Palatability Can Drive Feeding Independent of AgRP Neurons
Open accessAbstract
Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that integrate energy demand as well as the reinforcing and rewarding aspects of food. Understanding the net contribution of homeostatic and reward-driven feeding has become critical because of the ubiquitous source of energy-dense foods and the consequent obesity epidemic. Hypothalamic agouti-related peptide-secreting neurons (AgRP neurons) provide the primary orexigenic drive of homeostatic feeding. Using models of neuronal inhibition or ablation, we demonstrate that the feeding response to a fast ghrelin or serotonin receptor agonist relies on AgRP neurons. However, when palatable food is provided, AgRP neurons are dispensable for an appropriate feeding response. In addition, AgRP-ablated mice present exacerbated stress-induced anorexia and palatable food intake--a hallmark of comfort feeding. These results suggest that, when AgRP neuron activity is impaired, neural circuits sensitive to emotion and stress are engaged and modulated by food palatability and dopamine signaling.
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Ablation of AgRP neurons enhances isolation stress-induced anorexia and palatability-driven feeding.
“Paradoxically, ablation of AgRP neurons has been reported to enhance isolation stress-induced anorexia and palatability-driven feeding [28].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [28]
AgRP neurons in the ARC of the hypothalamus contribute to reward-driven feeding and food-seeking behavior.
“A number of studies have shown that AgRP neurons in the ARC of the hypothalamus contribute to reward-driven feeding [28] and food-seeking behavior [26, 27].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [28]
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- Authors
- Denis, R. G. P., Joly-Amado, A., Webber, E., Langlet, F., Schaeffer, M., Padilla, S. L., Cansell, C., Dehouck, B., Castel, J., Delbès, A.-S., Martinez, S., Lacombe, A., Rouch, C., Kassis, N., Fehrentz, J.-A., Martinez, J., Verdié, P., Hnasko, T. S., Palmiter, R. D., Krashes, M. J., Güler, A. D., Magnan, C., & Luquet, S.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- National Institutes of Health (US)
- Inserm (FR)
- Howard Hughes Medical Institute (US)
- École Nationale Supérieure de Chimie de Montpellier (FR)
- University of California San Diego (US)
- Corresponding author
- Luquet, Serge
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 22
- Issue
- 4
- Pages
- 646-657
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC5024566
- OpenAlex
- W1863350518
- Cited by
- 164
- References
- 61
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 10 · 2023: 19 · 2022: 14 · 2021: 28 · 2020: 13 · 2019: 18 · 2018: 18 · 2017: 18 · 2016: 11 · 2015: 3
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Update notices
- erratum (2017-04-04)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- HAL (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Agence Nationale de la Recherche (ANR-09-BLAN-0267, ANR-11-BSV1-0021)
- National Institute on Drug Abuse (R01DA024908)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- agouti-related peptide neurons, palatability, emotional eating, stress-induced anorexia, ghrelin, serotonin receptor agonists, dopamine signaling, hypothalamus, obesity
- MeSH terms
- Animals, Dopamine, Eating, Hypothalamus, Mice, Inbred C57BL, Neurons, Signal Transduction, Mice, Knockout, Mice, Agouti-Related Protein
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