Mitochondrial DNA in innate immune responses and inflammatory pathology

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154

Circulating mitochondrial DAMPs cause inflammatory responses to injury

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049

Type I interferons in infectious disease

McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282

Mitochondrial DNA stress primes the antiviral innate immune response

West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature · doi:10.1038/nature14156 · Cited by 1,975

Mitochondrial form and function

Friedman, J. R., & Nunnari, J. (2014) · Nature · doi:10.1038/nature12985 · Cited by 1,803

Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

Lood, C., Blanco, L. P., Purmalek, M. M., Carmona-Rivera, C., De Ravin, S. S., Smith, C. K., Malech, H. L., Ledbetter, J. A., Elkon, K. B., & Kaplan, M. J. (2016) · Nature Medicine · doi:10.1038/nm.4027 · Cited by 1,570

PRRSV infection activates NLRP3 inflammasome through inducing cytosolic mitochondrial DNA stress

Li, H., Yang, X., Song, Y., Zhu, Q., Liao, Z., Liang, Y., Guo, J., Wan, B., & Bao, D. (2023) · Veterinary Microbiology · doi:10.1016/j.vetmic.2023.109673 · Cited by 35

The Foxo1-YAP-Notch1 axis reprograms STING-mediated innate immunity in NASH progression

Xu, D., Qu, X., Yang, T., Sheng, M., Bian, X., Zhan, Y., Tian, Y., Lin, Y., Jin, Y., Wang, X., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01280-5 · Cited by 32

Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia–reperfusion injury

Barakakis, P. A., Mavridis, T., Chlorogiannis, D., Barakakis, G., Laou, E., Sessler, D. I., Gkiokas, G., & Chalkias, A. F. (2024) · Clinical and Translational Medicine · doi:10.1002/ctm2.70136 · Cited by 32

Sequencing and characterizing human mitochondrial genomes in the biobank-based genomic research paradigm

Luo, L., Wang, M., Liu, Y., Li, J., Bu, F., Yuan, H., Tang, R., Liu, C.-L., & He, G. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2736-7 · Cited by 36

Comprehensive Evaluation of Differential Methylation Analysis Methods for Bisulfite Sequencing Data

Piao, Y., Xu, W., Park, K. H., Ryu, K. H., & Xiang, R. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18157975 · Cited by 31

Vitamin B12 Reduces TDP-43 Toxicity by Alleviating Oxidative Stress and Mitochondrial Dysfunction

Jeon, Y., Kwon, Y., Lee, S., Kim, S., Jo, M., Lee, S., Kim, S. R., Kim, K., & Kim, H. (2021) · Antioxidants · doi:10.3390/antiox11010082 · Cited by 32

Mitochondrial DNA Is a Vital Driving Force in Ischemia‐Reperfusion Injury in Cardiovascular Diseases

Liu, H., Liu, X., Zhou, J., & Li, T. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6235747 · Cited by 35

Extracellular Vesicles as Drivers of Immunoinflammation in Atherothrombosis

Suades, R., Greco, M. F., Padró, T., & Badimón, L. (2022) · Cells · doi:10.3390/cells11111845 · Cited by 32

Mitophagy-promoting miR-138-5p promoter demethylation inhibits pyroptosis in sepsis-associated acute lung injury

Liu, F., Yang, Y., Peng, W., Zhao, N., Chen, J., Xu, Z., Cui, Y., & Qian, K. (2022) · Inflammation Research · doi:10.1007/s00011-022-01675-y · Cited by 33

Extracellular vesicle mitochondrial DNA levels are associated with race and mitochondrial DNA haplogroup

Byappanahalli, A. M., Omoniyi, V., Hooten, N. N., Smith, J. T., Mode, N. A., Ezike, N., Zonderman, A. B., & Evans, M. K. (2023) · iScience · doi:10.1016/j.isci.2023.108724 · Cited by 31

