Mitochondrial DNA in innate immune responses and inflammatory pathology

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154

Circulating mitochondrial DAMPs cause inflammatory responses to injury

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049

Type I interferons in infectious disease

McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282

Mitochondrial DNA stress primes the antiviral innate immune response

West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature · doi:10.1038/nature14156 · Cited by 1,975

Mitochondrial form and function

Friedman, J. R., & Nunnari, J. (2014) · Nature · doi:10.1038/nature12985 · Cited by 1,803

Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

Lood, C., Blanco, L. P., Purmalek, M. M., Carmona-Rivera, C., De Ravin, S. S., Smith, C. K., Malech, H. L., Ledbetter, J. A., Elkon, K. B., & Kaplan, M. J. (2016) · Nature Medicine · doi:10.1038/nm.4027 · Cited by 1,570

Effects of acute endurance exercise and exhaustive exercise on innate immune signals induced by mtDNA

Ge, Z., Zhang, Z., & Ding, S. (2022) · European Journal of Inflammation · doi:10.1177/1721727x221134942 · Cited by 4

Circulating Cell-Free DNA in Inflammatory Bowel Disease: Liquid Biopsies with Mechanistic and Translational Implications

Chuah, C. S., Fischer, L., & Ho, G. (2023) · Faculty Reviews · doi:10.12703/r/12-14 · Cited by 5

Mitophagy Defects Exacerbate Inflammation and Aberrant Proliferation in Lymphocytic Thyroiditis

Lee, H. S., Lee, J., An, H., Sung, M. J., Heo, J. H., Lee, S., & Song, Y. S. (2024) · Thyroid · doi:10.1089/thy.2024.0125 · Cited by 4

Immune dysregulation of decidual NK cells mediated by GRIM19 downregulation contributes to the occurrence of recurrent pregnancy loss

Wang, Y., Guo, A.-L., Yang, L., Han, X., Li, Q., Liu, J., Han, Y., Yang, Y., & Lan, C. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05181-z · Cited by 4

Eosinophilic Fasciitis and Morphea Share Gene Signatures of Inflammatory Cell Death, Self-DNA Recognition, and Enhanced Jak/Signal Transducer and Activator of Transcription Signaling

Crisler, W. J., Rowley, R., Oke, O. H., Steuart, S. J., Modi, M. M., Davis, D. L., Chen, C., Gray, L., Teague, J. E., Zhan, Q., et al. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.05.023 · Cited by 6

Mitochondria: A Covert Chronic Infection Masquerading as a Symbiotic Partner?

Stefano, G. B. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl42854 · Cited by 5

Clonal heamatopoiesis and associated cardiovascular diseases

Tajiri, K., Suehara, Y., Suzuki, T., & Sekine, I. (2023) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyac210 · Cited by 4

RNA reports breaking news from mitochondria

Tadepalle, N., & Shadel, G. S. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.04.005 · Cited by 4

Oxidative stress leads to severe phenotypes in sepsis through activation of NLRP3-pyroptosis

Beltrán-García, J., Osca-Verdegal, R., García‐Giménez, J. L., & Pallardó, F. V. (2022) · Redox Experimental Medicine · doi:10.1530/rem-22-0006 · Cited by 4

Plasma extracellular DNA and neutrophilic leukocyte activity in patients with rheumatoid arthritis

Давидовна, Г. Е., Demchenko, E. N., Goiman, E. V., Александровна, Ч. О., Volskiy, N. N., Сизиков, А. Э., & Va, K. (2022) · Russian Journal of Immunology · doi:10.46235/1028-7221-1110-ped · Cited by 4

A protocol for studying the interaction between small-molecular drug and DNA using microdialysis sampling integrated with chemiluminescent detection

Wang, P., Zhou, Y., Ouyang, H., Wang, L., & Fu, Z. (2017) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2017.12.013 · Cited by 4

Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infectionPreprint

Weindel, C. G., Zhao, X. L., Martinez, E., Bell, S. L., Vail, K. J., Coleman, A. K., VanPortfliet, J. J., Zhao, B., Mabry, C. J., Li, P., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.18.469014 · Cited by 4

Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNAPreprint

Newman, L. E., Tadepalle, N., Novak, S. W., Schiavon, C. R., Rojas, G. R., Chevez, J. A., Lemersal, I., Medina, M., Rocha, S., Towers, C. G., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.12.511955 · Cited by 4

MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide

Rice, M. C., Imun, M., Jung, S., Park, C., Kim, J., Lai, R., Barr, C. R., Son, J., Tor, K., Kim, E., et al. (2023) · eLife · doi:10.1101/2023.03.02.530691 · Cited by 5

TGFβ primes alveolar-like macrophages to induce type I IFN following TLR2 activation

Thomas, S. M., McGee, A. P., Vielma, T. E., Ankley, L. M., Rapp, A. W., Conner, K. N., LeSage, F., Tanner, C., Scheeres, E. C., Obar, J. J., et al. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag090 · Cited by 4

GDF11 alleviates cardiac ischemia/reperfusion injury by suppressing the mtDNA damage-inflammatory response axis

Zhao, D., Wang, Z., Chen, Y., Wang, Z. P., Wei, Y., Zhang, L., Wei, Y., Li, S., Zheng, X., Wang, G., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177392 · Cited by 3

Diosgenin ameliorates colitis by inhibiting mitochondrial DNA synthesis in macrophages via STAT2-CMPK2 pathway

Qiao, X., Zhang, L., Wang, T., Liang, X., Yao, S., Wang, L., Ma, G., Yang, J., & Wen, X. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157605 · Cited by 5

A metal-immuno photosensitizer strategy: Iridium(III)-zidovudine conjugate triggering sequential organelle stress and synergizing with PD-L1 inhibitor in oral squamous cell carcinoma

Li, Y., Wang, P., Zhang, W.-Y., Zhou, R., Zhou, J., Chen, J., Wu, J., Cheng, B., Tan, C., & Wu, T. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.171674 · Cited by 3

Mitochondrial dysfunction as a bridge to pathology in acute pancreatitis: From molecular insights to novel therapeutic strategies

Xia, C., Xu, Y., Wang, Z., & Xu, G.-Q. (2025) · World Journal of Gastroenterology · doi:10.3748/wjg.v31.i48.113840 · Cited by 3

Nano-sized DNase scavenges cell-free DNA for acute lung injury treatment

Chen, R., Xu, Y., Ye, Z., Zhu, Y., Zhang, M., Lv, F., Wang, Y., Di, X., Lin, Y., Song, S., et al. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114846 · Cited by 4

Rethinking Mitochondria: The Extracellular Dimension

Pena-Couso, L., Makuch, M., & Nicolás-Ávila, J. Á. (2026) · Circulation Research · doi:10.1161/circresaha.125.326988 · Cited by 4

Intercellular Mitochondrial Transfer: Implications in Cardiovascular Health

Wang, Y., & Tian, R. H. (2026) · Circulation Research · doi:10.1161/circresaha.125.326986 · Cited by 3

Phospholipid Transfer Protein (PLTP) in Cholesterol Handling: Implications for Mitochondrial Lipid Homeostasis in Human iPSC-Derived Cardiomyocytes

Shahannaz, D. C., & Sugiura, T. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27083617 · Cited by 3

Tunneling nanotubes: a new dimension of intercellular communication and recent progress

Dong, X., Xuan, Y., Wang, M., Chang, S., Hu, X., & Han, Z. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02980-3 · Cited by 3

Mitochondrial respiration of a primary mixed culture of neurons from hippocampus at various stages of differentiation

Zelentsova, A. S., Borisova, A. Y., Shmigerova, V. S., Skorkina, M. Y., & Deykin, A. V. (2024) · Genes and Cells · doi:10.17816/gc529662 · Cited by 3

The role of cGAS/STING signaling in ophthalmological diseases

Wang, Q., Xu, X., Ye, J., & Zhang, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117078 · Cited by 3

Electro‐Responsive Nanotherapeutics for Tumor Therapy by Manipulating Accidental and Regulated Cell Death Pathway

Qu, C. F., Shao, X., Li, Y., Jia, R., Wang, J., & An, H. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400160 · Cited by 3

Coupling of β-adrenergic and Hippo pathway signaling: Implications for heart failure pathophysiology and metabolic therapy

Du, X., She, G., Wu, W., & Deng, X. (2024) · Mitochondrion · doi:10.1016/j.mito.2024.101941 · Cited by 3

Insights into regulatory T-cell and type-I interferon roles in determining abacavir-induced hypersensitivity or immune tolerance

