Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

The Protein Data Bank

Berman, H. M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.235 · Cited by 40,196

[20] Processing of X-ray diffraction data collected in oscillation mode

Otwinowski, Z., & Minor, W. (1997) · Methods in Enzymology · doi:10.1016/s0076-6879(97)76066-x · Cited by 33,475

Features and development of Coot

Emsley, P., Lohkamp, B., Scott, W. G., & Cowtan, K. (2010) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444910007493 · Cited by 29,915

Methods in Enzymology , Vol

Colowick, S. P., Joshi, M. D., Jagannathan, & KAPLAN, N. O. (1966) · Cited by 26,137

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197

Refinement of Macromolecular Structures by the Maximum-Likelihood Method

Murshudov, G. N., Vagin, A. A., & Dodson, E. J. (1997) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444996012255 · Cited by 14,796

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452

PRODRG: a tool for high-throughput crystallography of protein–ligand complexes

Schüttelkopf, A. W., & van Aalten, D. M. F. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904011679 · Cited by 4,837

Regulation of cancer cell metabolism

Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820

Nuclear translocation of metabolic enzyme PKM2 participates in high glucose-promoted HCC metastasis by strengthening immunosuppressive environment

Qian, J., Huang, C., Wang, M., Liu, Y., Zhao, Y., Li, M., Zhang, X., Gao, X., Zhang, Y., Wang, Y., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103103 · Cited by 24

Combination strategies of gut microbiota in cancer therapy through metabolic reprogramming and immune remodeling

Wang, L., Jiang, W., Yang, M., Danzeng, Q., Liu, S., & Cui, M. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02275-z · Cited by 28

Canonical and new generation anticancer drugs also target energy metabolism

Rodríguez‐Enríquez, S., Gallardo‐Pérez, J. C., Hernández‐Reséndiz, I., Marín‐Hernández, Á., Pacheco-Velázquez, S. C., López‐Ramírez, S. Y., Rumjanek, F. D., & Moreno‐Sánchez, R. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1246-2 · Cited by 24

Metabolic, autophagic, and mitophagic activities in cancer initiation and progression

Hjelmeland, A. B., & Zhang, J. (2016) · Biomedical Journal · doi:10.1016/j.bj.2015.10.002 · Cited by 24

Identification of a new pyruvate kinase M2 isoform ( PKM 2) activator for the treatment of non‐small‐cell lung cancer ( NSCLC )

Li, R., Fan, X., Shi, D., Zhu, G., Wang, Y., Luo, L., Pan, H., Yao, X., Leung, E. L., & Liu, L. (2018) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13354 · Cited by 26

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

Davidson, S. M., Heyman, J. E., O’Brien, J. P., Liu, A. C., Schmidt, D. R., Israelsen, W. J., Dayton, T. L., Sehgal, R., Bronson, R. T., Freinkman, E., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-2352 · Cited by 24

The “sweet” path to cancer: focus on cellular glucose metabolism

Iacobini, C., Vitale, M., Pugliese, G., & Menini, S. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1202093 · Cited by 23

Fluorescent Probes of the Apoptolidins and their Utility in Cellular Localization Studies

DeGuire, S. M., Earl, D. C., Du, Y., Crews, B. A., Jacobs, A. T., Ustione, A., Daniel, C. K., Chong, K. M., Marnett, L. J., Piston, D. W., et al. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201408906 · Cited by 24

Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators

Li, R., Ning, X., Zhou, S., Lin, Z., Wu, X., Chen, H., Bai, X., Wang, X., Ge, Z., Li, R., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.11.023 · Cited by 24

Quantification of folate metabolism using transient metabolic flux analysis

Tedeschi, P. M., Johnson-Farley, N. N., Lin, H., Shelton, L. M., Ooga, T., Mackay, G., van den Broek, N. J. F., Bertino, J. R., & Vázquez, A. (2015) · Cancer & Metabolism · doi:10.1186/s40170-015-0132-6 · Cited by 23

Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2

Srivastava, D., Nandi, S., & Dey, M. (2019) · Biochemistry · doi:10.1021/acs.biochem.9b00349 · Cited by 23

The fuel and engine: The roles of reprogrammed metabolism in metastasis of primary liver cancer

Zhu, W., Lü, M., Wang, X., Xu, Z., Gao, C., & Qin, L. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.01.016 · Cited by 25

