The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index; none of the 1 sources its claims cite is checked for support yet.
Distinct extended amygdala circuits for divergent motivational states
Open accessAbstract
The co-morbidity of anxiety and dysfunctional reward processing in illnesses such as addiction and depression suggests that common neural circuitry contributes to these disparate neuropsychiatric symptoms. The extended amygdala, including the bed nucleus of the stria terminalis (BNST), modulates fear and anxiety, but also projects to the ventral tegmental area (VTA), a region implicated in reward and aversion, thus providing a candidate neural substrate for integrating diverse emotional states. However, the precise functional connectivity between distinct BNST projection neurons and their postsynaptic targets in the VTA, as well as the role of this circuit in controlling motivational states, have not been described. Here we record and manipulate the activity of genetically and neurochemically identified VTA-projecting BNST neurons in freely behaving mice. Collectively, aversive stimuli exposure produced heterogeneous firing patterns in VTA-projecting BNST neurons. By contrast, in vivo optically identified glutamatergic projection neurons displayed a net enhancement of activity to aversive stimuli, whereas the firing rate of identified GABAergic (γ-aminobutyric acid-containing) projection neurons was suppressed. Channelrhodopsin-2-assisted circuit mapping revealed that both BNST glutamatergic and GABAergic projections preferentially innervate postsynaptic non-dopaminergic VTA neurons, thus providing a mechanistic framework for in vivo circuit perturbations. In vivo photostimulation of BNST glutamatergic projections resulted in aversive and anxiogenic behavioural phenotypes. Conversely, activation of BNST GABAergic projections produced rewarding and anxiolytic phenotypes, which were also recapitulated by direct inhibition of VTA GABAergic neurons. These data demonstrate that functionally opposing BNST to VTA circuits regulate rewarding and aversive motivational states, and may serve as a crucial circuit node for bidirectionally normalizing maladaptive behaviours.
Overview
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Written from the paper’s full text.
TL;DR
In mice, VTA-projecting BNST neurons comprise opposing glutamatergic and GABAergic subcircuits: aversive stimuli increase glutamatergic activity and suppress GABAergic activity, and optogenetic activation of these pathways produces aversive/anxiogenic versus rewarding/anxiolytic states, respectively. These findings identify a bidirectional BNST→VTA circuit node for motivational and emotional processing.
Key findings
- In vivo antidromic identification found 53/137 BNSTv→VTA projection neurons; aversive stimuli produced heterogeneous firing patterns across these neurons. Identified Vglut2BNSTv→VTA neurons (34/145) showed net enhanced firing during aversive events and shock-associated cues, whereas VgatBNSTv→VTA neurons (33/77) were principally suppressed.
- Circuit mapping showed that Vglut2BNSTv→VTA and VgatBNSTv→VTA terminals formed functional synapses primarily onto non-dopaminergic and medially located dopaminergic VTA neurons.
- Photostimulation of Vglut2BNSTv→VTA produced avoidance of a stimulation-paired chamber, reduced active reward seeking, and anxiety-like open-field behavior; the aversive phenotype was abolished by intra-VTA ionotropic glutamate receptor antagonists.
- Photostimulation of VgatBNSTv→VTA produced place preference, supported optical self-stimulation, and increased open-arm time in the elevated plus maze; these effects were prevented by an intra-VTA GABAA antagonist and recapitulated by direct inhibition of VTA GABAergic neurons. Concurrent VgatBNSTv→VTA stimulation during foot shock reduced freezing and increased later open-arm time/entries.
Methods
- Adult male C57BL/6J, Vgat-ires-cre, and Vglut2-ires-cre mice received stereotactic viral injections (ChR2-eYFP, NpHR) and optical fibers/MEA implants; experiments included anesthetized and behaving in vivo electrophysiology, patch-clamp recordings in VTA slices, unpredictable foot-shock sessions, and optogenetic behavioral assays.
- In vivo electrophysiology used a 16-channel MEA in BNSTv and optical fibers above VTA for antidromic identification; units were classified using spike latency, waveform correlation, and z-score firing changes during foot-shock sessions.
- Behavioral assays included real-time place preference, open field, sucrose self-administration, optical self-stimulation/self-inhibition, elevated plus maze, and foot-shock-induced freezing, with intra-VTA antagonist microinfusions in some experiments.
Limitations
- The paper states that shock artifacts prevented reliable quantification of neuronal firing 500–1000 ms after foot-shock onset, excluding approximately 0.8–1.66% of collected data during the foot-shock session.
- Evident from the text: all experiments used adult male mice, so sex differences and generalization to females are not addressed.
- Evident from the text: the paper does not include a dedicated limitations section; circuit specificity relies on viral targeting, optogenetic manipulation, slice physiology, and pharmacological blockade rather than fully selective circuit-silencing approaches.
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21 Own method · 15 Own result · 8 Own interpretation · 1 Not checked yet
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“in vivo optically-identified glutamatergic projection neurons displayed a net enhancement of activity to aversive stimuli”
- Also stated in: § Abstract · plain
“Collectively, exposure to the aversive event or associated cues alone enhanced the firing of Vglut2BNSTv→VTA neurons”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
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- Also stated in: § Abstract · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Collectively, aversive stimuli exposure produced heterogeneous firing patterns in VTA-projecting BNST neurons.”
