Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men

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Untitled work

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Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

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Central nervous insulin resistance: a promising target in the treatment of metabolic and cognitive disorders?

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Comparable Sensitivity of Postmenopausal and Young Women to the Effects of Intranasal Insulin on Food Intake and Working Memory

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Transcortical Direct Current Potential Shift Reflects Immediate Signaling of Systemic Insulin to the Human Brain

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Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

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Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans

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Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

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Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

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Intranasal Treatment of Central Nervous System Dysfunction in Humans

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The brain as an insulin-sensitive metabolic organ

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Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors

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Neuronal control of peripheral insulin sensitivity and glucose metabolism

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Impaired insulin action in the human brain: causes and metabolic consequences

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Central nervous pathways of insulin action in the control of metabolism and food intake

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Intranasal delivery of systemic-acting drugs: Small-molecules and biomacromolecules

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Brain insulin signalling in metabolic homeostasis and disease

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Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women

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Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

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Brain Insulin Signaling and Alzheimer's Disease: Current Evidence and Future Directions

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Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men

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Strategies To Deliver Peptide Drugs to the Brain

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Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism

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Brain insulin sensitivity is linked to adiposity and body fat distribution

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Insulin, Aging, and the Brain: Mechanisms and Implications

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Direct and indirect control of hepatic glucose production by insulin

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Obesity – A neuropsychological disease? Systematic review and neuropsychological model

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Thyroid Hormone Signaling and Homeostasis During Aging

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Intranasal insulin

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Insulin translates unfavourable lifestyle into obesity

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Safety of intranasal human insulin: A review

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Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions

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Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation

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Brain energy metabolism: A roadmap for future research

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Effects of intranasal hypocretin-1 (orexin A) on sleep in narcolepsy with cataplexy

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Intranasal insulin in Alzheimer's disease: Food for thought

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Hypothalamic Control of Systemic Glucose Homeostasis: The Pancreas Connection

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Hypothalamic Insulin Resistance in Obesity: Effects on Glucose Homeostasis

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Insulin Resistance as a Therapeutic Target in the Treatment of Alzheimer's Disease: A State-of-the-Art Review

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Intranasal Insulin Improves Age-Related Cognitive Deficits and Reverses Electrophysiological Correlates of Brain Aging

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Metabolic Dysfunction in Alzheimer’s Disease: From Basic Neurobiology to Clinical Approaches

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Regulation of Macronutrients in Insulin Resistance and Glucose Homeostasis during Type 2 Diabetes Mellitus

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Effects of Intranasal Insulin on Hepatic Fat Accumulation and Energy Metabolism in Humans

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GLP-1 receptor agonists show neuroprotective effects in animal models of diabetes

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Dose-Dependent Effects of Intranasal Insulin on Resting-State Brain Activity

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Insulin action in the brain: Roles in energy and glucose homeostasis

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Costs and benefits of group living in primates: an energetic perspective

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Central Insulin Administration Improves Odor-Cued Reactivation of Spatial Memory in Young Men

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Brain glucose metabolism in health, obesity, and cognitive decline-does insulin have anything to do with it? A narrative review

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The insulin resistant brain: impact on whole-body metabolism and body fat distribution

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Central Regulation of Glucose Homeostasis

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Intranasal Insulin Suppresses Systemic but Not Subcutaneous Lipolysis in Healthy Humans

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Intranasal Insulin Reduces Olfactory Sensitivity in Normosmic Humans

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Evidence for Central Regulation of Glucose Metabolism

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Single‐cell transcriptomics and functional target validation of brown adipocytes show their complex roles in metabolic homeostasis

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Effect of intranasally administered insulin on cerebral blood flow and perfusion; a randomized experiment in young and older adults

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Central actions of insulin during pregnancy and lactation

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Central Insulin Modulates Dopamine Signaling in the Human Striatum

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Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles

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Hypothalamic Estrogen Signaling and Adipose Tissue Metabolism in Energy Homeostasis

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Maternal insulin sensitivity is associated with oral glucose-induced changes in fetal brain activity

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Homeostatic Regulation of Glucose Metabolism by the Central Nervous System

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Neural circuits of long-term thermoregulatory adaptations to cold temperatures and metabolic demands

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Baseline Sympathetic Nervous System Activity Predicts Dietary Weight Loss in Obese Metabolic Syndrome Subjects

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Effects of Intranasal Insulin Administration on Cerebral Blood Flow and Cognitive Performance in Adults: A Systematic Review of Randomized, Placebo-Controlled Intervention Studies

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Central Nervous Insulin Signaling in Sleep-Associated Memory Formation and Neuroendocrine Regulation

