Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function
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Haploinsufficiency of the SYNGAP1 gene, which codes for a Ras GTPase-activating protein, impairs cognition both in humans and in mice. Decrease of Syngap1 in mice has been previously shown to cause cognitive deficits at least in part by inducing alterations in glutamatergic neurotransmission and premature maturation of excitatory connections. Whether Syngap1 plays a role in the development of cortical GABAergic connectivity and function remains unclear. Here, we show that Syngap1 haploinsufficiency significantly reduces the formation of perisomatic innervations by parvalbumin-positive basket cells, a major population of GABAergic neurons, in a cell-autonomous manner. We further show that Syngap1 haploinsufficiency in GABAergic cells derived from the medial ganglionic eminence impairs their connectivity, reduces inhibitory synaptic activity and cortical gamma oscillation power, and causes cognitive deficits. Our results indicate that Syngap1 plays a critical role in GABAergic circuit function and further suggest that Syngap1 haploinsufficiency in GABAergic circuits may contribute to cognitive deficits.
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Syngap1 deficiency selectively in GABAergic neurons decreases presynaptic bouton density on the soma and reduces terminal axon branching on cortical interneurons.
“Syngap1 deficiency selectively induced in GABAergic neurons results in decreased density of presynaptic boutons terminating on the soma as well as reduced terminal branching of axons on interneurons of the cortex [33].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [33]
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Cites
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Mechanisms of Gamma Oscillations
Buzsáki, G., & Wang, X.-J. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150444 · Cited by 2,796 · see citing works
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768 · see citing works
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603 · see citing works
Neocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454 · see citing works
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323 · see citing works
Neuronal gamma-band synchronization as a fundamental process in cortical computation
Fries, P. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135603 · Cited by 1,713 · see citing works
How Inhibition Shapes Cortical Activity
Isaacson, J. S., & Scanziani, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.027 · Cited by 1,678 · see citing works
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462 · see citing works
Cortical interneurons that specialize in disinhibitory control
Pi, H.-J., Hangya, B., Kvitsiani, D., Sanders, J. I., Huang, Z. J., & Kepecs, A. (2013) · Nature · doi:10.1038/nature12676 · Cited by 1,136 · see citing works
Interneuron cell types are fit to function
Kepecs, A., & Fishell, G. (2014) · Nature · doi:10.1038/nature12983 · Cited by 1,110 · see citing works
Enforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition
Pouille, F., & Scanziani, M. (2001) · Science · doi:10.1126/science.1060342 · Cited by 1,097 · see citing works
T-maze alternation in the rodent
Deacon, R. M. J., & Rawlins, J. N. P. (2006) · Nature Protocols · doi:10.1038/nprot.2006.2 · Cited by 901 · see citing works
Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1
Carvill, G. L., Heavin, S. B., Yendle, S. C., McMahon, J. M., O'Roak, B. J., Cook, J., Khan, A., Dorschner, M. O., Weaver, M., Calvert, S., et al. (2013) · Nature Genetics · doi:10.1038/ng.2646 · Cited by 687 · see citing works
Dani, V. S., Chang, Q., Maffei, A., Turrigiano, G. G., Jaenisch, R., & Nelson, S. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506071102 · Cited by 639 · see citing works
Origins of Cortical Interneuron Subtypes
Xu, Q., Cobos, I., De La Cruz, E., Rubenstein, J. L., & Anderson, S. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5667-03.2004 · Cited by 639 · see citing works
SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family
Kim, J. H., Liao, D., Lau, L.-F., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)81008-9 · Cited by 634 · see citing works