Ameliorating Mitochondrial Dysfunction for the Therapy of Parkinson's Disease

Zheng, Q. Y., Liu, H., Gao, Y., Cao, G., Wang, Y., & Li, Z. (2024) · Small · doi:10.1002/smll.202311571 · Cited by 32

The role of mitochondrial damage-associated molecular patterns in acute pancreatitis

Zhou, Y., Huang, X., Jin, Y., Qiu, M., Ambe, P. C., Basharat, Z., & Hong, W. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116690 · Cited by 32

The central role of nucleic acids in the pathogenesis of systemic lupus erythematosus

Pisetsky, D. S. (2019) · F1000Research · doi:10.12688/f1000research.17959.1 · Cited by 31

Exogenous Glutathione Protects IPEC-J2 Cells against Oxidative Stress through a Mitochondrial Mechanism

Chen, Q., Yu, M., Tian, Z., Cui, Y., Deng, D., Rong, T. Z., Liu, Z., Song, M., Li, Z., Ma, X., et al. (2022) · Molecules · doi:10.3390/molecules27082416 · Cited by 31

Loss of sterol metabolic homeostasis triggers inflammasomes — how and why

Dang, E. V., & Cyster, J. G. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.08.001 · Cited by 30

The underestimated role of mitochondria in vitiligo: From oxidative stress to inflammation and cell death

Lin, Y., Ding, Y., Wu, Y., Yang, Y., Liu, Z., Xiang, L. F., & Zhang, C. (2023) · Experimental Dermatology · doi:10.1111/exd.14856 · Cited by 32

Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells

Lee, D., Huntoon, K. M., Wang, Y., Kang, M., Lü, Y., Jeong, S. D., Link, T. M., Gallup, T. D., Qie, Y., Li, X., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01194-7 · Cited by 32

PGC-1α mediates migrasome secretion accelerating macrophage–myofibroblast transition and contributing to sepsis-associated pulmonary fibrosis

Peng, Y., Mei, S., Qi, X., Tang, R. N., Yang, W., Feng, J., Zhou, Y., Huang, X., Qian, G., Xing, S., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01426-z · Cited by 32

LPS-induced mitochondrial DNA synthesis and release facilitate RAD50-dependent acute lung injury

Zhan, X., Cui, R., Geng, X., Li, J., Zhou, Y., He, L., Cao, C., Zhang, C., Chen, Z., & Ying, S. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00494-7 · Cited by 31

Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort

Zhang, W. Z., Hoffman, K. L., Schiffer, K. T., Oromendia, C., Rice, M. C., Barjaktarević, I., Peters, S. P., Putcha, N., Bowler, R. P., Wells, J. M., et al. (2021) · Respiratory Research · doi:10.1186/s12931-021-01707-x · Cited by 29

A Genetic Bottleneck of Mitochondrial DNA During Human Lymphocyte Development

Tang, Z., Lu, Z., Chen, B., Zhang, W., Chang, H. Y., Hu, Z., & Xu, J. (2022) · Molecular Biology and Evolution · doi:10.1093/molbev/msac090 · Cited by 29

Mitochondria as a key player in systemic lupus erythematosus

Quintero-González, D. C., Muñoz-Urbano, M., & Vásquez, G. M. (2022) · Autoimmunity · doi:10.1080/08916934.2022.2112181 · Cited by 31

SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function

Gautam, M., Genç, B., Helmold, B., Ahrens, A., Kuka, J., Makrecka‐Kuka, M., Günay, A., Koçak, N., Aguilar-Wickings, I. R., Keefe, D., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106022 · Cited by 30

Toxicities of and inflammatory responses to moxifloxacin, cefuroxime, and vancomycin on retinal vascular cells

Miyake, H., Miyazaki, D., Shimizu, Y., Sasaki, S., Baba, T., Inoue, Y., & Matsuura, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-46236-2 · Cited by 30

Plasma mitochondrial DNA levels are associated with acute lung injury and mortality in septic patients

