Cited by 479Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesLipid metabolism and biosynthesis

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Hypothalamic sensing of fatty acids

Lam, Tony K T, Schwartz, Gary J, Rossetti, Luciano·2005·Nature Neuroscience

DOI 10.1038/nn1456

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Abstract

Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responses to changes in fuel availability. This review focuses on direct metabolic signaling within the hypothalamus. There is growing evidence supporting the idea that fatty acid metabolism within discrete hypothalamic regions can function as a sensor for nutrient availability that can integrate multiple nutritional and hormonal signals.

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Thupari, J.N., Landree, L.E., Ronnett, G.V. & Kuhajda, F.P. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc. Natl. Acad. Sci. USA 99, 9498–9502 (2002). · DOI

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Authors: Lam, T. K. T., Schwartz, G. J., & Rossetti, L.
Affiliations: Albert Einstein College of Medicine (US)
Corresponding author: Rossetti, Luciano
ORCID: Lam, Tony K T
Schwartz, Gary J
Rossetti, Luciano
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2005-04-26
Volume: 8
Issue: 5
Pages: 579-584
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1456
OpenAlex: W1977275538
Cited by: 478
References: 82
Citations by year: 2026: 6 · 2025: 9 · 2024: 14 · 2023: 9 · 2022: 10 · 2021: 18 · 2020: 20 · 2019: 14 · 2018: 16 · 2017: 28 · 2016: 17 · 2015: 24 · 2014: 27 · 2013: 34 · 2012: 39
FWCI: 3.33
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (P01AG021654, AG 21654, T32AG023475)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-48321, DK-47208, R01DK047208, DK20541, DK-45024)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: hypothalamus, fatty acid sensing, fatty acid metabolism, nutrient availability, metabolic signaling, nutritional status, energy homeostasis, fuel availability
MeSH terms: Acyl Coenzyme A, Animals, Appetite Regulation, Energy Metabolism, Fatty Acids, Humans, Hypothalamus, Insulin Resistance, Obesity, Signal Transduction, Feedback, Physiological

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Hypothalamic sensing of fatty acids

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