- Also stated in: § Abstract · boosted
“Identified BNSTv→VTA neurons segregated into three functionally distinct classes based on changes in their normalized firing rates throughout the foot-shock session (Supplementary Fig. 3), demonstrating that BNSTv→VTA neurons differentially encode information related to aversive stimuli and their associated contextual cues.”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
boostedcorrelational- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“whereas the firing rate of identified GABAergic projection neurons was suppressed”
- Also stated in: § Abstract · plain
“while simultaneously suppressing the activity of VgatBNSTv→VTA neurons.”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
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- Also stated in: § Abstract · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“activation of BNST GABAergic projections produced rewarding and anxiolytic phenotypes”
- Also stated in: § Abstract · hedged
“Photostimulation of the VgatBNSTv→VTA pathway and direct inhibition of VgatVTA neurons significantly increased time spent in the open arms of an elevated plus maze, indicative of anxiolysis”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
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- Also stated in: § Abstract · hedged
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“VgatBNSTv→VTA::ChR2 mice spent significantly less time frozen (Fig. 5h)”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“as well as significantly more open-arm time and entries in the elevated-plus maze relative to controls (Supplementary Fig. 18)”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
plain- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In vivo photostimulation of BNST glutamatergic projections resulted in aversive and anxiogenic behavioral phenotypes.”
- Also stated in: § Abstract · hedged
“inescapable activation of this pathway for 20 min in an open field resulted in significantly less center- and more corner-time in Vglut2BNSTv→VTA::ChR2 mice in the 10 min following stimulation offset compared to controls”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
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- Also stated in: § Abstract · hedged
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“VTA infusions of a GABAA receptor antagonist prevented the VgatBNSTv→VTA mediated place preference compared to saline injections”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Vglut2BNSTv→VTA and VgatBNSTv→VTA terminals formed functional synapses primarily onto non-dopaminergic and medially located dopaminergic neurons”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
plaincorrelational- Asserted: passes — The authors put it forward as true.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“activation of BNST GABAergic projections produced rewarding and anxiolytic phenotypes”
- Also stated in: § Abstract · plain
“20 Hz photostimulation in VgatBNSTv→VTA::ChR2 mice resulted in a significant place preference”
- Also stated in: § Abstract · plain
“VgatBNSTv→VTA::ChR2 mice readily nose poked to receive photostimulation”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 9
- Probably not a substantial claim. 19
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“photostimulation of the CaMKIIaBNSTv→VTA pathway produced both glutamatergic and γ-aminobutyric acid (GABAergic) currents in VTA neurons (Supplementary Fig. 4), demonstrating that neurochemically distinct BNSTv neurons project to the VTA.”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
boosteddirect- Asserted: passes — The authors put it forward as true.
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In the paper
“photostimulation of ChR2-containing fibers originating from Vglut2 (Vglut2BNSTv→VTA::ChR2) or Vgat (VgatBNSTv→VTA::ChR2) expressing BNSTv neurons produced excitatory or inhibitory postsynaptic currents respectively”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Thus, data collected during these time epochs were excluded from analysis.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo electrophysiology
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In the paper
“into the VTA in a counter balanced design (all drugs from Tocris).”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > Intra-VTA injection of antagonists and photostimulation of Vglut2BNSTv→VTA::ChR2 and VgatBNSTv→VTA::ChR2 projections during real-time place preference
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“Together, these results show that reward-related responses to VgatBNSTv→VTA activation are recapitulated by directly inhibiting VgatVTA neurons, thus providing a circuit mechanism for the VgatBNSTv→VTA pathway to regulate motivated behavior.”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
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In the paper
“Briefly, discrimination of individual units was performed offline using principal component analysis to separate individual units from the same electrode. In addition, auto- and cross-correlograms, firing characteristics, and inter-spike interval distributions were examined to ensure units were well-isolated.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo electrophysiology
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In the paper
“Placements of recording electrode tips within the BNSTv and optical fibers within the VTA were verified with histological examination of brain tissue following the experiments.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo anesthetized electrophysiology
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“This represents an approximate loss of 0.8 – 1.66% of the collected data during the foot-shock session.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo electrophysiology
hedged- Asserted: passes — The authors put it forward as true.
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“During the time epoch surrounding the individual delivered foot shocks, large shock artifact were readily apparent.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo electrophysiology
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In the paper
“Resulting data was binned in 30 s epochs in order to minimize the skewing of our results due to data lost by the shock artifacts.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo electrophysiology
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Electrical stimulation of the BNST produces both excitatory and inhibitory responses in VTA neurons in vivo6 implying that distinct subcircuits may exist.”
