Cited by 531Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

The DOI matches its Crossref record; 147 of the 147 references it cites were found in a registry or an index.

What the orbitofrontal cortex does not do

Open access

Stalnaker, Thomas A, Cooch, Nisha K, Schoenbaum, Geoffrey·2015·Nature Neuroscience

DOI 10.1038/nn.3982PMC PMC5541252

Open this paper in CoChat — free account

Abstract

The number of papers about the orbitofrontal cortex (OFC) has grown from 1 per month in 1987 to a current rate of over 50 per month. This publication stream has implicated the OFC in nearly every function known to cognitive neuroscience and in most neuropsychiatric diseases. However, new ideas about OFC function are typically based on limited data sets and often ignore or minimize competing ideas or contradictory findings. Yet true progress in our understanding of an area's function comes as much from invalidating existing ideas as proposing new ones. Here we consider the proposed roles for OFC, critically examining the level of support for these claims and highlighting the data that call them into question.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nn.3982

Cites

147 of 147 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
Learning to predict by the methods of temporal differences
Sutton, R. S. (1988) · Machine Learning · doi:10.1007/bf00115009 · Cited by 5,148
Classical conditioning II: Current research and theory.
Black, A. H., & Prokasy, W. F. (1972) · Appleton-Century-Crofts eBooks · Cited by 4,449
Deciding advantageously before knowing the advantageous strategy
Bechara, A., Damasio, H., Tranel, D., & Damasio, A. R. (1997) · Science · doi:10.1126/science.275.5304.1293 · Cited by 3,547
A model for Pavlovian learning: Variations in the effectiveness of conditioned but not of unconditioned stimuli.
Pearce, J. M., & Hall, G. (1980) · Psychological Review · doi:10.1037/0033-295x.87.6.532 · Cited by 3,023
The Logic of Scientific Discovery
Popper, K. R., & Weiss, G. (1959) · Physics Today · doi:10.1063/1.3060577 · Cited by 2,717
The Organization of Networks within the Orbital and Medial Prefrontal Cortex of Rats, Monkeys and Humans
Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627
Uncertainty-based competition between prefrontal and dorsolateral striatal systems for behavioral control
Daw, N. D., Niv, Y., & Dayan, P. (2005) · Nature Neuroscience · doi:10.1038/nn1560 · Cited by 2,533
Inhibition and the right inferior frontal cortex: one decade on
Aron, A. R., Robbins, T. W., & Poldrack, R. A. (2014) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.12.003 · Cited by 2,166
Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making
Bechara, A., Damasio, H., Damasio, A. R., & Lee, G. P. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05473.1999 · Cited by 2,001

Flagged first, then by citations

Show all 147 references

Research works printed but not linked: 5

Harlow, J.M. Recovery after passage of an iron bar through the head. Pub. Mass. Med. Soc. 2, 329–346 (1868).
Izquierdo, A.D. & Murray, E.A. Bilateral orbital prefrontal cortex lesions disrupt reinforcer devaluation effects in rhesus monkeys. Soc. Neurosci. Abstr. 26, 978 (2000).
von Neumann, J. & Morgenstern, O. Theory of Games and Economic Behavior (Princeton University Press, 1947).
Sutton, R.S. Learning to predict by the method of temporal difference. Mach. Learn. 3, 9–44 (1988).
Schoenbaum, G., Setlow, B. & Gallagher, M. Orbitofrontal cortex: modeling prefrontal function in rats. in The Neuropsychology of Memory (eds. L. Squire & D. Schacter) 463–477 (Guilford Press, 2002).

