Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

Grathwohl, Stefan A, Kälin, Roland E, Bolmont, Tristan, Prokop, Stefan, Winkelmann, Georg, Kaeser, Stephan A, Odenthal, Jörg, Radde, Rebecca +8 more·2009·Nature Neuroscience
DOI 10.1038/nn.2432

Cited by (402)

Items 101–200 of 402

  1. Homeostasis of Microglia in the Adult Brain: Review of Novel Microglia Depletion Systems
    Waisman, Ari, Ginhoux, Florent, Greter, Melanie, Bruttger, Julia · 2015 · Trends in Immunology
  2. Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia
    Fu, Hongjun, Liu, Bin, Frost, Jeffrey L., Hong, Soyon, Jin, Ming, Ostaszewski, Beth, Shankar, Ganesh M., Costantino, Isabel M., Carroll, Michael C., Mayadas, Tanya N. et al. · 2012 · Glia
  3. Transgenic mouse models of alzheimer disease: Developing a better model as a tool for therapeutic interventions.
    Kitazawa, Masashi, Medeiros, Rodrigo, M. LaFerla, Frank · 2012 · Current Pharmaceutical Design
  4. Alzheimer's disease, autoimmunity and inflammation. The good, the bad and the ugly
    F. Sardi, Lorenzo Fassina, Letizia Venturini, M. Inguscio, Fabio Guerriero, Elio Rolfo, Giovanni Ricevuti · 2011 · Autoimmunity Reviews
  5. Graphene quantum dots conjugated neuroprotective peptide improve learning and memory capability
    Xiao, Songhua, Zhou, Daoyou, Luan, Ping, Gu, Beibei, Feng, Longbao, Fan, Shengnuo, Liao, Wang, Fang, Wenli, Yang, Lianhong, Tao, Enxiang et al. · 2016 · Biomaterials
  6. Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina
    Levi J. Todd, Isabella Palazzo, Lilianna Suarez, Xiaoyu Liu, Leo I. Volkov, Thanh V. Hoang, Warren A. Campbell, Seth Blackshaw, Ning Quan, Andy J. Fischer · 2019 · Journal of Neuroinflammation
  7. Hypothalamic innate immune reaction in obesity
    Kälin, Stefanie, Heppner, Frank L., Bechmann, Ingo, Prinz, Marco, Tschöp, Matthias H., Yi, Chun-Xia · 2015 · Nature Reviews Endocrinology
  8. Sphingolipids: Critical players in Alzheimer’s disease
    Gerhild van Echten‐Deckert, Jochen Walter · 2012 · Progress in Lipid Research
  9. Inhibition of Microglial Activation Protects Hippocampal Neurogenesis and Improves Cognitive Deficits in a Transgenic Mouse Model for Alzheimer’s Disease
    Biscaro, Barbara, Lindvall, Olle, Tesco, Giuseppina, Ekdahl, Christine T., Nitsch, Roger M. · 2012 · Neurodegenerative Diseases
  10. Clearance of Amyloid-β Peptides By Microglia and Macrophages: the Issue of What, When and Where
    Aaron Y. Lai, JoAnne McLaurin · 2012 · Future Neurology
  11. Distinct inflammatory phenotypes of microglia and monocyte‐derived macrophages in Alzheimer's disease models: effects of aging and amyloid pathology
    Martin, Elodie, Boucher, Céline, Fontaine, Bertrand, Delarasse, Cécile · 2017 · Aging Cell
  12. TREM2 Function in Alzheimer’s Disease and Neurodegeneration
    Ulrich, Jason D., Holtzman, David M. · 2016 · ACS Chemical Neuroscience
  13. In Vitro Microfluidic Models for Neurodegenerative Disorders
    Tatsuya Osaki, Yoojin Shin, Vivek Sivathanu, M. Campisi, R. Kamm · 2018 · Advanced Healthcare Materials
  14. Microglia inflict delayed brain injury after subarachnoid hemorrhage
    Ulf Christoph Schneider, Anja‐Maria Davids, Susan Brandenburg, Annett Müller, Anna Elke, Salima Magrini, Etienne Ndzie Atangana, Kati Turkowski, Tobias Finger, Angelika Gutenberg et al. · 2015 · Acta Neuropathologica
  15. Ketones block amyloid entry and improve cognition in an Alzheimer's model
    Yin, Jun Xiang, Maalouf, Marwan, Han, Pengcheng, Zhao, Minglei, Gao, Ming, Dharshaun, Turner, Ryan, Christopher, Whitelegge, Julian, Wu, Jie, Eisenberg, David et al. · 2016 · Neurobiology of Aging
