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A new subtype of progenitor cell in the mouse embryonic neocortex
Open accessAbstract
A hallmark of mammalian brain evolution is cortical expansion, which reflects an increase in the number of cortical neurons established by the progenitor cell subtypes present and the number of their neurogenic divisions. Recent studies have revealed a new class of radial glia-like (oRG) progenitor cells in the human brain, which reside in the outer subventricular zone. Expansion of the subventricular zone and appearance of oRG cells may have been essential evolutionary steps leading from lissencephalic to gyrencephalic neocortex. Here we show that oRG-like progenitor cells are present in the mouse embryonic neocortex. They arise from asymmetric divisions of radial glia and undergo self-renewing asymmetric divisions to generate neurons. Moreover, mouse oRG cells undergo mitotic somal translocation whereby centrosome movement into the basal process during interphase precedes nuclear translocation. Our finding of oRG cells in the developing rodent brain fills a gap in our understanding of neocortical expansion.
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“The oRG population is largely missing in mouse brain development47, and human cellular models therefore provide a unique opportunity to study this cell population.”
From The use of brain organoids to investigate neural development and disease (2017) · cites this paper as [47]
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Metadata
- Authors
- Wang, X., Tsai, J.-W., LaMonica, B., & Kriegstein, A. R.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Wang, Xiaoqun
- Kriegstein, Arnold R
- Venue
- Nature Neuroscience
- Published
- 2011-04-10
- Volume
- 14
- Issue
- 5
- Pages
- 555-561
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3083489
- OpenAlex
- W2072710787
- Cited by
- 507
- References
- 37
- Citations by year
- 2026: 13 · 2025: 24 · 2024: 26 · 2023: 36 · 2022: 29 · 2021: 39 · 2020: 45 · 2019: 42 · 2018: 27 · 2017: 34 · 2016: 19 · 2015: 34 · 2014: 43 · 2013: 50 · 2012: 26
- FWCI
- 14.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Bernard Osher Foundation
- National Institute of General Medical Sciences (T32GM007618)
- National Institute of Neurological Disorders and Stroke (R01NS072630, R01NS035710, R01NS021223)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- outer radial glia, embryonic neocortex, asymmetric cell division, cortical expansion, neurogenesis, mouse brain development
- MeSH terms
- Age Factors, Animals, Cell Differentiation, Cell Division, Cell Movement, Embryo, Mammalian, Luminescent Proteins, Mice, Transgenic, Nerve Tissue Proteins, Neuroglia, Neurons, Organ Culture Techniques, Stem Cells, Time Factors, Centrosome, Gene Expression Regulation, Developmental, Microscopy, Confocal, Neocortex, Green Fluorescent Proteins, Mice
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