Production and purification of lentiviral vectors

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., & Trono, D. (1996) · Science · doi:10.1126/science.272.5259.263 · Cited by 4,903

A Third-Generation Lentivirus Vector with a Conditional Packaging System

Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., & Naldini, L. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8463-8471.1998 · Cited by 3,341

Development of a self-inactivating lentivirus vector

Miyoshi, H., Blömer, U., Takahashi, M., Gage, F. H., & Verma, I. M. (1998) · Journal of Virology · doi:10.1128/jvi.72.10.8150-8157.1998 · Cited by 1,196

Quantitative assessment on the cloning efficiencies of lentiviral transfer vectors with a unique clone site

Zhang, G., & Tandon, A. (2012) · Scientific Reports · doi:10.1038/srep00415 · Cited by 1,012

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

DuPage, M., Dooley, A. L., & Jacks, T. (2009) · Nature Protocols · doi:10.1038/nprot.2009.95 · Cited by 894

Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132

Edbauer, D., Neilson, J. R., Foster, K. A., Wang, C.-F., Seeburg, D. P., Batterton, M. N., Tada, T., Dolan, B. M., Sharp, P. A., & Sheng, M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.005 · Cited by 735

Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats

Jessberger, S., Clark, R. E., Broadbent, N. J., Clemenson, G. D., Consiglio, A., Lie, D. C., Squire, L. R., & Gage, F. H. (2009) · Learning & Memory · doi:10.1101/lm.1172609 · Cited by 654

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.003 · Cited by 643

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases

Spencer, B., Potkar, R., Trejo, M., Rockenstein, E., Patrick, C., Gindi, R., Adame, A., Wyss-Coray, T., & Masliah, E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4390-09.2009 · Cited by 595

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

Gabel, H. W., Kinde, B., Stroud, H., Gilbert, C. S., Harmin, D. A., Kastan, N. R., Hemberg, M., Ebert, D. H., & Greenberg, M. E. (2015) · Nature · doi:10.1038/nature14319 · Cited by 569

Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor

Moon, E. K., Carpenito, C., Sun, J., Wang, L.-C. S., Kapoor, V., Predina, J., Powell, D. J., Riley, J. L., June, C. H., & Albelda, S. M. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0351 · Cited by 537

Reversible Disruption of mSWI/SNF (BAF) Complexes by the SS18-SSX Oncogenic Fusion in Synovial Sarcoma

Kadoch, C., & Crabtree, G. R. (2013) · Cell · doi:10.1016/j.cell.2013.02.036 · Cited by 484

MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease

Hu, S., Huang, M., Li, Z., Jia, F., Ghosh, Z., Lijkwan, M. A., Fasanaro, P., Sun, N., Wang, X., Martelli, F., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.928424 · Cited by 462

DNA Transposons: Nature and Applications in Genomics

Munoz-Lopez, M., & Garcia-Perez, J. (2010) · Current Genomics · doi:10.2174/138920210790886871 · Cited by 447

Dynamics and Memory of Heterochromatin in Living Cells

Hathaway, N. A., Bell, O., Hodges, C., Miller, E. L., Neel, D. S., & Crabtree, G. R. (2012) · Cell · doi:10.1016/j.cell.2012.03.052 · Cited by 446

CasX enzymes comprise a distinct family of RNA-guided genome editors

Liu, J.-J., Orlova, N., Oakes, B. L., Ma, E., Spinner, H. B., Baney, K. L. M., Chuck, J., Tan, D., Knott, G. J., Harrington, L. B., et al. (2019) · Nature · doi:10.1038/s41586-019-0908-x · Cited by 446

P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis

Yamakuchi, M., Lotterman, C. D., Bao, C., Hruban, R. H., Karim, B., Mendell, J. T., Huso, D., & Lowenstein, C. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911082107 · Cited by 430

Npas4 regulates excitatory-inhibitory balance within neural circuits through cell-type-specific gene programs

Spiegel, I., Mardinly, A. R., Gabel, H. W., Bazinet, J. E., Couch, C. H., Tzeng, C. P., Harmin, D. A., & Greenberg, M. E. (2014) · Cell · doi:10.1016/j.cell.2014.03.058 · Cited by 416

Autocrine VEGF–VEGFR2–Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth

Hamerlik, P., Lathia, J. D., Rasmussen, R., Wu, Q., Bartkova, J., Lee, M., Moudry, P., Bartek, J., Fischer, W., Lukas, J., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20111424 · Cited by 406

