REM sleep reorganizes hippocampal excitability
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SUMMARY Sleep is composed of an alternating sequence of REM and non-REM episodes, but their respective roles are not known. We found that the overall firing rates of hippocampal CA1 neurons decreased across sleep concurrent with an increase in the recruitment of neuronal spiking to brief “ripple” episodes, resulting in a net increase in neural synchrony. Unexpectedly, within non-REM episodes, overall firing rates gradually increased together with a decrease in the recruitment of spiking to ripples. The rate increase within non-REM episodes was counteracted by a larger and more rapid decrease of discharge frequency within the interleaved REM episodes. Both the decrease in firing rates and the increase in synchrony during the course of sleep were correlated with the power of theta activity during REM episodes. These findings assign a prominent role of REM sleep in sleep-related neuronal plasticity.
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Cortical and hippocampal neuronal activity showed more robust decreases across periods of REM sleep than SWS.
“Moreover, cortical and hippocampal neuronal activity showed more robust decreases across periods of REM sleep than SWS.166,232”
From Sleep—A brain-state serving systems memory consolidation (2023) · cites this paper as [232]
The Results report that hippocampal firing rates decreased during REM episodes but increased during non-REM episodes. The Discussion says it remains unknown whether these CA1 findings extend to other cortical regions, so the claim’s cortical component is not supported by this paper. (LLM, conf=0.90)
Experimental — accuracy not yet measuredBrain activation during intervening REM sleep periods might contribute to overall downscaling of neuronal firing rates observed across sleep.
“In fact, a recent study showed that brain activation during intervening REM sleep periods might contribute to an overall downscaling of neuronal firing rates observed across sleep (485).”
From About Sleep's Role in Memory (2013) · cites this paper as [485]
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Self-citation
- Authors
- Grosmark, A. D., Mizuseki, K., Pastalkova, E., Diba, K., & Buzsáki, G.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Buzsáki, György
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 75
- Issue
- 6
- Pages
- 1001-1007
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3608095
- OpenAlex
- W1973294321
- Semantic Scholar
- 2dd8dab084947dd7a597f942e3d9260c4c157224
- Cited by
- 344
- References
- 47
- Citations by year
- 2026: 20 · 2025: 19 · 2024: 20 · 2023: 21 · 2022: 24 · 2021: 32 · 2020: 17 · 2019: 51 · 2018: 18 · 2017: 32 · 2016: 19 · 2015: 23 · 2014: 20 · 2013: 26 · 2012: 2
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH054671, MH54671)
- National Institute of General Medical Sciences (R25GM096161)
- National Institute of Neurological Disorders and Stroke (R01NS034994, NS-34994)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- REM sleep, CA1 pyramidal neurons, neuronal firing rate, neuronal synchronization, theta oscillations, NREM sleep, hippocampal excitability
- MeSH terms
- Action Potentials, Animals, Electric Stimulation, Male, Neurons, Sleep Stages, Sleep, REM, Spectrum Analysis, Theta Rhythm, Time Factors, Wakefulness, Long-Term Potentiation, Patch-Clamp Techniques, Rats, CA1 Region, Hippocampal
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