The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Hypothalamic sensing of fatty acids
Abstract
Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Free fatty acid sensing by the hypothalamus is a well-established modulator of neuronal activity57, affecting peripheral metabolism58–60”
From IDOL regulates systemic energy balance through control of neuronal VLDLR expression (2019) · cites this paper as [59]
In the citing paper
“However, basal levels of FAO enzymes and FA transport proteins (such as FATP-1, FATP-4, and FAT/CD36) are expressed in hypothalamic neurons ([93](#B93), [95](#B95)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [93]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117
Environmental Contributions to the Obesity Epidemic
Hill, J. O., & Peters, J. C. (1998) · Science · doi:10.1126/science.280.5368.1371 · Cited by 2,258
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235
Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature · doi:10.1038/nature02440 · Cited by 1,637
Cholecystokinin decreases food intake in rats.
Gibbs, J., Young, R. C., & Smith, G. P. (1973) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0034870 · Cited by 1,502
Identification of targets of leptin action in rat hypothalamus.
Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,499
The role of depot fat in the hypothalamic control of food intake in the rat
Gc, K. (1953) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1953.0009 · Cited by 1,432
Flagged first, then by citations
Research works printed but not linked: 1
- Thupari, J.N., Landree, L.E., Ronnett, G.V. & Kuhajda, F.P. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc. Natl. Acad. Sci. USA 99, 9498–9502 (2002). · DOI
Cited by
Sorted by citations
Polyunsaturated fatty acids and their metabolites in brain function and disease
Bazinet, R. P., & Layé, S. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3820 · Cited by 1,703
Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity
Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell · doi:10.1016/j.cell.2008.07.043 · Cited by 1,350
Hypothalamic mTOR Signaling Regulates Food Intake
Cota, D., Proulx, K., Smith, K. A. B., Kozma, S. C., Thomas, G., Woods, S. C., & Seeley, R. J. (2006) · Science · doi:10.1126/science.1124147 · Cited by 1,278
Circadian rhythms, sleep, and metabolism
Huang, W., Ramsey, K. M., Marcheva, B., & Bass, J. T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46043 · Cited by 749
UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals
Andrews, Z. B., Liu, Z.-W., Walllingford, N., Erion, D. M., Borok, E., Friedman, J. M., Tschöp, M. H., Shanabrough, M., Cline, G., Shulman, G. I., et al. (2008) · Nature · doi:10.1038/nature07181 · Cited by 710
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
López, M., Varela, L., Vazquez, M. J., Rodríguez‐Cuenca, S., González, C. R., Velagapudi, V., Morgan, D. A., Schoenmakers, E., Agassandian, K., Lage, R., et al. (2010) · Nature Medicine · doi:10.1038/nm.2207 · Cited by 686
Allen, M. S., Bradford, B. J., & Oba, M. (2009) · Journal of Animal Science · doi:10.2527/jas.2009-1779 · Cited by 674
Valdearcos, M., Robblee, M. M., Benjamin, D. I., Nomura, D. K., Xu, A. W., & Koliwad, S. K. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.018 · Cited by 629
Molecular and anatomical determinants of central leptin resistance
Münzberg, H., & Myers, M. G. (2005) · Nature Neuroscience · doi:10.1038/nn1454 · Cited by 550
Regulation of lipid stores and metabolism by lipophagy
Liu, K., & Czaja, M. J. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2012.63 · Cited by 542
Lipophagy: Connecting Autophagy and Lipid Metabolism
Singh, R., & Cuervo, A. M. (2012) · International Journal of Cell Biology · doi:10.1155/2012/282041 · Cited by 497
Diabetes and the Brain: Oxidative Stress, Inflammation, and Autophagy
Muriach, M., Flores‐Bellver, M., Romero, F. J., & Barcia, J. M. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/102158 · Cited by 495
Genetic links between diet and lifespan: shared mechanisms from yeast to humans
Bishop, N. A., & Guarente, L. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2188 · Cited by 426
The central melanocortin system directly controls peripheral lipid metabolism
Nogueiras, R., Wiedmer, P., Perez-Tilve, D., Veyrat-Durebex, C., Keogh, J. M., Sutton, G. M., Pfluger, P. T., Castaneda, T. R., Neschen, S., Hofmann, S. M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31743 · Cited by 396