From Glucose to Lactate and Transiting Intermediates Through Mitochondria, Bypassing Pyruvate Kinase: Considerations for Cells Exhibiting Dimeric PKM2 or Otherwise Inhibited Kinase Activity

Chinopoulos, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.543564 · Cited by 23

Targeting Cancer Metabolism and Current Anti-Cancer Drugs

Sukjoi, W., Ngamkham, J., Attwood, P. V., & Jitrapakdee, S. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-55035-6_2 · Cited by 23

Discovery of Novel Sesquiterpene Lactone Derivatives as Potent PKM2 Activators for the Treatment of Ulcerative Colitis

Wang, P., Yang, H., Lin, W., Zhou, J., Liu, Y., Ma, L., Li, M., Hu, Y., Yu, C., Zhang, Y., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01856 · Cited by 23

Tumor metabolism rewiring in epithelial ovarian cancer

Wang, M., Zhang, J., & Wu, Y. (2023) · Journal of Ovarian Research · doi:10.1186/s13048-023-01196-0 · Cited by 27

Oridonin inhibits the occurrence and development of colorectal cancer by reversing the Warburg effect via reducing PKM2 dimer formation and preventing its entry into the nucleus

Chen, F., Liao, J., Wu, P., Li, C., Ma, Y., Zhang, L., Leng, X.-M., Zhu, X., Liu, Z., & Xie, F. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175856 · Cited by 23

The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells

Brault, C., & Schulze, A. (2016) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-42118-6_1 · Cited by 22

Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms

Futamura, Y., Muroi, M., Aono, H., Kawatani, M., Hayashida, M., Sekine, T., Nogawa, T., & Osada, H. (2018) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2018.06.001 · Cited by 23

T‐cell–derived extracellular vesicles regulate B‐cell IgG production via pyruvate kinase muscle isozyme 2

Yang, J., Dang, G., Lü, S., Liu, H., Ma, X., Han, L., Deng, J., Miao, Y., Li, X., Shao, F., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900863r · Cited by 22

Pyruvate Kinase M2 Expression: A Potential Metabolic Biomarker to Differentiate Endometrial Precancer and Cancer that is Associated with Poor Outcomes in Endometrial Carcinoma

Lai, Y.-J., Chou, Y., Lin, Y., Yu, M.-H., Ou, Y., Chu, P.-W., Wu, C., Wang, Y.-C., & Chao, T. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16234589 · Cited by 23

β-Cell Mitochondrial Dysfunction: Underlying Mechanisms and Potential Therapeutic Strategies

Darwish, R., Alcibahy, Y., Abu-Sharia, G., & Butler, A. E. (2025) · Cells · doi:10.3390/cells14231861 · Cited by 25

Native Mass Spectrometry Gives Insight into the Allosteric Binding Mechanism of M2 Pyruvate Kinase to Fructose-1,6-Bisphosphate

Gavriilidou, A. F. M., Holding, F. P., Mayer, D., Coyle, J. E., Veprintsev, D. B., & Zenobi, R. (2018) · Biochemistry · doi:10.1021/acs.biochem.7b01270 · Cited by 22

Dihydropyrimidinase Like 2 Promotes Bladder Cancer Progression via Pyruvate Kinase M2-Induced Aerobic Glycolysis and Epithelial–Mesenchymal Transition

Zou, J., Huang, R., Chen, Y., Huang, X., Li, H., Liang, P., & Chen, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.2139/ssrn.3745779 · Cited by 22

Structural basis of PKM2 regulation

Yang, W. (2015) · Protein & Cell · doi:10.1007/s13238-015-0146-4 · Cited by 22

Development of a fluorescent monoclonal antibody‐based assay to measure the allosteric effects of synthetic peptides on self‐oligomerization of AGR2 protein

Gray, T. A., Murray, E., Nowicki, M. W., Remnant, L., Scherl, A., Müller, P., Vojtesek, B., & Hupp, T. R. (2013) · Protein Science · doi:10.1002/pro.2299 · Cited by 22

Metabolic Pathway Inhibition in Liver Cancer

Zarrinpar, A. (2017) · SLAS TECHNOLOGY · doi:10.1177/2472630317698683 · Cited by 23

Branched-chain amino acids contribute to diabetic kidney disease progression via PKM2-mediated podocyte metabolic reprogramming and apoptosis

Zhao, H., Sun, D., Wang, S., Liu, Y., Zhao, X., Tian, W., Dou, X., Liu, J., Xu, J., Peng, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62890-9 · Cited by 24