Sorted by citations

The Neurobiology of Human Attachments
Feldman, R. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.11.007 · Cited by 839
The neural basis of reversal learning: An updated perspective
Izquierdo, A., Brigman, J. L., Radke, A. K., Rudebeck, P. H., & Holmes, A. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.021 · Cited by 670
Human orbitofrontal cortex represents a cognitive map of state space
Schuck, N. W., Cai, M. B., Wilson, R. C., & Niv, Y. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.019 · Cited by 602
Over the river, through the woods: cognitive maps in the hippocampus and orbitofrontal cortex
Wikenheiser, A. M., & Schoenbaum, G. M. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.56 · Cited by 368
Self-citation
Learning task-state representations
Niv, Y. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0470-8 · Cited by 356
Active control of arousal by a locus coeruleus GABAergic circuit
Breton‐Provencher, V., & Sur, M. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0305-z · Cited by 377
The prefrontal cortex, pathological anxiety, and anxiety disorders
Kenwood, M. M., Kalin, N. H., & Barbas, H. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01109-z · Cited by 379
The neuroscience of positive emotions and affect: Implications for cultivating happiness and wellbeing
Alexander, R., Aragón, O. R., Bookwala, J., Cherbuin, N., Gatt, J. M., Kahrilas, I. J., Kästner, N., Lawrence, A. B., Lowe, L. J., Morrison, R., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.002 · Cited by 364
Large-Scale Meta-Analysis of Human Medial Frontal Cortex Reveals Tripartite Functional Organization
de la Vega, A. I., Chang, L. J., Banich, M. T., Wager, T. D., & Yarkoni, T. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4402-15.2016 · Cited by 304
Adaptive learning under expected and unexpected uncertainty
Soltani, A., & Izquierdo, A. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0180-y · Cited by 286
Deep reinforcement learning and its neuroscientific implications
Botvinick, M., Wang, J. X., Dabney, W., Miller, K. J., & Kurth-Nelson, Z. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.014 · Cited by 269
Orbitofrontal cortex
Rudebeck, P. H., & Rich, E. L. (2018) · Current Biology · doi:10.1016/j.cub.2018.07.018 · Cited by 291
Functional Heterogeneity within Rat Orbitofrontal Cortex in Reward Learning and Decision Making
Izquierdo, A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1678-17.2017 · Cited by 269
Circuit Mechanisms of Reward, Anhedonia, and Depression
Höflich, A., Michenthaler, P., Kasper, S., & Lanzenberger, R. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy081 · Cited by 253
Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation
Gremel, C. M., Chancey, J. H., Atwood, B. K., Luo, G., Neve, R., Ramakrishnan, C., Deisseroth, K., Lovinger, D. M., & Costa, R. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.04.043 · Cited by 251
Dorsal hippocampus contributes to model-based planning
Miller, K. J., Botvinick, M., & Brody, C. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4613 · Cited by 252
Neural Signatures of Value Comparison in Human Cingulate Cortex during Decisions Requiring an Effort-Reward Trade-off
Klein-Flügge, M. C., Kennerley, S. W., Friston, K. J., & Bestmann, S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0292-16.2016 · Cited by 271
Medial and orbital frontal cortex in decision-making and flexible behavior
Klein-Flügge, M. C., Bongioanni, A., & Rushworth, M. F. S. (2022) · Neuron · doi:10.1016/j.neuron.2022.05.022 · Cited by 244
Meta-analysis of reward processing in major depressive disorder reveals distinct abnormalities within the reward circuit
Ng, T. H., Alloy, L. B., & Smith, D. V. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0644-x · Cited by 244
The self in context: brain systems linking mental and physical health
Koban, L., Gianaros, P. J., Hedy Kober, A., & Wager, T. D. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00446-8 · Cited by 258
Interactions between human orbitofrontal cortex and hippocampus support model-based inference
Wang, F., Schoenbaum, G. M., & Kahnt, T. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000578 · Cited by 223
Self-citation
Frontal cortex neuron types categorically encode single decision variables
Hirokawa, J., Vaughan, A., Masset, P., Ott, T., & Kepecs, Á. (2019) · Nature · doi:10.1038/s41586-019-1816-9 · Cited by 223
