Cited by 1,115Immune Response and Inflammationinterferon and immune responsesInflammasome and immune disorders

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Mitochondrial DNA in innate immune responses and inflammatory pathology

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West, A. Phillip, Shadel, Gerald S.·2017·Nature Reviews Immunology

DOI 10.1038/nri.2017.21PMC PMC7289178

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Abstract

Mitochondrial DNA (mtDNA) - which is well known for its role in oxidative phosphorylation and maternally inherited mitochondrial diseases - is increasingly recognized as an agonist of the innate immune system that influences antimicrobial responses and inflammatory pathology. On entering the cytoplasm, extracellular space or circulation, mtDNA can engage multiple pattern-recognition receptors in cell-type- and context-dependent manners to trigger pro-inflammatory and type I interferon responses. Here, we review the expanding research field of mtDNA in innate immune responses to highlight new mechanistic insights and discuss the physiological and pathological relevance of this exciting area of mitochondrial biology.

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Authors: West, A. P., & Shadel, G. S.
Affiliations: Texas A&M Health Science Center (US)
Yale University (US)
Corresponding author: West, A. Phillip
Shadel, Gerald S.
ORCID: West, A. Phillip
Shadel, Gerald S.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2017-04-10
Volume: 17
Issue: 6
Pages: 363-375
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri.2017.21
PMC: PMC7289178
OpenAlex: W2606232917
Cited by: 1,115
References: 121
Citations by year: 2026: 171 · 2025: 157 · 2024: 147 · 2023: 113 · 2022: 134 · 2021: 147 · 2020: 88 · 2019: 79 · 2018: 62 · 2017: 17
FWCI: 6.92
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (R01AG047632)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: mitochondrial DNA, innate immunity, pattern recognition receptors, type I interferon, inflammation, cellular stress, antimicrobial response, mitochondrial disease, oxidative phosphorylation
MeSH terms: Alarmins, Animals, DNA, Mitochondrial, Humans, Immunity, Innate, Inflammation

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Mitochondrial DNA in innate immune responses and inflammatory pathology

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