Origin and Molecular Specification of Striatal Interneurons
Marín, Ó., Anderson, S. A., & Rubenstein, J. L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06063.2000 · Cited by 627 · see citing works
Chattopadhyaya, B., Di Cristo, G., Higashiyama, H., Knott, G. W., Kuhlman, S. J., Welker, E., & Huang, Z. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1851-04.2004 · Cited by 596 · see citing works
Self-citationA Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II
Chen, H.-J., Rojas-Soto, M., Oguni, A., & Kennedy, M. B. (1998) · Neuron · doi:10.1016/s0896-6273(00)80471-7 · Cited by 590 · see citing works
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
Costa, R. M., Federov, N. B., Kogan, J. H., Murphy, G. G., Stern, J. N. H., Ohno, M., Kucherlapati, R., Jacks, T., & Silva, A. J. (2002) · Nature · doi:10.1038/nature711 · Cited by 586 · see citing works
Buzsáki, G., & Watson, B. O. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.4/gbuzsaki · Cited by 579 · see citing works
Fate mapping Nkx2.1‐lineage cells in the mouse telencephalon
Xu, Q., Tam, M., & Anderson, S. A. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21529 · Cited by 560 · see citing works
Autism-related deficits via dysregulated eIF4E-dependent translational control
Gkogkas, C. G., Khoutorsky, A., Ran, I., Rampakakis, E., Nevarko, T., Weatherill, D. B., Vasuta, C., Yee, S., Truitt, M., Dallaire, P., et al. (2013) · Nature · doi:10.1038/nature11628 · Cited by 522 · see citing works
Self-citationAlterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia
Gonzalez-Burgos, G., Cho, R. Y., & Lewis, D. A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.010 · Cited by 497 · see citing works
Kim, M. J., Dunah, A. W., Wang, Y. T., & Sheng, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.031 · Cited by 494 · see citing works
Specific GABA <sub>A</sub> Circuits for Visual Cortical Plasticity
Fagiolini, M., Fritschy, J.-M., Löw, K., Möhler, H., Rudolph, U., & Hensch, T. K. (2004) · Science · doi:10.1126/science.1091032 · Cited by 471 · see citing works
Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning
Cui, Y., Costa, R. M., Murphy, G. G., Elgersma, Y., Zhu, Y., Gutmann, D. H., Parada, L. F., Módy, I., & Silva, A. J. (2008) · Cell · doi:10.1016/j.cell.2008.09.060 · Cited by 434 · see citing works
De Novo Mutations in Moderate or Severe Intellectual Disability
Hamdan, F. F., Srour, M., Capo-Chichi, J.-M., Daoud, H., Nassif, C., Patry, L., Massicotte, C., Ambalavanan, A., Spiegelman, D., Diallo, O., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004772 · Cited by 419 · see citing works
Self-citationFogarty, M., Grist, M., Gelman, D., Marín, O., Pachnis, V., & Kessaris, N. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1629-07.2007 · Cited by 412 · see citing works
Clement, J. P., Aceti, M., Creson, T. K., Ozkan, E. D., Shi, Y., Reish, N. J., Almonte, A. G., Miller, B. H., Wiltgen, B. J., Miller, C. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.045 · Cited by 385 · see citing works
Komiyama, N. H., Watabe, A. M., Carlisle, H. J., Porter, K., Charlesworth, P., Monti, J., Strathdee, D. J. C., O'Carroll, C. M., Martin, S. J., Morris, R. G. M., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09721.2002 · Cited by 382 · see citing works
Hamdan, F. F., Gauthier, J., Araki, Y., Lin, D.-T., Yoshizawa, Y., Higashi, K., Park, A.-R., Spiegelman, D., Dobrzeniecka, S., Piton, A., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.02.001 · Cited by 349 · see citing works
Mutations in <i>SYNGAP1</i> in Autosomal Nonsyndromic Mental Retardation
Hamdan, F. F., Gauthier, J., Spiegelman, D., Noreau, A., Yang, Y., Pellerin, S., Dobrzeniecka, S., Côté, M., Perreau-Linck, E., Carmant, L., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805392 · Cited by 336 · see citing works
Self-citationCharacterization of Nkx6-2-Derived Neocortical Interneuron Lineages
Sousa, V. H., Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., & Fishell, G. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp038 · Cited by 328 · see citing works
Bateup, H. S., Johnson, C. A., Denefrio, C. L., Saulnier, J. L., Kornacker, K., & Sabatini, B. L. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.017 · Cited by 327 · see citing works