  16. Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease
    Zhao, Ruohe, Hu, Wanling, Tsai, Julia, Li, Wei, Gan, Wen-Biao · 2017 · Molecular Neurodegeneration
  17. Intranasal Delivery of Bone Marrow-Derived Mesenchymal Stem Cells, Macrophages, and Microglia to the Brain in Mouse Models of Alzheimer's and Parkinson's Disease
    Lusine Danielyan, Sandra Beer‐Hammer, Alexandra Stolzing, Richard Schäfer, Georg Siegel, Claire Fabian, Philipp J. Kahle, Tilo Biedermann, Ali Lourhmati, Marine Buadze et al. · 2014 · Cell Transplantation
  18. Microglia and Monocyte-Derived Macrophages in Stroke
    Eunhee Kim, Sunghee Cho · 2016 · Neurotherapeutics
  19. Amyloid-β-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE
    Jones, Raasay S., Minogue, Aedín M., Connor, Thomas J., Lynch, Marina A. · 2013 · Journal of Neuroimmune Pharmacology
  20. The development and use of facial grimace scales for pain measurement in animals
    Jeffrey S. Mogil, Daniel Pang, Gabrielle Guanaes Silva Dutra, Christine T. Chambers · 2020 · Neuroscience & Biobehavioral Reviews
  21. What is microglia neurotoxicity (Not)?
    Knut P. H. Biber, Trevor Owens, Erik Boddeke · 2014 · Glia
  22. A neuroprotective role for microglia in prion diseases
    Zhu, Caihong, Herrmann, Uli S., Falsig, Jeppe, Abakumova, Irina, Nuvolone, Mario, Schwarz, Petra, Frauenknecht, Katrin, Rushing, Elisabeth J., Aguzzi, Adriano · 2016 · Journal of Experimental Medicine
  23. Potassium Channel Kv1.3 Is Highly Expressed by Microglia in Human Alzheimer's Disease
    Rangaraju, Srikant, Gearing, Marla, Jin, Lee-Way, Levey, Allan · 2015 · Journal of Alzheimer's Disease
  24. Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature
    Richard Lathe, Alexandra A. Tsitrina, Yuri V. Kotelevtsev · 2014 · BMC Geriatrics
  25. Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration
    Christina Ising, Michael Thomas Heneka · 2018 · Cell Death and Disease
  26. Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer’s Disease
    Benoît Melchior, Angie Garcia, Bor‐Kai Hsiung, Katherine M Lo, Jonathan M. Doose, J. Cameron Thrash, Anna Katharina Stalder, Matthias Staufenbiel, Harald Neumann, Monica J. Carson · 2010 · ASN NEURO
  27. Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy
    Kevin A. Clayton, Alicia A. Van Enoo, Tsuneya Ikezu · 2017 · Frontiers in Neuroscience
  28. The endocytic pathway in microglia during health, aging and Alzheimer’s disease
    Solé-Domènech, Santiago, Cruz, Dana L., Capetillo-Zarate, Estibaliz, Maxfield, Frederick R. · 2016 · Ageing Research Reviews
  29. Microglia-Mediated Neuroprotection, TREM2, and Alzheimer’s Disease: Evidence From Optical Imaging
    Condello, Carlo, Yuan, Peng, Grutzendler, Jaime · 2018 · Biological Psychiatry
  30. The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects
    Sleegers, Kristel, Lambert, Jean-Charles, Bertram, Lars, Cruts, Marc, Amouyel, Philippe, Van Broeckhoven, Christine · 2010 · Trends in Genetics
  31. Microglia in Alzheimer’s Disease: A Target for Therapeutic Intervention
    Guimei Zhang, Zicheng Wang, Huiling Hu, Meng Zhao, Li Sun · 2021 · Frontiers in Cellular Neuroscience
  32. Glia and Mast Cells as Targets for Palmitoylethanolamide, an Anti-inflammatory and Neuroprotective Lipid Mediator
    Stephen D. Skaper, Laura Facci, Pietro Giusti · 2013 · Molecular Neurobiology
  33. The brain’s best friend: microglial neurotoxicity revisited
    Hellwig, Sabine, Heinrich, Annette, Biber, Knut · 2013 · Frontiers in Cellular Neuroscience
  34. Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?