Mao, J.-Y., Li, D., Zhang, H., Wang, X., & Liu, D.-W. (2021) · BMC Pulmonary Medicine · doi:10.1186/s12890-021-01437-2 · Cited by 29

Mitochondria-mediated ferroptosis contributes to the inflammatory responses of bovine viral diarrhea virus (BVDV) in vitro

Li, Z., Zhao, B. Y., Zhang, Y., Fan, W., Xue, Q., Chen, X., Wang, J., & Qi, X. (2024) · Journal of Virology · doi:10.1128/jvi.01880-23 · Cited by 29

Ancestral allele of DNA polymerase gamma modifies antiviral tolerance

Kang, Y., Hepojoki, J., Sartori-Maldonado, R., Mito, T., Terzioglu, M., Manninen, T., Kant, R., Singh, S. K., Othman, A., Verma, R., et al. (2024) · Nature · doi:10.1038/s41586-024-07260-z · Cited by 32

Mitochondria in aging and age-associated diseases

Pahal, S., Mainali, N., Balasubramaniam, M., Reis, R. J. S., & Ayyadevara, S. (2025) · Mitochondrion · doi:10.1016/j.mito.2025.102022 · Cited by 32

CLEC16A in astrocytes promotes mitophagy and limits pathology in a multiple sclerosis mouse model

Kadowaki, A., Wheeler, M. A., Li, Z., Andersen, B. M., Lee, H., Illouz, T., Lee, J.-H., Ndayisaba, A., Zandee, S., Basu, H., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01875-9 · Cited by 30

Therapeutic targeting of metabolic alterations in acute respiratory distress syndrome

Robinson, M. J., & Krasnodembskaya, A. D. (2020) · European Respiratory Review · doi:10.1183/16000617.0114-2020 · Cited by 29

VDAC oligomer pores: A mechanism in disease triggered by mtDNA release

Yan, J., Liu, W., Feng, F., & Chen, L. (2020) · Cell Biology International · doi:10.1002/cbin.11427 · Cited by 30

Sparsely methylated mitochondrial cell free DNA released from cardiomyocytes contributes to systemic inflammatory response accompanied by atrial fibrillation

Yamazoe, M., Sasano, T., Ihara, K., Takahashi, K., Nakamura, W., Takahashi, N., Komuro, H., Hamada, S., & Furukawa, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-85204-7 · Cited by 29

Interferon-γ Preferentially Promotes Necroptosis of Lung Epithelial Cells by Upregulating MLKL

Hao, Q., Shetty, S., Tucker, T. A., Idell, S., & Tang, H. (2022) · Cells · doi:10.3390/cells11030563 · Cited by 29

The impact of perceived stress on the hair follicle: Towards solving a psychoneuroendocrine and neuroimmunological puzzle

O’Sullivan, J. D. B., Peters, E. M. J., Amer, Y., Atuluru, P., Chéret, J., Rosenberg, A. M., Picard, M. A., & Paus, R. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.101008 · Cited by 32

Targeting mitochondria in the regulation of neurodegenerative diseases: A comprehensive review

Maurya, S. K., Gupta, S., Bakshi, A., Kaur, H., Jain, A., Senapati, S., & Baghel, M. S. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25110 · Cited by 31

Potential roles of NLRP3 inflammasome in the pathogenesis of Kawasaki disease

Shahi, A., Afzali, S., Firoozi, Z., Mohaghegh, P., Moravej, A., Hosseinipour, A., Bahmanyar, M., & Mansoori, Y. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.30948 · Cited by 31

Cell-free mitochondrial DNA increases in maternal circulation during healthy pregnancy: a prospective, longitudinal study

Cushen, S. C., Sprouse, M. L., Blessing, A., Sun, J., Jarvis, S. S., Okada, Y., Fu, Q., Romero, S. A., Phillips, N., & Goulopoulou, S. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00324.2019 · Cited by 27

Role of intrinsic apoptosis in environmental exposure health outcomes

Johnson, L., & Sarosiek, K. A. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.11.003 · Cited by 28