§ Distinct extended amygdala circuits for divergent motivational states > Abstract
What the sources say
- Not checked yetcites [6] Georges, F. & Aston-Jones, G. Potent regulation of midbrain dopamine neurons by the bed nucleus of the stria terminalis. J. Neurosci. 21, RC160 (2001) source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“BNSTv neurons were classified as antidromic-responsive, if the following 3 criteria were met: 1) stable antidromic spike latency (< 0.2 ms), 2) ability to respond reliably to high frequency photostimulation, 3) collision between orthodromic- and antidromic-evoked spikes.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo anesthetized electrophysiology
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In the paper
“Neuronal units were included in the data if the signal-to-noise ratio was high, and the mean firing rate was between 0.5 – 25 Hz during baseline recording periods.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo electrophysiology
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In the paper
“Mice had 2 days off between each VTA microinjection.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > Intra-VTA injection of antagonists and photostimulation of Vglut2BNSTv→VTA::ChR2 and VgatBNSTv→VTA::ChR2 projections during real-time place preference
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In the paper
“In addition, recording sites was verified histologically using electrolytic lesions at 200 µA for 5 s.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo electrophysiology
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In the paper
“neuronal firing responses in the 500 – 1000 ms following foot shock onset could not be reliably quantified”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo electrophysiology
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In the paper
“All mice were infused at a rate of 0.1 µl per minute. The injector remained in place for approximately 2 min following infusion to ensure proper diffusion of drug into the VTA.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > Intra-VTA injection of antagonists and photostimulation of Vglut2BNSTv→VTA::ChR2 and VgatBNSTv→VTA::ChR2 projections during real-time place preference
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In the paper
“Recorded BNSTv units were classified as light-responsive, and thus VTA-projecting, if they met both of the following two criteria. 1) The latency of the first spike after light stimulation onset was less than 20 ms for ≥ 20% of the trials. 2) Light-evoked and spontaneous waveform shapes had a correlation coefficient of > 0.90.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo electrophysiology
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In the paper
“Neural activity was recorded from the same mice during the cue exposure, foot shock, and cue re-exposure sessions, therefore we were able to reliably record activity from the same population of neurons during each of the three sessions.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo electrophysiology
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In the paper
“In addition, timestamp data to signify the start and end of foot-shock sessions, and the delivery of light pulses to optical fibers was synchronized with electrophysiological data.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo electrophysiology
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In the paper
“Following the 1 day 20 Hz training session, mice were run daily at each photostimulation frequency (1, 5, 10, 20, 40 Hz) in a counter-balanced design.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > Optical self-stimulation of VgatBNSTv→VTA::ChR2 projections
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“While these were easily isolated and excluded from the analyzed waveform data using offline spike sorting”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo electrophysiology
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In the paper
“The injector needle (33 gauge steel tube, McMasters-Carr) extended approximately 1 mm past the cannula to ensure drug delivery 0.5 mm below the optical fiber.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > Intra-VTA injection of antagonists and photostimulation of Vglut2BNSTv→VTA::ChR2 and VgatBNSTv→VTA::ChR2 projections during real-time place preference
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In the paper
“Once stable nose-poking behavior for 15% sucrose was observed (approx. 100 active nose pokes on at least 2 consecutive days), all mice received constant 20 Hz photostimulation during the entire 30 min sucrose session.”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > Photostimulation of Vglut2BNSTv→VTA::ChR2 projections during sucrose self-administration
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Claims other papers make about this one
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The cited source says what the claim attributes to it.
In the citing paper
“Our results provide further evidence of the importance of long-range GABAergic projection neurons in the control of anxiety (Jennings et al., 2013; Kim et al., 2013).”
From Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit (2014) · cites this paper as Jennings et al., 2013
The cited source says what the claim attributes to it.
In the citing paper
“This is supported by optogenetic studies showing the projection-specific effects of BNST neurons on behavior (87–90).”
From Sexual differentiation of neural mechanisms of stress sensitivity during puberty (2023) · cites this paper as [89]
In the citing paper
“Moreover, individual subregions of the BNST have been shown to differentially regulate separable features of the anxiety phenotype31,85 (Fig. 3).”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [85]
In the citing paper
“activity in glutamatergic ventral BNST neurons projecting to the VTA produces anxiety-like behaviors, whereas GABAergic neurons in the ventral BNST exert anxiolysis via a parallel pathway85.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [85]
In the citing paper
“It has recently been shown that the BNST contains distinct anxiogenic and anxiolytic GABAergic neuronal subsets with unique patterns of long-range connections (Jennings et al., 2013; Kim et al., 2013).”
From Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit (2014) · cites this paper as Jennings et al., 2013
In the citing paper
“In contrast, photostimulation of glutamatergic projections from ventral BNST to the ventral tegmental area (VTA) (Jennings et al., 2013) was sufficient to induce a persistent elevation in anxiety.”
From Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit (2014) · cites this paper as Jennings et al., 2013
In the citing paper
“Notably, BNST neurons have been shown to inhibit dopamine neurons involved in conventional reward processing by activating local GABAergic neurons63–65, suggesting that anxiety-related circuits may interfere with appetitive learning and behavior.”
From Dopamine dynamics as a regulatory mechanism for shifting between defensive and reward-seeking behaviors (2026) · cites this paper as [63]
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Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > Experimental subjects and stereotactic surgery
“For all in vivo electrophysiology experiments, mice were implanted with a 16-wire (4 × 4 configuration, wire diameter∼30µm) tungsten multielectrode array (MEA)”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo anesthetized electrophysiology
“Extracellular neural activity was recorded using a glass recording electrode (5 − 10 MΩ: and filled with 0.5 M NaCl).”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > Experimental subjects and stereotactic surgery
“For all in vivo electrophysiology experiments, male mice were unilaterally injected with 0.5 µl of purified and concentrated adeno-associated virus (AAV)”
§ Distinct extended amygdala circuits for divergent motivational states > Online methods > In vivo anesthetized electrophysiology
“C57BL/6J mice were bilaterally injected with 0.3 µl of AAV5-CaMKIIa-ChR2-eYFP into the BNSTv.”
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Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data
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“Using in vivo electrophysiological recordings, we previ- ously showed that neurons in the bed nucleus of the stria terminalis (BNST) show strong responses to unpredictable footshock stimuli (Jennings et al., 2013).”
Self-citationA framework for studying emotions across species
Anderson, D. J., & Adolphs, R. (2014) · Cell · doi:10.1016/j.cell.2014.03.003 · Cited by 691
“…example of such an instantiation in mammals is the amygdala, which has long been associated with negative emotions such as fear, but which has increasingly been associated with positive emotions as well (Gallagher and Chiba, 1996; Paton et al., 2006; Tye et al., 2011; Jennings et al., 2013).”
