Mitochondrial DNA in innate immune responses and inflammatory pathology

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049

Type I interferons in infectious disease

McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282

Mitochondrial DNA stress primes the antiviral innate immune response

West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature · doi:10.1038/nature14156 · Cited by 1,975

Mitochondrial form and function

Friedman, J. R., & Nunnari, J. (2014) · Nature · doi:10.1038/nature12985 · Cited by 1,803

Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

Lood, C., Blanco, L. P., Purmalek, M. M., Carmona-Rivera, C., De Ravin, S. S., Smith, C. K., Malech, H. L., Ledbetter, J. A., Elkon, K. B., & Kaplan, M. J. (2016) · Nature Medicine · doi:10.1038/nm.4027 · Cited by 1,570

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680

Mitochondrial TCA cycle metabolites control physiology and disease

Martínez-Reyes, I., & Chandel, N. S. (2020) · Nature Communications · doi:10.1038/s41467-019-13668-3 · Cited by 2,813

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins

Singh, R., Letai, A., & Sarosiek, K. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0089-8 · Cited by 2,111

Inflammation and immune dysfunction in Parkinson disease

Tansey, M. G., Wallings, R. L., Houser, M. C., Herrick, M. K., Keating, C. E., & Joers, V. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-022-00684-6 · Cited by 1,382

L1 drives IFN in senescent cells and promotes age-associated inflammation

De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature · doi:10.1038/s41586-018-0784-9 · Cited by 1,255

Mitochondrial dysfunction: mechanisms and advances in therapy

Yao, Z., Li, H., Liao, P., Chen, L., Pan, Y., Zheng, Y., Zhang, C., Liu, D., Zheng, M., & Gao, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01839-8 · Cited by 1,382

Detection of immunogenic cell death and its relevance for cancer therapy

Fucikova, J., Kepp, O., Kasikova, L., Petroni, G., Yamazaki, T., Liu, P., Zhao, L., Spisek, R., Kroemer, G., & Galluzzi, L. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-03221-2 · Cited by 1,138

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., San Chin, H., et al. (2018) · Science · doi:10.1126/science.aao6047 · Cited by 1,072

Mitochondrial and metabolic dysfunction in ageing and age-related diseases

Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990

DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation

Zindel, J., & Kubes, P. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032847 · Cited by 915

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Xian, H., Watari, K., Sanchez-Lopez, E., Offenberger, J., Onyuru, J., Sampath, H., Ying, W., Hoffman, H. M., Shadel, G. S., & Karin, M. (2022) · Immunity · doi:10.1016/j.immuni.2022.06.007 · Cited by 850

VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease

Kim, J., Gupta, R., Blanco, L. P., Yang, S., Shteinfer-Kuzmine, A., Wang, K., Zhu, J., Yoon, H. E., Wang, X., Kerkhofs, M., et al. (2019) · Science · doi:10.1126/science.aav4011 · Cited by 793

Liquid–liquid phase separation in human health and diseases

Wang, B., Zhang, L., Dai, T., Qin, Z., Lu, H., Zhang, L., & Zhou, F. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00678-1 · Cited by 784

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

Shpilka, T., & Haynes, C. M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.110 · Cited by 742

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

Dhir, A., Dhir, S., Borowski, L. S., Jimenez, L., Teitell, M., Rötig, A., Crow, Y. J., Rice, G. I., Duffy, D., Tamby, C., et al. (2018) · Nature · doi:10.1038/s41586-018-0363-0 · Cited by 631

Mitochondrial signal transduction

Picard, M. A., & Shirihai, O. S. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.10.008 · Cited by 688

Mitochondria in health, disease, and aging

Harrington, J. S., Ryter, S. W., Plataki, M. E., Price, D. R., & Choi, A. M. K. (2023) · Physiological Reviews · doi:10.1152/physrev.00058.2021 · Cited by 641

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

Riley, J. S., Quarato, G., Cloix, C., Lopez, J., O'Prey, J., Pearson, M., Chapman, J., Sesaki, H., Carlin, L. M., Passos, J. F., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201899238 · Cited by 551

Mitochondrial fusion, fission, and mitochondrial toxicity

Meyer, J. N., Leuthner, T. C., & Luz, A. L. (2017) · Toxicology · doi:10.1016/j.tox.2017.07.019 · Cited by 535

Mitochondria as Signaling Organelles Control Mammalian Stem Cell Fate

Chakrabarty, R. P., & Chandel, N. S. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.02.011 · Cited by 496