Synaptic Signaling by All-Trans Retinoic Acid in Homeostatic Synaptic Plasticity

Aoto, J., Nam, C. I., Poon, M. M., Ting, P., & Chen, L. (2008) · Neuron · doi:10.1016/j.neuron.2008.08.012 · Cited by 397

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

Mazur, P. K., Herner, A., Mello, S. S., Wirth, M., Hausmann, S., Sánchez-Rivera, F. J., Lofgren, S. M., Kuschma, T., Hahn, S. A., Vangala, D., et al. (2015) · Nature Medicine · doi:10.1038/nm.3952 · Cited by 397

MiR-26a Inhibits Cell Growth and Tumorigenesis of Nasopharyngeal Carcinoma through Repression of EZH2

Lu, J., He, M.-L., Wang, L., Chen, Y., Liu, X., Dong, Q., Chen, Y.-C., Peng, Y., Yao, K.-T., Kung, H.-F., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1850 · Cited by 381

Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes

Staahl, B. T., Benekareddy, M., Coulon-Bainier, C., Banfal, A. A., Floor, S. N., Sabo, J. K., Urnes, C., Munares, G. A., Ghosh, A., & Doudna, J. A. (2017) · Nature Biotechnology · doi:10.1038/nbt.3806 · Cited by 355

PKH26 labeling of extracellular vesicles: Characterization and cellular internalization of contaminating PKH26 nanoparticles

Pužar Dominkuš, P., Stenovec, M., Sitar, S., Lasič, E., Zorec, R., Plemenitaš, A., Žagar, E., Kreft, M., & Lenassi, M. (2018) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2018.03.013 · Cited by 357

MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity

Issler, O., Haramati, S., Paul, E. D., Maeno, H., Navon, I., Zwang, R., Gil, S., Mayberg, H. S., Dunlop, B. W., Menke, A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.042 · Cited by 318

Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1

Peng, S., Xiao, W., Ju, D., Sun, B., Hou, N., Liu, Q., Wang, Y., Zhao, H., Gao, C., Zhang, S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau7116 · Cited by 312

α-Synuclein Sequesters Dnmt1 from the Nucleus

Desplats, P., Spencer, B., Coffee, E., Patel, P., Michael, S., Patrick, C., Adame, A., Rockenstein, E., & Masliah, E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.c110.212589 · Cited by 305

A human microprotein that interacts with the mRNA decapping complex

D'Lima, N. G., Ma, J., Winkler, L., Chu, Q., Loh, K. H., Corpuz, E. O., Budnik, B. A., Lykke-Andersen, J., Saghatelian, A., & Slavoff, S. A. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2249 · Cited by 304

Production of lentiviral vectors

Merten, O.-W., Hebben, M., & Bovolenta, C. (2016) · Molecular Therapy - Methods & Clinical Development · doi:10.1038/mtm.2016.17 · Cited by 294

Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection

Beckwith, K. S., Beckwith, M. S., Ullmann, S., Sætra, R. S., Kim, H., Marstad, A., Åsberg, S. E., Strand, T. A., Haug, M., Niederweis, M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16143-6 · Cited by 282

Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, α-Synuclein Accumulation, and Neurotoxicity

Usenovic, M., Tresse, E., Mazzulli, J. R., Taylor, J. P., & Krainc, D. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5575-11.2012 · Cited by 291

Axonal transcription factors signal retrogradely in lesioned peripheral nerve

Ben‐Yaakov, K., Dagan, S. Y., Segal‐Ruder, Y., Shalem, O., Vuppalanchi, D., Willis, D. E., Yudin, D., Rishal, I., Rother, F., Bader, M., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.494 · Cited by 285

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a

Kosar, M., Bartkova, J., Hubackova, S., Hodny, Z., Lukas, J., & Bartek, J. (2011) · Cell Cycle · doi:10.4161/cc.10.3.14707 · Cited by 283

SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling

Palty, R., Raveh, A., Kaminsky, I., Meller, R., & Reuveny, E. (2012) · Cell · doi:10.1016/j.cell.2012.01.055 · Cited by 273

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

Minakaki, G., Menges, S., Kittel, A., Emmanouilidou, E., Schaeffner, I., Barkovits, K., Bergmann, A., Rockenstein, E., Adame, A., Marxreiter, F., et al. (2018) · Autophagy · doi:10.1080/15548627.2017.1395992 · Cited by 272

TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia

Lee, J.-W., Nam, H., Kim, L. E., Jeon, Y., Min, H., Ha, S., Lee, Y., Kim, S.-Y., Lee, S. J., Kim, E.-K., et al. (2019) · Autophagy · doi:10.1080/15548627.2018.1556946 · Cited by 260

Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo

Liu, Y., Miao, Q., Yuan, J., Han, S., Zhang, P., Li, S., Rao, Z., Zhao, W., Ye, Q., Geng, J., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3975-14.2015 · Cited by 259

microRNA as Repressors of Stress-Induced Anxiety: The Case of Amygdalar miR-34

Haramati, S., Navon, I., Issler, O., Ezra-Nevo, G., Gil, S., Zwang, R., Hornstein, E., & Chen, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1673-11.2011 · Cited by 252

CtIP Links DNA Double-Strand Break Sensing to Resection

You, Z., Shi, L. Z., Zhu, Q., Wu, P., Zhang, Y.-W., Basilio, A., Tonnu, N., Verma, I. M., Berns, M. W., & Hunter, T. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.12.002 · Cited by 231

Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons

Mardinly, A. R., Spiegel, I., Patrizi, A., Centofante, E., Bazinet, J. E., Tzeng, C. P., Mandel-Brehm, C., Harmin, D. A., Adesnik, H., Fagiolini, M., et al. (2016) · Nature · doi:10.1038/nature17187 · Cited by 176

Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits

Jung, S., Choe, S., Woo, H., Jeong, H., An, H.-K., Moon, H., Ryu, H. Y., Yeo, B. K., Lee, Y. W., Choi, H., et al. (2020) · Autophagy · doi:10.1080/15548627.2019.1630222 · Cited by 183

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

Wang, M., Li, A., Sekiya, M., Beckmann, N. D., Quan, X., Schrode, N., Fernando, M. B., Yu, A., Zhu, L., Cao, J., et al. (2021) · Neuron · doi:10.1016/j.neuron.2020.11.002 · Cited by 185

Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells

Ho, S.-M., Hartley, B. J., TCW, J., Beaumont, M., Stafford, K., Slesinger, P. A., & Brennand, K. J. (2016) · Methods · doi:10.1016/j.ymeth.2015.11.019 · Cited by 184

Hippocampal dopamine/DRD1 signaling dependent on the ghrelin receptor

Kern, A., Mavrikaki, M., Ullrich, C., Albarran-Zeckler, R., Brantley, A. F., & Smith, R. G. (2015) · Cell · doi:10.1016/j.cell.2015.10.062 · Cited by 136

Usp16 contributes to somatic stem-cell defects in Down’s syndrome

Adorno, M., Sikandar, S., Mitra, S. S., Kuo, A., Nicolis di Robilant, B., Haro-Acosta, V., Ouadah, Y., Quarta, M., Rodriguez, J., Qian, D., et al. (2013) · Nature · doi:10.1038/nature12530 · Cited by 134

Cell death during crisis is mediated by mitotic telomere deprotection

Hayashi, M. T., Cesare, A. J., Rivera, T., & Karlseder, J. (2015) · Nature · doi:10.1038/nature14513 · Cited by 125

Current challenges in biotherapeutic particles manufacturing

Moleirinho, M. G., Silva, R. J. S., Alves, P. M., Carrondo, M. J. T., & Peixoto, C. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2020.1693541 · Cited by 123

Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4

Sailaja, B. S., Cohen-Carmon, D., Zimmerman, G., Soreq, H., & Meshorer, E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209990110 · Cited by 121

MicroRNA-29b is a Therapeutic Target in Cerebral Ischemia Associated with Aquaporin 4

Wang, Y., Huang, J., Ma, Y., Tang, G., Liu, Y., Chen, X., Zhang, Z., Zeng, L., Wang, Y., Ouyang, Y.-B., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.156 · Cited by 121

D-serine in glia and neurons derives from 3-phosphoglycerate dehydrogenase

Ehmsen, J. T., Ma, T. M., Sason, H., Rosenberg, D., Ogo, T., Furuya, S., Snyder, S. H., & Wolosker, H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4914-12.2013 · Cited by 118

Purification and direct transformation of epithelial progenitor cells from primary human prostate

Goldstein, A. S., Drake, J. M., Burnes, D. L., Finley, D. S., Zhang, H., Reiter, R. E., Huang, J., & Witte, O. N. (2011) · Nature Protocols · doi:10.1038/nprot.2011.317 · Cited by 107

MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons

Wang, W., Zhang, F., Li, L., Tang, F., Siedlak, S. L., Fujioka, H., Liu, Y., Su, B., Pi, Y., & Wang, X. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.617167 · Cited by 103

Site-Specific Genetic Manipulation of Amygdala Corticotropin-Releasing Factor Reveals Its Imperative Role in Mediating Behavioral Response to Challenge