Iron Chelation Therapy Elicits Innate Immune Control of Metastatic Ovarian Cancer

Sandoval, T. A., Salvagno, C., Chae, C.-S., Awasthi, D., Giovanelli, P., Falco, M. M., Hwang, S., Terán-Cabanillas, E., Suominen, L., Yamazaki, T., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-1451 · Cited by 29

Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder

Yamashita, K., Kinoshita, M., Miyamoto, K., Namba, A., Shimizu, M., Koda, T., Sugimoto, T., Mori, Y., Yoshioka, Y., Nakatsuji, Y., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1162-0 · Cited by 28

Outlook of PINK1/Parkin signaling in molecular etiology of Parkinson’s disease, with insights into Pink1 knockout models

Wang, Z., Chan, S.-W., Zhao, H., Miu, K.-K., & Chan, W. (2023) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2022.406 · Cited by 28

Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity

Clark, M. L., Simeonov, K. P., Mowel, W. K., Michieletto, M. F., Joannas, L. D., Wright, J. M., Erickson, I., Johnson, L. R., Krishnan, R., de la Fuente‐Núñez, C., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.06.006 · Cited by 29

Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity

Liu, D., Zhou, C., Wang, X., Luo, Z., Xu, R., Huo, S., Guo, L., Luo, X., Yang, S., Click, A., et al. (2026) · Science · doi:10.1126/science.adq9006 · Cited by 32

Proteomic analysis of murine macrophages mitochondria and lysosomes reveal Cathepsin D as a potential broad-spectrum antimicrobial protein

Fu, Q., Yuan, J., Wang, L., Ran, H., Li, F., Liu, F., Zhang, J., Liu, W., Huang, W. Y., Huang, Y., et al. (2020) · Journal of Proteomics · doi:10.1016/j.jprot.2020.103821 · Cited by 27

Protective Role of the Nucleic Acid Sensor STING in Pulmonary Fibrosis

Savigny, F., Schricke, C., Lacerda‐Queiroz, N., Meda, M., Nascimento, M., Huot-Marchand, S., Monteiro, F. D. G., Ryffel, B., Gombault, A., Bert, M. L., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.588799 · Cited by 27

Sevoflurane Improves Hemorrhagic Shock and Resuscitation‐Induced Cognitive Impairments and Mitochondrial Dysfunctions through SIRT1‐Mediated Autophagy

Shu, J., Huang, X., Liao, Q., Wang, J., Zhou, Y., Chen, Y., Chen, M., Qian, C., Zhang, Y., Hu, X., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9771743 · Cited by 27

An overview of programmed cell death: Apoptosis and pyroptosis—Mechanisms, differences, and significance in organism physiology and pathophysiology

Kowalski, S., Karska, J., Łapińska, Z., Hetnał, B., Saczko, J., & Kulbacka, J. (2023) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30413 · Cited by 27

Advanced nanomaterials targeting activation of STING for enhanced cancer immunotherapy

Tan, J., Wang, M., Ding, B., Ma, P., & Lin, J. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215316 · Cited by 28

DNA‐Based Biomaterials for Immunoengineering

Maeda, M., Kojima, T., Song, Y., & Takayama, S. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201801243 · Cited by 27

The anti-viral dynamin family member MxB participates in mitochondrial integrity

Cao, H., Krueger, E. W., Chen, J., Drizyte-Miller, K., Schulz, M. E., & McNiven, M. A. (2020) · Nature Communications · doi:10.1038/s41467-020-14727-w · Cited by 25

Controlled Hypothermic Storage for Lung Preservation: Leaving the Ice Age Behind

Cenik, I., Slambrouck, J. V., Provoost, A., Barbarossa, A., Vanluyten, C., Boelhouwer, C., Vanaudenaerde, B. M., Vos, R., Pirenne, J., Raemdonck, D. E. V., et al. (2024) · Transplant International · doi:10.3389/ti.2024.12601 · Cited by 26

