The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Open accessAbstract
Cortical gamma oscillations (20-80 Hz) predict increases in focused attention, and failure in gamma regulation is a hallmark of neurological and psychiatric disease. Current theory predicts that gamma oscillations are generated by synchronous activity of fast-spiking inhibitory interneurons, with the resulting rhythmic inhibition producing neural ensemble synchrony by generating a narrow window for effective excitation. We causally tested these hypotheses in barrel cortex in vivo by targeting optogenetic manipulation selectively to fast-spiking interneurons. Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8-200 Hz) selectively amplifies gamma oscillations. In contrast, pyramidal neuron activation amplifies only lower frequency oscillations, a cell-type-specific double dissociation. We found that the timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses. Our data directly support the fast-spiking-gamma hypothesis and provide the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation.
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“strong evidence supporting the view that PV-expressing basket cells have critical roles in the generation and maintenance of gamma, theta and ripple oscillations”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Cardin et al., 2009
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In the citing paper
“Gamma activity was analysed because of its close link to neuronal spiking47, which IIT considers a constituent property of the physical substrate of consciousness5.”
From Adversarial testing of global neuronal workspace and integrated information theories of consciousness (2025) · cites this paper as [47]
In the citing paper
“Cortical PV cells contribute to synchronous oscillatory activity (Cardin et al., 2009; Sohal et al., 2009; Uhlhaas et al., 2009), particularly in the gamma range (∼30–100 Hz).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Cardin et al., 2009
In the citing paper
“FS-PV interneurons are at the origin of gamma oscillation in the cortex and contribute to cognitive functions.29, 30”
From Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin (2015) · cites this paper as [29]
In the citing paper
“Two foundational optogenetic studies demonstrated that optogenetically driving inhibitory interneurons specifically enhances slow gamma frequency oscillations throughout cortex, reducing circuit noise while amplifying circuit signal [201, 202].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [201]
In the citing paper
“They are critical for high-frequency neuronal synchrony, reflected in gamma band oscillations (30–80 Hz) (Cardin et al., 2009; Fuchs et al., 2007; Gulyas et al., 2010; Massi et al., 2012; Sohal et al., 2009), but can also modulate neuronal activity in the theta band (4–8 Hz), as well as theta-gamma coupling (Korotkova et al., 2010; Wulff et al., 2009).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Cardin et al., 2009
In the citing paper
“Stimulation of PV-INs leads to an increase in gamma oscillation patterns, while inhibition of PV-INs or downregulation of PV at cortical synapses reduces gamma oscillations [76][77][78].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [76]
In the citing paper
“In contrast, increasing PV-interneuron-mediated feedback inhibition by boosting principal cell activity enhanced gamma-band power (Cardin et al., 2009”
From Neuronal Dynamics and Neuropsychiatric Disorders: Toward a Translational Paradigm for Dysfunctional Large-Scale Networks (2012) · cites this paper as Cardin et al., 2009
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Metadata
- Authors
- Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I.
- Affiliations
- McGovern Institute for Brain Research (US)
- Broad Institute (US)
- Stanford University (US)
- Corresponding author
- Deisseroth, Karl
- Tsai, Li-Huei
- Moore, Christopher I.
- ORCID
- Venue
- Nature
- Published
- 2009-04-26
- Volume
- 459
- Issue
- 7247
- Pages
- 663-667
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3655711
- OpenAlex
- W2149561999
- Cited by
- 2,603
- References
- 36
- Citations by year
- 2026: 110 · 2025: 145 · 2024: 160 · 2023: 121 · 2022: 172 · 2021: 171 · 2020: 183 · 2019: 154 · 2018: 161 · 2017: 147 · 2016: 151 · 2015: 178 · 2014: 158 · 2013: 157 · 2012: 137
- FWCI
- 70.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Neurological Disorders and Stroke (R01NS045130)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- fast-spiking interneurons, parvalbumin interneurons, optogenetic stimulation, barrel cortex, sensory evoked potentials, pyramidal neurons, neuronal synchronization, attention, schizophrenia, signal-to-noise ratio
- MeSH terms
- Animals, Electrophysiology, Gene Expression Regulation, Interneurons, Photic Stimulation, Rhodopsin, Somatosensory Cortex, Chlamydomonas reinhardtii, Pyramidal Cells, Mice, Gene Knock-In Techniques
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