Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

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PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas

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Inhibition of sphingosine kinase 1 attenuates LPS-induced acute lung injury by suppressing endothelial cell pyroptosis

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PDIA3 orchestrates effector T cell program by serving as a chaperone to facilitate the non-canonical nuclear import of STAT1 and PKM2

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Synthesis of novel sulfonamide derivatives containing pyridin-3-ylmethyl 4-(benzoyl)piperazine-1-carbodithioate moiety as potent PKM2 activators

Li, R., Ning, X., He, J., Lin, Z., Su, Y., Li, R., & Yin, Y. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104653 · Cited by 13

Characterization of RNA-binding proteins in the cell nucleus and cytoplasm

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Pyruvate Kinase M2 Supports Muscle Progenitor Cell Proliferation but Is Dispensable for Skeletal Muscle Regeneration after Injury

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Exploring the Altered Dynamics of Mammalian Central Carbon Metabolic Pathway in Cancer Cells: A Classical Control Theoretic Approach

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Pyruvate kinase M2-mediated histone lactylation alters three-dimensional genomic architecture in polycystic ovary syndrome

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Absence of retbindin blocks glycolytic flux, disrupts metabolic homeostasis, and leads to photoreceptor degeneration

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Druggable Metabolic Vulnerabilities Are Exposed and Masked during Progression to Castration Resistant Prostate Cancer

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The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging

Nahálková, J. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2836-5 · Cited by 13

18F-fluorodeoxyglucose uptake predicts PKM2 expression in lung adenocarcinoma

Huang, P., Zhao, X., Xiao, W., Dong, Y., & Hu, G. (2017) · Oncotarget · doi:10.18632/oncotarget.17377 · Cited by 12

Ras related GTP binding D promotes aerobic glycolysis of hepatocellular carcinoma

Ding, L., & Liang, X. (2021) · Annals of Hepatology · doi:10.1016/j.aohep.2021.100307 · Cited by 12

Area light source‐triggered latent angiogenic molecular mechanisms intensify therapeutic efficacy of adult stem cells

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Allosteric regulation of metabolism in cancer: endogenous mechanisms and considerations for drug design

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Pyruvate kinase M2 activation maintains mitochondrial metabolism by regulating the interaction between HIF-1α and PGC-1α in diabetic kidney disease

Park, J., Joo, Y. S., Nam, B. Y., Kim, G., Park, J. T., Yoo, T., Kang, S., & Han, S. H. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01320-4 · Cited by 13

Succinate-driven PKM2 succinylation and dimerization accelerates age-associated cardiac fibrosis

Wang, Z., Zhang, Z., Ping, Z., Yang, S., Li, Y., Jiang, T., Zheng, X., Zhang, Q., Liu, Z., Zhang, X., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09337-5 · Cited by 11

Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis

Wubben, T. J., Chaudhury, S., Watch, B. T., Stuckey, J. A., Weh, E., Fernando, R., Goswami, M. T., Pawar, M. D., Rech, J. C., & Besirli, C. G. (2023) · Pharmaceuticals · doi:10.3390/ph16050705 · Cited by 11

A comprehensive analysis of the pyruvate kinase M1/2 (PKM) in human cancer

Xue, S., Luo, Z., Mao, Y., & Liu, S. (2024) · Gene · doi:10.1016/j.gene.2024.149155 · Cited by 11

Coptisine improves LPS-induced anxiety-like behaviors by regulating the Warburg effect in microglia via PKM2

Qi, Y., Zhao, X., Wu, W., Wang, N., Ge, P., Guo, S., Lei, S., Zhou, P., Zhao, L., Tang, Z., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117837 · Cited by 11

AllohubPy: Detecting Allosteric Signals Through An Information-theoretic Approach

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PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymes

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Measuring the Nutrient Metabolism of Adherent Cells in Culture

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Rapid and sensitive profiling and quantification of the human cell line proteome by LC‐MS/MS without prefractionation

