Cued memory reactivation during sleep influences skill learning
Open accessAbstract
Information acquired during waking can be reactivated during sleep, promoting memory stabilization. After people learned to produce two melodies in time with moving visual symbols, we enhanced relative performance by presenting one melody during an afternoon nap. Electrophysiological signs of memory processing during sleep corroborated the notion that appropriate auditory stimulation that does not disrupt sleep can nevertheless bias memory consolidation in relevant brain circuitry.
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When only one of two melodies learned on a piano keyboard was presented again during posttraining SWS, performance on just this reactivated melody was improved at a later retest compared with the nonreactivated melody.
“When only one of the melodies was presented again during a period of posttraining SWS, performance on just this reactivated melody was improved at a later retest, compared with performance on the nonreactivated melody.”
From About Sleep's Role in Memory (2013) · cites this paper as [40]
Information flow during coordinated reactivation events appears organized in a loop-like manner, with cortical activity predicting hippocampal reactivations during SPW-Rs, and hippocampal reactivations leading extrahippocampal regions.
“information flow during such coordinated reactivation events appears be organized in a loop-like manner, with activity in cortical regions predicting the content of hippocampal reactivations during SPW-Rs, 89 and hippocampal reactivations, in turn, leading reactivations in extrahippocampal regions.”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [102]
The paper’s Abstract discusses sleep-cued memory reactivation and spindle activity, and its Online Methods describe scalp EEG recordings. Neither passage addresses cortical activity predicting hippocampal reactivation during SPW-Rs or hippocampal reactivation leading extrahippocampal activity. Searches for both directional relationships found no passage supporting the claimed loop-like information flow. (LLM, conf=0.77)
Experimental — accuracy not yet measuredParallel recordings revealed close temporal coordination of reactivation across hippocampus and cortical/subcortical regions.
“parallel recordings from both hippocampus and cortical or subcortical regions revealed a close temporal coordination of reactivation across sites 92,100,102”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [102]
The Online Methods, ‘Sleep Recording’ section (page not provided) describes scalp EEG recordings, not parallel recordings from the hippocampus and cortical or subcortical sites. The copy does not report temporal coordination of reactivation across those sites; searches for parallel recordings and hippocampal–cortical coordination found no such passage. (LLM, conf=0.75)
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- Authors
- Antony, J. W., Gobel, E. W., O'Hare, J. K., Reber, P. J., & Paller, K. A.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Paller, Ken A
- Venue
- Nature Neuroscience
- Published
- 2012-06-26
- Volume
- 15
- Issue
- 8
- Pages
- 1114-1116
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3498459
- OpenAlex
- W2077366486
- Semantic Scholar
- b7cc11357e30d7e377a771b3ab151cfc9498e9d0
- Cited by
- 309
- References
- 25
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 19 · 2023: 12 · 2022: 27 · 2021: 18 · 2020: 21 · 2019: 52 · 2018: 24 · 2017: 26 · 2016: 20 · 2015: 18 · 2014: 23 · 2013: 17 · 2012: 5
- FWCI
- 10.33
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5t32ag020418-08)
- National Institute on Aging (T32-AG020418, T32AG020506)
- National Institute of Neurological Disorders and Stroke (T32NS047987)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- sleep-dependent memory consolidation, memory reactivation, motor sequence learning, napping, skill acquisition, memory stabilization
- MeSH terms
- Adult, Auditory Perception, Cues, Electroencephalography, Female, Humans, Learning, Male, Memory, Music, Neuropsychological Tests, Mental Recall, Sleep, Recognition, Psychology, Young Adult
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