Faecalibaculum rodentium Alleviates Ionizing Radiation‐Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate

Zhu, H., Guo, H., Sun, N., Xiao, R., Ji, B., Jiang, R., Dong, F., Yao, C., Wang, X., Li, R., et al. (2025) · Advanced Science · doi:10.1002/advs.202509383 · Cited by 26

Metabolic Reprogramming in HIV-Associated Neurocognitive Disorders

Allen, C. N. S., Arjona, S. P., Santerre, M., de Lucia, C., Koch, W. J., & Sawaya, B. E. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.812887 · Cited by 21

Emerging Approaches for Targeting Metabolic Vulnerabilities in Malignant Glioma

Clark, P. M., Mai, W. X., Cloughesy, T. F., & Nathanson, D. A. (2016) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-015-0613-6 · Cited by 21

Tumor M2-PK: A novel urine marker of bladder cancer

Liu, W., Woolbright, B. L., Pirani, K., Didde, R. D., Abbott, E., Kaushik, G., Martin, P. B., Hamilton‐Reeves, J. M., Taylor, J. A., Holzbeierlein, J. M., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218737 · Cited by 21

Imbalance in Glucose Metabolism Regulates the Transition of Microglia from Homeostasis to Disease-Associated Microglia Stage 1

Liu, Y., Kwok, W., Yoon, H., Ryu, J. C., Stevens, P., Hawkinson, T. R., Shedlock, C. J., Ribas, R. A., Medina, T., Keohane, S. B., et al. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1563-23.2024 · Cited by 21

Regulation of Ptbp1-controlled alternative splicing of pyruvate kinase muscle by liver kinase B1 governs vascular smooth muscle cell plasticity in vivo

Cai, Z., Satyanarayana, G., Song, P., Zhao, F., You, S., Liu, Z., Mu, J., Ding, Y., He, B., & Zou, M. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae187 · Cited by 20

PKM2 controls cochlear development through lactate-dependent transcriptional regulation

Wu, M., Jia, G., Liu, Y., Lou, Y., Li, Y., Xia, M., Li, H., & Li, W. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2410829122 · Cited by 22

Changes in Enzyme Structural Dynamics Studied by Hydrogen Exchange-Mass Spectrometry: Ligand Binding Effects or Catalytically Relevant Motions?

Fast, C. S., Vahidi, S., & Konermann, L. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b03506 · Cited by 20

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues

Fan, T. W. ‐., Daneshmandi, S., Cassel, T., Uddin, M. B., Sledziona, J., Thompson, P. T., Lin, P., Higashi, R. M., & Lane, A. N. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200178 · Cited by 20

PKM2/STAT1-mediated PD-L1 upregulation on neutrophils during sepsis promotes neutrophil organ accumulation by serving an anti-apoptotic role

Li, Y., Tan, R., Li, R., Tian, R., Liu, Z., Wang, X., Chen, E., Pan, T., & Qu, H. (2023) · Journal of Inflammation · doi:10.1186/s12950-023-00341-2 · Cited by 21

Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role

Anastasakis, D. G., Apostolidi, M., Garman, K. A., Polash, A. H., Umar, M. I., Meng, Q., Scutenaire, J., Jarvis, J. E., Wang, X., Haase, A. D., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.07.025 · Cited by 21

The greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism?

Lv, J., Wang, J., Chang, S., Liu, M., & Pang, X. (2015) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv102 · Cited by 22

Sarsaparilla ( Smilax Glabra Rhizome) Extract Inhibits Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy via Redox-Dependent ERK1/2 Pathway

She, T., Qu, L., Wang, L., Yang, X., Xu, S., Feng, J., Gao, Y., Zhao, C., Han, Y. K., Cai, S., et al. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0372 · Cited by 20

Development of [18F]DASA-23 for Imaging Tumor Glycolysis Through Noninvasive Measurement of Pyruvate Kinase M2

Beinat, C., Alam, I. S., James, M. L., Srinivasan, A., & Gambhir, S. S. (2017) · Molecular Imaging and Biology · doi:10.1007/s11307-017-1068-8 · Cited by 20

Glioblastomas: Hijacking Metabolism to Build a Flexible Shield for Therapy Resistance

Bailleul, J., & Vlashi, E. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0088 · Cited by 22