Cardone, M., Baghdassarian, H., Khalaj, M., Sivakumar, K. K., Hwang, S., Gebreyohannes, S., Takeda, K., Jang, Y., Lewis, N. E., Norcross, M. A., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1612451 · Cited by 3

Astrocytic lipidopathy and bioenergetic failure in ApoE4-associated late-onset Alzheimer's disease: A unifying hypothesis

Garrahy, J. P. (2025) · Journal of Alzheimer’s Disease · doi:10.1177/13872877251350338 · Cited by 6

The role of mitochondria-related proteins in inflammation and autoimmune diseases: a causal analysis using Mendelian randomization and colocalization

Hong, Y. (2025) · Health Information Science and Systems · doi:10.1007/s13755-025-00358-2 · Cited by 5

Reframing primary mitochondrial disease as a sterile interferonopathy

Morava, É., Elsharkawi, I., & Kozicz, T. (2025) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2025.109217 · Cited by 3

Chemo-/radiotherapy-induced cardiomyopathy: roles of mitochondria and endoplasmic reticulum

Suliman, M., Altalbawy, F. M. A., Malathi, H., Kazmi, S. W., Sharma, A., Kumar, M., Alamir, H. T. A., Mohammed, F., KADHIM, A. J., & Alhadrawi, M. (2025) · Strahlentherapie und Onkologie · doi:10.1007/s00066-025-02471-3 · Cited by 4

Targeting the Mitochondrion in Diabetic Neuropathy

Hedayat, A. F., Chandrasekaran, K., Zilliox, L. A., & Russell, J. W. (2023) · Contemporary diabetes · doi:10.1007/978-3-031-15613-7_17 · Cited by 3

Pathogenetic Mechanisms of Organ Dysfunction in Severe Concomitant Trauma

Булава, Г. В. (2023) · Russian Sklifosovsky Journal Emergency Medical Care · doi:10.23934/2223-9022-2023-12-1-92-98 · Cited by 3

Low-grade glioma risk SNP rs11706832 is associated with type I interferon response pathway genes in cell lines

Rosenbaum, A., Dahlin, A. M., Andersson, U., Björkblom, B., Wu, W., Hedman, H., Wibom, C., & Melin, B. S. (2023) · Scientific Reports · doi:10.1038/s41598-023-33923-4 · Cited by 3

A comparison of the impact on neuronal transcriptome and cognition of rAAV5 transduction with three different doses in the mouse hippocampus

Liu, Y.-S., Wang, M., Hu, N.-Y., Li, Z., Wu, J., Li, H., Li, J., Li, X., Yang, J., Gao, T., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1195327 · Cited by 3

Multifunctional photosensitizers for the activation and visualization of pyroptotic cell death under photodynamic therapy

Pham, L. B. H., Chung, K. L., Kim, S., & Lee, J. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.134799 · Cited by 3

mtDNA extramitochondrial replication mediates mitochondrial defect effects

Shan, Z., Li, S., Gao, Y., Jian, C., Ti, X., Zuo, H., Wang, Y., Zhao, G., Wang, Y., & Zhang, Q. (2024) · iScience · doi:10.1016/j.isci.2024.108970 · Cited by 3

Endosomal Toll-Like Receptors as Therapeutic Targets for Autoimmune Diseases

Miyake, K., Shibata, T., Fukui, R., Murakami, Y., Sato, R., & Hiranuma, R. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-9781-7_7 · Cited by 3

Mendelian disorders of immunity related to an upregulation of type I interferon

Frémond, M., & Crow, Y. J. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816768-7.00032-6 · Cited by 3

Role of Mitochondrial DNA in Inflammatory Airway Diseases

Snyder, R. J., & Kleeberger, S. R. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200010 · Cited by 5

Defective mitochondrial-lysosomal axis promotes extracellular vesicles release of mitochondrial components in Huntington’s DiseasePreprint

Beatriz, M., Vilaça, R., Anjo, S. I., Manadas, B. J., Januário, C., Rego, A. C., & Lopes, C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.13.480262 · Cited by 3

Mitochondrial dysfunction in sepsis

Schroder, E. A., Callahan, L. A., Wang, L., & Supinski, G. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85666-9.00016-4 · Cited by 2

Blood transfusion and the presence of biological structures in the circulation

Tanos, R., & Thierry, A. R. (2022) · Cellular and Molecular Biology · doi:10.14715/cmb/2022.68.10.1 · Cited by 2