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CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety
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Visualizing Hypothalamic Network Dynamics for Appetitive and Consummatory Behaviors
Jennings, J. H., Ung, R. L., Resendez, S. L., Stamatakis, A. M., Taylor, J. G., Huang, J. H., Veleta, K., Kantak, P. A., Aita, M., Shilling-Scrivo, K. V., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.026 · Cited by 550
“Applying established viral procedures (Jennings et al., 2013b), we first expressed channelrhodopsin-2 conjugated to enhanced yellow fluorescent protein (AAV5-EF1a-DIO-hChR2(H134R)-eYFP) selectively in GABAergic neurons located within the anterior and dorsolateral subdivisions of the LH (Figures 1A and 1B) in Vgat-IRES…”
BackgroundMethodInfluentialSelf-citationLateral hypothalamic circuits for feeding and reward
Stuber, G. D., & Wise, R. A. (2016) · Nature Neuroscience · doi:10.1038/nn.4220 · Cited by 544
Self-citationA Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System
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A Network Model of the Emotional Brain
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Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics
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“Real-time place preference has become a common tool for neuroscientists to assess the behavioral valence of photostimulated neural circuits or cell bodies in a freely moving animal (Jennings et al., 2013; Kim et al., 2013a; Siuda et al., 2015; Stamatakis and Stuber, 2012; Stamatakis et al., 2013; Tan et al., 2012).”
The Inhibitory Circuit Architecture of the Lateral Hypothalamus Orchestrates Feeding
Jennings, J. H., Rizzi, G., Stamatakis, A. M., Ung, R. L., & Stuber, G. D. (2013) · Science · doi:10.1126/science.1241812 · Cited by 493
Self-citationA whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei
Pollak Dorocic, I., Fürth, D., Xuan, Y., Johansson, Y., Pozzi, L., Silberberg, G., Carlén, M., & Meletis, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.002 · Cited by 451
“The extended amygdala circuit also includes the bed nuclei of stria terminalis (BST), which controls anxiety-related behaviors (Jennings et al., 2013; Kim et al., 2013).”
Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala
Marcinkiewcz, C. A., Mazzone, C. M., D’Agostino, G., Halladay, L. R., Hardaway, J. A., DiBerto, J. F., Navarro, M., Burnham, N., Cristiano, C., Dorrier, C. E., et al. (2016) · Nature · doi:10.1038/nature19318 · Cited by 456
Divergent routing of positive and negative information from the amygdala during memory retrieval
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“Recently, the in vivo activity of projection-target-defined cells has been examined by expressing ChR2 in neurons of interest and using light-evoked firing as an instrument to identify these neurons in intact animals (Ciocchi et al., 2015; Jennings et al., 2013; Zhang et al., 2013a).”
Overlapping Brain Circuits for Homeostatic and Hedonic Feeding
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“Intracranial selfstimulation sites, which depend on dopamine release, have often been found to promote feeding and depend on the current satiety state of the subject (Abrahamsen et al., 1995; Adamantidis et al., 2011; Carr and Wolinsky, 1993; Jennings et al., 2013a; Stuber et al., 2011).”
BackgroundInfluentialSelf-citationStamatakis, A. M., Jennings, J. H., Ung, R. L., Blair, G. A., Weinberg, R. J., Neve, R. L., Boyce, F., Mattis, J., Ramakrishnan, C., Deisseroth, K., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.023 · Cited by 364
“This preference was dependent on GABAA signaling within the LHb, as intra-LHbmicroinjections of a GABAA receptor antagonist (gabazine) through guide cannulas interfacedwith the optical fibers (Jennings et al., 2013) blocked the preference for the stimulation-paired side (Figures 7D and S7).”
BackgroundMethodSelf-citationWireless and battery-free technologies for neuroengineering
Won, S. M., Cai, L., Gutruf, P., & Rogers, J. A. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00683-3 · Cited by 360
The human BNST: functional role in anxiety and addiction
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Selective information routing by ventral hippocampal CA1 projection neurons
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Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior
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“…and numerous groups have demonstrated bidirectional control of realtime place preference and aversion behaviors within this system (Siuda et al., 2015b; Jennings et al., 2013; Lammel et al., 2012; Stamatakis and Stuber, 2012; Tan et al., 2012; van Zessen et al., 2012; Isingrini et al., 2016).”
BackgroundSelf-citationResendez, S. L., Jennings, J. H., Ung, R. L., Namboodiri, V. M. K., Zhou, Z. C., Otis, J. M., Nomura, H., McHenry, J. A., Kosyk, O., & Stuber, G. D. (2016) · Nature Protocols · doi:10.1038/nprot.2016.021 · Cited by 326
Self-citationWiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences
Li, Y., Allen, W. E., Thompson, K. R., Tian, Q., Hsueh, B., Ramakrishnan, C., Wang, A.-C., Jennings, J. H., Adhikari, A., Halpern, C. H., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.010 · Cited by 338
“…projection anatomy is one of the most important features that might resolve principal cell population types involved in such distinct processes (Jennings et al., 2013; Kim et al., 2013; Lammel et al., 2012; Namburi et al., 2015), but this feature has been difficult to explore in a brain-wide…”
Self-citationCollateral Pathways from the Ventromedial Hypothalamus Mediate Defensive Behaviors
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“…could cause spiking activity in cell bodies, if VMHdm/c cells bifurcate to both AHN and PAG, the VMH/AHN-like response elicited by VMH/ PAG stimulation could be caused by the backpropagation of action potentials from PAG to VMH cell bodies, which in turn recruit AHN (Jennings et al., 2013).”