A Clinical PET Imaging Tracer ([18F]DASA-23) to Monitor Pyruvate Kinase M2–Induced Glycolytic Reprogramming in Glioblastoma

Beinat, C., Patel, C. B., Haywood, T., Murty, S., Naya, L., Castillo, J. B., Reyes, S. T., Phillips, M., Buccino, P. J., Shen, B., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-0544 · Cited by 19

Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase

Nain‐Perez, A., Füchtbauer, A. F., Håversen, L., Lulla, A., Gao, C., Matić, J., Monjas, L., Rodríguez, A., Brear, P., Kim, W., et al. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114270 · Cited by 19

Tissue-specific metabolic profile drives iNKT cell function during obesity and liver injury

de Aguiar, C. F., Corrêa‐da‐Silva, F., Gonzatti, M. B., Angelim, M. K. S. C., Pretti, M. A. M., Davanzo, G. G., Castelucci, B. G., Monteiro, L. D. B., Castro, G., Virgílio-da-Silva, J. V., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112035 · Cited by 19

Recent Advances on PKM2 Inhibitors and Activators in Cancer Applications

Chen, P., Lou, L., Sharma, B., Li, M., Xie, C., Yang, F., Wu, Y., Xiao, Q., & Gao, L. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867331666230714144851 · Cited by 20

Tetramerization of PKM2 Alleviates Traumatic Brain Injury by Ameliorating Mitochondrial Damage in Microglia

Zhu, H., Zhang, H., Zhao, X.-J., Zhang, L., Liu, X., Zhang, Z., Ren, Y., & Feng, Y. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10138-6 · Cited by 21

Expanding antitumor therapeutic windows by targeting cancer-specific nicotinamide adenine dinucleotide phosphate-biogenesis pathways

Chakrabarti, G., Boothman, D. A., & Gerber, D. E. (2015) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s79760 · Cited by 22

Subcellular functions of proteins under fluorescence single-cell microscopy

Kohnhorst, C. L., Schmitt, D. L., Sundaram, A., & An, S. (2015) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2015.05.014 · Cited by 21

Metabolic clues to salubrious longevity in the brain of the longest‐lived rodent: the naked mole‐rat

Triplett, J. C., Swomley, A. M., Kirk, J. M., Hardell, K. N. L., Orr, M. E., Rodriguez, K. A., Cai, J., Klein, J. B., Buffenstein, R., & Butterfield, D. A. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13149 · Cited by 18

The CXCL12/CXCR4/ACKR3 Signaling Axis Regulates PKM2 and Glycolysis

Luker, K. E., & Luker, G. D. (2022) · Cells · doi:10.3390/cells11111775 · Cited by 18

Glucometabolic reprogramming: From trigger to therapeutic target in hepatocellular carcinoma

Xia, H., Huang, Z., Wang, Z., Liu, S., Zhao, X., You, J., Xu, Y., Yam, J. W. P., & Cui, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.953668 · Cited by 18

Targeting protein conformations with small molecules to control protein complexes

Zacharioudakis, E., & Gavathiotis, E. (2022) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2022.07.002 · Cited by 19

Expression of PKM2 in wound keratinocytes is coupled to angiogenesis during skin repair in vivo and in HaCaT keratinocytes in vitro

Sych, K., Nold, S. P., Pfeilschifter, J. M., Vutukuri, R., Meisterknecht, J., Wittig, I., Frank, S., & Goren, I. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02280-6 · Cited by 19

Peptide deregulated in hypertrophic scar-1 alleviates hypertrophic scar fibrosis by targeting focal adhesion kinase and pyruvate kinase M2 and remodeling the metabolic landscape

Li, J., Yin, Y., Zhang, E., Gui, M., Chen, L., & Li, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123809 · Cited by 18

Chlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2

Abbruzzese, C., Matteoni, S., Matarrese, P., Signore, M., Ascione, B., Iessi, E., Gurtner, A., Sacconi, A., Ricci‐Vitiani, L., Pallini, R., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06353-3 · Cited by 19

Upregulated expression of ubiquitin ligase TRIM21 promotes PKM2 nuclear translocation and astrocyte activation in experimental autoimmune encephalomyelitis

Yang, L., Hu, C., Chen, X., Zhang, J., Feng, Z., Xiao, Y., He, W., Cui, T., Zhang, X., Yang, Y., et al. (2024) · eLife · doi:10.7554/elife.98181.3 · Cited by 18

