Mitochondrial DNA in innate immune responses and inflammatory pathology

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049

Type I interferons in infectious disease

McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282

Mitochondrial DNA stress primes the antiviral innate immune response

West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature · doi:10.1038/nature14156 · Cited by 1,975

Mitochondrial form and function

Friedman, J. R., & Nunnari, J. (2014) · Nature · doi:10.1038/nature12985 · Cited by 1,803

Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

Lood, C., Blanco, L. P., Purmalek, M. M., Carmona-Rivera, C., De Ravin, S. S., Smith, C. K., Malech, H. L., Ledbetter, J. A., Elkon, K. B., & Kaplan, M. J. (2016) · Nature Medicine · doi:10.1038/nm.4027 · Cited by 1,570

Bone regeneration strategies based on organelle homeostasis of mesenchymal stem cells

Xin, L., Wen, Y., Song, J., Chen, T., & Zhai, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1151691 · Cited by 14

A state-of-the-science review of using mitochondrial DNA copy number as a biomarker for environmental exposure

Cheng, Q., Liu, Q., & Lu, C. A. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123642 · Cited by 15

Revolutionizing Antiviral Therapeutics: Unveiling Innovative Approaches for Enhanced Drug Efficacy

Megantara, S., Rusdin, A., Budiman, A., Shamsuddin, S., Mohtar, N., & Muchtaridi, M. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s447721 · Cited by 14

Mitochondrial dysfunction in kidney stones and relief of kidney stones after reducing mtROS

Xu, Y., Li, G., Ge, D., Chen, Y., Hou, B., & Hao, Z. (2024) · Urolithiasis · doi:10.1007/s00240-024-01614-y · Cited by 14

The role of mitochondria in cytokine and chemokine signalling during ageing

Kalykaki, M., Rubio‐Tomás, T., & Tavernarakis, N. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111993 · Cited by 14

Mitochondria at the crossroad of dysregulated inflammatory and metabolic processes in bipolar disorders

Bernard, J., Tamouza, R., Godin, O., Berk, M., Andreazza, A. C., & Leboyer, M. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.008 · Cited by 15

The role of the cGAS-STING pathway in chronic pulmonary inflammatory diseases

Tian, M., Li, F., Pei, H., Liu, X., & Nie, H. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1436091 · Cited by 15

Metabolic-driven analytics of traumatic brain injury and neuroprotection by ethyl pyruvate

Golovachev, N., Siebold, L., Sutton, R. L., Ghavim, S. S., Harris, N. G., & Bartnik‐Olson, B. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03280-8 · Cited by 14

Porcine Epidemic Diarrhea Virus Infection of Porcine Intestinal Epithelial Cells Causes Mitochondrial DNA Release and the Activation of the NLRP3 Inflammasome to Mediate Interleukin-1β Secretion

Bao, D., Yi, S., Zhao, L., Zhao, H., Liu, J., Wei, Y., Hu, G., & Liu, X. (2024) · Veterinary Sciences · doi:10.3390/vetsci11120643 · Cited by 18

Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease

VanPortfliet, J. J., Lei, Y., Ramanathan, M., Martinez, C. G., Wong, J. K., Stodola, T. J., Hoffmann, B. R., Pflug, K. M., Sitcheran, R., Kneeland, S. C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59907-8 · Cited by 18

Putative role of mitochondria in SARS-CoV-2 mediated brain dysfunctions: a prospect

Maurya, S. K., Baghel, M. S., Gaurav, G., Chaudhary, V., Kaushik, A. K., & Gautam, A. (2022) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2022.2108998 · Cited by 14

Stimulatory function of peroxiredoxin 1 in activating adaptive humoral immunity in a zebrafish model

Liu, G., Xiang, L., Shao, T., Lin, A., & Shao, J.-Z. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2018.03.004 · Cited by 14

Monomeric C-reactive protein promotes platelets to release mitochondrial DNA in anti-neutrophil cytoplasmic antibody-associated vasculitis

Chen, T., Xu, P., Gao, S., Hu, S., Wei, L., & Yan, T.-K. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.07.007 · Cited by 14

Small molecule inhibitor binds to NOD-like receptor family pyrin domain containing 3 and prevents inflammasome activation

Lackner, A., Cabral, J. E., Qiu, Y., Zhou, H., Leonidas, L., Pham, M. A., Macapagal, A., Lin, S., Armanus, E., & McNulty, R. (2024) · iScience · doi:10.1016/j.isci.2024.110459 · Cited by 16