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

Garg, A. D., & Agostinis, P. (2017) · Immunological Reviews · doi:10.1111/imr.12574 · Cited by 451

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

da Silveira, W. A., Fazelinia, H., Rosenthal, S. B., Laiakis, E. C., Kim, M. S., Meydan, C., Kidane, Y., Rathi, K. S., Smith, S. M., Stear, B., et al. (2020) · Cell · doi:10.1016/j.cell.2020.11.002 · Cited by 402

Mitochondria in innate immune signaling

Banoth, B., & Cassel, S. L. (2018) · Translational Research · doi:10.1016/j.trsl.2018.07.014 · Cited by 410

Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis

Weindel, C. G., Martinez, E. L., Zhao, X. L., Mabry, C. J., Bell, S. L., Vail, K. J., Coleman, A. K., VanPortfliet, J. J., Zhao, B., Wagner, A. R., et al. (2022) · Cell · doi:10.1016/j.cell.2022.06.038 · Cited by 404

STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis

Yu, Y., Liu, Y., An, W., Song, J., Zhang, Y., & Zhao, X. (2018) · Journal of Clinical Investigation · doi:10.1172/jci121842 · Cited by 393

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts

Torralba, D., Baixauli, F., Villarroya‐Beltri, C., Fernández‐Delgado, I., Latorre, A., Acín‐Pérez, R., Martin-Cofreces, N. B., Jaso-Tamame, A. L., Iborra, S., Jorge, I., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05077-9 · Cited by 386

New frontiers in the cGAS-STING intracellular DNA-sensing pathway

Dvorkin, S., Cambier, S., Volkman, H. E., & Stetson, D. B. (2024) · Immunity · doi:10.1016/j.immuni.2024.02.019 · Cited by 390

Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?

Kuo, C., Babuharisankar, A. P., Lin, Y., Lien, H., Lo, Y. K., Chou, H.-Y., Tangeda, V., Cheng, L.-C., Cheng, A. N., & Lee, A. Y. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00859-2 · Cited by 367

Mitochondrial DNA Release in Innate Immune Signaling

Newman, L. E., & Shadel, G. S. (2023) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-032620-104401 · Cited by 349

The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms

Kang, I., Chu, C. T., & Kaufman, B. A. (2018) · FEBS Letters · doi:10.1002/1873-3468.12989 · Cited by 334

Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells

Puhm, F., Afonyushkin, T., Resch, U., Obermayer, G., Rohde, M., Penz, T., Schuster, M., Wagner, G., Rendeiro, A. F., Melki, I., et al. (2019) · Circulation Research · doi:10.1161/circresaha.118.314601 · Cited by 306

cGAS-STING–mediated DNA sensing maintains CD8 + T cell stemness and promotes antitumor T cell therapy

Li, W., Lu, L., Lu, J., Wang, X., Yang, C., Jin, J., Wu, L., Hong, X., Li, F., Cao, D., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay9013 · Cited by 305

Mitochondrial DNA variation and cancer

Kopinski, P. K., Singh, L. N., Zhang, S., Lott, M. T., & Wallace, D. C. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00358-w · Cited by 301

Ulcerative colitis: Recent advances in the understanding of disease pathogenesis

Porter, R. J., Kalla, R., & Ho, G. (2020) · F1000Research · doi:10.12688/f1000research.20805.1 · Cited by 308

Type I Interferons in Autoimmune Disease

Crow, M. K., Olferiev, M., & Kirou, K. A. (2018) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-020117-043952 · Cited by 320

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

Lei, Y., VanPortfliet, J. J., Chen, Y., Bryant, J. D., Li, Y., Fails, D. M., Torres-Odio, S., Ragan, K. B., Deng, J., Mohan, A., et al. (2023) · Cell · doi:10.1016/j.cell.2023.05.039 · Cited by 299

STING-dependent sensing of self-DNA drives silica-induced lung inflammation

Benmerzoug, S., Rose, S., Bounab, B., Gosset, D., Duneau, L., Chenuet, P., Mollet, L., Bert, M. L., Lambers, C., Geleff, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07425-1 · Cited by 286

Oxidative stress and the role of redox signalling in chronic kidney disease

Kishi, S., Nagasu, H., Kidokoro, K., & Kashihara, N. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00775-0 · Cited by 297

Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases

Dela Cruz, C. S., & Kang, M.-J. (2018) · Mitochondrion · doi:10.1016/j.mito.2017.12.001 · Cited by 255