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A responsive fluorescent probe for detecting and imaging pyruvate kinase M2 in live cells

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Development of novel tetrazole-based pyruvate kinase M2 inhibitors targeting U87MG glioblastoma cells

Chowdhury, M. G., Kapoor, S., Muthukumar, V., Chatterjee, D. R., & Shard, A. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.108029 · Cited by 10

Nuclear accumulation of pyruvate kinase M2 promotes liver regeneration via activation of signal transducer and activator of transcription 3

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Characterizing the Effect of the Lysine Deacetylation Modification on Enzyme Activity of Pyruvate Kinase I and Pathogenicity of Vibrio alginolyticus

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A critical appraisal of the relative contribution of tissue architecture, genetics, epigenetics and cell metabolism to carcinogenesis

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Antiviral epithelial-macrophage crosstalk permits secondary bacterial infections

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Design and synthesis of novel quinazolinone-based pyruvate kinase M2 activators as selective inhibitors of oral cancer cells

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SH2 domain-containing phosphatase 1 regulates pyruvate kinase M2 in hepatocellular carcinoma

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LMW-PTP modulates glucose metabolism in cancer cells

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Targeting the Warburg effect for leukemia therapy: Magnitude matters

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Network, nodes and nexus: systems approach to multitarget therapeutics

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PKM2 promotes myoblast growth and inosine monophosphate-specific deposition in Jingyuan chicken

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Unveiling the anticancer potential of L-Asparaginase (ASNase) from novel Streptomyces isolate HB2AG: Purification and characterization study

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Interference with ENO2 promotes ferroptosis and inhibits glycolysis in clear cell renal cell carcinoma by regulating Hippo‑YAP1 signaling

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PKM2-mediated collagen XVII expression is critical for wound repair

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Dexmedetomidine alleviates sepsis-induced acute lung injury by inhibiting M1 macrophage polarization via inhibition of PKM2-mediated Warburg effect

He, Y., Xie, W., Zhou, H., Wang, Y., Chen, L., Xu, Z., Feng, Y., Liu, G., Liu, J., Li, X., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117130 · Cited by 9

Epithelial redox stress programs macrophage immunometabolism through a ZNF24-MIF–NF–κB pathway in chronic nonbacterial prostatitis

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In Scarcity and Abundance: Metabolic Signals Regulating Cell Growth

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Probing altered enzyme activity in the biochemical characterization of cancer

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Roadmap to Pyruvate Kinase M2 Modulation - A Computational Chronicle

Shard, A., Kapoor, S., Chatterjee, D. R., Chowdhury, M. G., & Das, R. (2023) · Current Drug Targets · doi:10.2174/1389450124666230330103126 · Cited by 9

Protein painting for structural and binding site analysis via intracellular lysine reactivity profiling with o -phthalaldehyde

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Genetic Variation of Kinases and Activation of Nucleotide Analog Reverse Transcriptase Inhibitor Tenofovir

Hamlin, A. N., Tillotson, J., & Bumpus, N. N. (2019) · Pharmacogenomics · doi:10.2217/pgs-2018-0140 · Cited by 9

Tetrameric PKM2 Activation Curbs CD4+ T Cell Overactivation

Jiang, S. (2020) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2020.04.001 · Cited by 10

Renoprotection of Microcystin-RR in Unilateral Ureteral Obstruction-Induced Renal Fibrosis: Targeting the PKM2-HIF-1α Pathway

Ren, Y., Wang, J., Guo, W., Chen, J., Wu, X., Gu, S., Xu, L., Wu, Z., & Wang, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.830312 · Cited by 9

Gas Chromatography Coupled to Mass Spectrometry (GC–MS) to Study Metabolism in Cultured Cells

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PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma

Voss, D. M., Kral, A. J., Sim, G., Utama, R., Lin, K., Cizmeciyan, C., Schäfer, B., Cunniff, P. J., Vakoc, C. R., Caruthers, M. H., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108345 · Cited by 9