Kidney epithelial targeted mitochondrial transcription factor A deficiency results in progressive mitochondrial depletion associated with severe cystic disease

Ishii, K. J., Kobayashi, H., Taguchi, K., Guan, N., Li, A. R., Tong, C., Davidoff, O., Tran, P. V., Sharma, M., Chandel, N. S., et al. (2020) · Kidney International · doi:10.1016/j.kint.2020.10.013 · Cited by 27

CRISPR/Cas9-mediated mutagenesis at microhomologous regions of human mitochondrial genome

Wang, B., Lv, X., Wang, Y., Wang, Z., Liu, Q., Lu, B., Liu, Y., & Gu, F. (2021) · Science China Life Sciences · doi:10.1007/s11427-020-1819-8 · Cited by 25

Role of Telomeres Shortening in Atherogenesis: An Overview

Yegorov, Y. E., Poznyak, A. V., Nikiforov, N. G., Starodubova, A. V., & Orekhov, A. N. (2021) · Cells · doi:10.3390/cells10020395 · Cited by 26

Circulating Mitochondrial DNA and Inter-Organelle Contact Sites in Aging and Associated Conditions

Picca, A., Guerra, F., Calvani, R., Romanò, R., Coelho‐Júnior, H. J., Damiano, F. P., Bucci, C., & Marzetti, E. (2022) · Cells · doi:10.3390/cells11040675 · Cited by 27

STING activation promotes inflammatory response and delays skin wound healing in diabetic mice

Feng, Z., Zang, C., Zhang, L., Yin, S., Zhuang, Q., & Wang, X. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.04.085 · Cited by 26

Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function

Tian, G., Katchur, S. R., Jiang, Y., Briand, J., Schaber, M. D., Kreatsoulas, C., Schwartz, B. J., Thrall, S. H., Davis, A. M., Duvall, S., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-18878-2 · Cited by 30

Regulation of cGAS/STING signaling and corresponding immune escape strategies of viruses

Ge, Z., & Ding, S. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.954581 · Cited by 28

Targeting Mitochondria to Control Ageing and Senescence

Protasoni, M., & Serrano, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020352 · Cited by 30

The Anti-Oxidative, Anti-Inflammatory, Anti-Apoptotic, and Anti-Necroptotic Role of Zinc in COVID-19 and Sepsis

Briassoulis, G. C., Briassoulis, P., Ilia, S., Miliaraki, M., & Briassouli, E. (2023) · Antioxidants · doi:10.3390/antiox12111942 · Cited by 30

NLRP3 level in cerebrospinal fluid of patients with neuromyelitis optica spectrum disorders: Increased levels and association with disease severity

Yu, P., Chen, J., Dai, Y., Jiang, Y., Qiu, W., Gu, Y., & Wang, H. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.101888 · Cited by 26

Mitochondrial dynamics and their role in the pathogenesis of age-related macular degeneration: A comprehensive review

Chen, K.-Y., Chan, H.-C., Lin, W., & Chan, C.-M. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103976 · Cited by 26

Mitochondria in the biology, pathogenesis, and treatment of hepatitis virus infections

Qu, C., Zhang, S., Li, Y., Wang, Y., Peppelenbosch, M. P., & Pan, Q. (2019) · Reviews in Medical Virology · doi:10.1002/rmv.2075 · Cited by 25

Mitochondrial DNA on Tumor-Associated Macrophages Polarization and Immunity

Guo, Y., Tsai, H., Zhang, L., & Zhu, H. (2022) · Cancers · doi:10.3390/cancers14061452 · Cited by 26

The poxvirus F17 protein counteracts mitochondrially orchestrated antiviral responses

Meade, N., Toreev, H. K., Chakrabarty, R. P., Hesser, C. R., Park, C., Chandel, N. S., & Walsh, D. (2023) · Nature Communications · doi:10.1038/s41467-023-43635-y · Cited by 25