    Sami Piirainen, Andrew M. Youssef, Cai Song, Allan V. Kalueff, Gary E. Landreth, Tarja Malm, Li Tian · 2017 · Neuroscience & Biobehavioral Reviews
  35. Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity
    Czirr, Eva, Castello, Nicholas A., Mosher, Kira I., Castellano, Joseph M., Hinkson, Izumi V., Lucin, Kurt M., Baeza-Raja, Bernat, Ryu, Jae Kyu, Li, Lulin, Farina, Sasha N. et al. · 2017 · Journal of Experimental Medicine
  36. Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review
    Edler, Melissa K., Mhatre-Winters, Isha, Richardson, Jason R. · 2021 · Cells
  37. Treatment Strategies Targeting Amyloid -Protein
    Dale Schenk, G.S. Basi, Menelas N. Pangalos · 2012 · Cold Spring Harbor Perspectives in Medicine
  38. Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer’s disease: preclinical proof of concept
    Maezawa, Izumi, Nguyen, Hai M, Di Lucente, Jacopo, Jenkins, David Paul, Singh, Vikrant, Hilt, Silvia, Kim, Kyoungmi, Rangaraju, Srikant, Levey, Allan I, Wulff, Heike et al. · 2018 · Brain
  39. Differential contribution of microglia and monocytes in neurodegenerative diseases
    Caroline Baufeld, Elaine K. O'Loughlin, Narghes Calcagno, Charlotte Madore, Oleg Butovsky · 2017 · Journal of Neural Transmission
  40. A deficiency in CCR2+ monocytes: the hidden side of Alzheimer’s disease
    Naert, Gaëlle, Rivest, Serge · 2013 · Journal of Molecular Cell Biology
  41. Inflammatory mechanisms in neurodegeneration
    Michael R. Nichols, Marie‐Kim St‐Pierre, Ann‐Christin Wendeln, Nyasha J. Makoni, Lisa K. Gouwens, Evan C. Garrad, Mona Sohrabi, Jonas J. Neher, Marie‐Ève Tremblay, Colin Kelly Combs · 2019 · Journal of Neurochemistry
  42. Modulation of inflammation in transgenic models of Alzheimer’s disease
    Amy M. Birch, Loukia Katsouri, Magdalena Sastre · 2014 · Journal of Neuroinflammation
  43. Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau
    Rayaprolu, Sruti, Higginbotham, Lenora, Bagchi, Pritha, Watson, Caroline M., Zhang, Tian, Levey, Allan I., Rangaraju, Srikant, Seyfried, Nicholas T. · 2021 · Neuropsychopharmacology
  44. Genetic targeting of microglia
    Peter Wieghofer, Klaus‐Peter Knobeloch, Marco Prinz · 2014 · Glia
  45. Mast cell–glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide
    Stephen D. Skaper, Laura Facci · 2012 · Philosophical Transactions of the Royal Society B Biological Sciences
  46. Inflammatory Events Following Subarachnoid Hemorrhage (SAH)
    Ulf Christoph Schneider, Ran Xu, Peter Vajkoczy · 2018 · Current Neuropharmacology
  47. Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer’s disease–like mice
    Prokop, Stefan, Miller, Kelly R., Drost, Natalia, Handrick, Susann, Mathur, Vidhu, Luo, Jian, Wegner, Anja, Wyss-Coray, Tony, Heppner, Frank L. · 2015 · Journal of Experimental Medicine
  48. Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease
    Brandy L. Wilkinson, Paige E. Cramer, Nicholas H. Varvel, Erin G. Reed-Geaghan, Qingguang Jiang, Alison Szabo, Karl Herrup, Bruce T. Lamb, Gary E. Landreth · 2010 · Neurobiology of Aging
  49. Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection
    Tal Iram, Dorit Trudler, David Kain, Sivan Kanner, Ronit Galron, Robert J. Vassar, Ari Barzilai, Pablo Blinder, Zvi Fishelson, Dan Frenkel · 2016 · Neurobiology of Disease
  50. Pharmacological approaches to mitigate neuroinflammation in Alzheimer’s disease
    Md. Sahab Uddin, Md. Tanvir Kabir, Abdullah Al Mamun, George Emilio Barreto, Mamunur Rashid, Asma Perveen, Ghulam Md Ashraf · 2020 · International Immunopharmacology
  51. Evidence for Age-Dependent in Vivo Conformational Rearrangement within Aβ Amyloid Deposits