The mouse prefrontal cortex: Unity in diversity
Le Merre, P., Ährlund-Richter, S., & Carlén, M. (2021) · Neuron · doi:10.1016/j.neuron.2021.03.035 · Cited by 207
Medial Orbitofrontal Cortex Mediates Outcome Retrieval in Partially Observable Task Situations
Bradfield, L. A., Dezfouli, A., van Holstein, M., Chieng, B. C. H., & Balleine, B. W. (2015) · Neuron · doi:10.1016/j.neuron.2015.10.044 · Cited by 211
Dorsal Striatal Circuits for Habits, Compulsions and Addictions
Lipton, D. M., Gonzales, B. J., & Citri, A. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2019.00028 · Cited by 222
The sensation of groove engages motor and reward networks
Matthews, T. E., Witek, M. A. G., Lund, T. E., Vuust, P., & Penhune, V. B. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116768 · Cited by 218
Brain Mechanisms of the Placebo Effect: An Affective Appraisal Account
Ashar, Y. K., Chang, L. J., & Wager, T. D. (2017) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-021815-093015 · Cited by 201
Multifaceted Contributions by Different Regions of the Orbitofrontal and Medial Prefrontal Cortex to Probabilistic Reversal Learning
Dalton, G. L., Wang, N. Y., Phillips, A. G., & Floresco, S. B. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.3366-15.2016 · Cited by 184
Common and distinct abnormal frontal-limbic system structural and functional patterns in patients with major depression and bipolar disorder
Chen, L., Wang, Y., Niu, C., Zhong, S., Hu, H., Chen, P., Zhang, S., Chen, G., Deng, F., Lai, S., et al. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.07.002 · Cited by 185
Direct electrical stimulation of lateral orbitofrontal cortex acutely improves mood in individuals with symptoms of depression
Rao, V. R., Sellers, K. K., Wallace, D. L., Lee, M. B., Bijanzadeh, M., Sani, O. G., Yang, Y., Shanechi, M. M., Dawes, H. E., & Chang, E. F. (2018) · Current Biology · doi:10.1016/j.cub.2018.10.026 · Cited by 181
Reward-based training of recurrent neural networks for cognitive and value-based tasks
Song, H., Yang, G. R., & Wang, X. (2017) · eLife · doi:10.7554/elife.21492 · Cited by 175
Specializations for reward-guided decision-making in the primate ventral prefrontal cortex
Murray, E. A., & Rudebeck, P. H. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0013-4 · Cited by 169
Contrasting effects of medial and lateral orbitofrontal cortex lesions on credit assignment and decision-making in humans
Noonan, M. P., Chau, B. K. H., Rushworth, M. F. S., & Fellows, L. K. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.0692-17.2017 · Cited by 167
Viewpoints: Dialogues on the functional role of the ventromedial prefrontal cortex
Delgado, M. R., Beer, J. S., Fellows, L. K., Huettel, S. A., Platt, M. L., Quirk, G. J., & Schiller, D. (2016) · Nature Neuroscience · doi:10.1038/nn.4438 · Cited by 173
Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits
Renteria, R., Baltz, E. T., & Gremel, C. M. (2018) · Nature Communications · doi:10.1038/s41467-017-02615-9 · Cited by 161
Cortico–Basal Ganglia Circuit Function in Psychiatric Disease
Gunaydin, L. A., & Kreitzer, A. C. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105355 · Cited by 155
Single-cell activity tracking reveals that orbitofrontal neurons acquire and maintain a long-term memory to guide behavioral adaptation
Namboodiri, V. M. K., Otis, J. M., van Heeswijk, K., Voets, E. S., Alghorazi, R. A., Rodriguez-Romaguera, J., Mihalas, S., & Stuber, G. D. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0408-1 · Cited by 150
Evolving schema representations in orbitofrontal ensembles during learning
Zhou, J., Jia, C., Montesinos-Cartagena, M., Gardner, M., Zong, W., & Schoenbaum, G. M. (2020) · Nature · doi:10.1038/s41586-020-03061-2 · Cited by 148
Self-citation
Integrating memories to guide decisions
Shohamy, D., & Daw, N. D. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.08.010 · Cited by 155
Values encoded in orbitofrontal cortex are causally related to economic choices
Ballesta, S., Shi, W., Conen, K. E., & Padoa‐Schioppa, C. (2020) · Nature · doi:10.1038/s41586-020-2880-x · Cited by 141
Midbrain dopamine neurons compute inferred and cached value prediction errors in a common framework
Sadacca, B. F., Jones, J. L., & Schoenbaum, G. M. (2016) · eLife · doi:10.7554/elife.13665 · Cited by 136
Self-citation