Chattopadhyaya, B., Cristo, G. D., Wu, C. Z., Knott, G. W., Kuhlman, S. J., Fu, Y., Palmiter, R. D., & Huang, Z. J. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.015 · Cited by 326 · see citing works
Self-citationTamás, G., Buhl, E. H., & Somogyi, P. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp022054 · Cited by 278 · see citing works
Deidda, G., Parrini, M., Naskar, S., Bozarth, I. F., Contestabile, A., & Cancedda, L. (2015) · Nature Medicine · doi:10.1038/nm.3827 · Cited by 268 · see citing works
Berryer, M. H., Hamdan, F. F., Klitten, L. L., Møller, R. S., Carmant, L., Schwartzentruber, J., Patry, L., Dobrzeniecka, S., Rochefort, D., Neugnot-Cerioli, M., et al. (2013) · Human Mutation · doi:10.1002/humu.22248 · Cited by 266 · see citing works
Self-citationRedin, C. E., Gérard, B., Lauer, J., Herenger, Y., Muller, J., Quartier, A., Masurel, A., Willems, M., Lesca, G., Chehadeh, S. E., et al. (2014) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2014-102554 · Cited by 263 · see citing works
SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons
Rumbaugh, G., Adams, J. P., Kim, J. H., & Huganir, R. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600084103 · Cited by 260 · see citing works
The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity
Kim, J. H., Lee, H.-K., Takamiya, K., & Huganir, R. L. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01119.2003 · Cited by 240 · see citing works
SynGAP regulates spine formation
Vazquez, L. E., Chen, H.-J., Sokolova, I., Knuesel, I., & Kennedy, M. B. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3213-04.2004 · Cited by 203 · see citing works
Di Cristo, G., Chattopadhyaya, B., Kuhlman, S. J., Fu, Y., Bélanger, M.-C., Wu, C. Z., Rutishauser, U., Maffei, L., & Huang, Z. J. (2007) · Nature Neuroscience · doi:10.1038/nn2008 · Cited by 201 · see citing works
Self-citationCitron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus
Zhang, W., Vazquez, L., Apperson, M., & Kennedy, M. B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-01-00096.1999 · Cited by 190 · see citing works
De Novo SYNGAP1 Mutations in Nonsyndromic Intellectual Disability and Autism
Hamdan, F. F., Daoud, H., Piton, A., Gauthier, J., Dobrzeniecka, S., Krebs, M.-O., Joober, R., Lacaille, J.-C., Nadeau, A., Milunsky, J. M., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.11.015 · Cited by 187 · see citing works
Self-citationNMDA Receptor Regulation Prevents Regression of Visual Cortical Function in the Absence of Mecp2
Durand, S., Patrizi, A., Quast, K. B., Hachigian, L., Pavlyuk, R., Saxena, A., Carninci, P., Hensch, T. K., & Fagiolini, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.12.004 · Cited by 172 · see citing works
Kuhlman, S. J., & Huang, Z. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002005 · Cited by 171 · see citing works
Neurofibromin regulates corticostriatal inhibitory networks during working memory performance
Shilyansky, C., Karlsgodt, K. H., Cummings, D. M., Sidiropoulou, K., Hardt, M. E., James, A. S., Ehninger, D., Bearden, C. E., Poirazi, P., Jentsch, J. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004829107 · Cited by 169 · see citing works
Cristo, G. D., Wu, C., Chattopadhyaya, B., Ango, F., Knott, G. W., Welker, E., Svoboda, K., & Huang, Z. J. (2004) · Nature Neuroscience · doi:10.1038/nn1334 · Cited by 161 · see citing works
Self-citationSocial learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase
Molosh, A. I., Johnson, P. L., Spence, J. P., Arendt, D. H., Federici, L. M., Bernabe, C., Janasik, S. P., Segu, Z. M., Khanna, R., Goswami, C. P., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3822 · Cited by 137 · see citing works
Ozkan, E. D., Creson, T. K., Kramár, E. A., Rojas, C., Seese, R. R., Babyan, A. H., Shi, Y., Lucero, R., Xu, X., Noebels, J. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.015 · Cited by 137 · see citing works
Guo, X., Hamilton, P. J., Reish, N. J., Sweatt, J. D., Miller, C. A., & Rumbaugh, G. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.223 · Cited by 120 · see citing works
Wu, X., Fu, Y., Knott, G. W., Lu, J., Cristo, G. D., & Huang, Z. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3189-11.2012 · Cited by 111 · see citing works
Developmental origin dictates interneuron AMPA and NMDA receptor subunit composition and plasticity