Mitochondrial function in immune cells in health and disease

Faas, M. M., & de Vos, P. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165845 · Cited by 252

Mitocellular communication: Shaping health and disease

Mottis, A., Herzig, S., & Auwerx, J. H. (2019) · Science · doi:10.1126/science.aax3768 · Cited by 241

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

Yambire, K. F., Rostosky, C. M., Watanabe, T., Pacheu‐Grau, D., Torres-Odio, S., Sanchez-Guerrero, A., Senderovich, O., Meyron‐Holtz, E. G., Milošević, I., Frahm, J., et al. (2019) · eLife · doi:10.7554/elife.51031 · Cited by 232

Danger-Associated Molecular Patterns (DAMPs): Molecular Triggers for Sterile Inflammation in the Liver

Mihm, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103104 · Cited by 232

Mitochondrial DNA-triggered innate immune response: mechanisms and diseases

Hu, M.-M., & Shu, H. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01086-x · Cited by 263

Molecular Mechanisms of mtDNA-Mediated Inflammation

Gaetano, A. D., Solodka, K., Zanini, G., Selleri, V., Mattioli, A. V., Nasi, M., & Pinti, M. (2021) · Cells · doi:10.3390/cells10112898 · Cited by 241

TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

Willemsen, J., Neuhoff, M., Hoyler, T., Noir, E., Tessier, C., Sarret, S., Thorsen, T. N., Littlewood-Evans, A. J., Zhang, J., Hasan, M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109977 · Cited by 228

Mitochondrial diseases: from molecular mechanisms to therapeutic advances

Wen, H., Deng, H., Li, B., Chen, J., Zhu, J., Zhang, X., Yoshida, S., & Zhou, Y. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02044-3 · Cited by 284

Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis

Tyrrell, D. J., Blin, M. G., Song, J., Wood, S. C., Zhang, M., Beard, D. A., & Goldstein, D. R. (2019) · Circulation Research · doi:10.1161/circresaha.119.315644 · Cited by 230

The Crosstalk Between Tumor-Associated Macrophages (TAMs) and Tumor Cells and the Corresponding Targeted Therapy

Ge, Z., & Ding, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.590941 · Cited by 231

Neutrophil Extracellular Traps in Inflammatory Bowel Disease: Pathogenic Mechanisms and Clinical Translation

Drury, B., Hardisty, G. R., Gray, R. D., & Ho, G. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.03.002 · Cited by 233

Melatonin inhibits cytosolic mitochondrial DNA–induced neuroinflammatory signaling in accelerated aging and neurodegeneration

Jauhari, A., Baranov, S. V., Suofu, Y., Kim, J., Singh, T., Yablonska, S., Li, F., Wang, X., Oberly, P. J., Minnigh, M. B., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135026 · Cited by 215

Mitochondria and Critical Illness

Supinski, G. S., Schroder, E. A., & Callahan, L. A. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.08.2182 · Cited by 212

Damage-associated molecular patterns in trauma

Relja, B., & Land, W. G. (2019) · European Journal of Trauma and Emergency Surgery · doi:10.1007/s00068-019-01235-w · Cited by 225

Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes

Ma, X. M., Geng, K., Law, B. Y. K., Wang, P., Pu, Y. L., Chen, Q., Xu, H. W., Tan, X. Z., Jiang, Z. Z., & Xu, Y. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09692-z · Cited by 206

Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1–mediated immunoescape via STING-IFN signaling and extracellular vesicles

Cheng, A. N., Cheng, L.-C., Kuo, C., Lo, Y. K., Chou, H.-Y., Chen, C., Wang, Y., Chuang, T., Cheng, S., & Lee, A. Y. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001372 · Cited by 210

Mitochondrial dysfunction as a trigger of innate immune responses and inflammation

West, A. P. (2017) · Toxicology · doi:10.1016/j.tox.2017.07.016 · Cited by 206

Cell Death and Inflammation: The Role of Mitochondria in Health and Disease

Picca, A., Calvani, R., Coelho‐Júnior, H. J., & Marzetti, E. (2021) · Cells · doi:10.3390/cells10030537 · Cited by 207

Mitochondria as Cellular and Organismal Signaling Hubs

Shen, K., Pender, C. L., Bar‐Ziv, R., Zhang, H., Wickham, K., Willey, E., Durieux, J., Ahmad, Q., & Dillin, A. G. (2022) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-120420-015303 · Cited by 214

Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism

Borsche, M., König, I. R., Delcambre, S., Petrucci, S., Balck, A., Brüggemann, N., Zimprich, A. A., Wasner, K., Pereira, S. L., Avenali, M., et al. (2020) · Brain · doi:10.1093/brain/awaa246 · Cited by 210

Mitochondria-Striking a balance between host and endosymbiont

Youle, R. J. (2019) · Science · doi:10.1126/science.aaw9855 · Cited by 199

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts

Guarnieri, J. W., Dybas, J. M., Fazelinia, H., Kim, M. S., Frere, J. J., Zhang, Y., Albrecht, Y. E. S., Murdock, D. G., Angelin, A., Singh, L. N., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abq1533 · Cited by 235

Mitochondrial function in development and disease

Rossmann, M. P., Dubois, S. M., Agarwal, S., & Zon, L. I. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048912 · Cited by 200

The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway

Hu, Q., Ren, J., Li, G., Wu, J., Wu, X., Wang, G., Gu, G., Ren, H., Hong, Z., & Li, J. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0436-x · Cited by 183

Roles of neutrophil granule proteins in orchestrating inflammation and immunity

Othman, A., Sekheri, M., & Filep, J. G. (2021) · FEBS Journal · doi:10.1111/febs.15803 · Cited by 200

Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations

Trumpff, C., Michelson, J., Lagranha, C. J., Taleon, V., Karan, K. R., Sturm, G., Lindqvist, D., Fernström, J., Moser, D., Kaufman, B. A., et al. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.04.002 · Cited by 190

Blood mitochondrial DNA copy number: What are we counting?

Picard, M. A. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.06.010 · Cited by 183

Apoptosis in Cancer Biology and Therapy

Moyer, A. F., Tanaka, K., & Cheng, E. H. Y. (2025) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-051222-115023 · Cited by 212

TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA

Liu, H., Zhen, C., Xie, J., Luo, Z., Zeng, L., Zhao, G., Lu, S., Zhuang, H., Fan, H., Li, X., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01419-6 · Cited by 189

DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways

Huang, Y., Jiang, W., & Zhou, R. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01027-3 · Cited by 208

The World Goes Bats: Living Longer and Tolerating Viruses

Gorbunova, V., Seluanov, A., & Kennedy, B. K. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.013 · Cited by 162

Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

Lai, P., Liu, L., Bancaro, N., Troiani, M., Calì, B., Li, Y., Chen, J., Singh, P. K., Arzola, R. A., Attanasio, G., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.03.005 · Cited by 174

KDM5 histone demethylases repress immune response via suppression of STING

Wu, L., Cao, J. P., Cai, W. L., Lang, S. M., Horton, J. R., Jansen, D. J., Liu, Z. Z., Chen, J. F.-Y., Zhang, M., Mott, B. T., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2006134 · Cited by 182

Understanding the Physiological Links Between Physical Frailty and Cognitive Decline

Ma, L., & Chan, P. (2020) · Aging and Disease · doi:10.14336/ad.2019.0521 · Cited by 180

Host mitochondria influence gut microbiome diversity: A role for ROS

Yardeni, T., Tanes, C., Bittinger, K. L., Mattei, L. M., Schaefer, P. M., Singh, L. N., Wu, G. D., Murdock, D. G., & Wallace, D. C. (2019) · Science Signaling · doi:10.1126/scisignal.aaw3159 · Cited by 172

Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity

Sprenger, H., MacVicar, T., Bahat, A., Fiedler, K. U., Hermans, S., Ehrentraut, D., Ried, K., Milenkovic, D., Bonekamp, N. A., Larsson, N., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00385-9 · Cited by 170

Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway

Li, Y., Chen, H., Yang, Q., Wan, L., Zhao, J., Wu, Y., Wang, J., Yang, Y., Niu, M., Liu, H., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02262-z · Cited by 175

Untangling “NETosis” from NETs

Yousefi, S., Stojkov, D., Germič, N., Simon, D., Wang, X., Benarafa, C., & Simon, H. (2019) · European Journal of Immunology · doi:10.1002/eji.201747053 · Cited by 168

Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets

Tezel, G. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100998 · Cited by 175

Roles of reactive oxygen species in inflammation and cancer

Yu, Y., Liu, S., Yang, L., Song, P., Liu, Z., Liu, X., Yan, X., & Dong, Q. (2024) · MedComm · doi:10.1002/mco2.519 · Cited by 180

SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation

Li, S., Li, H., Zhang, Y.-L., Xin, Q., Guan, Z., Chen, X., Zhang, X., Li, X., Xiao, G., Lozach, P., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.105 · Cited by 163

Mitochondrial DNA in liver inflammation and oxidative stress

Zhang, X., Wu, X., Hu, Q., Wu, J., Wang, G., Hong, Z., & Ren, J. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.05.020 · Cited by 170

Mitochondria and Inflammatory Bowel Diseases: Toward a Stratified Therapeutic Intervention

Ho, G., & Theiss, A. L. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-060821-083306 · Cited by 166

Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases

Nakayama, H., & Otsu, K. (2018) · Biochemical Journal · doi:10.1042/bcj20170714 · Cited by 160

Cardiolipin in Immune Signaling and Cell Death

Pizzuto, M., & Pelegrı́n, P. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.09.004 · Cited by 157

Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells

Szczęsny, B., Marcatti, M., Ahmad, A., Montalbano, M., Brunyánszki, A., Bibli, S., Papapetropoulos, A., & Szabó, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-19216-1 · Cited by 155

Mitochondrial Metabolism Regulation of T Cell–Mediated Immunity

Steinert, E. M., Vasan, K., & Chandel, N. S. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101819-082015 · Cited by 161

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Liu, N., Pang, X., Zhang, H., & Ji, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.814709 · Cited by 159

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Borrajo, A., Spuch, C., Penedo, M. A., Olivares, J. M., & Agís‐Balboa, R. C. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1814962 · Cited by 150

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Guo, Y., Gu, R., Gan, D., Hu, F., Li, G., & Xu, G. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00637-3 · Cited by 155

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Thangaraj, A., Periyasamy, P., Liao, K., Bendi, V. S., Callen, S. E., Pendyala, G., & Buch, S. J. (2018) · Autophagy · doi:10.1080/15548627.2018.1476810 · Cited by 150

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Boyapati, R. K., Dorward, D. A., Tamborska, A., Kalla, R., Ventham, N. T., Doherty, M. K., Whitfield, P. D., Gray, M., Loane, J., Rossi, A. G., et al. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy095 · Cited by 153

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Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C. C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.12.001 · Cited by 146

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Wu, Z., Oeck, S., West, A. P., Mangalhara, K. C., Sainz, A. G., Newman, L. E., Zhang, X.-O., Wu, L., Yan, Q., Bosenberg, M., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0150-8 · Cited by 147

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Zhou, L., Zhang, Y.-F., Yang, F.-H., Mao, H., Chen, Z., & Zhang, L. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00738-7 · Cited by 145

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Balsa, E., Perry, E. A., Bennett, C. F., Jedrychowski, M. P., Gygi, S. P., Doench, J. G., & Puigserver, P. (2020) · Nature Communications · doi:10.1038/s41467-020-16423-1 · Cited by 141

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Jiang, H., Guo, Y., Wei, C., Hu, P., & Shi, J. (2021) · Advanced Materials · doi:10.1002/adma.202008065 · Cited by 141

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Wang, M., Sooreshjani, M. A., Mikek, C. G., Opoku‐Temeng, C., & Sintim, H. O. (2018) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0322 · Cited by 144

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Zhao, S., Chen, F., Yin, Q., Wang, D., Han, W., & Zhang, Y. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.571810 · Cited by 145

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Vercesi, A. E., Castilho, R. F., Kowaltowski, A. J., Oliveira, H. C. F., de Souza-Pinto, N. C., Figueira, T. R., & Busanello, E. N. B. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.034 · Cited by 146

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Miliotis, S., Nicolalde, B., Ortega, M., Yepez, J., & Caicedo, A. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.02.002 · Cited by 138

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Riley, J. S., & Tait, S. W. G. (2020) · EMBO Reports · doi:10.15252/embr.201949799 · Cited by 910

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VanPortfliet, J. J., Chute, C., Lei, Y., Shutt, T. E., & West, A. P. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae031 · Cited by 70

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Kausar, S., Yang, L., Abbas, M. N., Hu, X., Zhao, Y., Zhu, Y., & Cui, H. (2020) · Genes · doi:10.3390/genes11010086 · Cited by 40

Mitochondrial DNA in the regulation of innate immune responses

Fang, C., Wei, X., & Wei, Y. (2015) · Protein & Cell · doi:10.1007/s13238-015-0222-9 · Cited by 174

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Tao, G., Liao, W., Hou, J., Jiang, X., Deng, X., Chen, G., & Ding, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24029 · Cited by 51