Cited by 531Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

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What the orbitofrontal cortex does not do

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Stalnaker, Thomas A, Cooch, Nisha K, Schoenbaum, Geoffrey·2015·Nature Neuroscience

DOI 10.1038/nn.3982PMC PMC5541252

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Abstract

The number of papers about the orbitofrontal cortex (OFC) has grown from 1 per month in 1987 to a current rate of over 50 per month. This publication stream has implicated the OFC in nearly every function known to cognitive neuroscience and in most neuropsychiatric diseases. However, new ideas about OFC function are typically based on limited data sets and often ignore or minimize competing ideas or contradictory findings. Yet true progress in our understanding of an area's function comes as much from invalidating existing ideas as proposing new ones. Here we consider the proposed roles for OFC, critically examining the level of support for these claims and highlighting the data that call them into question.

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See all 531

Authors: Stalnaker, T. A., Cooch, N. K., & Schoenbaum, G.
Affiliations: National Institutes of Health (US)
Corresponding author: Schoenbaum, Geoffrey
ORCID: Stalnaker, Thomas A
Cooch, Nisha K
Schoenbaum, Geoffrey
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2015-04-28
Volume: 18
Issue: 5
Pages: 620-627
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.3982
PMC: PMC5541252
OpenAlex: W2020689320
Cited by: 531
References: 147
Citations by year: 2026: 15 · 2025: 41 · 2024: 45 · 2023: 34 · 2022: 45 · 2021: 59 · 2020: 77 · 2019: 55 · 2018: 60 · 2017: 33 · 2016: 50 · 2015: 16
FWCI: 5.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Health and Human Services
National Institutes of Health (Z99 DA999999)
National Institute on Aging
National Institute of Mental Health
National Institute on Drug Abuse (ZIADA000587)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: orbitofrontal cortex, neuropsychiatric disorders, cognitive neuroscience
MeSH terms: Animals, Brain Mapping, Decision Making, Emotions, Humans, Inhibition, Psychological, Judgment, Learning, Models, Neurological, Models, Psychological, Primates, Reward, Prefrontal Cortex, Rats

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