Taking stock of value in the orbitofrontal cortex
Knudsen, E. B., & Wallis, J. D. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00589-2 · Cited by 148
Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals
Farokhnia, M., Grodin, E. N., Lee, M. R., Oot, E. N., Blackburn, A. N., Stangl, B. L., Schwandt, M. L., Farinelli, L. A., Momenan, R., Ramchandani, V. A., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.226 · Cited by 127
A connectional hub in the rostral anterior cingulate cortex links areas of emotion and cognitive control
Tang, W., Jbabdi, S., Zhu, Z., Cottaar, M., Grisot, G., Lehman, J. F., Yendiki, A., & Haber, S. N. (2019) · eLife · doi:10.7554/elife.43761 · Cited by 127
Two Anatomically and Computationally Distinct Learning Signals Predict Changes to Stimulus-Outcome Associations in Hippocampus
Boorman, E. D., Rajendran, V. G., O’Reilly, J. X., & Behrens, T. E. J. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.014 · Cited by 116
The case against economic values in the orbitofrontal cortex (or anywhere else in the brain).
Hayden, B. Y., & Niv, Y. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000448 · Cited by 127
An Integrated Model of Action Selection: Distinct Modes of Cortical Control of Striatal Decision Making
Sharpe, M. J., Stalnaker, T. A., Schuck, N. W., Killcross, S., Schoenbaum, G. M., & Niv, Y. (2018) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-102824 · Cited by 117
Self-citation
Deciphering Decision Making: Variation in Animal Models of Effort- and Uncertainty-Based Choice Reveals Distinct Neural Circuitries Underlying Core Cognitive Processes
Winstanley, C. A., & Floresco, S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1713-16.2016 · Cited by 123
The role of the orbitofrontal cortex in alcohol use, abuse, and dependence
Moorman, D. E. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.010 · Cited by 114
The Medial Orbitofrontal Cortex Regulates Sensitivity to Outcome Value
Gourley, S. L., Zimmermann, K. S., Allen, A. G., & Taylor, J. R. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4253-15.2016 · Cited by 119
Behavior- and Modality-General Representation of Confidence in Orbitofrontal Cortex
Masset, P., Ott, T., Lak, A., Hirokawa, J., & Kepecs, A. (2020) · Cell · doi:10.1016/j.cell.2020.05.022 · Cited by 109
Suppression of Ventral Hippocampal Output Impairs Integrated Orbitofrontal Encoding of Task Structure
Wikenheiser, A. M., Marrero-Garcia, Y., & Schoenbaum, G. M. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.003 · Cited by 109
Self-citation
Multi-channel fiber photometry for population neuronal activity recording
Guo, Q., Zhou, J., Feng, Q., Lin, R., Gong, H., Luo, Q., Zeng, S., Luo, M., & Fu, L. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.003919 · Cited by 107
Neural Correlates of Prosocial Behavior: Compensating Social Exclusion in a Four-Player Cyberball Game
van der Meulen, M., van IJzendoorn, M. H., & Crone, E. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159045 · Cited by 100
Distance and Direction Codes Underlie Navigation of a Novel Semantic Space in the Human Brain
Viganò, S., & Manuela Piazza, A. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1849-19.2020 · Cited by 99
Roles of the medial and lateral orbitofrontal cortex in major depression and its treatment
Zhang, B., Rolls, E. T., Wang, X., Xie, C., Cheng, W., & Feng, J. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02380-w · Cited by 107
Neural Mechanisms of Domain-general Inhibitory Control
Wessel, J. R., & Anderson, M. C. (2023) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2023.09.008 · Cited by 117
Converging models of schizophrenia – Network alterations of prefrontal cortex underlying cognitive impairments
Sakurai, T., Gamo, N. J., Hikida, T., Kim, S.-H., Murai, T., Tomoda, T., & Sawa, A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.010 · Cited by 102
Identity prediction errors in the human midbrain update reward-identity expectations in the orbitofrontal cortex
Howard, J. D., & Kahnt, T. (2018) · Nature Communications · doi:10.1038/s41467-018-04055-5 · Cited by 95
The false dichotomy: a refutation of the Neandertal indistinguishability claim.
Wynn, T., Overmann, K. A., & Coolidge, F. L. (2016) · PubMed · doi:10.4436/jass.94022 · Cited by 93
Orbitofrontal neurons signal sensory associations underlying model-based inference in a sensory preconditioning task
