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Cited by 89Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Radial glial cells in the adult dentate gyrus: what are they and where do they come from?

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Berg, Daniel A., Bond, Allison M., Ming, Guo-li, Song, Hongjun·2018·F1000Research
DOI 10.12688/f1000research.12684.1PMC PMC5840617
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Abstract

Adult neurogenesis occurs in the dentate gyrus in the mammalian hippocampus. These new neurons arise from neural precursor cells named radial glia-like cells, which are situated in the subgranular zone of the dentate gyrus. Here, we review the emerging topic of precursor heterogeneity in the adult subgranular zone. We also discuss how this heterogeneity may be established during development and focus on the embryonic origin of the dentate gyrus and radial glia-like stem cells. Finally, we discuss recently developed single-cell techniques, which we believe will be critical to comprehensively investigate adult neural stem cell origin and heterogeneity.

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  • The process by which newly generated neurons in normal development are incorporated into the granular cell layer is well established and involves expression of specific markers and development of defined neuronal morphology.

    “The process by which newly generated neurons in normal development are incorporated into the granular cell layer is well established and involves expression of specific markers and development of defined neuronal morphology24,26,34,35.”

    From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [26]

    The ‘Classic homogeneous radial glia-like cell population model’ section describes adult-born neuroblasts expressing DCX, developing a bipolar shape, migrating into the granule cell layer, and maturing into Prox1-positive neurons. The ‘Origin of adult neural stem cells’ section describes markers during embryonic development, but does not establish the same marker-and-morphology sequence for neurons incorporated during normal development. The claim blends the paper’s adult neurogenesis account with its developmental account. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Radial glial cells, stem cell precursors, and astrocytes all express GFAP and are found in the dentate gyrus.

    “Radial glial cells, stem cell precursors, and astrocytes - all reported to express GFAP (reviewed in ref.26) - are found in the dentate gyrus2,27,28.”

    From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [26]

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Cited by

Sorted by citations

Authors
Berg, D. A., Bond, A. M., Ming, G.-L., & Song, H.
Affiliations
University of Pennsylvania (US)
Corresponding author
Song, Hongjun
ORCID
Venue
F1000Research
Publisher
F1000 Research Ltd
Published
2018-03-05
Volume
7
Pages
277
ISSN
2046-1402 (ISSN-L)
DOI
10.12688/f1000research.12684.1
PMC
PMC5840617
OpenAlex
W2794183473
Cited by
89
References
12
Citations by year
2026: 2 · 2025: 9 · 2024: 8 · 2023: 9 · 2022: 12 · 2021: 11 · 2020: 16 · 2019: 14 · 2018: 8
FWCI
1.54
Type
journal article
Language
en
Open access
Licence
Locations
  • F1000Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (R35NS097370, R37NS047344)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
radial glia, adult neurogenesis, dentate gyrus, hippocampus, subgranular zone, neural progenitor cells, embryonic origin, neural stem cells, single-cell analysis

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