Mitochondrial DNA in innate immune responses and inflammatory pathology

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Type I interferons in infectious disease

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

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Mitochondrial DNA stress primes the antiviral innate immune response

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Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

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Mitochondria in innate immune responses

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Mitochondrial ROS Signaling in Organismal Homeostasis

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STING: infection, inflammation and cancer.

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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

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NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

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MITOCHONDRIAL DNA MAINTENANCE IN VERTEBRATES

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Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

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Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

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Mitochondria in the Regulation of Innate and Adaptive Immunity

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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

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Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

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Initiation and perpetuation of NLRP 3 inflammasome activation and assembly

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Converging roles of caspases in inflammasome activation, cell death and innate immunity

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The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

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ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

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DNA methylation on N6-adenine in mammalian embryonic stem cells

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The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

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An uncoupling channel within the c-subunit ring of the F 1 F O ATP synthase is the mitochondrial permeability transition pore

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The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

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The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology

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The Mitochondrial Proteome and Human Disease

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Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

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Nucleic acid recognition by the innate immune system

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Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan

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DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

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Similarity of Human Mitochondrial Transcription Factor 1 to High Mobility Group Proteins

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Recognition of Endogenous Nucleic Acids by the Innate Immune System

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Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses

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Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

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Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

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Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy

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Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

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Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

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Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

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Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

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Minimizing the damage: repair pathways keep mitochondrial DNA intact

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Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi–Goutières Syndrome

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Cytosolic RNA:DNA hybrids activate the cGAS–STING axis

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The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases

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MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

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Protecting the mitochondrial powerhouse

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Initiation and Beyond: Multiple Functions of the Human Mitochondrial Transcription Machinery

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Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

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Neutrophil Extracellular Trap Mitochondrial DNA and Its Autoantibody in Systemic Lupus Erythematosus and a Proof‐of‐Concept Trial of Metformin

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In D-loop: 40years of mitochondrial 7S DNA

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Hypoxia induced HMGB1 and mitochondrial DNA interactions mediate tumor growth in hepatocellular carcinoma through Toll-like receptor 9

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The Control Region of Mitochondrial DNA Shows an Unusual CpG and Non-CpG Methylation Pattern

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Mitochondrial DNA Damage as a Potential Mechanism for Age-Related Macular Degeneration

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Mitochondrial DNA Variation in Human Radiation and Disease

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Investigating Mitochondria as a Target for Treating Age-Related Macular Degeneration

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Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response

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The genomic landscape of polymorphic human nuclear mitochondrial insertions

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Oxidant stress in mitochondrial DNA damage, autophagy and inflammation in atherosclerosis

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Circulating mitochondrial DNA and Toll-like receptor 9 are associated with vascular dysfunction in spontaneously hypertensive rats

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Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis

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Mitochondrial DNA Released by Trauma Induces Neutrophil Extracellular Traps

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cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response to Francisella Infection

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Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery

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Ogg1 -Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis

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The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent

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Regionally specific and genome-wide analyses conclusively demonstrate the absence of CpG methylation in human mitochondrial DNA

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High-Resolution Enzymatic Mapping of Genomic 5-Hydroxymethylcytosine in Mouse Embryonic Stem Cells

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Mitochondrial permeability transition triggers the release of mtDNA fragments

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Mitochondrial damage contributes toPseudomonas aeruginosaactivation of the inflammasome and is downregulated by autophagy

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Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model

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Herpes simplex virus eliminates host mitochondrial DNA

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Membrane-associated DNA Transport MachinesPreprint

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Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escaping from Autophagic Recognition

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