An evolutionary perspective on immunometabolism
Wang, A., Luan, H. H., & Medzhitov, R. M. (2019) · Science · doi:10.1126/science.aar3932 · Cited by 398
Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance
Kaushik, S., Rodriguez-Navarro, J. A., Arias, E., Kiffin, R., Sahu, S., Schwartz, G. J., Cuervo, A. M., & Singh, R. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.008 · Cited by 382
Self-citationNeurobiology of Feeding and Energy Expenditure
Gao, Q., & Horvath, T. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094324 · Cited by 346
Glycerolipid Metabolism and Signaling in Health and Disease
Prentki, M., & Madiraju, S. R. M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0007 · Cited by 331
The Homeostatic Force of Ghrelin
Yanagi, S., Sato, T., Kangawa, K., & Nakazato, M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.008 · Cited by 332
AMPK: Lessons from transgenic and knockout animals
Viollet, B. (2009) · Frontiers in bioscience · doi:10.2741/3229 · Cited by 314
Hyperleptinemia Is Required for the Development of Leptin Resistance
Knight, Z. A., Hannan, K. S., Greenberg, M. L., & Friedman, J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011376 · Cited by 311
Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice
Ishimoto, T., Lanaspa, M. A., Le, M. T., García, G., Diggle, C. P., MacLean, P. S., Jackman, M. R., Asipu, A., Roncal-Jiménez, C. A., Kosugi, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119908109 · Cited by 308
Cross-Talk between AMPK and mTOR in Regulating Energy Balance
Xu, J., Ji, J., & Yan, X. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.500245 · Cited by 312
Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production
Wang, P. Y. T., Caspi, L., Lam, C., Chari, M., Li, X., Light, P. E., Juárez, R. G., Ang, M. L. T., Schwartz, G. J., & Lam, T. K. T. (2008) · Nature · doi:10.1038/nature06852 · Cited by 297
Self-citationThe Pathogenesis of Obesity-Associated Adipose Tissue Inflammation
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_9 · Cited by 299
Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding
Dietrich, M. O., Zimmer, M. R., Bober, J., & Horváth, T. L. (2015) · Cell · doi:10.1016/j.cell.2015.02.024 · Cited by 271
Pancreatic signals controlling food intake; insulin, glucagon and amylin
Woods, S. C., Lutz, T. A., Geary, N., & Langhans, W. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1858 · Cited by 301
Mechanisms Regulating Feed Intake, Energy Expenditure, and Body Weight in Poultry
Richards, M. P., & Proszkowiec‐Weglarz, M. (2007) · Poultry Science · doi:10.1093/ps/86.7.1478 · Cited by 275
Lipid Processing in the Brain: A Key Regulator of Systemic Metabolism
Bruce, K. D., Zsombok, A., & Eckel, R. H. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00060 · Cited by 279
Rizki, G., Arnaboldi, L., Gabrielli, B., Yan, J. S., Lee, G. S., Ng, R. K., Turner, S., Badger, T. M., Pitas, R. E., & Maher, J. J. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600198-jlr200 · Cited by 265
Neuroinflammation and neurodegeneration in overnutrition-induced diseases
Cai, D. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2012.11.003 · Cited by 256
Taste of Fat: A Sixth Taste Modality?
Besnard, P., Passilly‐Degrace, P., & Khan, N. A. (2016) · Physiological Reviews · doi:10.1152/physrev.00002.2015 · Cited by 269
Mitochondrial fatty acid oxidation in obesity
Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246
Blouet, C., Jo, Y., Li, X., & Schwartz, G. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1668-09.2009 · Cited by 256
Self-citationObesity and adipokines: effects on sympathetic overactivity
Smith, M. M., & Minson, C. T. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.221036 · Cited by 245
Regulation of Pancreatic β Cell Mass by Neuronal Signals from the Liver
Imai, J., Katagiri, H., Yamada, T., Ishigaki, Y., Suzuki, T., Kudo, H., Uno, K., Hasegawa, Y., Gao, J., Kaneko, K., et al. (2008) · Science · doi:10.1126/science.1163971 · Cited by 235
Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress Regulate Energy Balance
Contreras, C., González‐García, I., Martínez‐Sánchez, N., Seoane‐Collazo, P., Jacas, J., Morgan, D. A., Serra, D., Gallego, R., González, F., Casals, N., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.057 · Cited by 244
