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Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism
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Cites
Rooijen, N. V., & Sanders, A. (1994) · Journal of Immunological Methods · doi:10.1016/0022-1759(94)90012-4 · Cited by 1,779
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A., Dikalov, S., Goronzy, J., Weyand, C., & Harrison, D. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070657 · Cited by 1,736
Molecular Mechanisms of Human Hypertension
Lifton, R. P., Gharavi, A. G., & Geller, D. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00241-0 · Cited by 1,686
Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice
Jeltsch, M., Kaipainen, A., Joukov, V., Meng, X., Lakso, M., Rauvala, H., Swartz, M., Fukumura, D., Jain, R. K., & Alitalo, K. (1997) · Science · doi:10.1126/science.276.5317.1423 · Cited by 1,283
Self-citationSchoppmann, S. F., Birner, P., Stöckl, J., Kalt, R., Ullrich, R., Caucig, C., Kriehuber, E., Nagy, K., Alitalo, K., & Kerjaschki, D. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64255-1 · Cited by 794
Self-citationProteolytic processing regulates receptor specificity and activity of VEGF-C
Joukov, V., Sorsa, T., Kumar, V., Jeltsch, M., Claesson-Welsh, L., Cao, Y., Saksela, O., Kalkkinen, N., & Alitalo, K. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3898 · Cited by 773
Self-citationSodium and Potassium in the Pathogenesis of Hypertension
Adrogué, H. J., & Madias, N. E. (2007) · New England Journal of Medicine · doi:10.1056/nejmra064486 · Cited by 763
Kärpänen, T., Egeblad, M., Karkkainen, M. J., Kubo, H., Ylä‐Herttuala, S., Jäättelä, M., & Alitalo, K. K. (2001) · PubMed · Cited by 651
Self-citationPhysiology of the Kidney and Body Fluids
PITTS, R. F., & JACOBY, J. (1963) · Anesthesiology · doi:10.1097/00000542-196309000-00036 · Cited by 613
Miyakawa, H., Woo, S. K., Dahl, S. C., Handler, J. S., & Kwon, H. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2538 · Cited by 580
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Kleinewietfeld, M., Manzel, A., Titze, J., Kvakan, H., Yosef, N., Linker, R. A., Muller, D. N., & Hafler, D. A. (2013) · Nature · doi:10.1038/nature11868 · Cited by 1,394
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Alitalo, K. (2011) · Nature Medicine · doi:10.1038/nm.2545 · Cited by 962
Self-citationWiig, H., & Swartz, M. A. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2011 · Cited by 722
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Elijovich, F., Weinberger, M. H., Anderson, C. A. M., Appel, L. J., Bursztyn, M., Cook, N. R., Dart, R. A., Newton-Cheh, C. H., Sacks, F. M., & Laffer, C. L. (2016) · Hypertension · doi:10.1161/hyp.0000000000000047 · Cited by 482
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Raffort, J., Lareyre, F., Clément, M., Hassen-Khodja, R., Chinetti, G., & Mallat, Z. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.52 · Cited by 432
Ma, Y., Mouton, A. J., & Lindsey, M. L. (2018) · Translational Research · doi:10.1016/j.trsl.2017.10.001 · Cited by 405
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Kleinewietfeld, M., & Hafler, D. A. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.009 · Cited by 389
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Lee, C., Kim, M.-J., Kumar, A., Lee, H.-W., Yang, Y., & Kim, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02249-0 · Cited by 365
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Mu, S., Shimosawa, T., Ogura, S., Wang, H., Uetake, Y., Kawakami-Mori, F., Marumo, T., Yatomi, Y., Geller, D. S., Tanaka, H., et al. (2011) · Nature Medicine · doi:10.1038/nm.2337 · Cited by 236
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Hall, J. E., Granger, J. P., do Carmo, J. M., da Silva, A. A., Dubinion, J., George, E., Hamza, S., Speed, J., & Hall, M. E. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110058 · Cited by 232
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Jalkanen, S., & Salmi, M. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0281-x · Cited by 226
Reed, R. K., & Rubin, K. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq143 · Cited by 209
Body Fluid Dynamics: Back to the Future
Bhave, G., & Neilson, E. G. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011080865 · Cited by 215
Salt and hypertension: is salt dietary reduction worth the effort?
Frisoli, T. M., Schmieder, R. E., Grodzicki, T., & Messerli, F. H. (2012) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.10.023 · Cited by 200
Skin Sodium Concentration Correlates with Left Ventricular Hypertrophy in CKD
Schneider, M. P., Raff, U., Kopp, C., Scheppach, J. B., Toncar, S., Wanner, C., Schlieper, G., Saritas, T., Floege, J., Schmid, M., et al. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016060662 · Cited by 195
Self-citationSodium in the microenvironment regulates immune responses and tissue homeostasis
Müller, D. N., Wilck, N., Haase, S., Kleinewietfeld, M., & Linker, R. A. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0113-4 · Cited by 149
Self-citationSodium balance is not just a renal affair
Titze, J. (2014) · Current Opinion in Nephrology and Hypertension · doi:10.1097/01.mnh.0000441151.55320.c3 · Cited by 130
Self-citationTimeline of History of Hypertension Treatment
Saklayen, M. G., & Deshpande, N. V. (2016) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2016.00003 · Cited by 96
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Rossitto, G., Mary, S., Chen, J. Y., Boder, P., Chew, K. S., Neves, K. B., Alves, R. L., Montezano, A. C., Welsh, P., Petrie, M. C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17820-2 · Cited by 94
Hammon, M., Grossmann, S., Linz, P., Kopp, C., Dahlmann, A., Garlichs, C., Janka, R., Cavallaro, A., Luft, F. C., Uder, M., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0141336 · Cited by 93
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Scallan, J. P., Davis, M. J., & Huxley, V. H. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.260042 · Cited by 49
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Deng, Z., Zhou, L., Wang, Y., Liao, S., Huang, Y., Shan, Y., Tan, S., Zeng, Q., Peng, L., Huang, H., et al. (2020) · Aging · doi:10.18632/aging.103348 · Cited by 34
Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation
Radvanyi, Z., Yoo, E. J., Kandasamy, P., Salas-Bastos, A., Monnerat, S., Refardt, J., Christ-Crain, M., Hayashi, H., Kondo, Y., Jantsch, J., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105480 · Cited by 9
Self-citationThe Genetics of Blood Pressure Regulation
Lin, H. J., Guo, X., & Rotter, J. I. (2020) · Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics · doi:10.1016/b978-0-12-812532-8.00006-9 · Cited by 3
Metadata
- Authors
- Machnik, A., Neuhofer, W., Jantsch, J., Dahlmann, A., Tammela, T., Machura, K., Park, J.-K., Beck, F.-X., Müller, D. N., Derer, W., Goss, J., Ziomber, A., Dietsch, P., Wagner, H., van Rooijen, N., Kurtz, A., Hilgers, K. F., Alitalo, K., Eckardt, K.-U., Luft, F. C., Kerjaschki, D., & Titze, J.
- Venue
- Nature Medicine
- Published
- 2009-05
- Volume
- 15
- Issue
- 5
- Pages
- 545-552
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2017821597
- Cited by
- 963
- References
- 38
- FWCI
- 19.54
- Type
- journal article
- Language
- en
- Open access
- closed
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