NODs: intracellular proteins involved in inflammation and apoptosis

Death Receptors: Signaling and Modulation

Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866

Toll-like receptors: critical proteins linking innate and acquired immunity

Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777

Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB

Inohara, N., Koseki, T., del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, J., Liu, D., Ni, J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.14560 · Cited by 742

The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1

Srinivasula, S. M., Poyet, J.-L., Razmara, M., Datta, P., Zhang, Z., & Alnemri, E. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200179200 · Cited by 573

Toll-like receptor signalling

Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312

Shared Principles in NF-κB Signaling

Hayden, M. S., & Ghosh, S. (2008) · Cell · doi:10.1016/j.cell.2008.01.020 · Cited by 4,494

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251

Interactions Between the Microbiota and the Immune System

Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173

Toll-like receptors in innate immunity

Takeda, K. (2004) · International Immunology · doi:10.1093/intimm/dxh186 · Cited by 3,328

The Inflammasomes: Guardians of the Body

Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436

Inflammatory bowel disease: cause and immunobiology

Baumgart, D. C., & Carding, S. R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60750-8 · Cited by 2,147

Tissue-resident macrophages

Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

Franchi, L., Eigenbrod, T., Muñoz-Planillo, R., & Nuñez, G. (2009) · Nature Immunology · doi:10.1038/ni.1703 · Cited by 1,834

Negative regulation of Toll-like receptor-mediated immune responses

Liew, F. Y., Xu, D., Brint, E. K., & O'Neill, L. A. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1630 · Cited by 1,509

Inflammatory and immune pathways in the pathogenesis of periodontal disease

Cekici, A., Kantarci, A., Hasturk, H., & Van Dyke, T. E. (2014) · Periodontology 2000 · doi:10.1111/prd.12002 · Cited by 1,415

Ubiquitin signalling in the NF-κB pathway

Chen, Z. J. (2005) · Nature Cell Biology · doi:10.1038/ncb0805-758 · Cited by 1,184

NF-κB and the immune response

Hayden, M. S., West, A. P., & Ghosh, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209943 · Cited by 1,178

Kupffer cells in the liver

Dixon, L. J., Barnes, M., Tang, H., Pritchard, M. T., & Nagy, L. E. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c120026 · Cited by 628

Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

Martinon, F., Agostini, L., Meylan, E., & Tschopp, J. (2004) · Current Biology · doi:10.1016/j.cub.2004.10.027 · Cited by 579

The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota

Liévin-Le Moal, V., & Servin, A. L. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.315-337.2006 · Cited by 568

Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria

Franchi, L., Kanneganti, T.-D., Dubyak, G. R., & Núñez, G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610762200 · Cited by 356

Bacterial Peptidoglycan Triggers Candida albicans Hyphal Growth by Directly Activating the Adenylyl Cyclase Cyr1p

Xu, X.-L., Lee, R. T. H., Fang, H.-M., Wang, Y.-M., Li, R., Zou, H., Zhu, Y., & Wang, Y. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.05.014 · Cited by 289

Macrophage and dendritic cell phenotypic diversity in the context of biomaterials

Kou, P. M., & Babensee, J. E. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32971 · Cited by 190

The Nuclear IκB Protein IκBNS Selectively Inhibits Lipopolysaccharide-Induced IL-6 Production in Macrophages of the Colonic Lamina Propria

Hirotani, T., Lee, P. Y., Kuwata, H., Yamamoto, M., Matsumoto, M., Kawase, I., Akira, S., & Takeda, K. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3650 · Cited by 167

TLRs: Professor Mechnikov, sit on your hat

O'Neill, L. A. J. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.10.005 · Cited by 140

Principles of inflammasome priming and inhibition: implications for psychiatric disorders

Herman, F. J., & Pasinetti, G. M. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.06.010 · Cited by 115

Intracellular survival of Shigella

Ogawa, M., & Sasakawa, C. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00652.x · Cited by 89

CARD15 variants in patients with sporadic Parkinson’s disease

Bialecka, M., Kurzawski, M., Klodowska-Duda, G., Opala, G., Juzwiak, S., Kurzawski, G., Tan, E.-K., & Drozdzik, M. (2007) · Neuroscience Research · doi:10.1016/j.neures.2006.11.012 · Cited by 79

Association of the NOD2 genotype with bacterial translocation via altered cell–cell contacts in Crohnʼs disease patients

Kosovac, K., Brenmoehl, J., Holler, E., Falk, W., Schoelmerich, J., Hausmann, M., & Rogler, G. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21223 · Cited by 43

The streptococcal Blr and Slr proteins define a family of surface proteins with leucine-rich repeats: camouflaging by other surface structures

Waldemarsson, J., Areschoug, T., Lindahl, G., & Johnsson, E. (2006) · Journal of Bacteriology · doi:10.1128/jb.188.2.378-388.2006 · Cited by 36

Nephrocan, a Novel Member of the Small Leucine-rich Repeat Protein Family, Is an Inhibitor of Transforming Growth Factor-β Signaling

Mochida, Y., Parisuthiman, D., Kaku, M., Hanai, J.-I., Sukhatme, V. P., & Yamauchi, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604787200 · Cited by 34

Quiescent Hepatic Stellate Cells Functionally Contribute to the Hepatic Innate Immune Response via TLR3

Wilson, C. L., Mann, J., Walsh, M., Perrugoria, M. J., Oakley, F., Wright, M. C., Brignole, C., Di Paolo, D., Perri, P., Ponzoni, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083391 · Cited by 31

Mortality from cirrhosis: lack of progress over the last 35 years

Gluud, C. (2005) · Gut · doi:10.1136/gut.2005.072876 · Cited by 17

Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells

Xiang, C., Chen, P., Zhang, Q., Li, Y., Pan, Y., Xie, W., Sun, J., & Liu, Z. (2021) · iScience · doi:10.1016/j.isci.2021.102849 · Cited by 15

Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression

Adcox, H. E., Hunt, J. R., Allen, P. E., Siff, T. E., Rodino, K. G., Ottens, A. K., & Carlyon, J. A. (2024) · Nature Communications · doi:10.1038/s41467-024-52119-6 · Cited by 13

Innovative Vaccine Strategy: Self-Adjuvanting Conjugate Vaccines

Manabe, Y., & Fukase, K. (2023) · Methods in Molecular Biology · doi:10.1007/978-1-0716-2910-9_5 · Cited by 5