Sadacca, B. F., Wied, H. M., Lopatina, N., Saini, G. K., Nemirovsky, D., & Schoenbaum, G. M. (2018) · eLife · doi:10.7554/elife.30373 · Cited by 100
Self-citation
Sadism: Review of an elusive construct
Foulkes, L. (2019) · Personality and Individual Differences · doi:10.1016/j.paid.2019.07.010 · Cited by 90
Brain structure in pediatric Tourette syndrome
and The Tourette Association of America Neuroimaging Consortium, Greene, D. J., Williams III, A. C., Koller, J. M., Schlaggar, B. L., & Black, K. J. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.194 · Cited by 89
Global reward state affects learning and activity in raphe nucleus and anterior insula in monkeys
Wittmann, M. K., Fouragnan, E. F., Folloni, D., Klein-Flügge, M. C., Chau, B. K. H., Khamassi, M., & Rushworth, M. F. S. (2020) · Nature Communications · doi:10.1038/s41467-020-17343-w · Cited by 88
Consolidating the Circuit Model for Addiction
Lüscher, C., & Janak, P. H. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-092920-123905 · Cited by 94
Rule Encoding in Orbitofrontal Cortex and Striatum Guides Selection
Sleezer, B. J., Castagno, M. D., & Hayden, B. Y. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1766-16.2016 · Cited by 90
Targeted Stimulation of Human Orbitofrontal Networks Disrupts Outcome-Guided Behavior
Howard, J. D., Reynolds, R., Smith, D. E., Voss, J. L., Schoenbaum, G. M., & Kahnt, T. (2020) · Current Biology · doi:10.1016/j.cub.2019.12.007 · Cited by 86
Self-citation
Inference-Based Decisions in a Hidden State Foraging Task: Differential Contributions of Prefrontal Cortical Areas
Vertechi, P., Lottem, E., Sarra, D., Godinho, B., Treves, I. N., Quendera, T., Lohuis, M. N. O., & Mainen, Z. F. (2020) · Neuron · doi:10.1016/j.neuron.2020.01.017 · Cited by 85
Computational models of adaptive behavior and prefrontal cortex
Soltani, A., & Koechlin, É. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01123-1 · Cited by 86
Central taste anatomy and physiology
Vincis, R., & Fontanini, A. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63855-7.00012-5 · Cited by 88
Effects of stress on behavioral flexibility in rodents
Hurtubise, J. L., & Howland, J. G. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.007 · Cited by 87
Neural representation of abstract task structure during generalization
Vaidya, A. R., Jones, H. M., Castillo, J., & Badre, D. (2021) · eLife · doi:10.7554/elife.63226 · Cited by 90
The prediction-error hypothesis of schizophrenia: new data point to circuit-specific changes in dopamine activity
Millard, S. J., Bearden, C. E., Karlsgodt, K. H., & Sharpe, M. J. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01188-y · Cited by 83
Nonsuicidal self-injury and suicidal behaviors in girls: The case for targeted prevention in preadolescence
Beauchaine, T. P., Hinshaw, S. P., & Bridge, J. A. (2019) · Clinical Psychological Science · doi:10.1177/2167702618818474 · Cited by 80
Rewards and Cognitive Control in the Human Prefrontal Cortex
Duverne, S., & Koechlin, É. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx210 · Cited by 79
A decade of decoding reward-related fMRI signals and where we go from here
Kahnt, T. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.03.067 · Cited by 79
Lateral Orbitofrontal Inactivation Dissociates Devaluation-Sensitive Behavior and Economic Choice
Gardner, M., Conroy, J. S., Shaham, M. H., Styer, C. V., & Schoenbaum, G. M. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.026 · Cited by 80
Self-citation
The role of the lateral orbitofrontal cortex in creating cognitive maps
Costa, K. M., Scholz, R., Lloyd, K., Moreno‐Castilla, P., Gardner, M., Dayan, P., & Schoenbaum, G. M. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01216-0 · Cited by 75
Self-citation
Social brain volume is associated with in-degree social network size among older adults
Kwak, S., Joo, W.-T., Youm, Y., & Chey, J. (2018) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2017.2708 · Cited by 71
Aberrant Frontostriatal Connectivity in Negative Symptoms of Schizophrenia
Shukla, D. K., Chiappelli, J., Sampath, H., Kochunov, P. V., Hare, S., Wisner, K., Rowland, L. M., & Hong, L. E. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby165 · Cited by 69
Orbitofrontal overactivation in reward processing in borderline personality disorder: the role of non-suicidal self-injury
