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TGFβ signalling: a complex web in cancer progression
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Citations
Cites
Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907
TGF-β-induced epithelial to mesenchymal transition
Xu, J., Lamouille, S., & Derynck, R. (2009) · Cell Research · doi:10.1038/cr.2009.5 · Cited by 2,804
TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275
pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest
Hannon, G. J., & Beach, D. (1994) · Nature · doi:10.1038/371257a0 · Cited by 1,950
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
Feng, X.-H., & Derynck, R. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.022404.142018 · Cited by 1,869
Targeted tumor therapy with the TGF-β2 antisense compound AP 12009
SCHLINGENSIEPEN, K., SCHLINGENSIEPEN, R., STEINBRECHER, A., HAU, P., BOGDAHN, U., FISCHERBLASS, B., & JACHIMCZAK, P. (2006) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.09.002 · Cited by 195
TGF-β1–induced expression of human Mdm2 correlates with late-stage metastatic breast cancer
Araki, S., Eitel, J. A., Batuello, C. N., Bijangi-Vishehsaraei, K., Xie, X.-J., Danielpour, D., Pollok, K. E., Boothman, D. A., & Mayo, L. D. (2010) · Journal of Clinical Investigation · doi:10.1172/jci39194 · Cited by 133
Cited by
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology
Morikawa, M., Derynck, R., & Miyazono, K. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021873 · Cited by 1,321
Self-citationTGFβ biology in cancer progression and immunotherapy
Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944
Specificity, versatility, and control of TGF-β family signaling
Derynck, R., & Budi, E. H. (2019) · Science Signaling · doi:10.1126/scisignal.aav5183 · Cited by 785
Novel therapies emerging in oncology to target the TGF‐β pathway
Kim, B.-G., Malek, E., Choi, S. H., Ignatz-Hoover, J. J., & Driscoll, J. J. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01053-x · Cited by 453
Role of ABL family kinases in cancer: from leukaemia to solid tumours
Greuber, E. K., Smith-Pearson, P., Wang, J., & Pendergast, A. M. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3563 · Cited by 432
The RUNX family: developmental regulators in cancer
Ito, Y., Bae, S.-C., & Chuang, L. S. H. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3877 · Cited by 399
TGF-β Signaling in Control of Cardiovascular Function
Goumans, M.-J., & ten Dijke, P. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022210 · Cited by 360
TGF-beta in CAF-mediated tumor growth and metastasis
Calon, A., Tauriello, D. V. F., & Batlle, E. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.12.008 · Cited by 342
Interaction of tumor cells with the microenvironment
Ungefroren, H., Sebens, S., Seidl, D., Lehnert, H., & Hass, R. (2011) · Cell Communication and Signaling · doi:10.1186/1478-811x-9-18 · Cited by 333
Role of the tumor microenvironment in tumor progression and the clinical applications (Review)
YUAN, Y., JIANG, Y.-C., SUN, C.-K., & CHEN, Q.-M. (2016) · Oncology Reports · doi:10.3892/or.2016.4660 · Cited by 320
Carcinoma‐associated fibroblasts: Non‐neoplastic tumour‐promoting mesenchymal cells
Polanska, U. M., & Orimo, A. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24347 · Cited by 208
Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasis
Cao, Y. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.05.002 · Cited by 190
ALK1 as an emerging target for antiangiogenic therapy of cancer.
Cunha, S. I., & Pietras, K. (2011) · Blood · doi:10.1182/blood-2011-01-330142 · Cited by 184
The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance
Ahmed, S., Bradshaw, A.-D., Gera, S., Dewan, M., & Xu, R. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6010005 · Cited by 174
Feedback regulation of TGF-β signaling
Yan, X., Xiong, X., & Chen, Y.-G. (2018) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx129 · Cited by 128
Rocca, Y. S., Roberti, M. P., Juliá, E. P., Pampena, M. B., Bruno, L., Rivero, S., Huertas, E., Sánchez Loria, F., Pairola, A., Caignard, A., et al. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00413 · Cited by 97
Kimura, Y., Fukuda, A., Ogawa, S., Maruno, T., Takada, Y., Tsuda, M., Hiramatsu, Y., Araki, O., Nagao, M., Yoshikawa, T., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.03.039 · Cited by 90
Downregulation of CXCL12 in mesenchymal stromal cells by TGFβ promotes breast cancer metastasis
Yu, P. F., Huang, Y., Xu, C. L., Lin, L. Y., Han, Y. Y., Sun, W. H., Hu, G. H., Rabson, A. B., Wang, Y., & Shi, Y. F. (2017) · Oncogene · doi:10.1038/onc.2016.252 · Cited by 88
Gencer, S., Oleinik, N., Kim, J., Panneer Selvam, S., De Palma, R., Dany, M., Nganga, R., Thomas, R. J., Senkal, C. E., Howe, P. H., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aam7464 · Cited by 83
Upadhyay, G., Yin, Y., Yuan, H., Li, X., Derynck, R., & Glazer, R. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103441108 · Cited by 75
Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination
Xie, F., Zhang, Z., Van Dam, H., Zhang, L., & Zhou, F. (2014) · Cells · doi:10.3390/cells3040981 · Cited by 70
Romano, G., Santi, L., Bianco, M. R., Giuffrè, M. R., Pettinato, M., Bugarin, C., Garanzini, C., Savarese, L., Leoni, S., Cerrito, M. G., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7895 · Cited by 66
“TGF-β is known to be a main player in the processes of tumor development, metastasis and angiogenesis [1–3, 14, 27]; the TGF-β pathway has been recently associated to drug resistance [17], but very little is known about TGF-β pathway specific activation in the context of chemotherapeutic…”
Li, Y., Liu, Y., Chiang, Y. J., Huang, F., Li, Y., Li, X., Ning, Y., Zhang, W., Deng, H., & Chen, Y.-G. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.045 · Cited by 61
The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels
Alsina‐Sanchis, E., Figueras, A., Lahiguera, Á., Vidal, A., Casanovas, O., Graupera, M., Villanueva, A., & Viñals, F. (2016) · International Journal of Cancer · doi:10.1002/ijc.30233 · Cited by 57
Penheiter, S. G., Deep Singh, R., Repellin, C. E., Wilkes, M. C., Edens, M., Howe, P. H., Pagano, R. E., & Leof, E. B. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-12-1019 · Cited by 57
The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer
Nam, H., Kundu, A., Karki, S., Brinkley, G. J., Chandrashekar, D. S., Kirkman, R. L., Liu, J., Liberti, M. V., Locasale, J. W., Mitchell, T., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.148438 · Cited by 36
Quan, Q., Zhong, F., Wang, X., Chen, K., & Guo, L. (2019) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504018x15442985680348 · Cited by 29
Tang, Y., & Cheng, L. (2017) · Protein & Cell · doi:10.1007/s13238-017-0373-y · Cited by 22
Transcriptional regulators ensuring specific gene expression and decision-making at high TGFβ doses
Hartmann, L., Kristofori, P., Li, C., Becker, K., Hexemer, L., Bohn, S., Lenhardt, S., Weiss, S., Voss, B., Loewer, A., et al. (2025) · Life Science Alliance · doi:10.26508/lsa.202402859 · Cited by 4
Metadata
- Authors
- Ikushima, H., & Miyazono, K.
- Venue
- Nature Reviews Cancer
- Published
- 2010-06
- Volume
- 10
- Issue
- 6
- Pages
- 415-424
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2051190668
- Cited by
- 1,173
- References
- 7
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- closed
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