Role of Mitochondrial DNA in Inflammatory Airway Diseases

Snyder, R. J., & Kleeberger, S. R. (2021) · Comprehensive physiology · doi:10.1002/j.2040-4603.2021.tb00159.x · Cited by 2

Protective Role of Plastoquinone in the Early Stages of Second-Degree Thermal Skin Burn

Pashkevich, N. I., Pykhova, E. S., Ашихмин, А. А., Vetoshkina, D. V., Стефанович, О. С., & Borisova‐Mubarakshina, M. M. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297925601297 · Cited by 2

Mitochondria‐Targeted Molecular Tools in Precise Tumor Therapy

Wang, X., Tang, Y., & Li, Q. (2025) · Angewandte Chemie · doi:10.1002/ange.202511230 · Cited by 2

Innate Immune Surveillance and Recognition of Epigenetic Marks

Wang, Y. (2025) · Epigenomes · doi:10.3390/epigenomes9030033 · Cited by 2

The chitosan nanoparticle-based adjuvant CH-100 orchestrates multifaceted innate immune activation via STING-dependent and -independent pathways

Nagai, E., Ori, D., Kano, N., Ikegawa, M., Kobiyama, K., Ishii, K. J., Kawasaki, T., & Kawai, T. (2025) · International Immunology · doi:10.1093/intimm/dxaf054 · Cited by 2

The development and emerging trends in Parkinson’s disease from the perspective of mitochondrial dysfunction: a bibliometric analysis using CiteSpace

Lu, Y., Chen, X., & Lai, Y. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13472-8 · Cited by 2

Association of peripheral blood mitochondrial DNA gene variation and methylation levels with rheumatoid arthritis

Huang, Q., Cai, X.-Q., Li, Z., Liu, Y., & Pan, H. (2025) · Clinical Immunology · doi:10.1016/j.clim.2025.110641 · Cited by 2

LncRNA-encoded peptide LRRC75A-AS1-ORF3 suppresses anti-tumor immunity in colorectal cancer through mitophagy-mediated attenuation of cGAS-STING signaling

Wu, Q., Li, Z., He, X., Yu, S., Zhang, M., Mo, H., He, S., Li, J., & Ni, W. (2025) · Carcinogenesis · doi:10.1093/carcin/bgaf092 · Cited by 2

Elevated circulating cell-free mitochondrial DNA in fabry disease: insights into inflammatory activation

Yuan, Y., Zhang, X., Zhao, Y., Wang, Y., Huang, J., Wang, Q., Song, X., Deng, J., Wang, Z., Yuan, Y., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1706045 · Cited by 2

CREG1 restricts ALV-J replication via the mitochondrial dysfunction–driven activation of innate immunity and apoptosis

Zhang, Q., Wang, M., Pan, M., Xia, J., Xu, T., Luo, W., & Zhang, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1760120 · Cited by 2

Knockout of the C4BPA Gene Promotes Mitophagy via Activation of the Pink1/Parkin Pathway and Alleviates the Inflammatory Response by Inhibiting the NF-κB Signalling Pathway in Bovine Mammary Epithelial Cells

Zhou, Y., Zhao, Z., Chen, X., Shao, W., Lu, Q., 陶秋燕, Xu, Q., Chen, R., Jiang, P., Lin, Z., et al. (2026) · Veterinary Sciences · doi:10.3390/vetsci13020151 · Cited by 2

P2X7R Signaling and Differential Regulation of Neuroinflammatory and Behavior Responses in Male and Female Mice During Chronic Ethanol Exposure

Togre, N. S., Bhoj, P. S., Mekala, N. K., Trivedi, J., Winfield, M., Hancock, R. E., Sriram, U., Rom, S., & Persidsky, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052332 · Cited by 2

Mitochondrial dysfunction in the bovine mammary gland: regulatory mechanisms and therapeutic strategies

Shen, T., Li, M., Sun, X., Deng, Z., Pitts, H., Nolan, D. T., Loor, J. J., & Xu, C. (2026) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-026-01361-7 · Cited by 2

Composite nanovesicles for enhanced chemodynamic cancer therapy via decitabine-mediated epigenetic reactivation

Zhao, X., & Qiu, L. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114849 · Cited by 2

The Bat Blueprint: Translating Mitochondrial Adaptations into Next-generation Therapeutics