A Telomerase-Derived Peptide Exerts an Anti-Hepatitis B Virus Effect via Mitochondrial DNA Stress-Dependent Type I Interferon Production

Choi, Y.-M., Kim, H., Lee, S., Lee, S. Y., & Kim, B. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00652 · Cited by 26

A Polymer-Based Antigen Carrier Activates Two Innate Immune Pathways for Adjuvant-Free Subunit Vaccines

Chen, H., Wang, L., Zhao, X., Jiang, H., Wu, M., Ding, Y., Jia, X., Zhang, Y., Li, T., Zhang, Y., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c00925 · Cited by 24

Sleep Deprivation Triggers Mitochondrial DNA Release in Microglia to Induce Neural Inflammation: Preventative Effect of Hydroxytyrosol Butyrate

Hu, Y., Wang, Y., Wang, Y., Zhang, Y., Wang, Z., Xu, X., Zhang, T., Zhang, T., Zhang, S., Hu, R., et al. (2024) · Antioxidants · doi:10.3390/antiox13070833 · Cited by 29

Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver

Aich, A., Boshnakovska, A., Witte, S., Gall, T., Unthan-Fechner, K., Yousefi, R., Chowdhury, A., Dahal, D., Methi, A., Kaufmann, S. V., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51109-y · Cited by 25

Bidirectional regulation of the cGAS-STING pathway in the immunosuppressive tumor microenvironment and its association with immunotherapy

Zhang, Y., Wang, Y., Mu, P., Zhu, X. G., & Dong, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1470468 · Cited by 24

Repurposing levomilnacipran to attenuate premature ovarian insufficiency induced by cyclophosphamide in female Wistar albino rats through modulation of TLR4/p38-MAPK/NF-κB p65, caspase-3-driven apoptosis, and Klotho protein expression

Rofaeil, R. R., Sharata, E. E., Attya, M. E., Abo‐Youssef, A. M., Hemeida, R. A. M., & Khalaf, M. M. (2025) · Food and Chemical Toxicology · doi:10.1016/j.fct.2025.115406 · Cited by 24

The Dynll1-Cox4i1 Complex Regulates Intracellular Pathogen Clearance via Release of Mitochondrial Reactive Oxygen Species

Yuan, J., Zheng, Z., Wang, L., Ran, H., Tang, X., Xie, X., Li, F., Liu, F., Wang, X., Zhang, J., et al. (2020) · Infection and Immunity · doi:10.1128/iai.00738-19 · Cited by 24

Lipid‐based gene delivery to macrophage mitochondria for atherosclerosis therapy

Zakirov, F., Zhang, D., Grechko, A. V., Wu, W., Poznyak, A. V., & Orekhov, A. N. (2020) · Pharmacology Research & Perspectives · doi:10.1002/prp2.584 · Cited by 24

Increased Plasma Levels of Mitochondrial DNA and Normal Inflammasome Gene Expression in Monocytes Characterize Patients With Septic Shock Due to Multidrug Resistant Bacteria

Busani, S., Biasi, S. D., Nasi, M., Paolini, A., Venturelli, S., Tosi, M., Girardis, M., & Cossarizza, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00768 · Cited by 24

Promising Anti-Mitochondrial Agents for Overcoming Acquired Drug Resistance in Multiple Myeloma

Innao, V., Rizzo, V., Allegra, A. G., Musolino, C., & Allegra, A. (2021) · Cells · doi:10.3390/cells10020439 · Cited by 24

Cytoplasmic DNA in cancer cells: Several pathways that potentially limit DNase2 and TREX1 activities

Anindya, R. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119278 · Cited by 24

Mitochondrial DNA Changes in Blood and Urine Display a Specific Signature in Relation to Inflammation in Normoalbuminuric Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients

Petrică, L., Vlad, A., Gădălean, F., Muntean, D. M., Vlad, M., Dumitraşcu, V., Bob, F. R., Milas, L. O., Suteanu‐Simulescu, A., Glavan, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129803 · Cited by 24