Regev, L., Tsoory, M., Gil, S., & Chen, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.036 · Cited by 93

High efficacy and safety of CD38 and BCMA bispecific CAR-T in relapsed or refractory multiple myeloma

Tang, Y., Yin, H., Zhao, X., Jin, D., Liang, Y., Xiong, T., Li, L., Tang, W., Zhang, J., Liu, M., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02214-z · Cited by 89

Perifornical Urocortin-3 mediates the link between stress-induced anxiety and energy homeostasis

Kuperman, Y., Issler, O., Regev, L., Musseri, I., Navon, I., Neufeld-Cohen, A., Gil, S., & Chen, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003969107 · Cited by 81

Double-Stranded RNA Analog Poly(I:C) Inhibits Human Immunodeficiency Virus Amplification in Dendritic Cells via Type I Interferon-Mediated Activation of APOBEC3G

Trapp, S., Derby, N. R., Singer, R., Shaw, A., Williams, V. G., Turville, S. G., Bess, J. W., Lifson, J. D., & Robbiani, M. (2009) · Journal of Virology · doi:10.1128/jvi.00023-08 · Cited by 79

Dnmt3a in the Medial Prefrontal Cortex Regulates Anxiety-Like Behavior in Adult Mice

Elliott, E., Manashirov, S., Zwang, R., Gil, S., Tsoory, M., Shemesh, Y., & Chen, A. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0971-15.2016 · Cited by 78

MicroRNA miR-21 Attenuates Human Cytomegalovirus Replication in Neural Cells by Targeting Cdc25a

Fu, Y.-R., Liu, X.-J., Li, X.-J., Shen, Z.-Z., Yang, B., Wu, C.-C., Li, J.-F., Miao, L.-F., Ye, H.-Q., Qiao, G.-H., et al. (2015) · Journal of Virology · doi:10.1128/jvi.01740-14 · Cited by 69

Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells

Ha, S., Jeong, S.-H., Yi, K., Chung, K. M., Hong, C. J., Kim, S. W., Kim, E.-K., & Yu, S.-W. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.780874 · Cited by 61

MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy

Valera, E., Spencer, B., Mott, J., Trejo, M., Adame, A., Mante, M., Rockenstein, E., Troncoso, J. C., Beach, T. G., Masliah, E., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00329 · Cited by 55

Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays

Rezende, F., Prior, K.-K., Löwe, O., Wittig, I., Strecker, V., Moll, F., Helfinger, V., Schnütgen, F., Kurrle, N., Wempe, F., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.019 · Cited by 46

In vitro exploration of ACAT contributions to lipid droplet formation during adipogenesis

Zhu, Y., Chen, C.-Y., Li, J., Cheng, J.-X., Jang, M., & Kim, K.-H. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m081745 · Cited by 43

Amygdala-Specific Reduction of α1-GABA A Receptors Disrupts the Anticonvulsant, Locomotor, and Sedative, But Not Anxiolytic, Effects of Benzodiazepines in Mice

Heldt, S. A., & Ressler, K. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0693-10.2010 · Cited by 42

Genetic approach for intracerebroventricular delivery

Regev, L., Ezrielev, E., Gershon, E., Gil, S., & Chen, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907059107 · Cited by 35

Fibroblast Growth Factor Receptor-3 (FGFR-3) Regulates Expression of Paneth Cell Lineage-specific Genes in Intestinal Epithelial Cells through both TCF4/β-Catenin-dependent and -independent Signaling Pathways

Brodrick, B., Vidrich, A., Porter, E., Bradley, L., Buzan, J. M., & Cohn, S. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.229252 · Cited by 29

Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression

Grundman, J., Spencer, B., Sarsoza, F., & Rissman, R. A. (2021) · PLOS ONE · doi:10.1371/journal.pone.0251611 · Cited by 27

Long non-coding RNA Peg13 attenuates the sevoflurane toxicity against neural stem cells by sponging microRNA-128-3p to preserve Sox13 expression

Jiang, Y., Wang, Y., Sun, Y., & Jiang, H. (2020) · PLOS ONE · doi:10.1371/journal.pone.0243644 · Cited by 24

SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice

Mashiko, D., Tonai, S., Miyata, H., Matzuk, M. M., & Ikawa, M. (2025) · eLife · doi:10.7554/elife.107494.3

SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice

Mashiko, D., Tonai, S., Miyata, H., Matzuk, M. M., & Ikawa, M. (2025) · eLife · doi:10.7554/elife.107494