Recent discoveries in the cycling, growing and aging of the p53 field

McCubrey, J. A., & Demidenko, Z. N. (2012) · Aging · doi:10.18632/aging.100529 · Cited by 18

ERK2-Pyruvate Kinase Axis Permits Phorbol 12-Myristate 13-Acetate-induced Megakaryocyte Differentiation in K562 Cells

Chaman, N., Iqbal, M. A., Siddiqui, F. A., Prakasam, G., & Bamezai, R. N. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.657411 · Cited by 18

Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism

Audet-Delage, Y., Rouleau, M., Rouleau, M., Roberge, J., Miard, S., Picard, F., Têtu, B., & Guillemette, C. (2017) · Molecular Pharmacology · doi:10.1124/mol.116.106161 · Cited by 18

Pyruvate kinase M2 and the mitochondrial ATPase Inhibitory Factor 1 provide novel biomarkers of dermatomyositis: a metabolic link to oncogenesis

Santacatterina, F., Sánchez‐Aragó, M., Catalán‐García, M., Garrabou, G., de Arenas, C. N., Grau, J. M., Cardellach, F., & Cuezva, J. M. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1136-5 · Cited by 18

Non-Coding RNA Networks in Pulmonary Hypertension

Zang, H., Zhang, Q., & Li, X. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.703860 · Cited by 18

Understanding and Targeting Metabolic Vulnerabilities in Acute Myeloid Leukemia: An Updated Comprehensive Review

Addanki, S., Kim, L. E., & Stevens, A. M. (2025) · Cancers · doi:10.3390/cancers17081355 · Cited by 18

Metabolism of glioblastoma: a review of metabolic adaptations and metabolic therapeutic interventions

Chung, J., Saad, J., Kafri, A., Rossignol, J., Verbrugge, M., & Bakke, J. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1712576 · Cited by 19

Proteins moonlighting in tumor metabolism and epigenetics

Lv, L., & Lei, Q. (2021) · Frontiers of Medicine · doi:10.1007/s11684-020-0818-1 · Cited by 18

Ellagic Acid and Its Metabolites as Potent and Selective Allosteric Inhibitors of Liver Pyruvate Kinase

Battisti, U. M., Gao, C., Akladios, F. N., Kim, W., Yang, H., Bayram, C., Bolat, İ., Kılıçlıoğlu, M., Yuksel, N., Tozlu, Ö. Ö., et al. (2023) · Nutrients · doi:10.3390/nu15030577 · Cited by 17

Discovery of genetic variants of the kinases that activate tenofovir among individuals in the United States, Thailand, and South Africa: HPTN067

Figueroa, D. B., Tillotson, J., Li, M., Piwowar‐Manning, E., Hendrix, C. W., Holtz, T. H., Bokoch, K., Bekker, L., van Griensven, F., Mannheimer, S., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195764 · Cited by 17

Protein kinase CK2 modulation of pyruvate kinase M isoforms augments the Warburg effect in cancer cells

Yang, K. M., & Kim, K. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27078 · Cited by 17

Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1

Liu, T., Kuwana, T., Zhang, H., Heiden, M. G. V., Lerner, R. A., & Newmeyer, D. D. (2019) · PLoS Biology · doi:10.1371/journal.pbio.2004413 · Cited by 17

Human biodistribution and radiation dosimetry of [18F]DASA-23, a PET probe targeting pyruvate kinase M2

Beinat, C., Patel, C. B., Haywood, T., Shen, B., Naya, L., Gandhi, H., Holley, D., Khalighi, M. M., Iagaru, A. H., Davidzon, G., et al. (2020) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-04687-0 · Cited by 17

Pyruvate kinase M2 activation protects against the proliferation and migration of pulmonary artery smooth muscle cells

Zhang, A., Yu, F., Yu, W., Ye, P., Liu, P., Gu, Y., Chen, S., & Zhang, H. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03245-2 · Cited by 17

Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing

Patle, R., Shinde, S., Patel, S., Maheshwari, R., Jariyal, H., Srivastava, A., Chauhan, N., Globisch, C., Jain, A. K., Tekade, R. K., et al. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128062 · Cited by 17

Dual Covalent Inhibition of PKM and IMPDH Targets Metabolism in Cutaneous Metastatic Melanoma

Zerhouni, M., Martin, A. R., Furstoss, N., Gutierrez, V., Jaune, E., Tekaya, N., Béranger, G. E., Abbe, P., Regazzetti, C., Amdouni, H., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-20-2114 · Cited by 16