Experimental Type 2 diabetes and lipotoxicity-associated neuroinflammation involve mitochondrial DNA-mediated cGAS/STING axis: implication of Type-1 interferon response in cognitive impairment

Kumari, P., Sood, A., Fernandes, V., Khan, I., Khatri, D. K., & Singh, S. B. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03933-y · Cited by 24

Platelets and IgE: Shaping the Innate Immune Response in Systemic Lupus Erythematosus

Brilland, B., Scherlinger, M., Khoryati, L., Goret, J., Duffau, P., Lazaro, E., Charrier, M., Guillotin, V., Richez, C., & Blanco, P. (2019) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08744-x · Cited by 26

Know your enemy: Genetics, aging, exposomic and inflammation in the war against triple negative breast cancer

Fabbri, F., Salvi, S., & Bravaccini, S. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.10.015 · Cited by 27

Between good and evil: Complexation of the human cathelicidin LL-37 with nucleic acids

Zielke, C., Nielsen, J. E., Lin, J. S., & Barron, A. E. (2023) · Biophysical Journal · doi:10.1016/j.bpj.2023.10.035 · Cited by 25

Gut-lung immunometabolic crosstalk in sepsis: from microbiota to respiratory failure

Li, Q., Song, X.-C., Li, K., & Wang, J. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1685044 · Cited by 25

Heat stress-induced mitochondrial damage and its impact on leukocyte function

Iba, T., Helms, J., Nagaoka, I., Ferrer, R., & Levy, J. H. (2025) · Journal of Intensive Care · doi:10.1186/s40560-025-00832-9 · Cited by 23

Metabolic Modulation of Macrophage Function Post Myocardial Infarction

Zhao, M., Wang, D. D.-H., Liu, X., & Tian, R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00674 · Cited by 23

TLR9–IL-2 axis exacerbates allergic asthma by preventing IL-17A hyperproduction

Murakami, Y., Ishii, T., Nunokawa, H., Kurata, K., Narita, T., & Yamashita, N. (2020) · Scientific Reports · doi:10.1038/s41598-020-75153-y · Cited by 23

Simulated aeromedical evacuation exacerbates burn induced lung injury: targeting mitochondrial DNA for reversal

Xiao, M., Zou, X., Li, B., Li, B.-L., Wu, S.-J., & Zhang, B. (2021) · Military Medical Research · doi:10.1186/s40779-021-00320-9 · Cited by 24

Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases

Feng, Y., Huang, W. C., Paul, C., Liu, X., Sadayappan, S., Wang, Y., & Pauklin, S. (2021) · Basic Research in Cardiology · doi:10.1007/s00395-021-00889-1 · Cited by 22

Mitochondrial DNA copy number in autism spectrum disorder and attention deficit hyperactivity disorder: a systematic review and meta-analysis

Al‐Kafaji, G., Jahrami, H., Alwehaidah, M. S., Alshammari, Y. H., & Husni, M. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1196035 · Cited by 23

Temporal profile of serum mitochondrial DNA (mtDNA) in patients with aneurysmal subarachnoid hemorrhage (aSAH)

Chaudhry, S. R., Frede, S., Seifert, G., Kinfe, T. M., Niemela, M. R., Lamprecht, A., & Muhammad, S. (2018) · Mitochondrion · doi:10.1016/j.mito.2018.12.001 · Cited by 23

Proteome Analysis Reveals Distinct Mitochondrial Functions Linked to Interferon Response Patterns in Activated CD4+ and CD8+ T Cells

Gerner, M. C., Niederstaetter, L., Ziegler, L. S., Bileck, A., Slany, A., Janker, L., Schmidt, R. L. J., Gerner, C., Favero, G. D., & Schmetterer, K. G. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00727 · Cited by 23

Metal-based nanoparticles promote the activation of cGAS-STING pathway for enhanced cancer immunotherapy

