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TIRAP: an adapter molecule in the Toll signaling pathway
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Citations
Cites
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 1×
“TLRs are germline-encoded nonclonal receptors that recognize conserved microbial products such as lipopolysaccharide (LPS), peptidoglycan, flagellin and unmethylated CpG motifs in bacterial DN”
Background
Cited by
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Self-citationAkira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
Self-citationMissing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
LPS/TLR4 signal transduction pathway
Lu, Y.-C., Yeh, W.-C., & Ohashi, P. S. (2008) · Cytokine · doi:10.1016/j.cyto.2008.01.006 · Cited by 3,301
Toll-like receptors in innate immunity
Takeda, K. (2004) · International Immunology · doi:10.1093/intimm/dxh186 · Cited by 3,328
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
O'Neill, L. A. J., & Bowie, A. G. (2007) · Nature Reviews Immunology · doi:10.1038/nri2079 · Cited by 2,667
Toll-like Receptors and the Control of Immunity
Fitzgerald, K. A., & Kagan, J. C. (2020) · Cell · doi:10.1016/j.cell.2020.02.041 · Cited by 2,168
The history of toll-like receptors - redefining innate immunity
O'Neill, L. A. J., Golenbock, D., & Bowie, A. G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3446 · Cited by 1,765
Innate Immune Pattern Recognition: A Cell Biological Perspective
Brubaker, S. W., Bonham, K. S., Zanoni, I., & Kagan, J. C. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112240 · Cited by 1,475
Viruses and interferon: a fight for supremacy
Katze, M. G., He, Y., & Gale, M. (2002) · Nature Reviews Immunology · doi:10.1038/nri888 · Cited by 1,419
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4
Pålsson‐McDermott, E. M., & O'Neill, L. A. J. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01976.x · Cited by 1,254
mRNA is an endogenous ligand for toll-like receptor 3
Karikó, K., Ni, H., Capodici, J., Lamphier, M., & Weissman, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310175200 · Cited by 1,062
Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
García, M. A., Gil, J., Ventoso, I., Guerra, S., Domingo, E., Rivas, C., & Esteban, M. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00027-06 · Cited by 818
MyD88: a central player in innate immune signaling
Deguine, J., & Barton, G. M. (2014) · F1000Prime Reports · doi:10.12703/p6-97 · Cited by 692
Self-citationJensen, S., & Thomsen, A. R. (2012) · Journal of Virology · doi:10.1128/jvi.05738-11 · Cited by 604
Matsunaga, N., Tsuchimori, N., Matsumoto, T., & Ii, M. (2011) · Molecular Pharmacology · doi:10.1124/mol.110.068064 · Cited by 597
Lee, J. Y., Ye, J., Gao, Z., Youn, H. S., Lee, W. H., Zhao, L., Sizemore, N., & Hwang, D. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305213200 · Cited by 524
Groeger, S., & Meyle, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00208 · Cited by 473
Microbial recognition by Toll-like receptors
Takeda, K., & Akira, S. (2004) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2003.10.002 · Cited by 285
The STIR-domain superfamily in signal transduction, development and immunity
Novatchkova, M., Leibbrandt, A., Werzowa, J., Neubüser, A., & Eisenhaber, F. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00067-7 · Cited by 255
Intestinal myofibroblasts in innate immune responses of the intestine
Otte, J.-M., Rosenberg, I. M., & Podolsky, D. K. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00403-7 · Cited by 242
MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival
Kim, Y., Zhou, P., Qian, L., Chuang, J.-Z., Lee, J., Li, C., Iadecola, C., Nathan, C., & Ding, A. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070868 · Cited by 234
Toll-like receptors and their therapeutic potential in Parkinson’s disease and α-synucleinopathies
Kouli, A., Horne, C. B., & Williams-Gray, C. H. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.042 · Cited by 143
Henneke, P., Takeuchi, O., Malley, R., Lien, E., Ingalls, R. R., Freeman, M. W., Mayadas, T., Nizet, V., Akira, S., Kasper, D. L., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3970 · Cited by 145
TLRs: Professor Mechnikov, sit on your hat
O'Neill, L. A. J. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.10.005 · Cited by 140
Hirotani, T., Yamamoto, M., Kumagai, Y., Uematsu, S., Kawase, I., Takeuchi, O., & Akira, S. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.12.184 · Cited by 135
Toll-like receptors in skin infections and inflammatory diseases
Lai, Y., & Gallo, R. (2008) · Infectious Disorders - Drug Targets · doi:10.2174/1871526510808030144 · Cited by 119
Abdul-Cader, M. S., Amarasinghe, A., & Abdul-Careem, M. F. (2016) · Archives of Virology · doi:10.1007/s00705-016-2904-x · Cited by 99
Responses of innate immune cells to group A Streptococcus.
Fieber, C., & Kovarik, P. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00140 · Cited by 56
Shi, M., Zhu, Y., Yan, J., Rouby, J., Summah, H., Monsel, A., & Qu, J. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.287 · Cited by 30
Metadata
- Authors
- Horng, T., Barton, G. M., & Medzhitov, R.
- Venue
- Nature Immunology
- Published
- 2001-09
- Volume
- 2
- Issue
- 9
- Pages
- 835-841
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W1519843522
- Cited by
- 969
- References
- 1
- FWCI
- 32.02
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