Vega, D., Ripollés, P., Soto, À., Torrúbia, R., Ribas, J., Monreal, J. A., Pascual, J. C., Salvador, R. M., Pomarol‐Clotet, E., Rodríguez‐Fornells, A., et al. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9687-x · Cited by 74
Common and different neural markers in major depression and anxiety disorders: A pilot structural magnetic resonance imaging study
Maggioni, E., Delvecchio, G., Grottaroli, M., Garzitto, M., Piccin, S., Bonivento, C., Maieron, M., D’Agostini, S., Perna, G., Balestrieri, M., et al. (2019) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2019.06.006 · Cited by 71
Cortical-subcortical interactions in goal-directed behavior
Cruz, K. G., Leow, Y. N., Le, N. M., Adam, E. M., Huda, R., & Sur, M. (2022) · Physiological Reviews · doi:10.1152/physrev.00048.2021 · Cited by 76
Learning, memory and consolidation mechanisms for behavioral control in hierarchically organized cortico‐basal ganglia systems
Rusu, S. I., & Pennartz, C. M. A. (2019) · Hippocampus · doi:10.1002/hipo.23167 · Cited by 63
Value representations in the rodent orbitofrontal cortex drive learning, not choice
Miller, K. J., Botvinick, M., & Brody, C. D. (2022) · eLife · doi:10.7554/elife.64575 · Cited by 72
Complementary Task Structure Representations in Hippocampus and Orbitofrontal Cortex during an Odor Sequence Task
Zhou, J., Montesinos-Cartagena, M., Wikenheiser, A. M., Gardner, M., Niv, Y., & Schoenbaum, G. M. (2019) · Current Biology · doi:10.1016/j.cub.2019.08.040 · Cited by 64
Self-citation
Primate Orbitofrontal Cortex Codes Information Relevant for Managing Explore–Exploit Tradeoffs
Costa, V. D., & Averbeck, B. B. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2355-19.2020 · Cited by 65
Grid-like and distance codes for representing word meaning in the human brain
Viganò, S., Rubino, V., Soccio, A. D., Buiatti, M., & Manuela Piazza, A. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.117876 · Cited by 59
Parallel inputs from the mediodorsal thalamus to the prefrontal cortex in the rat
Alcaraz, F., Marchand, A. R., Courtand, G., Coutureau, É., & Wolff, M. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13316 · Cited by 71
Human ventromedial prefrontal lesions alter incentivisation by reward
Manohar, S. G., & Husain, M. (2016) · Cortex · doi:10.1016/j.cortex.2016.01.005 · Cited by 62
Toward a theoretical role for tonic norepinephrine in the orbitofrontal cortex in facilitating flexible learning
Sadacca, B. F., Wikenheiser, A. M., & Schoenbaum, G. M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.04.017 · Cited by 59
Self-citation
Zebrafish capable of generating future state prediction error show improved active avoidance behavior in virtual reality
Torigoe, M., Islam, T., Kakinuma, H., Fung, C. C. A., Isomura, T., Shimazaki, H., Aoki, T., Fukai, T., & Okamoto, H. (2021) · Nature Communications · doi:10.1038/s41467-021-26010-7 · Cited by 61
Prefrontal circuit organization for executive control
Kamigaki, T. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.08.017 · Cited by 69
The rat's not for turning: Dissociating the psychological components of cognitive inflexibility
Nilsson, S. R. O., Alsiö, J., Somerville, E. M., & Clifton, P. G. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.06.015 · Cited by 60
A State Representation for Reinforcement Learning and Decision-Making in the Orbitofrontal Cortex
Schuck, N. W., Wilson, R., & Niv, Y. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812098-9.00012-7 · Cited by 66
Learning of distant state predictions by the orbitofrontal cortex in humans
Wimmer, G. E., & Büchel, C. (2019) · Nature Communications · doi:10.1038/s41467-019-10597-z · Cited by 60
To be specific: The role of orbitofrontal cortex in signaling reward identity.
Howard, J. D., & Kahnt, T. (2021) · Behavioral Neuroscience · doi:10.1037/bne0000455 · Cited by 57
Is the core function of orbitofrontal cortex to signal values or make predictions?
Zhou, J., Gardner, M. P., & Schoenbaum, G. (2021) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2021.02.011 · Cited by 57
Self-citation
Top-Down Cortical Control of Acute and Chronic Pain
Urien, L., & Wang, J. (2019) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000744 · Cited by 56
Dopamine Modulates the Functional Organization of the Orbitofrontal Cortex
Kahnt, T., & Tobler, P. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2827-16.2016 · Cited by 53