Molecular disruption of hypothalamic nutrient sensing induces obesity
He, W., Lam, T. K. T., Obici, S., & Rossetti, L. (2006) · Nature Neuroscience · doi:10.1038/nn1626 · Cited by 233
Self-citationDevelopment and Function of the Blood-Brain Barrier in the Context of Metabolic Control
Haddad-Tóvolli, R., Dragano, N. R. V., Ramalho, A. F. S., & Velloso, L. A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00224 · Cited by 226
Hypothalamic control of energy balance: insights into the role of synaptic plasticity
Dietrich, M. O., & Horvath, T. L. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.12.005 · Cited by 227
Fatty Acids in Energy Metabolism of the Central Nervous System
Panov, A., Orynbayeva, Z., Vavilin, V., & Lyakhovich, V. (2014) · BioMed Research International · doi:10.1155/2014/472459 · Cited by 227
Protein-Mediated Fatty Acid Uptake: Novel Insights from In Vivo Models
Doege, H., & Stahl, A. (2006) · Physiology · doi:10.1152/physiol.00014.2006 · Cited by 235
Obesity-Related Metabolic Syndrome: Mechanisms of Sympathetic Overactivity
Canale, M. P., di Villahermosa, S. M., Martino, G., Rovella, V., Noce, A., LORENZO, A. D., & Daniele, N. D. (2013) · International Journal of Endocrinology · doi:10.1155/2013/865965 · Cited by 224
Ghrelin: a hormone regulating food intake and energy homeostasis
Gil‐Campos, M., Aguilera, C. M., Cañete, R., & Gil, Á. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061787 · Cited by 218
Metabolic syndrome as a risk factor for neurological disorders
Farooqui, A. A., Farooqui, T., Panza, F., & Frisardi, V. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0840-1 · Cited by 213
Differential Accessibility of Circulating Leptin to Individual Hypothalamic Sites
Faouzi, M., Leshan, R. L., Björnholm, M., Hennessey, T., Jones, J. C., & Münzberg, H. (2007) · Endocrinology · doi:10.1210/en.2007-0655 · Cited by 212
Increased Brain Fatty Acid Uptake in Metabolic Syndrome
Karmi, A., Iozzo, P., Viljanen, A. P. M., Hirvonen, J., Fielding, B. A., Virtanen, K. A., Oikonen, V., Kemppainen, J., Viljanen, T., Guiducci, L., et al. (2010) · Diabetes · doi:10.2337/db09-0138 · Cited by 204
Serotonin Regulates C. elegans Fat and Feeding through Independent Molecular Mechanisms
Srinivasan, S., Sadegh, L., Elle, I. C., Christensen, A. G. L., Færgeman, N. J., & Ashrafi, K. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.012 · Cited by 205
Obesity and the regulation of fat metabolism
Ashrafi, K. (2007) · WormBook · doi:10.1895/wormbook.1.130.1 · Cited by 211
Brain insulin, energy and glucose homeostasis; genes, environment and metabolic pathologies
Gerozissis, K. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.050 · Cited by 204
The regulation of food intake by the gut-brain axis: implications for obesity
Hussain, S., & Bloom, S. R. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.93 · Cited by 204
Rojas-Gutierrez, E., Muñoz‐Arenas, G., Treviño, S., Espinosa, B., Chávez, R., Rojas, K., Flores, G., Díaz, A., & Guevara, J. (2017) · Synapse · doi:10.1002/syn.21990 · Cited by 205
Inflammatory cause of metabolic syndrome via brain stress and NF-κB
Cai, D., & Liu, T. (2012) · Aging · doi:10.18632/aging.100431 · Cited by 192
Forkhead Transcription Factor FoxO1 in Adipose Tissue Regulates Energy Storage and Expenditure
Nakae, J., Cao, Y., Oki, M., Orba, Y., Sawa, H., Kiyonari, H., Iskandar, K., Suga, K., Lombès, M., & Hayashi, Y. (2007) · Diabetes · doi:10.2337/db07-0698 · Cited by 189
A Model for Fatty Acid Transport into the Brain
Hamilton, J. A., & Brunaldi, K. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-0050-3 · Cited by 176
Doege, H., Grimm, D., Falcon, A., Tsang, B., Storm, T. A., Xu, H., Ortegon, A. M., Kazantzis, M., Kay, M. A., & Stahl, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803510200 · Cited by 171
Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids
Karnani, M., Apergis‐Schoute, J., Adamantidis, A., Jensen, L. T., de Lecea, L., Fugger, L. H., & Burdakov, D. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.027 · Cited by 171
Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans
Jauch‐Chara, K., Friedrich, A., Rezmer, M., Melchert, U. H., Scholand-Engler, H. G., Hallschmid, M., & Oltmanns, K. M. (2012) · Diabetes · doi:10.2337/db12-0025 · Cited by 163
Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis
Jordan, S. D., Könner, A. C., & Brüning, J. C. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0414-7 · Cited by 172