    Sofie Nyström, Katarzyna Maria Psonka-Antonczyk, Pål Gunnar Ellingsen, Leif B. G. Johansson, Nina Kristine Reitan, Susann Handrick, Stefan Prokop, Frank L. Heppner, Bettina M. Wegenast‐Braun, Mathias Jucker et al. · 2013 · ACS Chemical Biology
  52. High resolution dissection of reactive glial nets in Alzheimer’s disease
    Bouvier, David S., Jones, Emma V., Quesseveur, Gaël, Davoli, Maria Antonietta, A. Ferreira, Tiago, Quirion, Rémi, Mechawar, Naguib, Murai, Keith K. · 2016 · Scientific Reports
  53. Distinguishing features of microglia- and monocyte-derived macrophages after stroke
    Kronenberg, Golo, Uhlemann, Ria, Richter, Nadine, Klempin, Friederike, Wegner, Stephanie, Staerck, Lilian, Wolf, Susanne, Uckert, Wolfgang, Kettenmann, Helmut, Endres, Matthias et al. · 2018 · Acta Neuropathologica
  54. Systemic and CNS Inflammation Crosstalk: Implications for Alzheimer’s Disease
    Evi Paouri, Spiros Georgopoulos · 2019 · Current Alzheimer Research
  55. In vivo dynamics of innate immune sentinels in the CNS
    Nayak, Debasis, Zinselmeyer, Bernd H., Corps, Kara N., McGavern, Dorian B. · 2012 · IntraVital
  56. Macrophages in Alzheimer’s disease: the blood-borne identity
    Gate, David, Rezai-Zadeh, Kavon, Jodry, Dominique, Rentsendorj, Altan, Town, Terrence · 2010 · Journal of Neural Transmission
  57. Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia
    Bassil, Reina, Shields, Kenneth, Granger, Kevin, Zein, Ivan, Ng, Shirley, Chih, Ben · 2021 · Nature Communications
  58. Telomere shortening reduces Alzheimer’s disease amyloid pathology in mice
    Rolyan, Harshvardhan, Scheffold, Annika, Heinrich, Annette, Begus-Nahrmann, Yvonne, Langkopf, Britta Heike, Hölter, Sabine M., Vogt-Weisenhorn, Daniela M., Liss, Birgit, Wurst, Wolfgang, Lie, Dieter Chichung et al. · 2011 · Brain
  59. Microfluidic Chemotaxis Platform for Differentiating the Roles of Soluble and Bound Amyloid-β on Microglial Accumulation
    Hansang Cho, Tadafumi Hashimoto, Elisabeth A. Wong, Yukiko Hori, Levi Benjamin Wood, Lingzhi Zhao, Kevin M. Haigis, Bradley T. Hyman, Daniel Irimia · 2013 · Scientific Reports
  60. Deletion of CD14 Attenuates Alzheimer's Disease Pathology by Influencing the Brain's Inflammatory Milieu
    Erin G. Reed-Geaghan, Quillan W. Reed, Paige E. Cramer, Gary E. Landreth · 2010 · Journal of Neuroscience
  61. Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis
    Kaji, Seiji, Berghoff, Stefan A., Spieth, Lena, Schlaphoff, Lennart, Sasmita, Andrew O., Vitale, Simona, Büschgens, Luca, Kedia, Shreeya, Zirngibl, Martin, Nazarenko, Taisiia et al. · 2024 · Immunity
  62. Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency
    Bihua Bie, Jiang Wu, Hui Yang, Jijun J. Xu, David L Brown, Mohamed Naguib · 2014 · Nature Neuroscience
  63. Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice
    Julio Pozueta, Roger Lefort, Elena M. Ribé, Carol M. Troy, Ottavio Arancio, Michael L. Shelanski · 2013 · Nature Communications
  64. Plaque-associated local toxicity increases over the clinical course of Alzheimer disease
    Serrano-Pozo, Alberto, Betensky, Rebecca A., Frosch, Matthew P., Hyman, Bradley T. · 2016 · The American Journal of Pathology
  65. Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer’s disease
    Varvel, Nicholas H., Grathwohl, Stefan A., Degenhardt, Karoline, Resch, Claudia, Bosch, Andrea, Jucker, Mathias, Neher, Jonas J. · 2015 · Journal of Experimental Medicine
  66. Microglia in Alzheimer's Disease: It's All About Context
    Weitz, Tara M., Town, Terrence · 2012 · International Journal of Alzheimer's Disease
  67. Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrP<sup>Sc</sup>, even upon LPS stimulation
    Hughes, Martina M., Field, Robert H., Perry, V. Hugh, Murray, Carol L., Cunningham, Colm · 2010 · Glia