GABA and glutamate neurons in the VTA regulate sleep and wakefulness
Yu, X., Li, W., Ma, Y., Tossell, K., Harris, J. J., Harding, E. C., Ba, W., Miracca, G., Wang, D., Li, L., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0288-9 · Cited by 326
Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit
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InfluentialHormonal gain control of a medial preoptic area social reward circuit
McHenry, J. A., Otis, J. M., Rossi, M. A., Robinson, J. E., Kosyk, O., Miller, N. W., McElligott, Z. A., Budygin, E. A., Rubinow, D. R., & Stuber, G. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4487 · Cited by 317
Self-citationDorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli
Cho, J. R., Treweek, J. B., Robinson, J. E., Xiao, C., Bremner, L. R., Greenbaum, A., & Gradinaru, V. (2017) · Neuron · doi:10.1016/j.neuron.2017.05.020 · Cited by 276
“, 2016), two regions known to bi-directionally affect motivated behavior and regulate complex emotional states (Jennings et al., 2013), DRN neurons are uniquely positioned to provide excitatory signals about environmental salience and internal arousal state to downstream nuclei, which can in turn initiate appropriate…”
Genetics and epigenetics of eating disorders
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Contributions of the central extended amygdala to fear and anxiety
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“Likewise, both regions play a critical for role in regulating sustained responses to diffusely threatening contexts (Moreira et al., 2007; Zimmerman et al., 2007; Duvarci et al., 2009; Zimmerman and Maren, 2011; Jennings et al., 2013; Kim et al., 2013).”
BackgroundThe Corticotropin-Releasing Factor Family: Physiology of the Stress Response
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Extending the amygdala in theories of threat processing
Fox, A. S., Oler, J. A., Tromp, D., Fudge, J. L., & Kalin, N. H. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.03.002 · Cited by 267
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Rodent models of post-traumatic stress disorder: behavioral assessment
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Role of Dopamine Neurons in Reward and Aversion: A Synaptic Plasticity Perspective
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Prefrontal inputs to the amygdala instruct fear extinction memory formation
Bukalo, O., Pinard, C. R., Silverstein, S., Brehm, C., Hartley, N. D., Whittle, N., Colacicco, G., Busch, E., Patel, S., Singewald, N., et al. (2015) · Science Advances · doi:10.1126/sciadv.1500251 · Cited by 234
Tasks for inhibitory interneurons in intact brain circuits
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“Non-dopaminergic neurons of the VTA receive glutamatergic and GABAergic inputs from the bed nucleus of the stria terminalis (BNST) (Jennings et al., 2013).”
Distributed and Mixed Information in Monosynaptic Inputs to Dopamine Neurons
Tian, J., Huang, R., Cohen, J. Y., Osakada, F., Kobak, D., Machens, C. K., Callaway, E. M., Uchida, N., & Watabe-Uchida, M. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.018 · Cited by 224
“More recently, optogenetic stimulation or viral infection at axon terminals have been used in a similar manner (Jennings and Stuber, 2014; Jennings et al., 2013; Nieh et al., 2015).”
VTA GABA Neurons at the Interface of Stress and Reward
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Faget, L. C., Zell, V., Souter, E. A., McPherson, A. D., Ressler, R. L., Gutierrez-Reed, N. A., Yoo, J. H., Dulcis, D., & Hnasko, T. S. (2018) · Nature Communications · doi:10.1038/s41467-018-03125-y · Cited by 223
Functional heterogeneity in the bed nucleus of the stria terminalis
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“, 2009), this finding is consistent with evidence that glutamatergic BNST-AV cells exert an outsized influence over PVN and VTA neurons (Choi et al., 2007; Radley et al., 2009; Radley and Sawchenko, 2011; Jennings et al., 2013).”
BackgroundResultInfluentialA VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses
Zhou, Z., Liu, X., Chen, S., Zhang, Z., Liu, Y., Montardy, Q., Tang, Y., Wei, P., Liu, N., Li, L., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.05.027 · Cited by 221
Stress Modulation of Opposing Circuits in the Bed Nucleus of the Stria Terminalis
Daniel, S., & Rainnie, D. G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.178 · Cited by 224
“The use of optogenetic strategies, like those used in experiments by Kim et al (2013) and Jennings et al (2013), will be crucial in furthering our understanding of the role of specific inputs into the BNST as well as the local circuitry of the nucleus.”
BackgroundMethodInfluentialLocus-specific epigenetic remodeling controls addiction- and depression-related behaviors
Heller, E. A., Cates, H. M., Peña, C. J., Sun, H., Shao, N., Feng, J., Golden, S. A., Herman, J. P., Walsh, J. J., Mazei-Robison, M., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3871 · Cited by 227
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Distributed circuits underlying anxiety
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Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics
McCall, J. G., Kim, T., Shin, G., Huang, X. L., Jung, Y. H., Al‐Hasani, R., Omenetto, F. G., Bruchas, M. R., & Rogers, J. A. (2013) · Nature Protocols · doi:10.1038/nprot.2013.158 · Cited by 208
“(d,e) A completed wireless power harvester alone (d) and with (e) connection to the μ-ILED device (7) for wireless operation.”
MethodCholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways
Xiao, C., Cho, J. R., Zhou, C., Treweek, J. B., Chan, K. Y., McKinney, S. L., Yang, B., & Gradinaru, V. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.028 · Cited by 212
“Photo-excitation of terminals could potentially cause backpropagating action potentials (Jennings et al., 2013) in the vSNc projecting PPN ChAT neurons and recruit downstream nuclei other than the vSNc, with the PPN-to-vSNc connection playing only a minor role.”