Hypothalamic inflammation: a double‐edged sword to nutritional diseases
Cai, D., & Liu, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06388.x · Cited by 162
Characteristics and mechanisms of hypothalamic neuronal fatty acid sensing
Le Foll, C., Irani, B. G., Magnan, C., Dunn-Meynell, A. A., & Levin, B. E. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00223.2009 · Cited by 159
Fuel utilization by hypothalamic neurons: roles for ROS
Horváth, T. L., Andrews, Z. B., & Diano, S. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.10.003 · Cited by 165
Neuronal control of energy homeostasis
Gao, Q., & Horváth, T. L. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.063 · Cited by 160
Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins
Lam, T. K. T., Juárez, R. G., Pocai, A., Bhanot, S., Tso, P., Schwartz, G. J., & Rossetti, L. (2007) · Nature Medicine · doi:10.1038/nm1540 · Cited by 153
Self-citationLópez, M., Lelliott, C. J., Tovar, S. A., Kimber, W. L., Gallego, R., Virtue, S., Blount, M., Vazquez, M. J., Finer, N., Powles, T. J., et al. (2006) · Diabetes · doi:10.2337/db05-1356 · Cited by 151
Hypothalamic dysfunction in obesity
Williams, L. M. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s002966511200078x · Cited by 148
Neuroinflammatory basis of metabolic syndrome
Purkayastha, S., & Cai, D. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.09.005 · Cited by 150
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms
Pinkosky, S. L., Scott, J. W., Desjardins, E. M., Smith, B. K., Day, E. A., Ford, R. J., Langendorf, C. G., Ling, N. X. Y., Nero, T. L., Loh, K., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0245-2 · Cited by 145
Hypothalamic fatty acid metabolism: A housekeeping pathway that regulates food intake
López, M., Lelliott, C. J., & Vidal‐Puig, A. (2007) · BioEssays · doi:10.1002/bies.20539 · Cited by 150
Simopoulos, A. P. (2013) · Nutrients · doi:10.3390/nu5082901 · Cited by 146
Molecular physiology of weight regulation in mice and humans
Leibel, R. L. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.245 · Cited by 120
Stoll, E. A., Makin, R., Sweet, I. R., Trevelyan, A. J., Miwa, S., Horner, P. J., & Turnbull, D. M. (2015) · Stem Cells · doi:10.1002/stem.2042 · Cited by 144
Diurnal Regulation of Lipid Metabolism and Applications of Circadian Lipidomics
Gooley, J. J., & Chua, E. C.-P. (2014) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2014.04.001 · Cited by 140
Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system
Nakamoto, K., Nishinaka, T., Matsumoto, K., Kasuya, F., Mankura, M., Kōyama, Y., & Tokuyama, S. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.012 · Cited by 133
A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling
Vagena, E., Ryu, J. K., Baeza-Raja, B., Walsh, N. M., Syme, C. A., Day, J. P., Houslay, M. D., & Baillie, G. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0470-1 · Cited by 138
Genetic and epigenetic control of metabolic health
Schwenk, R. W., Vogel, H., & Schürmann, A. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.09.002 · Cited by 135
Regulation of hypothalamic malonyl-CoA by central glucose and leptin
Wolfgang, M. J., Cha, S. H., Sidhaye, A., Chohnan, S., Cline, G., Shulman, G. I., & Lane, M. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709778104 · Cited by 127
Role for Mitochondrial Reactive Oxygen Species in Brain Lipid Sensing
Bénani, A., Troy, S., Carmona, M. C., Fioramonti, X., Lorsignol, A., Leloup, C., Casteilla, L., & Pénicaud, L. (2006) · Diabetes · doi:10.2337/db06-0440 · Cited by 139
Appetite Regulation: An Overview
Dhillo, W. S. (2007) · Thyroid · doi:10.1089/thy.2007.0018 · Cited by 127
Hypothalamic CB1 Cannabinoid Receptors Regulate Energy Balance in Mice
Cardinal, P., Bellocchio, L., Clark, S., Cannich, A., Klugmann, M., Lutz, B., Marsicano, G., & Cota, D. (2012) · Endocrinology · doi:10.1210/en.2012-1405 · Cited by 123
The regulation of food intake in mammalian hibernators: a review
Florant, G. L., & Healy, J. E. (2011) · Journal of Comparative Physiology B · doi:10.1007/s00360-011-0630-y · Cited by 121
Integrative neurobiology of energy homeostasis-neurocircuits, signals and mediators
Sánchez-Lasheras, C., Könner, A. C., & Brüning, J. C. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.08.002 · Cited by 127