  68. Is RAGE Still A Therapeutic Target For Alzheimer’s Disease?
    Richard J. Deane · 2012 · Future Medicinal Chemistry
  69. Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity
    Wen Fu, Diya Shi, David A. Westaway, Jack H. Jhamandas · 2015 · Journal of Biological Chemistry
  70. Glial Control of Synapse Number in Healthy and Diseased Brain
    Eunbeol Lee, Won‐Suk Chung · 2019 · Frontiers in Cellular Neuroscience
  71. Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures
    Hellwig, Sabine, Masuch, Annette, Nestel, Sigrun, Katzmarski, Natalie, Meyer-Luehmann, Melanie, Biber, Knut · 2015 · Scientific Reports
  72. Amyloid-beta uptake by blood monocytes is reduced with ageing and Alzheimer’s disease
    Chen, Si-Han, Tian, Ding-Yuan, Shen, Ying-Ying, Cheng, Yuan, Fan, Dong-Yu, Sun, Hao-Lun, He, Chen-Yang, Sun, Pu-Yang, Bu, Xian-Le, Zeng, Fan et al. · 2020 · Translational Psychiatry
  73. NG2 glial cells regulate neuroimmunological responses to maintain neuronal function and survival
    Masayuki Nakano, Yasuhisa Tamura, Masanori Yamato, Satoshi Kume, Asami Eguchi, Kumi Takata, Yasuyoshi Watanabe, Yosky Kataoka · 2017 · Scientific Reports
  74. Transforming growth factor‐β stimulates β amyloid uptake by microglia through Smad3‐dependent mechanisms
    Juan Enrique Tichauer, Rommy von Bernhardi M. · 2012 · Journal of Neuroscience Research
  75. Targeting microglia for the treatment of Alzheimer’s disease
    Patrick L. McGeer, Edith G. McGeer · 2014 · Expert Opinion on Therapeutic Targets
  76. CD45 Deficiency Drives Amyloid-β Peptide Oligomers and Neuronal Loss in Alzheimer's Disease Mice
    Yuyan Zhu, Huayan Hou, Kavon P. Rezai-Zadeh, Brian N. Giunta, Amanda Ruscin, Carmelina Gemma, Jingji Jin, Natasa Dragicevic, Patrick C. Bradshaw, Suhail Rasool et al. · 2011 · Journal of Neuroscience
  77. Microglial Immunoreceptor Tyrosine-Based Activation and Inhibition Motif Signaling in Neuroinflammation
    Linnartz, Bettina, Wang, Yiner, Neumann, Harald · 2010 · International Journal of Alzheimer's Disease
  78. The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer’s disease
    Pedro M. Pimentel‐Coelho, Serge Rivest · 2012 · European Journal of Neuroscience
  79. Proliferation in the Alzheimer Hippocampus Is due to Microglia, Not Astroglia, and Occurs at Sites of Amyloid Deposition
    Marlatt, Michael W., Bauer, Jan, Aronica, Eleonora, van Haastert, Elise S., Hoozemans, Jeroen J. M., Joels, Marian, Lucassen, Paul J. · 2014 · Neural Plasticity
  80. The Evolving Biology of Microglia in Alzheimer's Disease
    Malm, Tarja M., Jay, Taylor R., Landreth, Gary E. · 2015 · Neurotherapeutics
  81. <i>In vivo</i> imaging of microglial activation by positron emission tomography with <scp>[<sup>11</sup>C]PBR28</scp> in the <scp>5XFAD</scp> model of <scp>A</scp>lzheimer's disease
    Mirzaei, Nazanin, Tang, Sac Pham, Ashworth, Sharon, Coello, Christopher, Plisson, Christophe, Passchier, Jan, Selvaraj, Vimal, Tyacke, Robin J., Nutt, David J., Sastre, Magdalena · 2016 · Glia
  82. Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer’s disease mice
    Kiyota, Tomomi, Machhi, Jatin, Lu, Yaman, Dyavarshetty, Bhagyalaxmi, Nemati, Maryam, Yokoyama, Izumi, Mosley, R.L., Gendelman, Howard E. · 2018 · Journal of Neuroimmunology
  83. Effects of n-3 FA supplementation on the release of proresolving lipid mediators by blood mononuclear cells: the OmegAD study[S]
    Xiu-Zhe Wang, E. Hjorth, I. Vedin, M. Eriksdotter, Y. Freund-Levi, L. Wahlund, T. Cederholm, J. Palmblad, M. Schultzberg · 2015 · Journal of Lipid Research