Pyruvate Kinase M2 Promotes Hair Regeneration by Connecting Metabolic and Wnt/β-Catenin Signaling

Ryu, Y. C., Kim, Y.-R., Park, J., Choi, S., Ryu, W., Kim, G.-U., Kim, E., Hwang, Y., Kim, H., Han, G., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14122774 · Cited by 11

Pyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis

Kuo, C.-W., Chen, D., Tsai, M., Lin, C., Cheng, H.-W., Tsay, Y., & Wang, H. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1151359 · Cited by 8

ILT4 reprograms glucose metabolism to promote tumor progression in triple-negative breast cancer

Zhang, H., Gao, A., Liu, Q., Zhang, F., Wang, S., Chen, X., Shi, W., Zhang, Y., Liu, Q., Zheng, Y., et al. (2023) · Journal of Cell Science · doi:10.1242/jcs.260964 · Cited by 8

FV-429 induces apoptosis by regulating nuclear translocation of PKM2 in pancreatic cancer cells

Jin, X., Min, Q., Wang, D., Wang, Y., Li, G., Wang, Z., Guo, Y., & Zhou, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29515 · Cited by 8

Deciphering the complex landscape of post-translational modifications on PKM2: Implications in head and neck cancer pathogenesis

Singla, P., & Jain, A. K. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122719 · Cited by 8

Drug Development Strategy for Type 2 Diabetes: Targeting Positive Energy Balances

Liu, Z., & Yang, B. (2018) · Current Drug Targets · doi:10.2174/1389450120666181217111500 · Cited by 8

Insights into Body Size Evolution: A Comparative Transcriptome Study on Three Species of Asian Sisoridae Catfish

Jiang, W., Guo, Y., Yang, K., Shi, Q., & Yang, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040944 · Cited by 8

Detection of Nail Oncometabolite SAICAR in Oral Cancer Patients and Its Molecular Interactions with PKM2 Enzyme

Patel, R., Kumar, A., Lokhande, K. B., Almasri, M., Alzahrani, K. J., Almeslet, A., Swamy, K. V., Sarode, G. S., Sarode, S. C., Patil, S., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182111225 · Cited by 8

β Cell–specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses

Emfinger, C. H., de Klerk, E., Schueler, K. L., Rabaglia, M. E., Stapleton, D. S., Simonett, S. P., Mitok, K. A., Wang, Z., Liu, X., Paulo, J. A., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.154198 · Cited by 9

Reciprocal abrogation of PKM isoforms: contradictory outcomes and differing impact of splicing signal on CRISPR /Cas9 mediates gene editing in keratinocytes

Nold, S. P., Sych, K., Imre, G., Fuhrmann, D. C., Pfeilschifter, J. M., Vutukuri, R., Schnütgen, F., Wittig, I., Meisterknecht, J., Frank, S., et al. (2022) · FEBS Journal · doi:10.1111/febs.16625 · Cited by 8

Pyruvate Kinase Isozyme M2 Plays a Critical Role in the Interactions Between Pancreatic Stellate Cells and Cancer Cells

Masamune, A., Hamada, S., Yoshida, N., Nabeshima, T., & Shimosegawa, T. (2018) · Digestive Diseases and Sciences · doi:10.1007/s10620-018-5051-2 · Cited by 8

Reprogrammed glucose metabolism in vascular smooth muscle cells and its implications for vascular diseases

Ma, Q., Cai, Y., Yang, Q., Zhang, W., Xu, S., & Huo, Y. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107995 · Cited by 8

Histone H4 lysine 12 lactylation-driven ZIP14 expression is involved in electroacupuncture therapy against cerebral ischemia/reperfusion injury in mice

Xu, F., Shi, L., Wang, S., Zhang, H., Chen, H., He, S., Chen, M., Fu, J., Yang, M., Wang, Y., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.12.038 · Cited by 8