From Malthus to motive: How the HPA axis engineers the phenotype, yoking needs to wants
Pecoraro, N. C., Dallman, M. F., Warne, J. P., Ginsberg, A. B., Laugero, K. D., la Fleur, S. E., Houshyar, H., Gómez-Oliver, F., Bhargava, A., & Akana, S. F. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.07.004 · Cited by 125
Hypothalamic resistin induces hepatic insulin resistance
Muse, E. D., Lam, T. K. T., Scherer, P. E., & Rossetti, L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30440 · Cited by 124
Self-citationThe Role of CNS Fuel Sensing in Energy and Glucose Regulation
Cota, D., Proulx, K., & Seeley, R. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.049 · Cited by 122
The role of the endocannabinoid system in the neuroendocrine regulation of energy balance
Bermúdez‐Silva, F. J., Cardinal, P., & Cota, D. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111408458 · Cited by 126
Hypothalamic Microglial Activation in Obesity: A Mini-Review
Mendes, N. F., Kim, Y., Velloso, L. A., & ARAUJO, E. P. D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00846 · Cited by 122
Vazquez, M. J., González, C. R., Varela, L., Lage, R., Tovar, S. A., Sangiao‐Alvarellos, S., Williams, L. M., Vidal‐Puig, A., Nogueiras, R., López, M., et al. (2008) · Endocrinology · doi:10.1210/en.2007-1708 · Cited by 118
The Role of Hypothalamic Malonyl-CoA in Energy Homeostasis
Wolfgang, M. J., & Lane, M. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600016200 · Cited by 115
Morita, S., & Miyata, S. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1421-9 · Cited by 121
Glucokinase activators in diabetes management
Coghlan, M. P., & Leighton, B. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.2.145 · Cited by 115
Tung, Y. L., Ma, M. K. L., Piper, S., Coll, A. P., O’Rahilly, S., & Yeo, G. S. H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3412-08.2008 · Cited by 111
Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome
Aguilera, C. M., Gil‐Campos, M., Cañete, R., & Gil, Á. (2008) · Clinical Science · doi:10.1042/cs20070115 · Cited by 112
Hypothalamic microinflammation: a common basis of metabolic syndrome and aging
Tang, Y., Purkayastha, S., & Cai, D. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.10.002 · Cited by 115
Köfalvi, A. (2007) · Springer eBooks · doi:10.1007/978-0-387-74349-3 · Cited by 110
Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes
Mountjoy, K. G. (2010) · Biochemical Journal · doi:10.1042/bj20091957 · Cited by 110
Dioxins, the aryl hydrocarbon receptor and the central regulation of energy balance
Lindén, J., Lensu, S., Tuomisto, J., & Pohjanvirta, R. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.07.002 · Cited by 108
Oleic Acid Directly Regulates POMC Neuron Excitability in the Hypothalamus
Jo, Y., Su, Y., Juárez, R. G., & Chua, S. C. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91294.2008 · Cited by 113
Hypothalamic Control of Lipid Metabolism: Focus on Leptin, Ghrelin and Melanocortins
Diéguez, C., Vazquez, M. J., Romero, A., López, M., & Nogueiras, R. (2011) · Neuroendocrinology · doi:10.1159/000328122 · Cited by 109
Kusunoki, J., Kanatani, A., & Moller, D. E. (2006) · Endocrine · doi:10.1385/endo:29:1:91 · Cited by 104
Metadata
- Authors
- Lam, T. K. T., Schwartz, G. J., & Rossetti, L.
- Affiliations
- Albert Einstein College of Medicine (US)
- Corresponding author
- Rossetti, Luciano
- Venue
- Nature Neuroscience
- Published
- 2005-04-26
- Volume
- 8
- Issue
- 5
- Pages
- 579-584
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W1977275538
- Cited by
- 478
- References
- 82
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 14 · 2023: 9 · 2022: 10 · 2021: 18 · 2020: 20 · 2019: 14 · 2018: 16 · 2017: 28 · 2016: 17 · 2015: 24 · 2014: 27 · 2013: 34 · 2012: 39
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (P01AG021654, AG 21654, T32AG023475)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-48321, DK-47208, R01DK047208, DK20541, DK-45024)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- hypothalamus, fatty acid sensing, fatty acid metabolism, nutrient availability, metabolic signaling, nutritional status, energy homeostasis, fuel availability
- MeSH terms
- Acyl Coenzyme A, Animals, Appetite Regulation, Energy Metabolism, Fatty Acids, Humans, Hypothalamus, Insulin Resistance, Obesity, Signal Transduction, Feedback, Physiological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