Matta, J. A., Pelkey, K. A., Craig, M. T., Chittajallu, R., Jeffries, B. W., & McBain, C. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3459 · Cited by 108 · see citing works
Clement, J. P., Ozkan, E. D., Aceti, M., Miller, C. A., & Rumbaugh, G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0765-13.2013 · Cited by 99 · see citing works
Neurofibromin is enriched in the endoplasmic reticulum of CNS neurons
Nordlund, M. L., Gu, X., Shipley, M., & Ratner, N. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-04-01588.1993 · Cited by 82 · see citing works
Muhia, M., Yee, B. K., Feldon, J., Markopoulos, F., & Knuesel, I. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07079.x · Cited by 71 · see citing works
Peiker, I., David, N., Schneider, T. R., Nolte, G., Schöttle, D., & Engel, A. K. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1442-15.2015 · Cited by 68 · see citing works
Hanson, J. E., Weber, M., Meilandt, W. J., Wu, T. Z., Luu, T., Deng, L., Shamloo, M., Sheng, M., Scearce-Levie, K. A., & Zhou, Q. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.19 · Cited by 55 · see citing works
A role for synGAP in regulating neuronal apoptosis
Knuesel, I., Elliott, A., Chen, H., Mansuy, I. M., & Kennedy, M. B. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03908.x · Cited by 54 · see citing works
Hagenbuch, N., Feldon, J., & Yee, B. K. (2005) · Behavioural Pharmacology · doi:10.1097/01.fbp.0000189811.77049.3e · Cited by 52 · see citing works
Porter, K., Komiyama, N. H., Vitalis, T., Kind, P. C., & Grant, S. G. N. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03874.x · Cited by 51 · see citing works
Chattopadhyaya, B., Baho, E., Huang, Z. J., Schachner, M., & Cristo, G. D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1306-12.2013 · Cited by 42 · see citing works
Self-citationBaho, E., & Cristo, G. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4352-11.2012 · Cited by 32 · see citing works
Trifonov, S., Yamashita, Y., Kase, M., et al. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-114 · Cited by 30 · see citing works
Differential distribution of synGAPα1 and synGAPβ isoforms in rat neurons
Moon, I. S., Sakagami, H., Nakayama, J., & Suzuki, T. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.033 · Cited by 16 · see citing works
Appetitively motivated instrumental learning in SynGAP heterozygous knockout mice.
Muhia, M., Feldon, J., Knuesel, I., & Yee, B. K. (2009) · Behavioral Neuroscience · doi:10.1037/a0017118 · Cited by 16 · see citing works
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- Authors
- Berryer, M. H., Chattopadhyaya, B., Xing, P., Riebe, I., Bosoi, C., Sanon, N., Antoine-Bertrand, J., Lévesque, M., Avoli, M., Hamdan, F. F., Carmant, L., Lamarche-Vane, N., Lacaille, J.-C., Michaud, J. L., & Di Cristo, G.
- Affiliations
- CHU Sainte-Justine Research Center (CA)
- Université de Montréal (CA)
- Montreal Neurological Institute and Hospital (CA)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- Corresponding author
- Michaud, Jacques L.
- ORCID
- Venue
- Nature Communications
- Published
- 2016-11-09
- Volume
- 7
- Issue
- 1
- Pages
- 13340-13340
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5105197
- OpenAlex
- W2553225945
- Cited by
- 93
- References
- 70
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 15 · 2023: 7 · 2022: 11 · 2021: 9 · 2020: 13 · 2019: 12 · 2018: 8 · 2017: 4
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- McGill University
- Savoy Foundation
- University of Edinburgh
- Universität Zürich
- Canadian Institutes of Health Research (130430, 10848, MOP-10848)
- Natural Sciences and Engineering Research Council of Canada
- Fonds de Recherche du Québec - Santé
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- SYNGAP1, haploinsufficiency, GABAergic neurons, basket cells, parvalbumin, inhibitory synapses, synaptic inhibition, medial ganglionic eminence, cognitive impairment, Ras GTPase-activating protein
- MeSH terms
- Animals, Cells, Cultured, Cognition, Cognition Disorders, Disease Models, Animal, Female, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Synaptic Transmission, Synapses, ras GTPase-Activating Proteins, Mice, Gene Knockdown Techniques, Haploinsufficiency, GABAergic Neurons, Primary Cell Culture
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