Li, Y., Zhu, Z., Hua, S., Wan, Y., Chen, Q., Gao, G., Zhang, H., Duan, W., Zheng, W., Guo, Y., et al. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102445 · Cited by 23

The mitochondria as a potential therapeutic target in cerebral I/R injury

Fang, S., Huang, W., Qu, X.-H., & Chai, W. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1500647 · Cited by 26

Engineering STING Nanoadjuvants for spatiotemporally-tailored innate immunity stimulation and cancer vaccination therapy

Chen, F., Zhang, H., Li, S. L., Ren, S., Huang, L., Cai, Z., Yin, L., Zheng, M., Liu, X., Xu, Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60927-7 · Cited by 22

Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

Gao, A. W., Alam, G. E., Lalou, A., Li, T. Y., Molenaars, M., Zhu, Y., Overmyer, K. A., Shishkova, E., Hof, K., Sleiman, M. S. B., et al. (2022) · iScience · doi:10.1016/j.isci.2022.103734 · Cited by 22

The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer

Kussainova, A., Bulgakova, O., Aripova, A., Khalid, Z., Bersimbaev, R. I., & Izzotti, A. (2022) · Biomedicines · doi:10.3390/biomedicines10020428 · Cited by 23

Intravitreal injection of mitochondrial DNA induces cell damage and retinal dysfunction in rats

Guo, Y., Gan, D., Hu, F., Cheng, Y., Yu, J. Y., Lei, B., Shu, Q., Gu, R., & Xu, G. (2022) · Biological Research · doi:10.1186/s40659-022-00390-6 · Cited by 22

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Li, T. Y., Gao, A. W., Li, X., Li, H., Liu, Y. J., Lalou, A., Neelagandan, N., Naef, F., Schoonjans, K., & Auwerx, J. H. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202205045 · Cited by 24

Therapeutic potential of melatonin and its derivatives in aging and neurodegenerative diseases

Verma, A. K., Singh, S., & Rizvi, S. I. (2022) · Biogerontology · doi:10.1007/s10522-022-10006-x · Cited by 23

Oxidative stress induces MUC5AC expression through mitochondrial damage‐dependent STING signaling in human bronchial epithelial cells

Nishida, Y., Yagi, H., Ota, M., Tanaka, A., Sato, K., Inoue, T., Yamada, S., Arakawa, N., Ishige, T., Kobayashi, Y., et al. (2023) · FASEB BioAdvances · doi:10.1096/fba.2022-00081 · Cited by 22

Single-Cell Transcriptome Analysis of Peripheral Neutrophils From Patients With Idiopathic Pulmonary Arterial Hypertension

Zhang, R., Zhang, J., Zhang, Y., Gong, S., Zhao, Q., Wang, X., Zhao, J., Jiang, R., Qiu, H., Li, H., et al. (2023) · Hypertension · doi:10.1161/hypertensionaha.123.21142 · Cited by 22

Mitochondrial DNA in inflammation and immunity

Riley, J. S., & Tait, S. W. G. (2020) · EMBO Reports · doi:10.15252/embr.201949799 · Cited by 902

Mitochondrial DNA release and sensing in innate immune responses

VanPortfliet, J. J., Chute, C., Lei, Y., Shutt, T. E., & West, A. P. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae031 · Cited by 70

Mitochondrial DNA: A Key Regulator of Anti-Microbial Innate Immunity

Kausar, S., Yang, L., Abbas, M. N., Hu, X., Zhao, Y., Zhu, Y., & Cui, H. (2020) · Genes · doi:10.3390/genes11010086 · Cited by 40

Mitochondrial DNA in the regulation of innate immune responses

Fang, C., Wei, X., & Wei, Y. (2015) · Protein & Cell · doi:10.1007/s13238-015-0222-9 · Cited by 174

Advances in crosstalk among innate immune pathways activated by mitochondrial DNA

Tao, G., Liao, W., Hou, J., Jiang, X., Deng, X., Chen, G., & Ding, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24029 · Cited by 51