Effective modulation of male aggression through lateral septum to medial hypothalamus projection
Wong, L. C., Wang, L., D’Amour, J. A., Yumita, T., Chen, G., Yamaguchi, T., Chang, B. C., Bernstein, H., You, X., Feng, J. E., et al. (2016) · Current Biology · doi:10.1016/j.cub.2015.12.065 · Cited by 213
Fox, A. S., & Shackman, A. J. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.11.056 · Cited by 206
Pathological circuit function underlying addiction and anxiety disorders
Lüthi, A., & Lüscher, C. (2014) · Nature Neuroscience · doi:10.1038/nn.3849 · Cited by 192
Regulating anxiety with extrasynaptic inhibition
Botta, P., Demmou, L., Kasugai, Y., Markovic, M., Xu, C., Fadok, J. P., Lu, T., Poe, M. M., Xu, L., Cook, J. M., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4102 · Cited by 192
“…the notion that increasing or decreasing the spontaneous activity of PKC δ + neurons has anxiogenic or anxiolytic effects, respectively, we assessed light-induced behavioral changes in the Open Field Test (OFT), in which anxious animals tend to avoid the center area of an open field arena 13,14 .”
InfluentialA craniofacial-specific monosynaptic circuit enables heightened affective pain
Rodriguez, E., Sakurai, K., Xu, J., Chen, Y., Toda, K., Zhao, S., Han, B.-X., Ryu, D., Yin, H. H., Liedtke, W., et al. (2017) · Nature Neuroscience · doi:10.1038/s41593-017-0012-1 · Cited by 192
To Approach or Avoid: An Introductory Overview of the Study of Anxiety Using Rodent Assays
La-Vu, M. Q., Tobias, B. C., Schuette, P. J., & Adhikari, A. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00145 · Cited by 198
Genetic-Based Dissection Unveils the Inputs and Outputs of Striatal Patch and Matrix Compartments
Smith, J. B., Klug, J. R., Ross, D. L., Howard, C. D., Hollon, N. G., Ko, V. I., Hoffman, H., Callaway, E. M., Gerfen, C. R., & Jin, X. (2016) · Neuron · doi:10.1016/j.neuron.2016.07.046 · Cited by 176
Amygdala-hippocampal dynamics during salient information processing
Zheng, J., Anderson, K. L., Leal, S. L., Shestyuk, A. Y., Gülşen, G., Mnatsakanyan, L., Vadera, S., Hsu, F. P. K., Yassa, M. A., Knight, R. T., et al. (2017) · Nature Communications · doi:10.1038/ncomms14413 · Cited by 190
The CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response
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“Recent optogenetic studies in mice have clearly implicated the BNST in the modulation of anxiety [134, 135].”
BackgroundReproductive Steroid Regulation of Mood and Behavior
Schiller, C. E., Johnson, S., Abate, A., Schmidt, P. J., & Rubinow, D. R. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150014 · Cited by 224
“…to the ventral tegmental reward circuitry increases avoidant behavior (i.e., avoiding a chamber where shock had been delivered previously) and decreases reward (sucrose) seeking in mice (140), behavioral phenotypes that are both relevant to depression (88, 270) and modulated by estrogen (166,336).”
Avery, S. N., Clauss, J. A., Winder, D. G., Woodward, N., Heckers, S., & Blackford, J. U. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.01.017 · Cited by 164
“Specific neural circuits—rather than specific brain regions—are crucial for complex behaviors, as recently demonstrated using optogenetics (Jennings et al., 2013; Kim et al., 2013).”
BackgroundAn update on the connections of the ventral mesencephalic dopaminergic complex
Yetnikoff, L., Lavezzi, H. N., Reichard, R. A., & Zahm, D. S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.010 · Cited by 189
“However, in the mean time, a number of groups have weighed in on a BST-VTA connection using modern chemico- and optogenetic methods (e.g., Kudo et al., 2012; Jennings et al., 2013; Kim et al., 2013) with the result of further complicating the issues of neural connectivity.”
MethodVolman, S. F., Lammel, S., Margolis, E. B., Kim, Y., Richard, J. M., Roitman, M. F., & Lobo, M. K. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3250-13.2013 · Cited by 168
“Their studies showed that rewarding and aversive behaviors in mice can be controlled by optogenetic stimulation (Lammel et al., 2012; Stamatakis and Stuber, 2012; Jennings et al., 2013).”
BackgroundCircuit dynamics of adaptive and maladaptive behaviour
Deisseroth, K. A. (2014) · Nature · doi:10.1038/nature12982 · Cited by 176
Diversity of Dopaminergic Neural Circuits in Response to Drug Exposure
Juarez, B., & Han, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.32 · Cited by 176
“…Lammel et al, 2012 LHb-VTA-PFC Lammel et al, 2012 BNST-VTA Georges and Aston-Jones, 2001; Georges and Aston-Jones, 2002; Geisler and Zahm, 2005; Jennings et al, 2013 LH-VTA Peyron et al, 1998; Fadel and Deutch, 2002 RMTg-VTA Barrot, 2014; Sanchez-Catalan et al, 2014 LC-VTA Mejias-Aponte et al,…”
BackgroundInfluentialDabrowska, J., Hazra, R., Guo, J., DeWitt, S., & Rainnie, D. G. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00156 · Cited by 163
“More recently, it has been proposed that neurons in the region of the fusiform nucleus are glutamatergic (Georges and Aston-Jones, 2002; Jennings et al., 2013).”
BackgroundPleil, K. E., Lowery‐Gionta, E. G., Crowley, N. A., Li, C., Marcinkiewcz, C. A., Rose, J. H., McCall, N. M., Maldonado‐Devincci, A. M., Morrow, A. L., Jones, S. R., et al. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.06.017 · Cited by 167
“…overlapping targets and cell types, the vBNST is more homogenous, with a large proportion of neurons identified as projection neurons to discrete downstream regions, such as the ventral tegmental area and nuclei of the hypothalamus (Herman, 2012; Herman et al., 1994; Jennings et al., 2013).”