An, K., Hwang, D., Park, S., Jung, D., Jeong, S.-H., Hyun-Seok, J. I. N., Kim, C., Ahn, K., Ahn, Y., & Hwang, Y.-K. (2026) · Journal of Experimental & Biomedical Sciences/Biomedical Science Letters · doi:10.15616/bsl.2026.32.1.1 · Cited by 2

Mitochondria at the heart of aging: structure, function, and failure

Marei, H. E. S. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08047-8 · Cited by 7

Drug-Induced Liver Injury: Mitochondrial Mechanisms, Biomarkers, and Emerging Therapeutic Strategies

Verma, B. K., Bhalgama, D., Thakur, P., & Banerjee, D. (2026) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6c00030 · Cited by 2

Mitophagy-mediated immune evasion: Shared strategies of pathogens

Li, J., Li, W., (34472), D. W., & Liu, Y. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104247 · Cited by 2

Immunometabolic reprogramming and mitochondrial dysfunction in acute respiratory distress syndrome: mechanisms, metabolic resilience, and therapeutic perspectives- a narrative review

Srinivas, T., Hanumaiah, G., Nagendra, D., Rao, S., Chaudhuri, S., Bhat, V. R., & Kamath, S. U. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08585-1 · Cited by 2

Mitochondrial dynamics and metabolic regulation in cellular inflammation: From mechanisms to precision therapeutics

Park, W. H. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109086 · Cited by 2

Anti-Inflammatory and Antioxidant Strategies in Epilepsy: From Molecular Mechanisms to Threshold Management

Трофимов, А. Н., Shcherbakova, K., Schwarz, A. P., Akbay, B., Karapina, O., Myrkhiyeva, Z., Shirokov, E., Kizatov, B., Zhukanov, K., Baktursyn, A., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156606 · Cited by 3

LC3-associated phagocytosis

Wong, S., Upadhyay, S., & Martinez, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820538-9.00005-3 · Cited by 2

Pathogenetic factors of ulcerative colitis: mainstream for 2020

Равильевна, Б. Г., Livzan, M. A., & Lozinskaya, M. Y. (2021) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2021-2-130-138 · Cited by 2

Epigallocatechin Gallate Prevents Burn Wound Progression Through Inhibiting Mitochondrial DNA-Induced Inflammation

Zou, X., Xiao, M., Zhang, B., & Li, B. (2021) · Indian Journal of Surgery · doi:10.1007/s12262-021-03101-9 · Cited by 2

Quantification of cytosolic DNA species by immunofluorescence microscopy and automated image analysis

Sato, A., Bloy, N., Galassi, C., Jiménez‐Cortegana, C., Klapp, V., Aretz, A., Guilbaud, E., Yamazaki, T., Petroni, G., Galluzzi, L., et al. (2022) · Methods in cell biology · doi:10.1016/bs.mcb.2022.05.004 · Cited by 2

Pathogenetic Mechanisms of Burn Pathology Associated with Oxidative Membrane Damage and Methods of their Correction

Vilyanen, D. V., Pashkevich, N. I., Borisova‐Mubarakshina, M. M., & Стефанович, О. С. (2023) · BIOPHYSICS · doi:10.1134/s0006350923010190 · Cited by 2

New perspectives on the role of mitochondria in Parkinson's disease

Yin, S., Zhang, Y., Wu, J., Song, R., Shen, M., Lai, X., & Yan, J. (2024) · Journal of Neurorestoratology · doi:10.1016/j.jnrt.2024.100112 · Cited by 2

Pseudotargeted metabolomics profiles potential damage-associated molecular patterns as machine learning predictors for acute pancreatitis

Cai, W.-L., Fang, C., Leng, H.-X., Zheng, J., Liu, L., Gong, G., & Xin, G.-Z. (2025) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2025.116874 · Cited by 2

Modulating mitochondria with natural extract compounds: from bench to clinical therapeutic opportunities for COPD

Wang, Q., Zeng, Z., Guo, L., Williams, K. E., Zhang, Y., Tang, H., Hu, H., Qin, G., Wang, K., & Wang, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1531302 · Cited by 2

Pathobiology of Pediatric Acute Respiratory Distress Syndrome

Smith, L. (2019) · Springer eBooks · doi:10.1007/978-3-030-21840-9_3 · Cited by 2

Unexpected link between mitochondrial DNA and T cell help in systemic lupus erythematosus