Pathogen-induced mitochondrial dysfunction: mechanistic insights, immune crosstalk, and therapeutic opportunities

Yang, Y., Zeng, Y., Liu, Z.-Y., & Huang, J.-A. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1714998 · Cited by 12

Neutrophil extracellular traps in cancer: immune modulation, therapy resistance, and the dilemma of targeting

Brambilla, M., Zanichelli, A., Cancila, V., Colombo, M. P., Chiodoni, C., & Sangaletti, S. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08218-3 · Cited by 18

IRGM1, a guardian of mitochondrial DAMP–mediated autoinflammation

Kaufman, B. A., & Mora, A. L. (2021) · Nature Immunology · doi:10.1038/s41590-021-00877-6 · Cited by 13

Peroxisome proliferator-activated receptor γ coactivator 1α maintains NAD+ bioavailability protecting against steatohepatitis

Shen, W., Wan, X., Hou, J., Liu, Z., Mao, G., Xu, X., Yu, C., Zhu, X., & Ju, Z. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac031 · Cited by 14

Downregulation of oxidative stress-mediated glial innate immune response suppresses seizures in a fly epilepsy model

Nukala, K. M., Lilienthal, A. J., Lye, S. H., Bassuk, A. G., Chtarbanova, S., & Manak, J. R. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112004 · Cited by 17

Gut Microbiota-Derived Trimethylamine Promotes Inflammation with a Potential Impact on Epigenetic and Mitochondrial Homeostasis in Caco-2 Cells

Bordoni, L., Petracci, I., Feliziani, G., de Simone, G., Rucci, C., & Gabbianelli, R. (2024) · Antioxidants · doi:10.3390/antiox13091061 · Cited by 13

Arsenic-induced mtDNA release promotes inflammatory responses through cGAS-STING signaling in chicken hepatocytes

Pan, H., Su, Q., Hong, P., You, Y., Zhou, L., Zou, J., Sun, J., Zhong, G., Liao, J., Zhang, H., et al. (2024) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2024.106129 · Cited by 14

RGD hydrogel-loaded ADSC extracellular vesicles mitigate uranium-induced renal injury via TLR4/NF-κB pathway inhibition

Chen, X., Dai, C.-M., Zhang, B., Zhang, W.-X., Huang, Z.-H., Jiang, J.-Y., Hu, S.-Q., Ma, J., & Feng, J. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03176-6 · Cited by 13

Neutrophil Extracellular Traps in Atherosclerosis: Research Progress

Shi, Z., Gong, S., Li, Y., Yan, K., Bao, Y., & Ning, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052336 · Cited by 13

Hyperandrogenism triggers mtDNA release to participate in ovarian inflammation via mPTP/cGAS/STING in PCOS

Cai, J., Zhu, Q., Xiang, Y., Weng, L., Liang, N., Hong, X., Xue, M., & Ge, H. (2025) · iScience · doi:10.1016/j.isci.2025.112391 · Cited by 13

Multiple pathways through which the gut microbiota regulates neuronal mitochondria constitute another possible direction for depression

Zhao, H., Qiu, X., Wang, S., Wang, Y., Xie, L., Xia, X., & Li, W. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1578155 · Cited by 14

Mitochondrial Transcription Factor A Regulates Mycobacterium bovis–Induced IFN-β Production by Modulating Mitochondrial DNA Replication in Macrophages

Song, Y., Hussain, T. A., Wang, J., Liao, Y., Yue, R., Sabir, N., Zhao, D., & Zhou, X. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz461 · Cited by 13

Immunity, virus evolution, and effectiveness of SARS-CoV-2 vaccines

Belizário, J. E. (2021) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x202010725 · Cited by 11

Dialysate cell-free mitochondrial DNA fragments as a marker of intraperitoneal inflammation and peritoneal solute transport rate in peritoneal dialysis

Xie, X., Wang, J., Xiang, S., Chen, Z., Zhang, X., & Chen, J. (2019) · BMC Nephrology · doi:10.1186/s12882-019-1284-3 · Cited by 13

Novel coronavirus disease (COVID-19) and cytokine storms. For more effective treatments from the viewpoints of an inflammatory pathophysiology perspective

Yokota, S., Kuroiwa, Y., & Nishioka, K. (2020) · Infectious diseases News Opinions Training · doi:10.33029/2305-3496-2020-9-4-13-25 · Cited by 16

