

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Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358
European guideline for the diagnosis and treatment of insomnia
Riemann, D., Baglioni, C., Bassetti, C., Bjorvatn, B., Dolenc Groselj, L., Ellis, J. G., Espie, C. A., Garcia‐Borreguero, D., Gjerstad, M., Gonçalves, M., et al. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12594 · Cited by 2,049
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Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
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Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.04.002 · Cited by 1,789
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Takahashi, J. S., Hong, H.-K., Ko, C. H., & McDearmon, E. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2430 · Cited by 1,611

See all 2,804

Authors: Saper, C. B., Scammell, T. E., & Lu, J.
Affiliations: Beth Israel Deaconess Medical Center (US)
Corresponding author: Saper, Clifford B.
ORCID: Saper, Clifford B.
Scammell, Thomas E.
Lu, Jun
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2005-10-26
Volume: 437
Issue: 7063
Pages: 1257-1263
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature04284
OpenAlex: W2002293846
Cited by: 2,804
References: 102
Citations by year: 2026: 101 · 2025: 121 · 2024: 162 · 2023: 136 · 2022: 134 · 2021: 161 · 2020: 119 · 2019: 166 · 2018: 145 · 2017: 132 · 2016: 151 · 2015: 122 · 2014: 122 · 2013: 151 · 2012: 144
FWCI: 8.23
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: U.S. Public Health Service
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: hypothalamus, sleep regulation, circadian rhythm, wakefulness, sleep-wake cycle, arousal system, thalamus, cerebral cortex, narcolepsy, neurotransmitters, sleep-promoting neurons, sleep medication
MeSH terms: Orexins, Animals, Arousal, Circadian Rhythm, Humans, Hypothalamus, Neuropeptides, Sleep, Wakefulness, Intracellular Signaling Peptides and Proteins

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Hypothalamic regulation of sleep and circadian rhythms

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