Pisetsky, D. S. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-215597 · Cited by 2

Circulating Mitochondrial DNA Is Associated With High Levels of Fatigue in Two Independent Sarcoidosis Cohorts

Fiorini, V., Hu, B., Sun, Y. S., Yu, S., McGovern, J., Gandhi, S., Woo, S., Turcotte-Foster, S. J., Pivarnik, T., Khan, Z., et al. (2023) · CHEST Journal · doi:10.1016/j.chest.2023.11.020 · Cited by 2

Impaired lysosomal acidification triggers iron deficiency, necrotic cell death and inflammation in vivoPreprint

Yambire, K. F., Rostosky, C. M., Watanabe, T., Pacheu‐Grau, D., Torres-Odio, S., Sanchez-Guerrero, A., Senderovich, O., Meyron‐Holtz, E. G., Milošević, I., Frahm, J., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/710798 · Cited by 2

Donor-derived mitochondrial DNA variant peptides elicit allo-specific immune response in transplant patientsPreprint

Marishta, A., Yang, Y., Hu, X., Jang, M. K., Cuttin, K., Jackson, A. M., Luikart, H. I., Deuse, T., Khush, K. K., Schrepfer, S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.04.134965 · Cited by 2

SARS-CoV-2 Viroporins Activate The NLRP3-Inflammasome Via The Mitochondrial Permeability Transition PorePreprint

Guarnieri, J. W., Angelin, A., Murdock, D. G., Portluri, P., Lie, T., & Wallace, D. C. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.19.481139 · Cited by 2

The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense PeptidePreprint

Rice, M. C., Kim, J., Imun, M., Jung, S., Park, C., Lai, R., Barr, C. R., Son, J., Tor, K., Kim, E., et al. (2023) · doi:10.7554/elife.87615.1 · Cited by 2

Nanodissection of Selected Viral Particles by Scanning Transmission Electron Microscopy/Focused Ion Beam for Genetic Identification

Horvitz, D., Milrot, E., Luria, N., Makdasi, E., Beth-Din, A., Glinert, I., Dombrovsky, A., & Laskar, O. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c01001 · Cited by 1

Mitochondrial Dysfunction-Triggered Innate Immune Response and Its Therapeutic Implications

He, Y., Shen, B., & Zhou, X. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1007130 · Cited by 2

Main active components of Sishen Wan may modulate T cells-related proinflammatory cytokines via alleviating mitochondrial damage caused by oxidative stress in dextran sulphate sodium-induced ulcerative colitis

Li, K., Lv, W., ZHANG, B., Han, S., Han, J., Zhang, Y. X., Wang, W., Zang, W., Yang, A., Wang, H., et al. (2025) · Chinese Journal of Analytical Chemistry · doi:10.1016/j.cjac.2025.100562 · Cited by 1

Therapeutic approaches to delay lung aging: understanding cellular and immune system changes in the older adults

Lin, Y., Yan, M., Shen, L., Wang, Y., He, H., Han, Z., Chen, H., & Liu, A. (2025) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaf149 · Cited by 1

Circulating Cell‐Free Mitochondrial DNA as a Prognostic Biomarker in Patients With HBV‐Related Acute‐on‐Chronic Liver Failure

Hu, Q., Han, J., Chen, C., Tao, S., Huang, C., Lin, J., Qi, X., Qian, Z., Lü, M., Li, X., et al. (2025) · Journal of Medical Virology · doi:10.1002/jmv.70551 · Cited by 1

Epigenetics of mitochondrial and inflammation in cardiac fibrosis

He, H., Lin, L.-C., Liu, Z., Liu, P., Mao, S., Cao, W., Zhao, J., & Tao, H. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112133 · Cited by 1

Dirty Ends: Formation, Repair, and Biological Relevance of Non-Canonical DNA Terminal Structures

Sothy, S., & Zhao, L. (2025) · Genes · doi:10.3390/genes16101188 · Cited by 1

Prevention of pressure natriuresis deterioration by dietary coenzyme Q10: Role of mitochondrial preservation in reduced renal mass and high-sodium diet

Porta, D. J., Pasqualini, M. E., Juncos, L. I., Domingo, C., Mukdsi, J. H., Rivoira, M. A., & Garcia, N. H. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110153 · Cited by 1

Psychological Science at the Cellular Level: Mitochondria’s Role in Health and Behavior