Methodological influences on circulating cell-free-mitochondrial and nuclear DNA concentrations in response to chronic stress

Daubermann, C., Herhaus, B., Neuberger, E. W. I., Simon, P. D., & Petrowski, K. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10369-7 · Cited by 12

Targeting mitochondria: Unveiling novel therapeutic frontiers in sepsis

Lai, B., Gu, M., Sun, J. L., & Zhang, J. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115078 · Cited by 14

Targeting TFAM downregulation mediated mtDNA-NLRP3 pathway suppresses TAM infiltration and HCC progression

Zhao, J., Cui, M., Yao, X., Jiang, Z., Qi, L., Chen, J., Fan, C., Bai, S., Zhou, C., Wei, R., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03467-0 · Cited by 12

Mitochondrial dysfunction–induced PANoptosis: Mechanisms, triggers, and disease implications

Pan, L., Fang, S., Kong, F., Ye, S., & Xiong, Y. (2026) · Mitochondrion · doi:10.1016/j.mito.2026.102115 · Cited by 13

Prognostic value of circulating mitochondrial DNA in prostate cancer and underlying mechanism

Borah, S., Mishra, R., Dey, S., Suchanti, S., Bhowmick, N. A., Giri, B., & Haldar, S. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.05.005 · Cited by 12

Mitochondrial Regulation of Macrophages in Innate Immunity and Diverse Roles of Macrophages During Cochlear Inflammation

Zhang, Y., Ye, F., Fu, X., Shen, L., Wang, L., Chen, Y., Li, H., Hao, S., Zhao, K., Feng, Q., et al. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01085-y · Cited by 12

Metabolic modulation of mitochondrial mass during CD4+ T cell activation

Kurmi, K., Liang, D., van de Ven, R., Georgiev, P., Gassaway, B. M., Han, S., Notarangelo, G., Harris, I. S., Yao, C.-H., Park, J. S., et al. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.08.008 · Cited by 12

Storage of Transfusion Platelet Concentrates Is Associated with Complement Activation and Reduced Ability of Platelets to Respond to Protease-Activated Receptor-1 and Thromboxane A2 Receptor

Andersson, L. I., Sjöström, D. J., Quach, H. Q., Hägerström, K., Hurler, L., Kajdácsi, E., Cervenak, L., Prohászka, Z., Toonen, E. J. M., Mohlin, C., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021091 · Cited by 12

Association between circulating cell-free mitochondrial DNA and inflammation factors in noninfectious diseases: A systematic review

Zhou, M., Zhang, H., Xu, X., Chen, H., & Qi, B. (2024) · PLoS ONE · doi:10.1371/journal.pone.0289338 · Cited by 12

Oxidative stress induces release of mitochondrial DNA into the extracellular space in human placental villous trophoblast BeWo cells

Gardner, J. J., Cushen, S. C., da Silva, R. D. N. O., Bradshaw, J. L., Hula, N., Gorham, I. K., Tucker, S. M., Zhou, Z., Cunningham, R. L., Phillips, N., et al. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00091.2024 · Cited by 15

Mitochondrial calcium uniporter complex: Unveiling the interplay between its regulators and calcium homeostasis

Guo, J., Wang, Y., Shi, C., Zhang, D., Zhang, Q., Wang, L., & Gong, Z. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111284 · Cited by 13

Regulation of Type I Interferon and Autophagy in Immunity against Mycobacterium Tuberculosis : Role of CGAS and STING1

Malik, A. A., Shariq, M., Sheikh, J. A., Fayaz, H., Srivastava, G., Thakuri, D., Ahuja, Y., Ali, S., Alam, A., Ehtesham, N. Z., et al. (2024) · Advanced Biology · doi:10.1002/adbi.202400174 · Cited by 13

Real-Time Monitoring of mtDNA Aggregation and Mitophagy Induced by a Fluorescent Platinum Complex in Living Cells

Liu, B., Sun, T., Wang, Y., Xia, X., Cao, S., Wang, K., Chen, Q., & Mao, Z. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c01128 · Cited by 12

Elevated serum mtDNA in COVID-19 patients is linked to SARS-CoV-2 envelope protein targeting mitochondrial VDAC1, inducing apoptosis and mtDNA release