The Interplay Between Reactive Oxygen Species, Glucose Metabolism and NF-kB in the Pathogenesis of Type 2 Diabetes

Mirmiranpour, H., & Arden, C. (2026) · Diabetology · doi:10.3390/diabetology7030053 · Cited by 8

The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging

Song, Z., Hu, H., Zhang, W., Zheng, X., Liang, L., Zhao, B., Song, G., Li, J., Li, S., Wen, Y., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01087-1 · Cited by 7

Metabolic Adaptations and Functional Activity of Macrophages in Homeostasis and Inflammation

Yurakova, T. R., Gorshkova, E. A., Nosenko, M. A., & Drutskaya, M. S. (2024) · Biochemistry (Moscow) · doi:10.1134/s0006297924050043 · Cited by 7

Novel sulfonamides unveiled as potent anti-lung cancer agents via tumor pyruvate kinase M2 activation

Das, R., Chatterjee, D. R., Kapoor, S., Vyas, H., & Shard, A. (2024) · RSC Medicinal Chemistry · doi:10.1039/d4md00367e · Cited by 7

Polyphyllin II Induces Apoptosis in Fibrosarcoma Cells via Activating Pyruvate Kinase M2

Wu, J., Ding, Z., Zhong, M., Xi, J., He, Y., Zhang, B., & Fang, J. (2024) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.4c00154 · Cited by 8

PKM2 regulates osteoclastogenesis by affecting osteoclast precursor cell fusion via downregulation of OC-STAMP and DC-STAMP

Cai, C., Jiang, J., Li, S., Gao, C., Pu, H., Zhao, L., & Xiao, J. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108439 · Cited by 7

Reprogramming of leukemic cell metabolism through the naphthoquinonic compound Quambalarine B

Vališ, K., Grobárová, V., Hernychová, L., Bugáňová, M., Kavan, D., Kalous, M., Černý, J., Stodůlková, E., Kuzma, M., Flieger, M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21663 · Cited by 7

Proteomic Profiling Change and Its Implies in the Early Mycosis Fungoides (MF) Using Isobaric Tags for Relative and Absolute Quantification (iTRAQ)

Zhu, M., Li, Y., Ding, C., Wang, J., Ma, Y., Zhao, L., Zhang, X., & Wang, P. (2020) · BioMed Research International · doi:10.1155/2020/9237381 · Cited by 7

Coordinated pyruvate kinase activity is crucial for metabolic adaptation and cell survival during mitochondrial dysfunction

Zhou, X., Mikaeloff, F., Curbo, S., Zhao, Q., Kuiper, R., Végvári, Á., Neogi, U., & Karlsson, A. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab168 · Cited by 7

Preventing pyruvate kinase muscle expression in Chinese hamster ovary cells curbs lactogenic behavior by altering glycolysis, gating pyruvate generation, and increasing pyruvate flux into the TCA cycle

Tang, D., Sandoval, W. N., Liu, P. X., Lam, C., Snedecor, B., & Misaghi, S. (2021) · Biotechnology Progress · doi:10.1002/btpr.3193 · Cited by 7

Metabolic targeting of malignant tumors: a need for systemic approach

Margetis, A. T. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04212-w · Cited by 7

Knowledge-driven design and optimization of potent symmetric anticancer molecules: A case study on PKM2 activators

Jaiswal, E., Globisch, C., & Jain, A. K. (2022) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.106313 · Cited by 7

Development of [18F]DASA-10 for enhanced imaging of pyruvate kinase M2

Kendırlı, M. T., Malek, R. S., Silveira, M. B., Acosta, C., Zhang, S., Azevedo, E. C., Nagy, S. C., Habte, F. G., James, M. L., Recht, L. D., et al. (2023) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2023.108382 · Cited by 7

Please Keep Me 2uned to PKM2

McKnight, S. L. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.02.022 · Cited by 7

Fluorescent Probes of the Apoptolidins and their Utility in Cellular Localization Studies

