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A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasisPreprint

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Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche

Kraiczy, J., McCarthy, N., Malagola, E., Tie, G., Madha, S., Boffelli, D., Wagner, D. E., Wang, T. C., & Shivdasani, R. A. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.03.004 · Cited by 112

Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration

Tomić, G., Morrissey, E. R., Kozar, S., Ben‐Moshe, S., Hoyle, A., Azzarelli, R., Kemp, R., Chilamakuri, C. S. R., Itzkovitz, S., Philpott, A., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.07.002 · Cited by 107

APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes

Parker, T. W., & Neufeld, K. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-59899-z · Cited by 107

IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis

Jeffery, V., Goldson, A. J., Dainty, J. R., Chieppa, M., & Sobolewski, A. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1600960 · Cited by 107

Direct visualization of a native Wnt in vivo reveals that a long-range Wnt gradient forms by extracellular dispersal

Pani, A. M., & Goldstein, B. (2018) · eLife · doi:10.7554/elife.38325 · Cited by 106

From single cells to tissue self‐organization

dos Santos, A. X. D. S., & Liberali, P. (2018) · FEBS Journal · doi:10.1111/febs.14694 · Cited by 109

Modulating Wnt signaling at the root: Porcupine and Wnt acylation

Torres, V. I., Godoy, J. A., & Inestrosa, N. C. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.02.009 · Cited by 105

Lymphatics and fibroblasts support intestinal stem cells in homeostasis and injury

Goto, N., Goto, S., Imada, S., Hosseini, S., Deshpande, V., & Yilmaz, Ö. H. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.06.013 · Cited by 106

Wnt Signalling in Gastrointestinal Epithelial Stem Cells

Flanagan, D. J., Austin, C. R., Vincan, E., & Phesse, T. J. (2018) · Genes · doi:10.3390/genes9040178 · Cited by 110

Dclk1-expressing tuft cells: critical modulators of the intestinal niche?

Middelhoff, M. A., Westphalen, C. B., Hayakawa, Y., Yan, K. S., Gershon, M. D., Wang, T. C., & Quante, M. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00073.2017 · Cited by 97

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

Huels, D. J., Bruens, L., Hodder, M. C., Cammareri, P., Campbell, A. D., Ridgway, R. A., Gay, D. M., Solar-Abboud, M., Faller, W. J., Nixon, C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03426-2 · Cited by 103

Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia

McKinley, K. L., Stuurman, N., Royer, L. A., Schartner, C., Castillo‐Azofeifa, D., Delling, M., Klein, O. D., & Vale, R. D. (2018) · eLife · doi:10.7554/elife.36739 · Cited by 95

Advanced 3D imaging and organoid bioprinting for biomedical research and therapeutic applications

Maharjan, S., Ma, C., Singh, B., Kang, H., Orive, G., Yao, J., & Zhang, Y. S. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115237 · Cited by 107

Making, Exporting, and Modulating Wnts

Langton, P. F., Kakugawa, S., & Vincent, J. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.05.011 · Cited by 98

Inflation-collapse dynamics drive patterning and morphogenesis in intestinal organoids

Tallapragada, N. P., Cambra, H. M., Wald, T., Jalbert, S. K., Abraham, D. M., Klein, O. D., & Klein, A. M. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.04.002 · Cited by 95

The Emerging Mechanisms of Wnt Secretion and Signaling in Development

Mehta, S., Hingole, S., & Chaudhary, V. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.714746 · Cited by 98

In situ modulation of intestinal organoid epithelial curvature through photoinduced viscoelasticity directs crypt morphogenesis

Yavitt, F. M., Kirkpatrick, B. E., Blatchley, M. R., Speckl, K. F., Mohagheghian, E., Moldovan, R., Wang, N., Dempsey, P. J., & Anseth, K. S. (2023) · Science Advances · doi:10.1126/sciadv.add5668 · Cited by 96

Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells

Farin, H. F., Van Es, J. H., & Clevers, H. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.08.031 · Cited by 655

Telocytes deliver essential Wnts directly to murine intestinal stem cells via synapse-like contacts

Greicius, G., Mittermeier, L., Liang, R., Sigmundsson, K., Chan, Y. K., Liao, P.-J., Ludwig, A., & Virshup, D. M. (2025) · Developmental Cell · doi:10.1016/j.devcel.2025.06.040 · Cited by 8

Abstract 5931: PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo

Greicius, G., Kabiri, Z., Sigmundsson, K., Liang, C., Bunte, R. M., Singh, M. K., & Virshup, D. M. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-5931 · Cited by 1

Wnt Secretion from Epithelial Cells and Subepithelial Myofibroblasts Is Not Required in the Mouse Intestinal Stem Cell Niche In Vivo

Roman, A. K. S., Jayewickreme, C. D., Murtaugh, L. C., & Shivdasani, R. A. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.12.012 · Cited by 133

ORIGINAL ARTICLE

Tomlinson, I. P. M. (2016)