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The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

Open access
Liu, Xiaojuan, Pu, Yang, Cron, Kyle, Deng, Liufu, Kline, Justin, Frazier, William A, Xu, Hairong, Peng, Hua, Fu, Yang-Xin, Xu, Meng Michelle·2015·Nature Medicine
DOI 10.1038/nm.3931
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Abstract

Macrophage phagocytosis of tumor cells mediated by CD47-specific blocking antibodies has been proposed to be the major effector mechanism in xenograft models. Here, using syngeneic immunocompetent mouse tumor models, we reveal that the therapeutic effects of CD47 blockade depend on dendritic cell but not macrophage cross-priming of T cell responses. The therapeutic effects of anti-CD47 antibody therapy were abrogated in T cell–deficient mice. In addition, the antitumor effects of CD47 blockade required expression of the cytosolic DNA sensor STING, but neither MyD88 nor TRIF, in CD11c+ cells, suggesting that cytosolic sensing of DNA from tumor cells is enhanced by anti-CD47 treatment, further bridging the innate and adaptive responses. Notably, the timing of administration of standard chemotherapy markedly impacted the induction of antitumor T cell responses by CD47 blockade. Together, our findings indicate that CD47 blockade drives T cell–mediated elimination of immunogenic tumors.

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Metadata

Authors
Liu, X., Pu, Y., Cron, K., Deng, L., Kline, J., Frazier, W. A., Xu, H., Peng, H., Fu, Y.-X., & Xu, M. M.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2015-08-31
Volume
21
Issue
10
Pages
1209-1215
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.3931
OpenAlex
W2133346943
Cited by
767
References
13
FWCI
21.02
Type
journal article
Language
en
Open access
green

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