Shteinfer‐Kuzmine, A., Verma, A., Bornshten, R., Chetrit, E. B., Yaʼacov, A. B., Pahima, H. T., Rubin, E., Mograbi, Y., Shteyer, E., & Shoshan‐Barmatz, V. (2024) · APOPTOSIS · doi:10.1007/s10495-024-02025-5 · Cited by 14

Extracellular Mitochondria Exacerbate Retinal Pigment Epithelium Degeneration in Diabetic Retinopathy

Nishikawa, K., Murakami, T., Yoshida, M., Terada, N., Ishihara, K., Mori, Y., Ito, S., & Tsujikawa, A. (2024) · Diabetes · doi:10.2337/db24-0040 · Cited by 12

Exercise intensity and training alter the innate immune cell type and chromosomal origins of circulating cell-free DNA in humans

Rodrigues, K. B., Weng, Z., Graham, Z., Lavin, K. M., McAdam, J. S., Tuggle, S. C., Peoples, B., Seay, R. S., Yang, S., Bamman, M. M., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2406954122 · Cited by 20

Extracellular mitochondria contribute to acute lung injury via disrupting macrophages after traumatic brain injury

Liu, Y., Li, F., Tang, L., Pang, K., Zhang, Y., Zhang, C., Guo, H., Ma, T., Zhang, X., Yang, G., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03390-x · Cited by 12

N-Formylated Peptide Induces Increased Expression of Both Formyl Peptide Receptor 2 (Fpr2) and Toll-Like Receptor 9 (TLR9) in Schwannoma Cells—An In Vitro Model for Early Inflammatory Profiling of Schwann Cells

Korimová, A., & Dubový, P. (2020) · Cells · doi:10.3390/cells9122661 · Cited by 12

Morin attenuates L-arginine induced acute pancreatitis in rats by downregulating myeloperoxidase and lipid peroxidation

Rehman, K., Rashid, U., Jabeen, K., & Akash, M. S. H. (2021) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/2221-1691.310201 · Cited by 12

Silver nanoparticles exert toxic effects in human monocytes and macrophages associated with the disruption of Δψm and release of pro-inflammatory cytokines

Sousa, A., Rufino, A. T., Fernandes, R., Malheiro, A., Carvalho, F. D., Fernandes, E. G. R., & Freitas, M. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03415-x · Cited by 12

Polyglutamine binding protein 1 (PQBP1) inhibits innate immune responses to cytosolic DNA

Shannon, J. L., Murphy, M. S., Kantheti, U., Burnett, J. M., Hahn, M., Dorrity, T. J., Bacas, C. J., Mattice, E. B., Corpuz, K. D., & Barker, B. R. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.05.014 · Cited by 12

RNA Signaling in Pulmonary Arterial Hypertension—A Double-Stranded Sword

Turton, H. A., Thompson, A. A. R., & Farkas, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093124 · Cited by 12

TREX1 exonuclease in immunity and disease

Shang, Z., Wang, L., & Zhou, W. (2025) · International Immunology · doi:10.1093/intimm/dxaf037 · Cited by 14

Borrelia burgdorferi Engages Mammalian Type I IFN Responses via the cGAS–STING Pathway

Farris, L. C., Torres-Odio, S., Adams, L. G., West, A. P., & Hyde, J. A. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200354 · Cited by 12

Mitochondrial DNA-Sensing Pathogen Recognition Receptors in Systemic Sclerosis-Associated Interstitial Lung Disease: a Review

Ghincea, A., Woo, S., Yu, S., Pivarnik, T., Fiorini, V., Herzog, E. L., & Ryu, C. (2023) · Current Treatment Options in Rheumatology · doi:10.1007/s40674-023-00211-1 · Cited by 11

The silent threat: Nanopolystyrene and chrysene pollutants disrupt the intestinal mucosal barrier, new insights from juvenile Siniperca chuatsi

Chen, T., Aly, R. S. S., Shen, Y., Tang, S., Zhao, Y., Zhao, J., & Chen, X. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.172001 · Cited by 11

cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice

Wei, Z., Zhao, S., Wei, R., Wang, Z., Zhang, F., Zong, F., & Zhang, H. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112185 · Cited by 11

SLE: a cognitive step forward—a synthesis of rethinking theories, causality, and ignored DNA structures

Rekvig, O. P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1393814 · Cited by 12

Early Plasma Nuclear DNA, Mitochondrial DNA, and Nucleosome Concentrations Are Associated With Acute Kidney Injury in Critically Ill Trauma Patients

Faust, H. E., Oniyide, O., Wang, Y., Forker, C. M., Dunn, T., Yang, W., Lanken, P. N., Sims, C. A., Yehya, N., Christie, J. D., et al. (2022) · Critical Care Explorations · doi:10.1097/cce.0000000000000663 · Cited by 11

Cell-Free Mitochondrial DNA in Acute Brain Injury

Kayhanian, S., Glynos, A., Mair, R. J., Lakatos, A., Hutchinson, P. J., Helmy, A. E., & Chinnery, P. F. (2022) · Neurotrauma Reports · doi:10.1089/neur.2022.0032 · Cited by 12

The Yin and Yang of Alarmins in Regulation of Acute Kidney Injury

Sabapathy, V., Venkatadri, R., Doğan, M., & Sharma, R. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00441 · Cited by 11

Aging aggravated liver ischemia and reperfusion injury by promoting oxidized mtDNA mediated-macrophage pyroptosis through acetylated MCU-dependent calcium uptake

Wu, X., Wang, R., Zhang, Q., Liu, T., Liu, J.-Y., Xu, X., & Gong, J.-H. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02746-9 · Cited by 10

The cGAS-STING Pathway in Pulmonary Diseases: Mechanisms and Therapeutic Potential

Zhang, Z., Jiang, J., Wu, G., Wei, X., Weng, Y., & Huang, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110423 · Cited by 11

Mitochondrial networks through the lens of mathematics

Lewis, G. R., & Marshall, W. F. (2023) · Physical Biology · doi:10.1088/1478-3975/acdcdb · Cited by 11

Super-resolution imaging of mitochondrial cristae using a more hydrophobic far-red Si-rhodamine probe

Sun, J., Ge, X., Jin, B., Li, S., Hou, Y., Zhong, S., Yang, Z., Xi, P., Li, M., & Gao, B. (2023) · Chemical Communications · doi:10.1039/d3cc04696f · Cited by 10

Mitochondrial disorders as a mechanism for the development of obese Sarcopenia

Liao, T., Xiong, L., Wang, X., Yang, S., & Liang, Z. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01192-w · Cited by 10

Research progress on mitochondria regulating tumor immunity

Li, J., Xu, P., & Chen, S. (2024) · Journal of Zhejiang University (Medical Sciences) · doi:10.3724/zdxbyxb-2023-0484 · Cited by 11

Mitochondrial damage and clearance in retinal pigment epithelial cells

Gurubaran, I. S. (2024) · Acta Ophthalmologica · doi:10.1111/aos.16661 · Cited by 11

When Our Best Friend Becomes Our Worst Enemy: The Mitochondrion in Trauma, Surgery, and Critical Illness

Torp, M., Stensløkken, K., & Vaage, J. (2024) · Journal of Intensive Care Medicine · doi:10.1177/08850666241237715 · Cited by 10

Oxidative damage to mitochondrial DNA in maternal zebrafish (Danio rerio) exposed to dibutyl phthalate at environmentally relevant level.

Hou, T., Yang, Z., Wang, L., Zhang, H., Ma, W., Zhang, D., & Fan, X. (2024) · Aquatic Toxicology · doi:10.1016/j.aquatox.2024.106980 · Cited by 11

The Mechanisms and Implications of Cardiolipin in the Regulation of Cell Death

Li, Z., Xiao, H., Hu, J., Xie, W., Wang, Z., Pan, Y., Li, X., & Yu, X. (2025) · Cell Biochemistry and Function · doi:10.1002/cbf.70066 · Cited by 12

Urolithin A alleviates radiation pneumonitis by activating PINK1/PRKN-mediated Mitophagy

Zhang, A., Luo, S., Li, P., Meng, L., Huang, L., Cheng, H., Zhao, C., Tu, H., & Gong, X. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114671 · Cited by 10

The cGAS-STING signaling pathway in the regulation of pulmonary infections: a systematic review

Xu, Q., & Zhu, J. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1628481 · Cited by 11

Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead‐Induced Hepatocytes Pyroptosis in Common Carp ( Cyprinus carpio L.)

Miao, Z., Ji, X., Wei, L., Miao, Z., & Xu, S. (2025) · Advanced Science · doi:10.1002/advs.202501041 · Cited by 10

A benchmarking of human mitochondrial DNA haplogroup classifiers from whole-genome and whole-exome sequence data

García‐Olivares, V., Muñoz‐Barrera, A., Lorenzo-Salazar, J. M., Zaragoza‐Trello, C., Rubio‐Rodríguez, L. A., Usera, A. D.-D., Jáspez, D., Íñigo-Campos, A., González‐Montelongo, R., & Flores, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-99895-5 · Cited by 9

Association of circulating MtDNA with CVD in hemodialysis patients and in vitro effect of exogenous MtDNA on cardiac microvascular inflammation

Fan, Z., Feng, Y., Zang, L., Guo, Y., & Zhong, X.-Y. (2023) · BMC Cardiovascular Disorders · doi:10.1186/s12872-023-03104-2 · Cited by 10

Diet, Trimethylamine Metabolism, and Mitochondrial DNA: An Observational Study

Bordoni, L., Malinowska, A. M., Petracci, I., Szwengiel, A., Gabbianelli, R., & Chmurzyńska, A. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200003 · Cited by 10

Mitochondrial DNA in Visceral Adipose Tissue in Severe Obesity: From Copy Number to D-Loop Methylation

Bordoni, L., Perugini, J., Petracci, I., Mercurio, E. D., Lezoche, G., Guerrieri, M., Giordano, A., & Gabbianelli, R. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2706172 · Cited by 10

Hijacking Host Immunity by the Human T-Cell Leukemia Virus Type-1: Implications for Therapeutic and Preventive Vaccines

Pise-Masison, C. A., & Franchini, G. (2022) · Viruses · doi:10.3390/v14102084 · Cited by 11

Effects of Dialysate Acidification With Citrate Versus Acetate on Cell Damage, Uremic Toxin Levels, and Inflammation in Patients Receiving Maintenance Hemodialysis

Jung, S. W., Kim, D. R., Cho, K. S., Seo, J.-W., Moon, H., Park, E. J., Kim, J. S., Lee, T. W., Ihm, C. G., Jeong, D. W., et al. (2018) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2018.09.010 · Cited by 10

The Pathophysiological Significance of “Mitochondrial Ejection” from Cells

Fan, Q., Maejima, Y., Wei, L., Nakagama, S., Shiheido‐Watanabe, Y., & Sasano, T. (2022) · Biomolecules · doi:10.3390/biom12121770 · Cited by 9

Lipopolysaccharide promotes NLRP3 inflammasome activation by inhibiting TFEB-mediated autophagy in NRK-52E cells

Song, D., Tao, W., Liu, F., Wu, X., Bi, H., Shu, J., Wang, D., & Li, X. (2023) · Molecular Immunology · doi:10.1016/j.molimm.2023.09.008 · Cited by 9

Molecular mechanisms underlying sarcopenia in heart failure

Rutledge, C. A. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.40 · Cited by 9

Integrative transcriptomic and genomic analyses unveil the IFI16 variants and expression as MASLD progression markers

Kim, D., Shah, M., Kim, J. H., Kim, J., Baek, Y.-H., Jeong, J., Han, S., Lee, Y. S., Park, G., Cho, J.-H., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000000805 · Cited by 9

Complex regulation of mitochondrial signaling by human adenovirus minor capsid protein VI

Schubert, E., Mun, K., Larsson, M., Panagiotou, S., Idevall‐Hagren, O., Svensson, C., & Punga, T. (2024) · Journal of Virology · doi:10.1128/jvi.00356-24 · Cited by 11

Arsenic trioxide induces innate immune response and inflammatory response in chicken liver via cGAS-STING/NF-κB pathway

Pan, H., Zhou, L., Zou, J., Sun, J., You, Y., Zhong, G., Liao, J., Zhang, H., Tang, Z., & Hu, L. (2024) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2024.110017 · Cited by 9

Mitochondrial Quality Control Orchestrates the Symphony of B Cells and Plays Critical Roles in B Cell‐Related Diseases

Li, W., Cai, P., Xu, Y., Tian, W., Jing, L., Lv, Q., Zhao, Y., Wang, H., & Shao, Q. (2024) · Journal of Immunology Research · doi:10.1155/2024/5577506 · Cited by 9

Correlation between circulating cell-free mitochondrial DNA content and severity of knee degeneration in patients with knee osteoarthritis: a cross-sectional study

Wu, Y., Wan, S.-G., Long, Y., Ye, H., Yang, J., Luo, Y., Zhong, Y.-B., Li, X., Chen, H., & Wang, M. (2024) · Arthritis Research & Therapy · doi:10.1186/s13075-024-03438-y · Cited by 10