DeGuire, S. M., Earl, D. C., Du, Y., Crews, B. A., Jacobs, A. T., Ustione, A., Daniel, C. K., Chong, K. M., Marnett, L. J., Piston, D. W., et al. (2014) · Angewandte Chemie · doi:10.1002/ange.201408906 · Cited by 7

Pyruvate Kinase M2 Links Metabolism and Epigenetics: A New Target for Liver Disease Treatment

Zhang, X., Zhang, D., Guo, J., Shi, C., & Gong, Z. (2025) · Biomolecules · doi:10.3390/biom15091327 · Cited by 6

Thiazole-Based Tumor Pyruvate Kinase M2 Inhibitors: A Paradigm-Shifting Therapeutic Strategy Targeting Metabolic and Microbial Synergy in Colorectal Cancer

Chowdhury, M. G., Singh, A. A., Bhattacharyya, M., Muthukumar, V., Kapoor, S., Srivastava, A., Kumar, H., & Shard, A. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c02169 · Cited by 6

Acrolein-induced PKM2 modification drives NETosis and glioma progression

Wang, H., Tong, Z.-J., Lin, Y.-R., Wei, K., Huang, C.-Y., Chen, P., Chen, K., Lin, Y.-J., & Tsai, H. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.10.006 · Cited by 6

Design, synthesis, and biological evaluation of benzenesulfonyl chloride-substituted evodiamine derivatives as potential PGAM1 inhibitors

Wei, B., Ma, J., Guo, H., Zhang, Y., Zhang, W., Chen, W., Guo, D., Wang, Y., & Tang, Y. (2023) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2023.105295 · Cited by 6

Terpenoids: Unlocking Their Potential on Cancer Glucose Metabolism

Muhammad, S. N. H., Ramli, R. R., Kamal, N. N. S. N. M., & Fauzi, A. N. (2024) · Phytotherapy Research · doi:10.1002/ptr.8346 · Cited by 6

Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach

Imran, M., Altamimi, A. S. A., Afzal, M., Babu, M. A., Goyal, K., Ballal, S., Sharma, P., Alanazi, F. J., Alruwaili, A. N., Aldhafeeri, N. A., et al. (2025) · Biogerontology · doi:10.1007/s10522-025-10189-z · Cited by 6

CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models

Cabrera, M., Armando, R. G., Czarnowski, I., Chinestrad, P., Blanco, R., Zinni, M. A., Gomez, D. E., Gómez, D. L. M., & Menna, P. L. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42238 · Cited by 7

Differential Regulation of PKM2, AMPK, and mTOR in Response to Insulin and Dietary Management

Broberg, E., English, J., Clarke, D. M., Shin, M. J., Bikman, B. T., Reynolds, P. R., & Arroyo, J. A. (2025) · Cells · doi:10.3390/cells14060416 · Cited by 6

Advances in the design and application of glycolysis-related nanodelivery systems for anti-tumor

Zhou, Y., Liu, M., Lü, N., Deng, X., Chen, X., Tang, L., Xie, Z., Lei, X., Yang, X., Zhou, S., et al. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114844 · Cited by 6

Transcriptomic signatures responding to PKM2 activator TEPP-46 in the hyperglycemic human renal proximal epithelial tubular cells

Wang, Z., Yu, J., Hao, D., Liu, X., & Wang, X. Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.965379 · Cited by 6

Establishment of prognostic model of bladder cancer based on apoptosis-related genes, in which P4HB promotes BLCA progression

Zou, Z., Li, Z. A., Sun, W., Gao, W., Liu, B., Liu, J., & Guo, Y. (2023) · BMC Urology · doi:10.1186/s12894-023-01331-5 · Cited by 6

Hyperpolarized pyruvate to measure the influence of PKM2 activation on glucose metabolism in the healthy kidney