Authors: Stalnaker, T. A., Cooch, N. K., & Schoenbaum, G.
Affiliations: National Institutes of Health (US)
Corresponding author: Schoenbaum, Geoffrey
ORCID: Stalnaker, Thomas A
Cooch, Nisha K
Schoenbaum, Geoffrey
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2015-04-28
Volume: 18
Issue: 5
Pages: 620-627
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.3982
PMC: PMC5541252
OpenAlex: W2020689320
Cited by: 531
References: 147
Citations by year: 2026: 15 · 2025: 41 · 2024: 45 · 2023: 34 · 2022: 45 · 2021: 59 · 2020: 77 · 2019: 55 · 2018: 60 · 2017: 33 · 2016: 50 · 2015: 16
FWCI: 5.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Health and Human Services
National Institutes of Health (Z99 DA999999)
National Institute on Aging
National Institute of Mental Health
National Institute on Drug Abuse (ZIADA000587)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: orbitofrontal cortex, neuropsychiatric disorders, cognitive neuroscience
MeSH terms: Animals, Brain Mapping, Decision Making, Emotions, Humans, Inhibition, Psychological, Judgment, Learning, Models, Neurological, Models, Psychological, Primates, Reward, Prefrontal Cortex, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

What the orbitofrontal cortex does not do

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks