The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Open accessAbstract
Cortical gamma oscillations (20-80 Hz) predict increases in focused attention, and failure in gamma regulation is a hallmark of neurological and psychiatric disease. Current theory predicts that gamma oscillations are generated by synchronous activity of fast-spiking inhibitory interneurons, with the resulting rhythmic inhibition producing neural ensemble synchrony by generating a narrow window for effective excitation. We causally tested these hypotheses in barrel cortex in vivo by targeting optogenetic manipulation selectively to fast-spiking interneurons. Here we show that light-driven activation of fast-spiking interneurons at varied frequencies (8-200 Hz) selectively amplifies gamma oscillations. In contrast, pyramidal neuron activation amplifies only lower frequency oscillations, a cell-type-specific double dissociation. We found that the timing of a sensory input relative to a gamma cycle determined the amplitude and precision of evoked responses. Our data directly support the fast-spiking-gamma hypothesis and provide the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation.
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“strong evidence supporting the view that PV-expressing basket cells have critical roles in the generation and maintenance of gamma, theta and ripple oscillations”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Cardin et al., 2009
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In the citing paper
“Gamma activity was analysed because of its close link to neuronal spiking47, which IIT considers a constituent property of the physical substrate of consciousness5.”
From Adversarial testing of global neuronal workspace and integrated information theories of consciousness (2025) · cites this paper as [47]
In the citing paper
“Cortical PV cells contribute to synchronous oscillatory activity (Cardin et al., 2009; Sohal et al., 2009; Uhlhaas et al., 2009), particularly in the gamma range (∼30–100 Hz).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Cardin et al., 2009
In the citing paper
“FS-PV interneurons are at the origin of gamma oscillation in the cortex and contribute to cognitive functions.29, 30”
From Cortical fast-spiking parvalbumin interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8, Adamts15 and Neprilysin (2015) · cites this paper as [29]
In the citing paper
“Two foundational optogenetic studies demonstrated that optogenetically driving inhibitory interneurons specifically enhances slow gamma frequency oscillations throughout cortex, reducing circuit noise while amplifying circuit signal [201, 202].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [201]
In the citing paper
“They are critical for high-frequency neuronal synchrony, reflected in gamma band oscillations (30–80 Hz) (Cardin et al., 2009; Fuchs et al., 2007; Gulyas et al., 2010; Massi et al., 2012; Sohal et al., 2009), but can also modulate neuronal activity in the theta band (4–8 Hz), as well as theta-gamma coupling (Korotkova et al., 2010; Wulff et al., 2009).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Cardin et al., 2009
In the citing paper
“Stimulation of PV-INs leads to an increase in gamma oscillation patterns, while inhibition of PV-INs or downregulation of PV at cortical synapses reduces gamma oscillations [76][77][78].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [76]
In the citing paper
“In contrast, increasing PV-interneuron-mediated feedback inhibition by boosting principal cell activity enhanced gamma-band power (Cardin et al., 2009”
From Neuronal Dynamics and Neuropsychiatric Disorders: Toward a Translational Paradigm for Dysfunctional Large-Scale Networks (2012) · cites this paper as Cardin et al., 2009
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Citations
Cites
Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 5,015
Self-citationInterneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954
Modulation of Oscillatory Neuronal Synchronization by Selective Visual Attention
Fries, P., Reynolds, J. H., Rorie, A. E., & Desimone, R. (2001) · Science · doi:10.1126/science.1055465 · Cited by 2,786
Stimulus-specific neuronal oscillations in orientation columns of cat visual cortex
Gray, C. M., & Singer, W. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.5.1698 · Cited by 2,463
Whittington, M. A., Traub, R. D., & Jefferys, J. G. R. (1995) · Nature · doi:10.1038/373612a0 · Cited by 1,613
Gamma Oscillation by Synaptic Inhibition in a Hippocampal Interneuronal Network Model
Wang, X., & Buzsáki, G. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-20-06402.1996 · Cited by 1,561
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
The Petilla Interneuron Nomenclature Group (PING) (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2402 · Cited by 1,491
Temporal binding and the neural correlates of sensory awareness.
Engel, A. K., & Singer, W. (2001) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01568-0 · Cited by 1,372
Grouping of brain rhythms in corticothalamic systems
Steriade, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.029 · Cited by 1,296
A Developmental Switch in the Response of DRG Neurons to ETS Transcription Factor Signaling
Hippenmeyer, S., Pecho‐Vrieseling, E., Sigrist, M., Portmann, T., Laengle, C., Ladle, D. R., & Arber, S. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030159 · Cited by 1,111
Fries, P., Nikolić, D., & Singer, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.05.005 · Cited by 1,044
A network of fast-spiking cells in the neocortex connected by electrical synapses
Galarreta, M., & Hestrin, S. (1999) · Nature · doi:10.1038/47029 · Cited by 960
Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits
Deisseroth, K. A., Feng, G., Majewska, A. K., Miesenböck, G., Ting, A. Y., & Schnitzer, M. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3863-06.2006 · Cited by 808
Self-citationMolecular and Physiological Diversity of Cortical Nonpyramidal Cells
Cauli, B., Audinat, E., Lambolez, B., Angulo, M. C., Ropert, N., Tsuzuki, K., Hestrin, S., & Rossier, J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03894.1997 · Cited by 738
A mechanism for generation of long-range synchronous fast oscillations in the cortex
Traub, R. D., Whittington, M. A., Stanford, I. M., & Jefferys, J. G. R. (1996) · Nature · doi:10.1038/383621a0 · Cited by 714
Hasenstaub, A. R., Shu, Y., Haider, B., Kraushaar, U., Duque, A., & McCormick, D. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.016 · Cited by 666
Uhlhaas, P. J., Haenschel, C., Nikolic, D., & Singer, W. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn062 · Cited by 629
Deans, M. R., Gibson, J. R., Sellitto, C., Connors, B. W., & Paul, D. L. (2001) · Neuron · doi:10.1016/s0896-6273(01)00373-7 · Cited by 579
Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice
Huber, D., Petreanu, L., Ghitani, N., Ranade, S., Hromádka, T., Mainen, Z., & Svoboda, K. (2008) · Nature · doi:10.1038/nature06445 · Cited by 539
Zeng, H., Chattarji, S., Barbarosie, M., Rondi-Reig, L., Philpot, B. D., Miyakawa, T., Bear, M. F., & Tonegawa, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00585-2 · Cited by 498
Rapid feature selective neuronal synchronization through correlated latency shifting
Fries, P., Neuenschwander, S., Engel, A. K., Goebel, R., & Singer, W. (2001) · Nature Neuroscience · doi:10.1038/84032 · Cited by 344
Background gamma rhythmicity and attention in cortical local circuits: A computational study
Börgers, C., Epstein, S., & Kopell, N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502366102 · Cited by 301
Electrophysiological Analysis of Synaptic Transmission
Graziane, N., & Dong, Y. (2022) · Neuromethods · doi:10.1007/978-1-0716-2589-7 · Cited by 294
Excess of High Frequency Electroencephalogram Oscillations in Boys with Autism
Orekhova, E. V., Stroganova, T. A., Nygren, G., Tsetlin, M. M., Posikera, I. N., Gillberg, C., & Elam, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.029 · Cited by 283
Electrophysiological Analysis of Synaptic Transmission
Clendenin, M. A. (1970) · Physical Therapy · doi:10.1093/ptj/50.10.1548a · Cited by 277
Effects of Noisy Drive on Rhythms in Networks of Excitatory and Inhibitory Neurons
Börgers, C., & Kopell, N. (2005) · Neural Computation · doi:10.1162/0899766053019908 · Cited by 208
Simulation of Gamma Rhythms in Networks of Interneurons and Pyramidal Cells
Traub, R. D., Jefferys, J. G. R., & Whittington, M. A. (1997) · Journal of Computational Neuroscience · doi:10.1023/a:1008839312043 · Cited by 207
Recurrent excitatory postsynaptic potentials induced by synchronized fast cortical oscillations
Whittington, M. A., Traub, R. D., Faulkner, H. J., Stanford, I. M., & Jefferys, J. G. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.12198 · Cited by 185
Mattfeld, D. C. (1996) · Physica-Verlag eBooks · doi:10.1007/978-3-662-11712-5_8 · Cited by 184
Sensory-Evoked Gamma Oscillations in Chronic Schizophrenia
Spencer, K. M., Niznikiewicz, M. A., Shenton, M. E., & McCarley, R. W. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.017 · Cited by 182
Kuhlman, S. J., & Huang, Z. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002005 · Cited by 179
On the electroencephalogram of man.
Berger, H. (1969) · PubMed · Cited by 167
Neuronal fast oscillations as a target site for psychoactive drugs
Whittington, M. A. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(00)00038-3 · Cited by 151
Ren, J. Q., Aika, Y., Heizmann, C. W., & Kosaka, T. (1992) · Experimental Brain Research · doi:10.1007/bf00230378 · Cited by 148
Gamma frequency oscillations gate temporally coded afferent inputs in the rat hippocampal slice
Burchell, T. R., Faulkner, H. J., & Whittington, M. A. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00676-4 · Cited by 76
Ishizaki, H., & Suzuki, A. (1992) · Progress in brain research · doi:10.1016/s0079-6123(08)61160-7 · Cited by 42
Flagged first, then by citations
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Jensen, O., & Mazaheri, A. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00186 · Cited by 3,237
Rhythms for cognition: communication through coherence
Fries, P. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.034 · Cited by 2,725
Mechanisms of Gamma Oscillations
Buzsáki, G., & Wang, X.-J. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150444 · Cited by 2,796
GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
Tremblay, R., Lee, S., & Rudy, B. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.033 · Cited by 2,033
Optogenetics in neural systems
Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.004 · Cited by 1,881
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Metadata
- Authors
- Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I.
- Affiliations
- McGovern Institute for Brain Research (US)
- Broad Institute (US)
- Stanford University (US)
- Corresponding author
- Deisseroth, Karl
- Tsai, Li-Huei
- Moore, Christopher I.
- ORCID
- Venue
- Nature
- Published
- 2009-04-26
- Volume
- 459
- Issue
- 7247
- Pages
- 663-667
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3655711
- OpenAlex
- W2149561999
- Cited by
- 2,603
- References
- 36
- Citations by year
- 2026: 110 · 2025: 145 · 2024: 160 · 2023: 121 · 2022: 172 · 2021: 171 · 2020: 183 · 2019: 154 · 2018: 161 · 2017: 147 · 2016: 151 · 2015: 178 · 2014: 158 · 2013: 157 · 2012: 137
- FWCI
- 70.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Neurological Disorders and Stroke (R01NS045130)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- fast-spiking interneurons, parvalbumin interneurons, optogenetic stimulation, barrel cortex, sensory evoked potentials, pyramidal neurons, neuronal synchronization, attention, schizophrenia, signal-to-noise ratio
- MeSH terms
- Animals, Electrophysiology, Gene Expression Regulation, Interneurons, Photic Stimulation, Rhodopsin, Somatosensory Cortex, Chlamydomonas reinhardtii, Pyramidal Cells, Mice, Gene Knock-In Techniques
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