Cited by 323Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Circuit organization of the rodent medial prefrontal cortex

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Anastasiades, Paul G., Carter, Adam G.·2021·Trends in Neurosciences

Abstract

The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous variety of projection neurons and interneurons. These cells are engaged by long-range inputs from other brain regions involved in cognition, motivation, and emotion. They also communicate in the local network via specific connections between excitatory and inhibitory cells. In this review, we describe the cellular diversity of the rodent mPFC, the impact of long-range afferents, and the specificity of local microcircuits. We highlight similarities with and differences between other cortical areas, illustrating how the circuit organization of the mPFC may give rise to its unique functional roles.

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Crossref · 10.1016/j.tins.2021.03.006

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  1. [45]Nakayama H (2018) Cell-Type-Specific Contributions of Medial Prefrontal Neurons to Flexible Behaviors. J Neurosci 38, 4490– 4504 29650697 PMC5943977

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Authors
Anastasiades, P. G., & Carter, A. G.
Affiliations
  • University of Bristol (GB)
  • New York University (US)
Corresponding author
Carter, Adam G.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2021-07
Volume
44
Issue
7
Pages
550-563
ISSN
0166-2236 (ISSN-L)
OpenAlex
W3159995594
Cited by
314
References
93
Citations by year
2026: 81 · 2025: 90 · 2024: 67 · 2023: 46 · 2022: 25 · 2021: 4
FWCI
5.56
Type
journal article
Language
en
Open access
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Explore Bristol Research (submittedVersion)
Funders
  • European Commission
  • National Alliance for Research on Schizophrenia and Depression
  • H2020 Marie Skłodowska-Curie Actions
  • National Institutes of Health (R01 MH085974)
  • Academy of Medical Sciences
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
medial prefrontal cortex, rodent brain, projection neurons, interneurons, excitatory-inhibitory interactions
MeSH terms
Animals, Humans, Interneurons, Rodentia, Prefrontal Cortex

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