Mitochondrial DNA in innate immune responses and inflammatory pathology

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Circulating mitochondrial DAMPs cause inflammatory responses to injury

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Type I interferons in infectious disease

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

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Mitochondrial DNA stress primes the antiviral innate immune response

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Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

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Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

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Self-Awareness: Nucleic Acid–Driven Inflammation and the Type I Interferonopathies

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Targeting mitochondria in cancer: current concepts and immunotherapy approaches

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Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression

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Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside

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Mitochondria at the interface between neurodegeneration and neuroinflammation

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Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice

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Acute psychological stress increases serum circulating cell-free mitochondrial DNA

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Increased neutrophil extracellular traps activate NLRP3 and inflammatory macrophages in adult-onset Still’s disease

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The cGAS‐STING pathway: The role of self‐DNA sensing in inflammatory lung disease

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Danger signals in liver injury and restoration of homeostasis

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Upregulated-gene expression of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) via TLRs following NF-κB and MAPKs in bovine mastitis

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IRGM1 links mitochondrial quality control to autoimmunity

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ATAD3B is a mitophagy receptor mediating clearance of oxidative stress‐induced damaged mitochondrial DNA

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Microglial Phenotypes and Functions in Multiple SclerosisPreprint

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Mitochondrial Double‐Stranded RNA in Exosome Promotes Interleukin‐17 Production Through Toll‐Like Receptor 3 in Alcohol‐associated Liver Injury

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Crosstalk Between Dysfunctional Mitochondria and Inflammation in Glaucomatous Neurodegeneration

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Lymphocytes eject interferogenic mitochondrial DNA webs in response to CpG and non-CpG oligodeoxynucleotides of class C

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Mitochondria and Inflammation: Cell Death Heats Up

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Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat

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Mitochondrial Extracellular Vesicles – Origins and Roles

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Mitochondrial Quality Control and Restraining Innate Immunity

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Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients

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ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

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The source of cell-free mitochondrial DNA in trauma and potential therapeutic strategies

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The role of the mitochondrial protein VDAC1 in inflammatory bowel disease: a potential therapeutic target

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DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages

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Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion

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Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus

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The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice

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15-Epi-LXA 4 and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation

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Mitochondrial dysfunction: A promising therapeutic target for liver diseases

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The sensing of mitochondrial DAMPs by non-immune cells

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Mitochondria transplantation protects traumatic brain injury via promoting neuronal survival and astrocytic BDNF

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Assessing Mitochondrial DNA Release into the Cytosol and Subsequent Activation of Innate Immune‐related Pathways in Mammalian Cells

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Infection with the dengue RNA virus activates TLR9 signaling in human dendritic cells

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The role of mitochondrial ROS in antibacterial immunity

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Accelerating research on biological aging and mental health: Current challenges and future directions.

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Prohibitin 1 regulates mtDNA release and downstream inflammatory responses

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Role of Damage Associated Molecular Pattern Molecules (DAMPs) in Aneurysmal Subarachnoid Hemorrhage (aSAH)

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Mitochondrial dysfunction and pulmonary hypertension: cause, effect, or both

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A STING to inflammation and autoimmunity

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Focusing on mitochondria in the brain: from biology to therapeutics

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Innate immunity and tolerance toward mitochondria

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Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells

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The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis

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The pathobiology of polycystic kidney disease from a metabolic viewpoint

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Recent progress in mitochondria-targeting-based nanotechnology for cancer treatment

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Mitohormesis Primes Tumor Invasion and Metastasis

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Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A

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Role of miR-2392 in driving SARS-CoV-2 infection

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Mitochondrial-targeted brequinar liposome boosted mitochondrial-related ferroptosis for promoting checkpoint blockade immunotherapy in bladder cancer

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Mitochondria as Key Players in the Pathogenesis and Treatment of Rheumatoid Arthritis

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Oxidized mitochondrial DNA: a protective signal gone awry

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Glaucoma: from pathogenic mechanisms to retinal glial cell response to damage

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PINK1-mediated mitophagy attenuates pathological cardiac hypertrophy by suppressing the mtDNA release-activated cGAS-STING pathway

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Metabolism and Innate Immunity Meet at the Mitochondria

Bahat, A., MacVicar, T., & Langer, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.720490 · Cited by 92

The role of mitophagy in innate immune responses triggered by mitochondrial stress

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The fate of damaged mitochondrial DNA in the cell

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Oxidative Stress in Intestinal Ischemia-Reperfusion

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Obesity-Driven Metabolic Disorders: The Interplay of Inflammation and Mitochondrial Dysfunction

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Mitochondrial DNA in Sepsis

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Circulating mitochondria in organ donors promote allograft rejection

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The effect of extracellular vesicles on the regulation of mitochondria under hypoxia

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Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment

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Manganese( ii ) complexes stimulate antitumor immunity via aggravating DNA damage and activating the cGAS-STING pathway

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Targets for protection and mitigation of radiation injury

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STING/NF-κB/IL-6-Mediated Inflammation in Microglia Contributes to Spared Nerve Injury (SNI)-Induced Pain Initiation

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TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise

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Mitochondrial dysfunction-targeted nanosystems for precise tumor therapeutics

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Affinity purification of cell-specific mitochondria from whole animals resolves patterns of genetic mosaicism

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Mitochondrial DNA: cellular genotoxic stress sentinel

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The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function

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Metal-Phenolic Vehicles Potentiate Cycle-Cascade Activation of Pyroptosis and cGAS-STING Pathway for Tumor Immunotherapy

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Role of released mitochondrial DNA in acute lung injury

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Quantifying organellar ultrastructure in cryo-electron tomography using a surface morphometrics pipeline

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The cGAS-STING Pathway: Novel Perspectives in Liver Diseases

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The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress

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Redox Activation of Mitochondrial DAMPs and the Metabolic Consequences for Development of Autoimmunity

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Nanomedicines harnessing cGAS-STING pathway: sparking immune revitalization to transform ‘cold’ tumors into ‘hot’ tumors

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