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Outcomes and clinical implications of intranasal insulin administration to the central nervous system

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Formulation strategies for nose-to-brain delivery of therapeutic molecules

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Intranasal Neuropeptide Administration To Target the Human Brain in Health and Disease

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Central Nervous Insulin Administration Does Not Potentiate the Acute Glucoregulatory Impact of Concurrent Mild Hyperinsulinemia

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Awake, long-term intranasal insulin treatment does not affect object memory, odor discrimination, or reversal learning in mice

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Unconditioned and conditioned effects of intranasally administered insulin vs placebo in healthy men: a randomised controlled trial

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Hypothalamic insulin responsiveness is associated with pancreatic insulin secretion in humans

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A Glimpse into Milestones of Insulin Resistance and an Updated Review of Its Management

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Intranasal delivery of mitochondria targeted neuroprotective compounds for traumatic brain injury: screening based on pharmacological and physiological properties

Pandya, J. D., Musyaju, S., Modi, H. R., Okada-Rising, S. L., Bailey, Z. S., Scultetus, A. H., & Shear, D. A. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04908-2 · Cited by 27 · see citing works

Insulin on the brain: The role of central insulin signalling in energy and glucose homeostasis

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Central KATP Channels Modulate Glucose Effectiveness in Humans and Rodents

Carey, M., Lontchi‐Yimagou, E., Mitchell, W. G., Reda, S. A., Zhang, K., Kehlenbrink, S., Koppaka, S., Maginley, S. R., Aleksić, S., Bhansali, S., et al. (2020) · Diabetes · doi:10.2337/db19-1256 · Cited by 25 · see citing works

Insulin sensing by astrocytes is critical for normal thermogenesis and body temperature regulation

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Brain insulin resistance mediated cognitive impairment and neurodegeneration: Type-3 diabetes or Alzheimer’s Disease

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Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent

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A mathematical model of potassium homeostasis: Effect of feedforward and feedback controls

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Chronic Intranasal Insulin Does Not Affect Hepatic Lipids but Lowers Circulating BCAAs in Healthy Male Subjects

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Is Brain Insulin Action Relevant to the Control of Plasma Glucose in Humans?

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In Vivo Changes in Central and Peripheral Insulin Sensitivity in a Large Animal Model of Obesity

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Insulin and Estrogen Independently and Differentially Reduce Macronutrient Intake in Healthy Men

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Odor Sensitivity After Intranasal Insulin Application Is Modulated by Gender

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Insights into Manipulating Postprandial Energy Expenditure to Manage Weight Gain in Polycystic Ovary Syndrome

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Metabolic neuroimaging of the brain in diabetes mellitus and hypoglycaemia

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Comparison of consumption behavior and appetite sensations among patients with type 2 diabetes mellitus after bariatric surgery

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Brain Insulin and Leptin Signaling in Metabolic Control

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Nose as a Route for Drug Delivery

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Regulation of Metabolic Health by an “Olfactory-Hypothalamic Axis” and Its Possible Implications for the Development of Therapeutic Approaches for Obesity and T2D

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Intranasal Insulin Boosts Gustatory Sensitivity

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Repurposing GLP1 agonists for neurodegenerative diseases

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Duodenal-Jejunal Bypass Ameliorates Type 2 Diabetes Mellitus by Activating Insulin Signaling and Improving Glucose Utilization in the Brain

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Diet induced thermogenesis, older and newer data with emphasis on obesity and diabetes mellitus - A narrative review

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Hindbrain insulin controls feeding behavior

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Molecular mechanisms underlying obesity-induced memory dysfunction: a comprehensive narrative review

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Central Regulation of Glucose Homeostasis

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Von der Nase ins Gehirn

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Influence of intranasally administered insulin on metabolic and hormonal parameters in adult male rats, impaired due to three-day fasting in the early postnatal period

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Bacillus-produced surfactin for intranasal delivery of insulin in diabetic mice

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Pathway and Effect of Intranasal Orexin

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BRIEF REPORT Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men

Benedict, C., Brede, S., Schiöth, H. B., Lehnert, H., Schultes, B., Jan Born, A., & Hallschmid, M. (2013)

Intranasal Insulin Suppresses Food Intake via Enhancement of Brain Energy Levels in Humans

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Intranasal Insulin Suppresses Systemic but Not Subcutaneous Lipolysis in Healthy Humans

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Perceiving Your Appetite

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Central Nervous Insulin Administration before Nocturnal Sleep Decreases Breakfast Intake in Healthy Young and Elderly Subjects

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