Bertelsen, L. B., Hansen, E. S. S., Sadowski, T., Ruf, S. G., & Laustsen, C. (2021) · NMR in Biomedicine · doi:10.1002/nbm.4583 · Cited by 6

A fuzzy logic controller based approach to model the switching mechanism of the mammalian central carbon metabolic pathway in normal and cancer cells

Dasgupta, A., Paul, D., & De, R. K. (2016) · Molecular BioSystems · doi:10.1039/c6mb00131a · Cited by 6

Isoform-specific regulation of PKM by acetylation

Pavlenko, D., Tamargo‐Azpilicueta, J., Nudelman, H., Ankri, Y., Shahar, A., Díaz‐Moreno, I., & Arbely, E. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2527086122 · Cited by 5

The moonlighting functions of glycolytic enzymes in tumorigenesis

Chen, X., Yang, J., & Ma, Y. (2026) · Cellular Oncology · doi:10.1007/s13402-025-01135-9 · Cited by 6

Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP‐Ribosylation

Lin, J., Yin, Y., Cao, J., Zou, B., Han, K., Chen, Y., Li, S., Huang, C., Chen, J., Lv, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202410058 · Cited by 5

Roles of Pyruvate Kinase M2 in Pulmonary Diseases: What Do We Know So Far?

Li, D., Liu, L., Qin, J., Shen, C., & Wang, B. (2025) · Lung · doi:10.1007/s00408-025-00821-7 · Cited by 5

A Similar Metabolic Profile Between the Failing Myocardium and Tumor Could Provide Alternative Therapeutic Targets in Chemotherapy-Induced Cardiotoxicity

Saleme, B., & Sutendra, G. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00061 · Cited by 5

High-Throughput Platform for Real-Time Monitoring of ATP-Generating Enzymes in Living Cells Based on a Lanthanide Probe

Gabr, M. T., Balupuri, A., & Kang, N. S. (2020) · ACS Sensors · doi:10.1021/acssensors.0c00897 · Cited by 5

Impact of the Whole Genome Duplication Event on PYK Activity and Effects of a PYK1 Mutation on Metabolism in S. cerevisiae

Chen, H., Blum, J., Thalacker‐Mercer, A. E., & Gu, Z. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.656461 · Cited by 5

Dysfunctional gene splicing in glucose metabolism may contribute to Alzheimer's disease

Deng, S., Peng, Y., Xu, M., Yi, Q., & Feng, J. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002214 · Cited by 5

Functional and structural characterization of Streptococcus pneumoniae pyruvate kinase involved in fosfomycin resistance

Taguchi, A., Nakashima, R., & Nishino, K. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104892 · Cited by 5

Pyruvate Kinase M2 Activators Inhibit Tumor Growth

(2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2012-148

Abstract 3226: PKM2 metabolic activator slows lung cancer xenograft growth

Parnell, M., Foulks, J. M., Nix, R. N., LUO, B. H., Senina, A. V., Xu, Y., Saunders, M. J., Ho, K.-K., McCullar, M. V., & Kanner, S. B. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-3226

Abstract B143: PKM2 metabolic activator slows lung cancer xenograft growth.

Parnell, K. M., Foulks, J. M., Clifford, A., Bullough, J., LUO, B. H., Vollmer, D., Liu, J., McCarthy, V., Shaffer, M. E., Senina, A. V., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.targ-11-b143

Abstract 1875: A novel series of metabolic activators of PKM2 alter oncogene-meditated changes in tumor cell metabolism.

Bahr, B. L., Stevens, J., Squire, S., Moreno, C., Call, L. T., Stephens, B. J., Mollard, A., Warner, S. L., & Bearss, D. J. (2013) · Cancer Research · doi:10.1158/1538-7445.am2013-1875 · Cited by 2

Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth

Parnell, K. M., Foulks, J. M., Nix, R. N., Clifford, A., Bullough, J., LUO, B. H., Senina, A. V., Vollmer, D., Liu, J., McCarthy, V., et al. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0026 · Cited by 73