  84. Microglia and Synapse: Interactions in Health and Neurodegeneration
    Šišková, Zuzana, Tremblay, Marie-Ève · 2013 · Neural Plasticity
  85. Alzheimer's Disease and Amyloid: Culprit or Coincidence?
    Stephen D. Skaper · 2012 · International review of neurobiology
  86. The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice
    Jiamei Li, Ting Hu, Xiao-Na Zhou, Ting Zhang, Jiahui Guo, Min-Yuan Wang, Yilin Wu, Wenjun Su, Chun‐Lei Jiang · 2023 · Journal of Neuroinflammation
  87. Migration of blood cells to β-amyloid plaques in Alzheimer's disease
    Hohsfield, Lindsay A., Humpel, Christian · 2015 · Experimental Gerontology
  88. Microglia as a critical player in both developmental and late-life CNS pathologies
    Derecki, Noël C., Katzmarski, Natalie, Kipnis, Jonathan, Meyer-Luehmann, Melanie · 2014 · Acta Neuropathologica
  89. Abnormal amyloid beta metabolism in systemic abnormalities and Alzheimer’s pathology: Insights and therapeutic approaches from periphery
    Ullah, Rahat, Park, Tae Ju, Huang, Xu, Kim, Myeong Ok · 2021 · Ageing Research Reviews
  90. Microglia and amyloid plaque formation in Alzheimer's disease – Evidence, possible mechanisms, and future challenges
    Stefanie Fruhwürth, Henrik Zetterberg, Søren R. Paludan · 2024 · Journal of Neuroimmunology
  91. Hyperbaric oxygen therapy ameliorates pathophysiology of 3xTg-AD mouse model by attenuating neuroinflammation
    Ronit Shapira, Beka Solomon, Shai Efrati, Dan Frenkel, Uri Ashery · 2017 · Neurobiology of Aging
  92. Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma
    Giorgia Mastrella, Mengzhuo Hou, Min Li, Veit Michael Stoecklein, Nina Zdouc, Marie N.M. Volmar, Hrvoje Miletić, Sören Reinhard, Christel C. Herold‐Mende, Susanne Kleber et al. · 2019 · Cancer Research
  93. Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease
    Munawara, Usma, Catanzaro, Michael, Xu, Weili, Tan, Crystal, Hirokawa, Katsuiku, Bosco, Nabil, Dumoulin, David, Khalil, Abdelouahed, Larbi, Anis, Lévesque, Simon et al. · 2021 · Immunity &amp; Ageing
  94. Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease
    Lee‐Way Jin, Jacopo Di Lucente, Hai Minh Nguyen, Vikrant Singh, Latika Singh, Monique Chavez, Trevor R. Bushong, Heike Wulff, Izumi Maezawa · 2019 · Annals of Clinical and Translational Neurology
  95. Microglia as Dynamic and Essential Components of the Amyloid Hypothesis
    Sam Gandy, Frank L. Heppner · 2013 · Neuron
  96. Innate Immunity in Alzheimer’s Disease: A Complex Affair
    Marie‐Victoire Guillot‐Sestier, Terrence Town · 2013 · CNS & Neurological Disorders - Drug Targets
  97. Aβ-directed Single-chain Antibody Delivery Via a Serotype-1 AAV Vector Improves Learning Behavior and Pathology in Alzheimer's Disease Mice
    Deborah A. Ryan, Michael A. Mastrangelo, Wade C. Narrow, Mark A. Sullivan, Howard J. Federoff, William J. Bowers · 2010 · Molecular Therapy
  98. The role of the immune system in driving neuroinflammation
    Ní Chasaide, Caitlín, Lynch, Marina A · 2020 · Brain and Neuroscience Advances
  99. Dysregulated Wnt Signalling in the Alzheimer’s Brain
    Aghaizu, Nozie D., Jin, Hanqing, Whiting, Paul J. · 2020 · Brain Sciences
  100. Neuroinflammation in Alzheimer's disease: an understanding of physiology and pathology
    Magisetty Obulesu, M. Jhansilakshmi · 2013 · International Journal of Neuroscience