Fagundes, C. P., Wu‐Chung, E. L., & Heijnen, C. J. (2025) · Current Directions in Psychological Science · doi:10.1177/09637214251380214 · Cited by 1

Cytosolic TOP3α facilitates mitochondrial DNA sensing by cGAS

Cai, D., Chen, C., Meekrathok, P., Zeng, W., Wang, Z., Peng, Z., Mo, Y., Xu, X., Wang, J., & Qiu, J. (2025) · EMBO Reports · doi:10.1038/s44319-025-00614-2 · Cited by 1

Dynamic imbalance of autophagy: A molecular link between age-related hearing loss and cognitive dysfunction

Fang, H., Liu, S., Qiu, Y., Chang, L., Chen, Y., Enzha, S., Liu, H., Ye, Y., & Yin, Z. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112997 · Cited by 2

PUMA upregulation promotes the necroptosis of hepatocytes in trichloroethylene-sensitized mice via mtDNA-mediated ZBP1 pathway

Peng, X., Zhu, L., Wan, C., Dong, L., Yang, W., Zhu, Q., Xie, H., & Zhang, J. (2025) · Toxicology Letters · doi:10.1016/j.toxlet.2025.111807 · Cited by 1

Tmem110 regulates the conformation of TRPML1 to maintain endolysosomal homeostasis and prevent mitochondrial DNA leakage and pathological self-DNA processing

Feng, Z., Pan, Y., Zhou, J., Chu, L., Li, Q., Zhang, X., Wu, P., Xu, Z., Huang, Y., Zou, J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68382-8 · Cited by 1

Circulating cell-free mitochondrial DNA as a candidate marker of hyperinflammation and immune activation in pre-adolescents, adolescents and young adults with COVID-19 and comorbidities

Novo, G. B., dos Santos, E. H., Rodrigues, K. A., Barreira, G. A., Saippa, M. O., Cruz, M. C. P., Pereira, M. F. B., Marques, H. H. D. S., & Okay, T. S. (2026) · Revista do Instituto de Medicina Tropical de São Paulo · doi:10.1590/s1678-9946202668006 · Cited by 1

The mitochondrial intermembrane space nuclease Nuc1 (endonuclease G) prevents mitophagy-mediated mtDNA escape in yeast

Cupo, R. R., Domínguez‐Martín, E., & Youle, R. (2026) · Current Biology · doi:10.1016/j.cub.2026.01.006 · Cited by 2

The second mitochondrial activator of caspases (SMAC) regulates growth, inflammation and mitochondrial integrity in cancer cells

Amer, T., Haimovici, A., Kirschnek, S., Vier, J., Moeed, A., Ukachukwu, U., Neugebauer, D., Neubert, P., Helmstädter, M., Kayser, S., et al. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01667-z · Cited by 1

The cGAS-STING pathway at the crossroads of neuroimmunology: bridging innate immunity to aging and neurodegeneration

Wu, Z., Jia, R., Zhang, Q., Huang, L.-Y., Yan, J.-T., Zhang, Y. H., & Fan, Y. (2026) · Biomarker Research · doi:10.1186/s40364-026-00906-2 · Cited by 2

The bio-intelligence circuit: a hypothesis-generating systems framework linking mitochondrial stress, innate immune signaling, and autonomic regulation in chronic inflammation

Subramaniyan, P., & Parthiban, V. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1750974 · Cited by 1

Prasugrel inhibits TLR7-driven autoimmunity in systemic lupus erythematosus by acetylating cGAS

Guo, Z.-L., Sun, L.-M., Jiang, S., Zhao, M., Li, Y., Qian, J., Fu, Y., Wu, C., Yuan, Y., Xue, W., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70794-5 · Cited by 1

Mitochondrial DNA in inflammation and immunity

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Mitochondrial DNA release and sensing in innate immune responses

VanPortfliet, J. J., Chute, C., Lei, Y., Shutt, T. E., & West, A. P. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae031 · Cited by 70

Mitochondrial DNA: A Key Regulator of Anti-Microbial Innate Immunity

Kausar, S., Yang, L., Abbas, M. N., Hu, X., Zhao, Y., Zhu, Y., & Cui, H. (2020) · Genes · doi:10.3390/genes11010086 · Cited by 40

Mitochondrial DNA in the regulation of innate immune responses

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Advances in crosstalk among innate immune pathways activated by mitochondrial DNA

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