Self-citationThe translational neural circuitry of anxiety
Robinson, O. J., Pike, A. C., Cornwell, B., & Grillon, C. (2019) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-321400 · Cited by 158
How the amygdala affects emotional memory by altering brain network properties
Hermans, E. J., Battaglia, F. P., Atsak, P., de Voogd, L. D., Fernández, G., & Roozendaal, B. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.02.005 · Cited by 173
“While recent studies using this technique concentrate on the modulation of anxiety and motivation (Jennings et al., 2013; Kim et al., 2013), it will be enticing to test the importance of the same connections for the joint modulation of memory by the amygdala (see, e.g., Huff, Miller, Deisseroth,…”
MethodMedial preoptic area antagonistically mediates stress-induced anxiety and parental behavior
Zhang, G., Shen, L., Tao, C., Jung, A.-H., Peng, B., Li, Z., Zhang, L. I., & Tao, H. W. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00784-3 · Cited by 162
Feelings about food: the ventral tegmental area in food reward and emotional eating
Meye, F. J., & Adan, R. A. H. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.11.003 · Cited by 164
A Central Extended Amygdala Circuit That Modulates Anxiety
Ahrens, S., Wu, M. V., Furlan, A., Hwang, G., Paik, R., Li, H., Penzo, M. A., Tollkühn, J., & Li, B. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0705-18.2018 · Cited by 157
“Both the CeA and the BNST are complex structures that contain heterogeneous neuronal populations, which likely form discrete neural circuits subserving distinct functions (Duvarci and Pare, 2014; Herry and Johansen, 2014; Stamatakis et al., 2014; Kash et al., 2015; Gungor and Paré, 2016).”
BackgroundReward Inhibits Paraventricular CRH Neurons to Relieve Stress
Yuan, Y., Wu, W., Chen, M., Cai, F., Fan, C., Shen, W., Sun, W., & Hu, J. (2019) · Current Biology · doi:10.1016/j.cub.2019.02.048 · Cited by 151
Optogenetic insights on the relationship between anxiety-related behaviors and social deficits
Allsop, S. A., Vander Weele, C. M., Wichmann, R., & Tye, K. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00241 · Cited by 150
“…Association, 2013), the prevalence of social anxiety disorder and the high rate of co-morbidity between anxiety and autism spectrum disorders highlights the need to understand the relationship between anxiety and social behavior (De Bruin et al., 2007; Simonoff et al., 2008; Stein and Stein, 2008).”
BackgroundMechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148
“When selectively activated by optogenetics, BNST-VTA GABA projection disinhibits the VTA DA neurons, whereas BNST-VTA glutamate projection indirectly inhibits the VTA DA neurons, producing rewarding and aversive/anxiety-like responding, respectively (Jennings et al., 2013).”
BackgroundDynorphin Controls the Gain of an Amygdalar Anxiety Circuit
Crowley, N. A., Bloodgood, D. W., Hardaway, J. A., Kendra, A. M., McCall, J. G., Al‐Hasani, R., McCall, N. M., Yu, W., Schools, Z. L., Krashes, M. J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.069 · Cited by 149
“The BNST orchestrates both rewarding and aversive behaviors (Jennings et al., 2013; Kim et al., 2013).”
BackgroundSelf-citationSpatiotemporal Control of Opioid Signaling and Behavior
Siuda, E. R., Copits, B. A., Schmidt, M. J., Baird, M. A., Al‐Hasani, R., Planer, W., Funderburk, S. C., McCall, J. G., Gereau, R. W., & Bruchas, M. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.066 · Cited by 146
“0) in the realtime preference assay (Figures S5J–S5L) as previously reported (Jennings et al., 2013).”
MethodAn excitatory ventral hippocampus to lateral septum circuit that suppresses feeding
Sweeney, P., & Yang, Y. (2015) · Nature Communications · doi:10.1038/ncomms10188 · Cited by 155
“Meanwhile, BNST neurons project to hypothalamic brain regions 36,44,45 and the ventral tegmental area 46,47 , brain regions responsible for anxiety and motivational behaviours 44–47 .”
Prefrontal neuronal circuits of contextual fear conditioning
Rozeske, R. R., Valério, S., Chaudun, F., & Herry, C. (2014) · Genes Brain & Behavior · doi:10.1111/gbb.12181 · Cited by 158
Optic Ataxia: From Balint’s Syndrome to the Parietal Reach Region
Andersen, R. A., Andersen, K. N., Hwang, E. J., & Hauschild, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.025 · Cited by 148
“Furthermore, projection neurons can be identified by extracellular recording in the upstreamareaduring antidromic photostimulation in the downstream area, and thus the response properties of projection neurons can be selectively characterized (Gradinaru et al., 2009; Jennings et al., 2013).”
BackgroundStress and VTA synapses: implications for addiction and depression
Polter, A. M., & Kauer, J. A. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12490 · Cited by 147
“In addition, roughly half of VTA GABAergic neurons have excitatory synapses originating in the BNST (Jennings et al., 2013).”
BackgroundInfluentialUnderstanding emotion with brain networks
Pessoa, L. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.09.005 · Cited by 155
Targeting glutamate uptake to treat alcohol use disorders
Rao, P. S. S., Bell, R. L., Engleman, E. A., & Sari, Y. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00144 · Cited by 136
Campbell, E. J., & Marchant, N. J. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14146 · Cited by 150
“For example, the human synapsin (hSyn) promoter is pan-neuronal, whereas calmodulin-dependent protein kinase II (CAMKII) predominately targets excitatory neurons, although not always (Jennings et al., 2013; Yizhar et al., 2011; Yau and Mcnally, 2015).”
