Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting

Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

Pinto, S., Roseberry, A. G., Liu, H., Diano, S., Shanabrough, M., Cai, X., Friedman, J. M., & Horvath, T. L. (2004) · Science · doi:10.1126/science.1089459 · Cited by 987 · cited 1×

Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex

Shepherd, G. M. G., Pologruto, T. A., & Svoboda, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00152-1 · Cited by 322

Central nervous system control of food intake and body weight

Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791

Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits

Chen, Y., Lin, Y.-C., Kuo, T.-W., & Knight, Z. A. (2015) · Cell · doi:10.1016/j.cell.2015.01.033 · Cited by 660

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

Krashes, M. J., Shah, B. P., Madara, J. C., Olson, D. P., Strochlic, D. E., Garfield, A. S., Vong, L., Pei, H., Watabe-Uchida, M., Uchida, N., et al. (2014) · Nature · doi:10.1038/nature12956 · Cited by 603

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

Gao, Q., Mezei, G., Nie, Y., Rao, Y., Choi, C. S., Bechmann, I., Leranth, C., Toran-Allerand, D., Priest, C. A., Roberts, J. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1525 · Cited by 416

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia

Tong, Q., Ye, C., McCrimmon, R. J., Dhillon, H., Choi, B., Kramer, M. D., Yu, J., Yang, Z., Christiansen, L. M., Lee, C. E., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.04.001 · Cited by 413

Leptin signaling and leptin resistance

Zhou, Y., & Rui, L. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0263-5 · Cited by 358

Neurobiology of Feeding and Energy Expenditure

Gao, Q., & Horvath, T. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094324 · Cited by 346

Leptin and the Central Nervous System Control of Glucose Metabolism

Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338

Gut Commensal E. coli Proteins Activate Host Satiety Pathways following Nutrient-Induced Bacterial Growth

Breton, J., Tennoune, N., Lucas, N., Francois, M., Legrand, R., Jacquemot, J., Goichon, A., Guérin, C., Peltier, J., Pestel-Caron, M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.017 · Cited by 321

Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity

Dietrich, M. O., Liu, Z.-W., & Horvath, T. L. (2013) · Cell · doi:10.1016/j.cell.2013.09.004 · Cited by 306

Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone

Liu, T., Kong, D., Shah, B. P., Ye, C., Koda, S., Saunders, A., Ding, J. B., Yang, Z., Sabatini, B. L., & Lowell, B. B. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.027 · Cited by 296

The lighter side of BDNF

Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00776.2010 · Cited by 284

Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons

Yang, S.-B., Tien, A.-C., Boddupalli, G., Xu, A. W., Jan, Y. N., & Jan, L. Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.043 · Cited by 242

Hypothalamic control of energy balance: insights into the role of synaptic plasticity

Dietrich, M. O., & Horvath, T. L. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.12.005 · Cited by 227

Circadian rhythms disrupted by light at night and mistimed food intake alter hormonal rhythms and metabolism

Meléndez-Fernández, O. H., Liu, J. A., & Nelson, R. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043392 · Cited by 227

Flavonoids as Antiobesity Agents: A Review

Rufino, A. T., Costa, V. M., Carvalho, F., & Fernandes, E. (2021) · Medicinal Research Reviews · doi:10.1002/med.21740 · Cited by 174

The physiological control of eating: signals, neurons, and networks

Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168

Brain regulation of energy balance and body weight

Rui, L. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9261-9 · Cited by 168

Hypothalamic inflammation and obesity: a mechanistic review

Seong, J., Kang, J. Y., Sun, J. S., & Kim, K. W. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01138-9 · Cited by 158

Synaptic plasticity in neuronal circuits regulating energy balance

Zeltser, L. M., Seeley, R. J., & Tschöp, M. H. (2012) · Nature Neuroscience · doi:10.1038/nn.3219 · Cited by 147

Conditional viral tracing reveals that steroidogenic factor 1-positive neurons of the dorsomedial subdivision of the ventromedial hypothalamus project to autonomic centers of the hypothalamus and hindbrain

Lindberg, D., Chen, P., & Li, C. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23338 · Cited by 125

Oxytocin and appetite

LENG, G., ONAKA, T., CAQUINEAU, C., SABATIER, N., TOBIN, V, & TAKAYANAGI, Y. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00413-5 · Cited by 112

Profiling of Glucose-Sensing Neurons Reveals that GHRH Neurons Are Activated by Hypoglycemia

Stanley, S., Domingos, A. I., Kelly, L., Garfield, A., Damanpour, S., Heisler, L., & Friedman, J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.002 · Cited by 110

AMPK and the neuroendocrine regulation of appetite and energy expenditure

Stark, R., Ashley, S. E., & Andrews, Z. B. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.012 · Cited by 94

Near-Perfect Synaptic Integration by Na v 1.7 in Hypothalamic Neurons Regulates Body Weight

Branco, T., Tozer, A., Magnus, C. J., Sugino, K., Tanaka, S., Lee, A. K., Wood, J. N., & Sternson, S. M. (2016) · Cell · doi:10.1016/j.cell.2016.05.019 · Cited by 89

Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis

Ameroso, D., Meng, A., Chen, S., Felsted, J., Dulla, C. G., & Rios, M. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00566-0 · Cited by 67

LRb signals act within a distributed network of leptin‐responsive neurones to mediate leptin action

Leinninger, G. M., & Myers, M. G. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01784.x · Cited by 56

Brain control of energy homeostasis: implications for anti-obesity pharmacotherapy

Johansen, V. B. I., Petersen, J., Lund, J., Mathiesen, C. V., Fenselau, H., & Clemmensen, C. (2025) · Cell · doi:10.1016/j.cell.2025.06.010 · Cited by 53

Hypothalamic primary cilium: A hub for metabolic homeostasis

Yang, D. J., Hong, J., & Kim, K. W. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00644-5 · Cited by 34

Regulation of synaptic functions in central nervous system by endocrine hormones and the maintenance of energy homoeostasis

Pang, Z. P., & Han, W. (2012) · Bioscience Reports · doi:10.1042/bsr20120026 · Cited by 34

Effects of direct QRFP-26 administration into the medial hypothalamic area on food intake in rats

Zagorácz, O., Kovács, A., László, K., Ollmann, T., Péczely, L., & Lénárd, L. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.09.004 · Cited by 20