A new class of HIV-1 inhibitors and the target identification via proteomic profiling

Ge, Y.-Z., Zhou, B., Xiao, R., Yuan, X., Zhou, H., Xu, Y., Wainberg, M. A., Han, Y.-S., & Yue, J. (2018) · Science China Chemistry · doi:10.1007/s11426-018-9283-3 · Cited by 17

Dichloroacetate-induced metabolic reprogramming improves lifespan in a Drosophila model of surviving sepsis

Bakalov, V., Reyes-Uribe, L., Deshpande, R., Maloy, A., Shapiro, S. D., Angus, D. C., Chang, C. H., Moyec, L. L., Wendell, S. G., & Kaynar, A. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241122 · Cited by 17

Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes

Li, Z., Zheng, W., Li, H., Li, C., & Gong, Z. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132319 · Cited by 17

HLA-F regulates the proliferation of trophoblast via PKM2-dependent glycolysis in the pathogenesis of preeclampsia

Xu, R., Huang, Y., Xie, W., Luo, D., Mei, J., Liu, X., Liu, F., & Luo, F. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01201-w · Cited by 16

Load and lock: An emerging class of therapeutics that influence macromolecular dissociation

Deshaies, R. J., & Potts, P. R. (2025) · Science · doi:10.1126/science.adx3595 · Cited by 17

Metabolic reprograming of cancer as a therapeutic target

Furukawa, T., Tabata, S., Minami, K., Yamamoto, M., Kawahara, K., & Tanimoto, A. (2022) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2022.130301 · Cited by 15

PKM2 Nuclear Translocation Promotes Glial Cell Activation and Aggravates the Brain Injury of Intracerebral Hemorrhage

Xiong, X., Liang, Y.-J., Zhang, X., Yang, S.-H., Zhong, Z., Liu, S., Sun, J., Tang, Y. M., & Yu, S. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2206168 · Cited by 16

Evaluation of Glycolytic Response to Multiple Classes of Anti-glioblastoma Drugs by Noninvasive Measurement of Pyruvate Kinase M2 Using [18F]DASA-23

Beinat, C., Patel, C. B., Xie, Y., & Gambhir, S. S. (2019) · Molecular Imaging and Biology · doi:10.1007/s11307-019-01353-2 · Cited by 16

Boronic acid derivative activates pyruvate kinase M2 indispensable for redox metabolism in oral cancer cells

Rihan, M., Nalla, L. V., Dharavath, A., Patel, S., Shard, A., & Khairnar, A. (2022) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2022.128539 · Cited by 16

PKM2 under hypoxic environment causes resistance to mTOR inhibitor in human castration resistant prostate cancer

Yasumizu, Y., Hongo, H., Kosaka, T., Mikami, S., Nishimoto, K., Kikuchi, E., & Oya, M. (2018) · Oncotarget · doi:10.18632/oncotarget.25498 · Cited by 16

Down-Regulation of Nfatc1 Suppresses Proliferation, Migration, Invasion, and Warburg Effect in Prostate Cancer Cells

Liu, Y., Liang, T., Qiu, X., Ye, X., Li, Z., Tian, B., & Yan, D. (2019) · Medical Science Monitor · doi:10.12659/msm.910998 · Cited by 16

SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer

Liu, X., Cui, Y., Gong, J., Yu, X., Cui, Y., & Xuan, Y. (2025) · Oncogene · doi:10.1038/s41388-025-03426-9 · Cited by 15

Potential Allosteric Sites Captured in Glycolytic Enzymes Via Residue-Based Network Models: Phosphofructokinase, Glyceraldehyde-3-Phosphate Dehydrogenase and Pyruvate Kinase

Çelebi, M., İnan, T., Kürkçüoğlu, Ö., & Akten, E. D. (2021) · Biophysical Chemistry · doi:10.1016/j.bpc.2021.106701 · Cited by 14

Impact of NSCLC metabolic remodeling on immunotherapy effectiveness

Lv, L., Huang, R. H., Li, J., Xu, J., & Gao, W. (2022) · Biomarker Research · doi:10.1186/s40364-022-00412-1 · Cited by 16

M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics

Guo, L., Wang, L., Qin, G., Zhang, J., Peng, J., Li, L., Chen, X., Wang, D., Qiu, J., & Wang, E. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04780-6 · Cited by 17

PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

Benzarti, M., Neises, L., Oudin, A., Krötz, C., Viry, E., Gargiulo, E., Pulido, C., Schmoetten, M., Pozdeev, V. I., Lorenz, N. I., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113868 · Cited by 14

A Simple and Reliable Method for Determination of Optimum PH in Coupled Enzyme Assays

Bowman, L., Motamed, R., Lee, P. Y. K., Aleem, K., Berawala, A. S., Hayden, K. L., Bzik, D. J., & Chattopadhyay, D. (2020) · BioTechniques · doi:10.2144/btn-2019-0126 · Cited by 15

Metabolite profiling of IMID‐2, a novel anticancer molecule of piperazine derivative: In silico prediction, in vitro and in vivo metabolite characterization using UPLC–QTOF–MS/MS

Panday, N. K., Thakkar, D., Patel, S., Shard, A., & Sengupta, P. (2021) · Biomedical Chromatography · doi:10.1002/bmc.5082 · Cited by 15

Non-Metabolic Role of PKM2 in Regulation of the HIV-1 LTR

Sen, S., Deshmane, S. L., Kaminski, R., Amini, S., & Datta, P. K. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25445 · Cited by 15

Metabolic reprogramming of the immune response in the tumor microenvironment

McCarthy, S. A., Mufson, R. A., Pearce, E. J., Rathmell, J. C., & Howcroft, T. K. (2013) · Cancer Biology & Therapy · doi:10.4161/cbt.23616 · Cited by 15

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Anastasiou, D., Yu, Y., Israelsen, W. J., Jiang, J.-K., Boxer, M. B., Hong, B. S., Tempel, W., Dimov, S., Shen, M., Jha, A., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio1212-1008b · Cited by 15

KATP channel activity and slow oscillations in pancreatic beta cells are regulated by mitochondrial ATP production

Corradi, J., Thompson, B. M., Fletcher, P. A., Bertram, R., Sherman, A., & Satin, L. S. (2023) · The Journal of Physiology · doi:10.1113/jp284982 · Cited by 15

L-arginine combination with 5-fluorouracil inhibit hepatocellular carcinoma cells through suppressing iNOS/NO/AKT-mediated glycolysis

Hu, Y., Xing, Y., Fan, G., Xie, H., Zhao, Q., & Liu, L. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1391636 · Cited by 16

Computer‐aided identification of a novel pyruvate kinase M2 activator compound

Li, Y., Bao, M., Yang, C., Chen, J., Zhou, S. W., Sun, R., Wu, C., Li, X., & Bao, J. (2018) · Cell Proliferation · doi:10.1111/cpr.12509 · Cited by 14

PD-1 Targeted Nanoparticles Inhibit Activated T Cells and Alleviate Autoimmunity via Suppression of Cellular Energy Metabolism Mediated by PKM2

Liu, Z., Xu, J., Li, H., Shu, J., Su, G., Zhou, C., & Yang, P. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s349360 · Cited by 14

Glucose and glutamine in the mitochondrial oxidative metabolism of stem cells

Nesci, S. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.04.004 · Cited by 14

Pyruvate Kinase M2 Activators Inhibit Tumor Growth

(2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2012-148

Abstract 3226: PKM2 metabolic activator slows lung cancer xenograft growth

Parnell, M., Foulks, J. M., Nix, R. N., LUO, B. H., Senina, A. V., Xu, Y., Saunders, M. J., Ho, K.-K., McCullar, M. V., & Kanner, S. B. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-3226

Abstract B143: PKM2 metabolic activator slows lung cancer xenograft growth.

Parnell, K. M., Foulks, J. M., Clifford, A., Bullough, J., LUO, B. H., Vollmer, D., Liu, J., McCarthy, V., Shaffer, M. E., Senina, A. V., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.targ-11-b143

Abstract 1875: A novel series of metabolic activators of PKM2 alter oncogene-meditated changes in tumor cell metabolism.

Bahr, B. L., Stevens, J., Squire, S., Moreno, C., Call, L. T., Stephens, B. J., Mollard, A., Warner, S. L., & Bearss, D. J. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-1875 · Cited by 2

Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth

Parnell, K. M., Foulks, J. M., Nix, R. N., Clifford, A., Bullough, J., LUO, B. H., Senina, A. V., Vollmer, D., Liu, J., McCarthy, V., et al. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0026 · Cited by 73