TLR9 in satellite glial cells promotes paclitaxel-induced neuropathic pain by reducing Kir4.1 transcription through histone methylation activation

Luo, Q., Jiang, J. W., Zhu, Q., 王飒爽, Wu, Y., Li, N., Ba, X., Wu, F., Liu, X., Luo, Y., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.03.037 · Cited by 9

Mitochondrial DNA: leakage, recognition and associated human diseases

Takamatsu, H. (2025) · The Journal of Biochemistry · doi:10.1093/jb/mvaf037 · Cited by 9

Rutin alleviates heat stress induced hepatic abnormal lipid metabolism of broilers via improving antioxidant capacity to maintain mitochondrial homeostasis

Ma, L., Liu, H., Ge, Z., Bai, B., Zhao, J., Chen, S., Zhou, B., Zhang, J., Wang, T., & Wang, C. (2025) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2025.104204 · Cited by 10

Mitochondrial echoes in the bloodstream: decoding ccf-mtDNA for the early detection and prognosis of hepatocellular carcinoma

Chu, Y., Chen, W., Lin, W.-R., Lai, M. W., & Yeh, C. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01456-0 · Cited by 11

Mitochondrial DNA: a novel indicator of active inflammation in ANCA-associated vasculitides

Giaglis, S., Daoudlarian, D., Thiel, J., Rizzi, M., Kyburz, D., Venhoff, N., & Walker, U. A. (2023) · Rheumatology · doi:10.1093/rheumatology/kead015 · Cited by 9

Mitochondrial network adaptations of microglia reveal sex-specific stress response after injury and UCP2 knockout

Maes, M. E., Colombo, G., Uiterkamp, F. E. S., Sternberg, F., Venturino, A., Pohl, E. E., & Siegert, S. (2023) · iScience · doi:10.1016/j.isci.2023.107780 · Cited by 9

What is the role of the neutrophil extracellular traps in the cardiovascular disease burden associated with hemodialysis bioincompatibility?

Cristol, J., Thierry, A. R., Bargnoux, A., Morena-Carrere, M., & Canaud, B. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1268748 · Cited by 9

Mitochondrial DNA copy number is associated with Crohn’s disease: a comprehensive Mendelian randomization analysis

Cai, X., Li, X., Liang, C., Zhang, M., Xu, Y., Dong, Z., Weng, Y., & Yu, W. (2023) · Scientific Reports · doi:10.1038/s41598-023-48175-5 · Cited by 8

Transposable Elements: Emerging Therapeutic Targets in Neurodegenerative Diseases

Singh, S., Borkar, M. R., & Bhatt, L. K. (2024) · Neurotoxicity Research · doi:10.1007/s12640-024-00688-1 · Cited by 11

Novel approaches for biomolecule immobilization in microscale systems

Chen, C., Liu, W., & Hong, T. (2019) · The Analyst · doi:10.1039/c9an00212j · Cited by 9

Methods to Detect Immunogenic Cell Death In Vivo

Yamazaki, T., Buqué, A., Rybstein, M. D., Chen, J., Sato, A., & Galluzzi, L. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9773-2_20 · Cited by 9

Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection

Sato-Kaneko, F., Yao, S., Lao, F. S., Nan, J., Shpigelman, J., Cheng, A., Saito, T., Messer, K. S., Pu, M., Shukla, N. M., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2025718118 · Cited by 9

Mitochondrial DNA in inflammation and immunity

Riley, J. S., & Tait, S. W. G. (2020) · EMBO Reports · doi:10.15252/embr.201949799 · Cited by 910

Mitochondrial DNA release and sensing in innate immune responses

VanPortfliet, J. J., Chute, C., Lei, Y., Shutt, T. E., & West, A. P. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae031 · Cited by 70

Mitochondrial DNA: A Key Regulator of Anti-Microbial Innate Immunity

Kausar, S., Yang, L., Abbas, M. N., Hu, X., Zhao, Y., Zhu, Y., & Cui, H. (2020) · Genes · doi:10.3390/genes11010086 · Cited by 40

Mitochondrial DNA in the regulation of innate immune responses

Fang, C., Wei, X., & Wei, Y. (2015) · Protein & Cell · doi:10.1007/s13238-015-0222-9 · Cited by 174

Advances in crosstalk among innate immune pathways activated by mitochondrial DNA

Tao, G., Liao, W., Hou, J., Jiang, X., Deng, X., Chen, G., & Ding, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24029 · Cited by 51