BackgroundKirouac, G. J. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.627633 · Cited by 140
Dedic, N., Kühne, C., Jakovcevski, M., Hartmann, J., Genewsky, A. J., Gomes, K. S., Anderzhanova, E. A., Pöhlmann, M. L., Chang, S., Kolarz, A., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0151-z · Cited by 135
Creed, M. C., Ntamati, N. R., & Tan, K. R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00008 · Cited by 141
Cha, J., Greenberg, T., Carlson, J. M., DeDora, D. J., Hajcak, G., & Mujica-Parodi, L. R. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3372-13.2014 · Cited by 147
“This is in accord with recent reports that distinct neural circuits are responsible for different aspects of anxious states in rodent models (Jennings et al., 2013; S. Y. Kim et al., 2013).”
ResultArchitectural Representation of Valence in the Limbic System
Namburi, P., Al‐Hasani, R., Calhoon, G. G., Bruchas, M. R., & Tye, K. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.358 · Cited by 148
Role of the bed nucleus of the stria terminalis in aversive learning and memoryPreprint
Goode, T. D., & Maren, S. (2017) · Learning & Memory · doi:10.1101/lm.044206.116 · Cited by 149
“Further, it is now understood that different populations of neurons within the BNST can bidirectionally regulate various unlearned anxiety-like responses (Jennings et al. 2013; Kim et al. 2013; Crowley et al. 2016; Marcinkiewcz et al. 2016; Mazzone et al. 2016).”
BackgroundInfluentialStamatakis, A. M., Sparta, D. R., Jennings, J. H., McElligott, Z. A., Decot, H., & Stuber, G. D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.046 · Cited by 132
Self-citationSex-specific effects of stress on oxytocin neurons correspond with responses to intranasal oxytocin
Steinman, M. Q., Duque-Wilckens, N., Greenberg, G. D., Hao, R., Campi, K. L., Laredo, S. A., Laman-Maharg, A., Manning, C. E., Doig, I. E., Lopez, E. M., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.007 · Cited by 131
“In the BNSTmv, which includes a population of excitatory neurons that induces aversion and reduces reward seeking (40), OT/c-fos cells were elevated immediately after a third day of defeat for both sexes (ANOVA, p 5 .”
Distinct preoptic‐BST nuclei dissociate paternal and infanticidal behavior in mice
Tsuneoka, Y., Tokita, K., Yoshihara, C., Amano, T., Esposito, G., Huang, A. J. Y., Yu, L. M. Y., Odaka, Y. S., Shinozuka, K., McHugh, T. J., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201591942 · Cited by 129
Sex differences in fear extinction
Velasco, E. R., Florido, A., Milad, M. R., & Andero, R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.020 · Cited by 132
“It can activate the hypothalamus when facing stress, and its multiple subnuclei are strongly regulated by neuropeptides and sex hormones (Glangetas and Georges, 2016; Jennings et al., 2013; Kash et al., 2015; Marcinkiewcz et al., 2016; Tillman et al., 2018).”
BackgroundWireless optofluidic brain probes for chronic neuropharmacology and photostimulation
Qazi, R., Gomez, A. M., Castro, D. C., Zou, Z., Sim, J. Y., Xiong, Y., Abdo, J., Kim, C. Y., Anderson, A., Lohner, F., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0432-1 · Cited by 128
van der Kooij, M. A., Hollis, F., Lozano, L., Zalachoras, I., Abad, S., Zanoletti, O., Grosse, J., Guillot de Suduiraut, I., Canto, C., & Sandi, C. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.135 · Cited by 127
A specific circuit in the midbrain detects stress and induces restorative sleep
Yu, X., Zhao, G., Wang, D., Wang, S., Li, R., Li, A., Wang, H., Nollet, M., Chun, Y. Y., Zhao, T., et al. (2022) · Science · doi:10.1126/science.abn0853 · Cited by 125
Metadata
- Authors
- Jennings, J. H., Sparta, D. R., Stamatakis, A. M., Ung, R. L., Pleil, K. E., Kash, T. L., & Stuber, G. D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Stuber, Garret D.
- ORCID
- Venue
- Nature
- Published
- 2013-03-20
- Volume
- 496
- Issue
- 7444
- Pages
- 224-228
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3778934
- OpenAlex
- W2067203693
- Semantic Scholar
- b094f8c7bc24b675130d787985a6c38dc2555363
- Cited by
- 704
- References
- 33
- Citations by year
- 2026: 34 · 2025: 53 · 2024: 30 · 2023: 44 · 2022: 35 · 2021: 65 · 2020: 43 · 2019: 55 · 2018: 57 · 2017: 55 · 2016: 78 · 2015: 66 · 2014: 58 · 2013: 29
- FWCI
- 37.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Foundation for the National Institutes of Health
- Whitehall Foundation
- National Institute on Alcohol Abuse and Alcoholism (F32AA018610, AA011605, AA 007573, F32AA021043, AA018610, AA021043, P60AA011605, T32AA007573)
- National Institute on Drug Abuse (F31DA034472, R01DA032750, DA034472, DA029325, R21DA029325, DA032750, R37DA032750)
- National Institute of Neurological Disorders and Stroke (P30NS045892, NS 007431, T32NS007431)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- bed nucleus of the stria terminalis, ventral tegmental area, extended amygdala, glutamatergic projections, GABAergic projections, anxiety, reward, aversion, motivational states, depression, channelrhodopsin-2, aversive stimuli
- MeSH terms
- Channelrhodopsins, Amygdala, Animals, Anxiety, Avoidance Learning, Behavior, Animal, Cues, Electroshock, Glutamine, Male, Mice, Inbred C57BL, Motivation, Phenotype, Reward, Septal Nuclei, Ventral Tegmental Area, Mice, GABAergic Neurons, Optogenetics
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